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P32214

- CALCR_RAT

UniProt

P32214 - CALCR_RAT

Protein

Calcitonin receptor

Gene

Calcr

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 121 (01 Oct 2014)
      Sequence version 1 (01 Oct 1993)
      Previous versions | rss
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    Functioni

    This is a receptor for calcitonin. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. The calcitonin receptor is thought to couple to the heterotrimeric guanosine triphosphate-binding protein that is sensitive to cholera toxin.

    GO - Molecular functioni

    1. calcitonin binding Source: RGD
    2. calcitonin receptor activity Source: RGD

    GO - Biological processi

    1. adenylate cyclase-activating G-protein coupled receptor signaling pathway Source: Ensembl
    2. adenylate cyclase-modulating G-protein coupled receptor signaling pathway Source: RGD
    3. negative regulation of ossification Source: Ensembl
    4. osteoclast differentiation Source: Ensembl
    5. positive regulation of cytosolic calcium ion concentration Source: Ensembl
    6. regulation of mRNA stability Source: Ensembl

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Calcitonin receptor
    Short name:
    CT-R
    Alternative name(s):
    C1A/C1B
    Gene namesi
    Name:Calcr
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 4

    Organism-specific databases

    RGDi621001. Calcr.

    Subcellular locationi

    GO - Cellular componenti

    1. acrosomal vesicle Source: Ensembl
    2. axon Source: RGD
    3. cilium Source: Ensembl
    4. integral component of membrane Source: UniProtKB-KW
    5. neuronal cell body Source: RGD
    6. neuron projection Source: RGD
    7. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2424Sequence AnalysisAdd
    BLAST
    Chaini25 – 516492Calcitonin receptorPRO_0000012810Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi28 – 281N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi55 ↔ 81By similarity
    Disulfide bondi72 ↔ 112By similarity
    Glycosylationi73 – 731N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi95 ↔ 134By similarity
    Glycosylationi125 – 1251N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi130 – 1301N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiP32214.
    PRIDEiP32214.

    PTM databases

    PhosphoSiteiP32214.

    Expressioni

    Gene expression databases

    GenevestigatoriP32214.

    Interactioni

    Subunit structurei

    Interacts with GPRASP2.By similarity

    Protein-protein interaction databases

    BioGridi250474. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliP32214.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini25 – 153129ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini174 – 1807CytoplasmicSequence Analysis
    Topological domaini201 – 25757ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini281 – 29717CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini318 – 33316ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini358 – 38023CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini399 – 41012ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini433 – 51684CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei154 – 17320Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei181 – 20020Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei258 – 28023Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei298 – 31720Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei334 – 35724Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei381 – 39818Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei411 – 43222Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG255868.
    GeneTreeiENSGT00750000117654.
    HOGENOMiHOG000230695.
    HOVERGENiHBG102129.
    InParanoidiP32214.
    KOiK04576.
    OMAiTHEAESY.
    OrthoDBiEOG712TW2.
    PhylomeDBiP32214.

    Family and domain databases

    InterProiIPR003287. GCPR_2_calcitonin_rcpt_fam.
    IPR017981. GPCR_2-like.
    IPR001688. GPCR_2_calcitonin_rcpt.
    IPR001879. GPCR_2_extracellular_dom.
    IPR000832. GPCR_2_secretin-like.
    IPR017983. GPCR_2_secretin-like_CS.
    [Graphical view]
    PfamiPF00002. 7tm_2. 1 hit.
    PF02793. HRM. 1 hit.
    [Graphical view]
    PRINTSiPR00361. CALCITONINR.
    PR01350. CTRFAMILY.
    PR00249. GPCRSECRETIN.
    SMARTiSM00008. HormR. 1 hit.
    [Graphical view]
    PROSITEiPS00649. G_PROTEIN_RECEP_F2_1. 1 hit.
    PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
    PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
    PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform B (identifier: P32214-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MRFLLLNRFT LLLLLLVSPT PVLQAPTNLT DSGLDQEPFL YLVGRKKLLD    50
    AQYKCYDRIQ QLPPYEGEGP YCNRTWDGWM CWDDTPAGVM SYQHCPDYFP 100
    DFDPTEKVSK YCDENGEWFR HPDSNRTWSN YTLCNAFTPD KLHNAYVLYY 150
    LALVGHSMSI AALIASMGIF LFFKNLSCQR VTLHKNMFLT YILNSIIIII 200
    HLVEVVPNGD LVRRDPMHIF HHNTYMWTMQ WELSPPLPLS AHEGKMDPHD 250
    SEVISCKILH FFHQYMMACN YFWMLCEGIY LHTLIVMAVF TEDQRLRWYY 300
    LLGWGFPIVP TIIHAITRAV YYNDNCWLST ETHLLYIIHG PVMAALVVNF 350
    FFLLNIVRVL VTKMRQTHEA EAYMYLKAVK ATMVLVPLLG IQFVVFPWRP 400
    SNKVLGKIYD YLMHSLIHFQ GFFVATIYCF CNHEVQVTLK RQWAQFKIQW 450
    SHRWGRRRRP TNRVVSAPRA VAFAEPGGLP IYICHQEPRN PPVSNNEGEE 500
    GTEMIPMNVI QQDSSA 516
    Length:516
    Mass (Da):60,292
    Last modified:October 1, 1993 - v1
    Checksum:i9B057B860E574378
    GO
    Isoform A (identifier: P32214-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         217-253: Missing.

    Show »
    Length:479
    Mass (Da):55,879
    Checksum:i03EE4D1A7F2266A8
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti148 – 1481L → S in AAA03031. (PubMed:8395656)Curated
    Sequence conflicti148 – 1481L → S in AAA03030. (PubMed:8395656)Curated
    Sequence conflicti459 – 4591Missing in AAA03031. (PubMed:8395656)Curated
    Sequence conflicti459 – 4591Missing in AAA03030. (PubMed:8395656)Curated
    Sequence conflicti479 – 4791L → R in AAA03031. (PubMed:8395656)Curated
    Sequence conflicti479 – 4791L → R in AAA03030. (PubMed:8395656)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei217 – 25337Missing in isoform A. CuratedVSP_001995Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L14618 mRNA. Translation: AAA65965.1.
    L14617 mRNA. Translation: AAA65964.1.
    L13040 mRNA. Translation: AAA03031.1.
    L13041 mRNA. Translation: AAA03030.1.
    PIRiA37430.
    I60800.
    S33746.
    RefSeqiNP_001029187.1. NM_001034015.1.
    NP_446268.2. NM_053816.2.
    UniGeneiRn.10062.

    Genome annotation databases

    EnsembliENSRNOT00000013910; ENSRNOP00000013910; ENSRNOG00000010053. [P32214-1]
    ENSRNOT00000013937; ENSRNOP00000013937; ENSRNOG00000010053. [P32214-2]
    GeneIDi116506.
    KEGGirno:116506.
    UCSCiRGD:621001. rat. [P32214-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L14618 mRNA. Translation: AAA65965.1 .
    L14617 mRNA. Translation: AAA65964.1 .
    L13040 mRNA. Translation: AAA03031.1 .
    L13041 mRNA. Translation: AAA03030.1 .
    PIRi A37430.
    I60800.
    S33746.
    RefSeqi NP_001029187.1. NM_001034015.1.
    NP_446268.2. NM_053816.2.
    UniGenei Rn.10062.

    3D structure databases

    ProteinModelPortali P32214.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 250474. 1 interaction.

    Chemistry

    BindingDBi P32214.
    ChEMBLi CHEMBL2107837.
    GuidetoPHARMACOLOGYi 43.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei P32214.

    Proteomic databases

    PaxDbi P32214.
    PRIDEi P32214.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000013910 ; ENSRNOP00000013910 ; ENSRNOG00000010053 . [P32214-1 ]
    ENSRNOT00000013937 ; ENSRNOP00000013937 ; ENSRNOG00000010053 . [P32214-2 ]
    GeneIDi 116506.
    KEGGi rno:116506.
    UCSCi RGD:621001. rat. [P32214-1 ]

    Organism-specific databases

    CTDi 799.
    RGDi 621001. Calcr.

    Phylogenomic databases

    eggNOGi NOG255868.
    GeneTreei ENSGT00750000117654.
    HOGENOMi HOG000230695.
    HOVERGENi HBG102129.
    InParanoidi P32214.
    KOi K04576.
    OMAi THEAESY.
    OrthoDBi EOG712TW2.
    PhylomeDBi P32214.

    Miscellaneous databases

    NextBioi 619119.
    PROi P32214.

    Gene expression databases

    Genevestigatori P32214.

    Family and domain databases

    InterProi IPR003287. GCPR_2_calcitonin_rcpt_fam.
    IPR017981. GPCR_2-like.
    IPR001688. GPCR_2_calcitonin_rcpt.
    IPR001879. GPCR_2_extracellular_dom.
    IPR000832. GPCR_2_secretin-like.
    IPR017983. GPCR_2_secretin-like_CS.
    [Graphical view ]
    Pfami PF00002. 7tm_2. 1 hit.
    PF02793. HRM. 1 hit.
    [Graphical view ]
    PRINTSi PR00361. CALCITONINR.
    PR01350. CTRFAMILY.
    PR00249. GPCRSECRETIN.
    SMARTi SM00008. HormR. 1 hit.
    [Graphical view ]
    PROSITEi PS00649. G_PROTEIN_RECEP_F2_1. 1 hit.
    PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
    PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
    PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning of two receptors from rat brain with high affinity for salmon calcitonin."
      Albrandt K.G., Mull E., Brady E.M., Herich J., Moore C.X., Beaumont K.
      FEBS Lett. 325:225-232(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Wistar.
      Tissue: Brain.
    2. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Brain.

    Entry informationi

    Entry nameiCALCR_RAT
    AccessioniPrimary (citable) accession number: P32214
    Secondary accession number(s): P32213
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1993
    Last sequence update: October 1, 1993
    Last modified: October 1, 2014
    This is version 121 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3