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P32214

- CALCR_RAT

UniProt

P32214 - CALCR_RAT

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Protein

Calcitonin receptor

Gene

Calcr

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

This is a receptor for calcitonin. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. The calcitonin receptor is thought to couple to the heterotrimeric guanosine triphosphate-binding protein that is sensitive to cholera toxin.

GO - Molecular functioni

  1. calcitonin binding Source: RGD
  2. calcitonin receptor activity Source: RGD

GO - Biological processi

  1. adenylate cyclase-activating G-protein coupled receptor signaling pathway Source: Ensembl
  2. adenylate cyclase-modulating G-protein coupled receptor signaling pathway Source: RGD
  3. negative regulation of ossification Source: Ensembl
  4. osteoclast differentiation Source: Ensembl
  5. positive regulation of cytosolic calcium ion concentration Source: Ensembl
  6. regulation of mRNA stability Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Recommended name:
Calcitonin receptor
Short name:
CT-R
Alternative name(s):
C1A/C1B
Gene namesi
Name:Calcr
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 4

Organism-specific databases

RGDi621001. Calcr.

Subcellular locationi

GO - Cellular componenti

  1. acrosomal vesicle Source: Ensembl
  2. axon Source: RGD
  3. cilium Source: Ensembl
  4. integral component of membrane Source: UniProtKB-KW
  5. neuronal cell body Source: RGD
  6. neuron projection Source: RGD
  7. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424Sequence AnalysisAdd
BLAST
Chaini25 – 516492Calcitonin receptorPRO_0000012810Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi28 – 281N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi55 ↔ 81By similarity
Disulfide bondi72 ↔ 112By similarity
Glycosylationi73 – 731N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi95 ↔ 134By similarity
Glycosylationi125 – 1251N-linked (GlcNAc...)Sequence Analysis
Glycosylationi130 – 1301N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP32214.
PRIDEiP32214.

PTM databases

PhosphoSiteiP32214.

Expressioni

Gene expression databases

GenevestigatoriP32214.

Interactioni

Subunit structurei

Interacts with GPRASP2.By similarity

Protein-protein interaction databases

BioGridi250474. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliP32214.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini25 – 153129ExtracellularSequence AnalysisAdd
BLAST
Topological domaini174 – 1807CytoplasmicSequence Analysis
Topological domaini201 – 25757ExtracellularSequence AnalysisAdd
BLAST
Topological domaini281 – 29717CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini318 – 33316ExtracellularSequence AnalysisAdd
BLAST
Topological domaini358 – 38023CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini399 – 41012ExtracellularSequence AnalysisAdd
BLAST
Topological domaini433 – 51684CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei154 – 17320Helical; Name=1Sequence AnalysisAdd
BLAST
Transmembranei181 – 20020Helical; Name=2Sequence AnalysisAdd
BLAST
Transmembranei258 – 28023Helical; Name=3Sequence AnalysisAdd
BLAST
Transmembranei298 – 31720Helical; Name=4Sequence AnalysisAdd
BLAST
Transmembranei334 – 35724Helical; Name=5Sequence AnalysisAdd
BLAST
Transmembranei381 – 39818Helical; Name=6Sequence AnalysisAdd
BLAST
Transmembranei411 – 43222Helical; Name=7Sequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG255868.
GeneTreeiENSGT00760000118800.
HOGENOMiHOG000230695.
HOVERGENiHBG102129.
InParanoidiP32214.
KOiK04576.
OMAiTHEAESY.
OrthoDBiEOG712TW2.
PhylomeDBiP32214.

Family and domain databases

InterProiIPR003287. GCPR_2_calcitonin_rcpt_fam.
IPR017981. GPCR_2-like.
IPR001688. GPCR_2_calcitonin_rcpt.
IPR001879. GPCR_2_extracellular_dom.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
[Graphical view]
PfamiPF00002. 7tm_2. 1 hit.
PF02793. HRM. 1 hit.
[Graphical view]
PRINTSiPR00361. CALCITONINR.
PR01350. CTRFAMILY.
PR00249. GPCRSECRETIN.
SMARTiSM00008. HormR. 1 hit.
[Graphical view]
PROSITEiPS00649. G_PROTEIN_RECEP_F2_1. 1 hit.
PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform B (identifier: P32214-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRFLLLNRFT LLLLLLVSPT PVLQAPTNLT DSGLDQEPFL YLVGRKKLLD
60 70 80 90 100
AQYKCYDRIQ QLPPYEGEGP YCNRTWDGWM CWDDTPAGVM SYQHCPDYFP
110 120 130 140 150
DFDPTEKVSK YCDENGEWFR HPDSNRTWSN YTLCNAFTPD KLHNAYVLYY
160 170 180 190 200
LALVGHSMSI AALIASMGIF LFFKNLSCQR VTLHKNMFLT YILNSIIIII
210 220 230 240 250
HLVEVVPNGD LVRRDPMHIF HHNTYMWTMQ WELSPPLPLS AHEGKMDPHD
260 270 280 290 300
SEVISCKILH FFHQYMMACN YFWMLCEGIY LHTLIVMAVF TEDQRLRWYY
310 320 330 340 350
LLGWGFPIVP TIIHAITRAV YYNDNCWLST ETHLLYIIHG PVMAALVVNF
360 370 380 390 400
FFLLNIVRVL VTKMRQTHEA EAYMYLKAVK ATMVLVPLLG IQFVVFPWRP
410 420 430 440 450
SNKVLGKIYD YLMHSLIHFQ GFFVATIYCF CNHEVQVTLK RQWAQFKIQW
460 470 480 490 500
SHRWGRRRRP TNRVVSAPRA VAFAEPGGLP IYICHQEPRN PPVSNNEGEE
510
GTEMIPMNVI QQDSSA
Length:516
Mass (Da):60,292
Last modified:October 1, 1993 - v1
Checksum:i9B057B860E574378
GO
Isoform A (identifier: P32214-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     217-253: Missing.

Show »
Length:479
Mass (Da):55,879
Checksum:i03EE4D1A7F2266A8
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti148 – 1481L → S in AAA03031. (PubMed:8395656)Curated
Sequence conflicti148 – 1481L → S in AAA03030. (PubMed:8395656)Curated
Sequence conflicti459 – 4591Missing in AAA03031. (PubMed:8395656)Curated
Sequence conflicti459 – 4591Missing in AAA03030. (PubMed:8395656)Curated
Sequence conflicti479 – 4791L → R in AAA03031. (PubMed:8395656)Curated
Sequence conflicti479 – 4791L → R in AAA03030. (PubMed:8395656)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei217 – 25337Missing in isoform A. CuratedVSP_001995Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L14618 mRNA. Translation: AAA65965.1.
L14617 mRNA. Translation: AAA65964.1.
L13040 mRNA. Translation: AAA03031.1.
L13041 mRNA. Translation: AAA03030.1.
PIRiA37430.
I60800.
S33746.
RefSeqiNP_001029187.1. NM_001034015.1.
NP_446268.2. NM_053816.2.
UniGeneiRn.10062.

Genome annotation databases

EnsembliENSRNOT00000013910; ENSRNOP00000013910; ENSRNOG00000010053. [P32214-1]
ENSRNOT00000013937; ENSRNOP00000013937; ENSRNOG00000010053. [P32214-2]
GeneIDi116506.
KEGGirno:116506.
UCSCiRGD:621001. rat. [P32214-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L14618 mRNA. Translation: AAA65965.1 .
L14617 mRNA. Translation: AAA65964.1 .
L13040 mRNA. Translation: AAA03031.1 .
L13041 mRNA. Translation: AAA03030.1 .
PIRi A37430.
I60800.
S33746.
RefSeqi NP_001029187.1. NM_001034015.1.
NP_446268.2. NM_053816.2.
UniGenei Rn.10062.

3D structure databases

ProteinModelPortali P32214.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 250474. 1 interaction.

Chemistry

BindingDBi P32214.
ChEMBLi CHEMBL2109231.
GuidetoPHARMACOLOGYi 43.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei P32214.

Proteomic databases

PaxDbi P32214.
PRIDEi P32214.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000013910 ; ENSRNOP00000013910 ; ENSRNOG00000010053 . [P32214-1 ]
ENSRNOT00000013937 ; ENSRNOP00000013937 ; ENSRNOG00000010053 . [P32214-2 ]
GeneIDi 116506.
KEGGi rno:116506.
UCSCi RGD:621001. rat. [P32214-1 ]

Organism-specific databases

CTDi 799.
RGDi 621001. Calcr.

Phylogenomic databases

eggNOGi NOG255868.
GeneTreei ENSGT00760000118800.
HOGENOMi HOG000230695.
HOVERGENi HBG102129.
InParanoidi P32214.
KOi K04576.
OMAi THEAESY.
OrthoDBi EOG712TW2.
PhylomeDBi P32214.

Miscellaneous databases

NextBioi 619119.
PROi P32214.

Gene expression databases

Genevestigatori P32214.

Family and domain databases

InterProi IPR003287. GCPR_2_calcitonin_rcpt_fam.
IPR017981. GPCR_2-like.
IPR001688. GPCR_2_calcitonin_rcpt.
IPR001879. GPCR_2_extracellular_dom.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
[Graphical view ]
Pfami PF00002. 7tm_2. 1 hit.
PF02793. HRM. 1 hit.
[Graphical view ]
PRINTSi PR00361. CALCITONINR.
PR01350. CTRFAMILY.
PR00249. GPCRSECRETIN.
SMARTi SM00008. HormR. 1 hit.
[Graphical view ]
PROSITEi PS00649. G_PROTEIN_RECEP_F2_1. 1 hit.
PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular cloning of two receptors from rat brain with high affinity for salmon calcitonin."
    Albrandt K.G., Mull E., Brady E.M., Herich J., Moore C.X., Beaumont K.
    FEBS Lett. 325:225-232(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Wistar.
    Tissue: Brain.
  2. Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiCALCR_RAT
AccessioniPrimary (citable) accession number: P32214
Secondary accession number(s): P32213
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: October 29, 2014
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3