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Protein

Calcitonin receptor

Gene

Calcr

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

This is a receptor for calcitonin. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. The calcitonin receptor is thought to couple to the heterotrimeric guanosine triphosphate-binding protein that is sensitive to cholera toxin.

GO - Molecular functioni

  • calcitonin binding Source: RGD
  • calcitonin receptor activity Source: RGD

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Calcitonin receptor
Short name:
CT-R
Alternative name(s):
C1A/C1B
Gene namesi
Name:Calcr
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi621001. Calcr.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini25 – 153ExtracellularSequence analysisAdd BLAST129
Transmembranei154 – 173Helical; Name=1Sequence analysisAdd BLAST20
Topological domaini174 – 180CytoplasmicSequence analysis7
Transmembranei181 – 200Helical; Name=2Sequence analysisAdd BLAST20
Topological domaini201 – 257ExtracellularSequence analysisAdd BLAST57
Transmembranei258 – 280Helical; Name=3Sequence analysisAdd BLAST23
Topological domaini281 – 297CytoplasmicSequence analysisAdd BLAST17
Transmembranei298 – 317Helical; Name=4Sequence analysisAdd BLAST20
Topological domaini318 – 333ExtracellularSequence analysisAdd BLAST16
Transmembranei334 – 357Helical; Name=5Sequence analysisAdd BLAST24
Topological domaini358 – 380CytoplasmicSequence analysisAdd BLAST23
Transmembranei381 – 398Helical; Name=6Sequence analysisAdd BLAST18
Topological domaini399 – 410ExtracellularSequence analysisAdd BLAST12
Transmembranei411 – 432Helical; Name=7Sequence analysisAdd BLAST22
Topological domaini433 – 516CytoplasmicSequence analysisAdd BLAST84

GO - Cellular componenti

  • axon Source: RGD
  • integral component of membrane Source: UniProtKB-KW
  • neuronal cell body Source: RGD
  • neuron projection Source: RGD
  • plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL2204.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 24Sequence analysisAdd BLAST24
ChainiPRO_000001281025 – 516Calcitonin receptorAdd BLAST492

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi28N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi55 ↔ 81By similarity
Disulfide bondi72 ↔ 112By similarity
Glycosylationi73N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi95 ↔ 134By similarity
Glycosylationi125N-linked (GlcNAc...)Sequence analysis1
Glycosylationi130N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP32214.
PRIDEiP32214.

PTM databases

PhosphoSitePlusiP32214.

Expressioni

Gene expression databases

BgeeiENSRNOG00000010053.
GenevisibleiP32214. RN.

Interactioni

Subunit structurei

Interacts with GPRASP2.By similarity

Protein-protein interaction databases

BioGridi250474. 1 interactor.
STRINGi10116.ENSRNOP00000013910.

Chemistry databases

BindingDBiP32214.

Structurei

3D structure databases

ProteinModelPortaliP32214.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4564. Eukaryota.
ENOG410XRS2. LUCA.
HOGENOMiHOG000230695.
HOVERGENiHBG102129.
InParanoidiP32214.
KOiK04576.
OrthoDBiEOG091G027C.
PhylomeDBiP32214.

Family and domain databases

InterProiIPR003287. GCPR_2_calcitonin_rcpt_fam.
IPR017981. GPCR_2-like.
IPR001688. GPCR_2_calcitonin_rcpt.
IPR001879. GPCR_2_extracellular_dom.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
[Graphical view]
PfamiPF00002. 7tm_2. 1 hit.
PF02793. HRM. 1 hit.
[Graphical view]
PRINTSiPR00361. CALCITONINR.
PR01350. CTRFAMILY.
PR00249. GPCRSECRETIN.
SMARTiSM00008. HormR. 1 hit.
[Graphical view]
PROSITEiPS00649. G_PROTEIN_RECEP_F2_1. 1 hit.
PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform B (identifier: P32214-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRFLLLNRFT LLLLLLVSPT PVLQAPTNLT DSGLDQEPFL YLVGRKKLLD
60 70 80 90 100
AQYKCYDRIQ QLPPYEGEGP YCNRTWDGWM CWDDTPAGVM SYQHCPDYFP
110 120 130 140 150
DFDPTEKVSK YCDENGEWFR HPDSNRTWSN YTLCNAFTPD KLHNAYVLYY
160 170 180 190 200
LALVGHSMSI AALIASMGIF LFFKNLSCQR VTLHKNMFLT YILNSIIIII
210 220 230 240 250
HLVEVVPNGD LVRRDPMHIF HHNTYMWTMQ WELSPPLPLS AHEGKMDPHD
260 270 280 290 300
SEVISCKILH FFHQYMMACN YFWMLCEGIY LHTLIVMAVF TEDQRLRWYY
310 320 330 340 350
LLGWGFPIVP TIIHAITRAV YYNDNCWLST ETHLLYIIHG PVMAALVVNF
360 370 380 390 400
FFLLNIVRVL VTKMRQTHEA EAYMYLKAVK ATMVLVPLLG IQFVVFPWRP
410 420 430 440 450
SNKVLGKIYD YLMHSLIHFQ GFFVATIYCF CNHEVQVTLK RQWAQFKIQW
460 470 480 490 500
SHRWGRRRRP TNRVVSAPRA VAFAEPGGLP IYICHQEPRN PPVSNNEGEE
510
GTEMIPMNVI QQDSSA
Length:516
Mass (Da):60,292
Last modified:October 1, 1993 - v1
Checksum:i9B057B860E574378
GO
Isoform A (identifier: P32214-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     217-253: Missing.

Show »
Length:479
Mass (Da):55,879
Checksum:i03EE4D1A7F2266A8
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti148L → S in AAA03031 (PubMed:8395656).Curated1
Sequence conflicti148L → S in AAA03030 (PubMed:8395656).Curated1
Sequence conflicti459Missing in AAA03031 (PubMed:8395656).Curated1
Sequence conflicti459Missing in AAA03030 (PubMed:8395656).Curated1
Sequence conflicti479L → R in AAA03031 (PubMed:8395656).Curated1
Sequence conflicti479L → R in AAA03030 (PubMed:8395656).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_001995217 – 253Missing in isoform A. CuratedAdd BLAST37

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L14618 mRNA. Translation: AAA65965.1.
L14617 mRNA. Translation: AAA65964.1.
L13040 mRNA. Translation: AAA03031.1.
L13041 mRNA. Translation: AAA03030.1.
PIRiA37430.
I60800.
S33746.
RefSeqiNP_001029187.1. NM_001034015.1.
NP_446268.2. NM_053816.2.
UniGeneiRn.10062.

Genome annotation databases

GeneIDi116506.
KEGGirno:116506.
UCSCiRGD:621001. rat. [P32214-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L14618 mRNA. Translation: AAA65965.1.
L14617 mRNA. Translation: AAA65964.1.
L13040 mRNA. Translation: AAA03031.1.
L13041 mRNA. Translation: AAA03030.1.
PIRiA37430.
I60800.
S33746.
RefSeqiNP_001029187.1. NM_001034015.1.
NP_446268.2. NM_053816.2.
UniGeneiRn.10062.

3D structure databases

ProteinModelPortaliP32214.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi250474. 1 interactor.
STRINGi10116.ENSRNOP00000013910.

Chemistry databases

BindingDBiP32214.
ChEMBLiCHEMBL2204.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSitePlusiP32214.

Proteomic databases

PaxDbiP32214.
PRIDEiP32214.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi116506.
KEGGirno:116506.
UCSCiRGD:621001. rat. [P32214-1]

Organism-specific databases

CTDi799.
RGDi621001. Calcr.

Phylogenomic databases

eggNOGiKOG4564. Eukaryota.
ENOG410XRS2. LUCA.
HOGENOMiHOG000230695.
HOVERGENiHBG102129.
InParanoidiP32214.
KOiK04576.
OrthoDBiEOG091G027C.
PhylomeDBiP32214.

Miscellaneous databases

PROiP32214.

Gene expression databases

BgeeiENSRNOG00000010053.
GenevisibleiP32214. RN.

Family and domain databases

InterProiIPR003287. GCPR_2_calcitonin_rcpt_fam.
IPR017981. GPCR_2-like.
IPR001688. GPCR_2_calcitonin_rcpt.
IPR001879. GPCR_2_extracellular_dom.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
[Graphical view]
PfamiPF00002. 7tm_2. 1 hit.
PF02793. HRM. 1 hit.
[Graphical view]
PRINTSiPR00361. CALCITONINR.
PR01350. CTRFAMILY.
PR00249. GPCRSECRETIN.
SMARTiSM00008. HormR. 1 hit.
[Graphical view]
PROSITEiPS00649. G_PROTEIN_RECEP_F2_1. 1 hit.
PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCALCR_RAT
AccessioniPrimary (citable) accession number: P32214
Secondary accession number(s): P32213
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: November 2, 2016
This is version 138 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.