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P32214

- CALCR_RAT

UniProt

P32214 - CALCR_RAT

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Protein

Calcitonin receptor

Gene
Calcr
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

This is a receptor for calcitonin. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. The calcitonin receptor is thought to couple to the heterotrimeric guanosine triphosphate-binding protein that is sensitive to cholera toxin.

GO - Molecular functioni

  1. calcitonin binding Source: RGD
  2. calcitonin receptor activity Source: RGD

GO - Biological processi

  1. adenylate cyclase-activating G-protein coupled receptor signaling pathway Source: Ensembl
  2. adenylate cyclase-modulating G-protein coupled receptor signaling pathway Source: RGD
  3. negative regulation of ossification Source: Ensembl
  4. osteoclast differentiation Source: Ensembl
  5. positive regulation of cytosolic calcium ion concentration Source: Ensembl
  6. regulation of mRNA stability Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Calcitonin receptor
Short name:
CT-R
Alternative name(s):
C1A/C1B
Gene namesi
Name:Calcr
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 4

Organism-specific databases

RGDi621001. Calcr.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini25 – 153129Extracellular Reviewed predictionAdd
BLAST
Transmembranei154 – 17320Helical; Name=1; Reviewed predictionAdd
BLAST
Topological domaini174 – 1807Cytoplasmic Reviewed prediction
Transmembranei181 – 20020Helical; Name=2; Reviewed predictionAdd
BLAST
Topological domaini201 – 25757Extracellular Reviewed predictionAdd
BLAST
Transmembranei258 – 28023Helical; Name=3; Reviewed predictionAdd
BLAST
Topological domaini281 – 29717Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei298 – 31720Helical; Name=4; Reviewed predictionAdd
BLAST
Topological domaini318 – 33316Extracellular Reviewed predictionAdd
BLAST
Transmembranei334 – 35724Helical; Name=5; Reviewed predictionAdd
BLAST
Topological domaini358 – 38023Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei381 – 39818Helical; Name=6; Reviewed predictionAdd
BLAST
Topological domaini399 – 41012Extracellular Reviewed predictionAdd
BLAST
Transmembranei411 – 43222Helical; Name=7; Reviewed predictionAdd
BLAST
Topological domaini433 – 51684Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. acrosomal vesicle Source: Ensembl
  2. axon Source: RGD
  3. cilium Source: Ensembl
  4. integral component of membrane Source: UniProtKB-KW
  5. neuronal cell body Source: RGD
  6. neuron projection Source: RGD
  7. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424 Reviewed predictionAdd
BLAST
Chaini25 – 516492Calcitonin receptorPRO_0000012810Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi28 – 281N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi55 ↔ 81 By similarity
Disulfide bondi72 ↔ 112 By similarity
Glycosylationi73 – 731N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi95 ↔ 134 By similarity
Glycosylationi125 – 1251N-linked (GlcNAc...) Reviewed prediction
Glycosylationi130 – 1301N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP32214.
PRIDEiP32214.

PTM databases

PhosphoSiteiP32214.

Expressioni

Gene expression databases

GenevestigatoriP32214.

Interactioni

Subunit structurei

Interacts with GPRASP2 By similarity.

Protein-protein interaction databases

BioGridi250474. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliP32214.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG255868.
GeneTreeiENSGT00750000117654.
HOGENOMiHOG000230695.
HOVERGENiHBG102129.
InParanoidiP32214.
KOiK04576.
OMAiTHEAESY.
OrthoDBiEOG712TW2.
PhylomeDBiP32214.

Family and domain databases

InterProiIPR003287. GCPR_2_calcitonin_rcpt_fam.
IPR017981. GPCR_2-like.
IPR001688. GPCR_2_calcitonin_rcpt.
IPR001879. GPCR_2_extracellular_dom.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
[Graphical view]
PfamiPF00002. 7tm_2. 1 hit.
PF02793. HRM. 1 hit.
[Graphical view]
PRINTSiPR00361. CALCITONINR.
PR01350. CTRFAMILY.
PR00249. GPCRSECRETIN.
SMARTiSM00008. HormR. 1 hit.
[Graphical view]
PROSITEiPS00649. G_PROTEIN_RECEP_F2_1. 1 hit.
PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform B (identifier: P32214-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MRFLLLNRFT LLLLLLVSPT PVLQAPTNLT DSGLDQEPFL YLVGRKKLLD    50
AQYKCYDRIQ QLPPYEGEGP YCNRTWDGWM CWDDTPAGVM SYQHCPDYFP 100
DFDPTEKVSK YCDENGEWFR HPDSNRTWSN YTLCNAFTPD KLHNAYVLYY 150
LALVGHSMSI AALIASMGIF LFFKNLSCQR VTLHKNMFLT YILNSIIIII 200
HLVEVVPNGD LVRRDPMHIF HHNTYMWTMQ WELSPPLPLS AHEGKMDPHD 250
SEVISCKILH FFHQYMMACN YFWMLCEGIY LHTLIVMAVF TEDQRLRWYY 300
LLGWGFPIVP TIIHAITRAV YYNDNCWLST ETHLLYIIHG PVMAALVVNF 350
FFLLNIVRVL VTKMRQTHEA EAYMYLKAVK ATMVLVPLLG IQFVVFPWRP 400
SNKVLGKIYD YLMHSLIHFQ GFFVATIYCF CNHEVQVTLK RQWAQFKIQW 450
SHRWGRRRRP TNRVVSAPRA VAFAEPGGLP IYICHQEPRN PPVSNNEGEE 500
GTEMIPMNVI QQDSSA 516
Length:516
Mass (Da):60,292
Last modified:October 1, 1993 - v1
Checksum:i9B057B860E574378
GO
Isoform A (identifier: P32214-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     217-253: Missing.

Show »
Length:479
Mass (Da):55,879
Checksum:i03EE4D1A7F2266A8
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei217 – 25337Missing in isoform A. VSP_001995Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti148 – 1481L → S in AAA03031. 1 Publication
Sequence conflicti148 – 1481L → S in AAA03030. 1 Publication
Sequence conflicti459 – 4591Missing in AAA03031. 1 Publication
Sequence conflicti459 – 4591Missing in AAA03030. 1 Publication
Sequence conflicti479 – 4791L → R in AAA03031. 1 Publication
Sequence conflicti479 – 4791L → R in AAA03030. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L14618 mRNA. Translation: AAA65965.1.
L14617 mRNA. Translation: AAA65964.1.
L13040 mRNA. Translation: AAA03031.1.
L13041 mRNA. Translation: AAA03030.1.
PIRiA37430.
I60800.
S33746.
RefSeqiNP_001029187.1. NM_001034015.1.
NP_446268.2. NM_053816.2.
UniGeneiRn.10062.

Genome annotation databases

EnsembliENSRNOT00000013910; ENSRNOP00000013910; ENSRNOG00000010053. [P32214-1]
ENSRNOT00000013937; ENSRNOP00000013937; ENSRNOG00000010053. [P32214-2]
GeneIDi116506.
KEGGirno:116506.
UCSCiRGD:621001. rat. [P32214-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L14618 mRNA. Translation: AAA65965.1 .
L14617 mRNA. Translation: AAA65964.1 .
L13040 mRNA. Translation: AAA03031.1 .
L13041 mRNA. Translation: AAA03030.1 .
PIRi A37430.
I60800.
S33746.
RefSeqi NP_001029187.1. NM_001034015.1.
NP_446268.2. NM_053816.2.
UniGenei Rn.10062.

3D structure databases

ProteinModelPortali P32214.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 250474. 1 interaction.

Chemistry

BindingDBi P32214.
ChEMBLi CHEMBL2107837.
GuidetoPHARMACOLOGYi 43.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei P32214.

Proteomic databases

PaxDbi P32214.
PRIDEi P32214.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000013910 ; ENSRNOP00000013910 ; ENSRNOG00000010053 . [P32214-1 ]
ENSRNOT00000013937 ; ENSRNOP00000013937 ; ENSRNOG00000010053 . [P32214-2 ]
GeneIDi 116506.
KEGGi rno:116506.
UCSCi RGD:621001. rat. [P32214-1 ]

Organism-specific databases

CTDi 799.
RGDi 621001. Calcr.

Phylogenomic databases

eggNOGi NOG255868.
GeneTreei ENSGT00750000117654.
HOGENOMi HOG000230695.
HOVERGENi HBG102129.
InParanoidi P32214.
KOi K04576.
OMAi THEAESY.
OrthoDBi EOG712TW2.
PhylomeDBi P32214.

Miscellaneous databases

NextBioi 619119.
PROi P32214.

Gene expression databases

Genevestigatori P32214.

Family and domain databases

InterProi IPR003287. GCPR_2_calcitonin_rcpt_fam.
IPR017981. GPCR_2-like.
IPR001688. GPCR_2_calcitonin_rcpt.
IPR001879. GPCR_2_extracellular_dom.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
[Graphical view ]
Pfami PF00002. 7tm_2. 1 hit.
PF02793. HRM. 1 hit.
[Graphical view ]
PRINTSi PR00361. CALCITONINR.
PR01350. CTRFAMILY.
PR00249. GPCRSECRETIN.
SMARTi SM00008. HormR. 1 hit.
[Graphical view ]
PROSITEi PS00649. G_PROTEIN_RECEP_F2_1. 1 hit.
PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular cloning of two receptors from rat brain with high affinity for salmon calcitonin."
    Albrandt K.G., Mull E., Brady E.M., Herich J., Moore C.X., Beaumont K.
    FEBS Lett. 325:225-232(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Wistar.
    Tissue: Brain.
  2. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiCALCR_RAT
AccessioniPrimary (citable) accession number: P32214
Secondary accession number(s): P32213
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: September 3, 2014
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi