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P32209 (RIR2_SWPVK) Reviewed, UniProtKB/Swiss-Prot

Last modified December 11, 2013. Version 78. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Ribonucleoside-diphosphate reductase small chain

EC=1.17.4.1
Alternative name(s):
Ribonucleotide reductase small subunit
Gene names
ORF Names:C14L
OrganismSwinepox virus (strain Kasza) (SWPV)
Taxonomic identifier10277 [NCBI]
Taxonomic lineageVirusesdsDNA viruses, no RNA stagePoxviridaeChordopoxvirinaeSuipoxvirus
Virus hostSus scrofa (Pig) [TaxID: 9823]

Protein attributes

Sequence length274 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Ribonucleoside-diphosphate reductase holoenzyme provides the precursors necessary for viral DNA synthesis. Allows virus growth in non-dividing cells. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides By similarity.

Catalytic activity

2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin.

Cofactor

Binds 2 iron ions per subunit By similarity.

Pathway

Genetic information processing; DNA replication.

Subunit structure

Heterodimer of a large and a small chain.

Sequence similarities

Belongs to the ribonucleoside diphosphate reductase small chain family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 274274Ribonucleoside-diphosphate reductase small chain
PRO_0000190500

Sites

Active site1081 By similarity
Metal binding701Iron 1 By similarity
Metal binding1011Iron 1 By similarity
Metal binding1011Iron 2 By similarity
Metal binding1041Iron 1 By similarity
Metal binding1631Iron 2 By similarity
Metal binding1971Iron 2 By similarity
Metal binding2001Iron 2 By similarity

Sequences

Sequence LengthMass (Da)Tools
P32209 [UniParc].

Last modified October 1, 1993. Version 1.
Checksum: F6F1A309EC75F411

FASTA27431,753
        10         20         30         40         50         60 
MEPILQESDS RFVIFPIKYH DIWKMYKQSV ASFWTVEEVD LSKDLDDWDK LTKDEKYFIK 

        70         80         90        100        110        120 
HILAFFASSD GIVNENLAER FYVDVQCSEA RCFYGFQIAM ENIHSEMYSL LIDTYVRDNI 

       130        140        150        160        170        180 
EKMHLFNAIE TMECVKKKAD WARKWISSNK VYGERVVAFA AVEGIFFSGS FAAIFWIKKR 

       190        200        210        220        230        240 
GLMPGLTFSN ELISRDEGLH CDFACLMFKH LLHPPSKEVI TSIIIDAVNI EKEFLTVAIP 

       250        260        270 
VDLIGMNCCL MSQYIEFVAD RLLTELGCEK SQCI 

« Hide

References

[1]"DNA sequence analysis of conserved and unique regions of swinepox virus: identification of genetic elements supporting phenotypic observations including a novel G protein-coupled receptor homologue."
Massung R.F., Jayarama V., Moyer R.W.
Virology 197:511-528(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
L22013 Unassigned RNA. Translation: AAC37857.1.

3D structure databases

ProteinModelPortalP32209.
SMRP32209. Positions 2-270.
ModBaseSearch...
MobiDBSearch...

Proteomic databases

PRIDEP32209.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayUPA00326.

Family and domain databases

Gene3D1.10.620.20. 1 hit.
InterProIPR009078. Ferritin-like_SF.
IPR012348. RNR-rel.
IPR000358. RNR_small.
[Graphical view]
PANTHERPTHR23409. PTHR23409. 1 hit.
PfamPF00268. Ribonuc_red_sm. 1 hit.
[Graphical view]
SUPFAMSSF47240. SSF47240. 1 hit.
PROSITEPS00368. RIBORED_SMALL. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameRIR2_SWPVK
AccessionPrimary (citable) accession number: P32209
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: December 11, 2013
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways