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P32209

- RIR2_SWPVK

UniProt

P32209 - RIR2_SWPVK

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Protein
Ribonucleoside-diphosphate reductase small chain
Gene
C14L
Organism
Swinepox virus (strain Kasza) (SWPV)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Ribonucleoside-diphosphate reductase holoenzyme provides the precursors necessary for viral DNA synthesis. Allows virus growth in non-dividing cells. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides By similarity.

Catalytic activityi

2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin.

Cofactori

Binds 2 iron ions per subunit By similarity.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi70 – 701Iron 1 By similarity
Metal bindingi101 – 1011Iron 1 By similarity
Metal bindingi101 – 1011Iron 2 By similarity
Metal bindingi104 – 1041Iron 1 By similarity
Active sitei108 – 1081 By similarity
Metal bindingi163 – 1631Iron 2 By similarity
Metal bindingi197 – 1971Iron 2 By similarity
Metal bindingi200 – 2001Iron 2 By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor Source: UniProtKB-EC

GO - Biological processi

  1. DNA replication Source: UniProtKB-UniPathway
  2. deoxyribonucleoside diphosphate metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

DNA replication

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00326.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonucleoside-diphosphate reductase small chain (EC:1.17.4.1)
Alternative name(s):
Ribonucleotide reductase small subunit
Gene namesi
ORF Names:C14L
OrganismiSwinepox virus (strain Kasza) (SWPV)
Taxonomic identifieri10277 [NCBI]
Taxonomic lineageiVirusesdsDNA viruses, no RNA stagePoxviridaeChordopoxvirinaeSuipoxvirus
Virus hostiSus scrofa (Pig) [TaxID: 9823]

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 274274Ribonucleoside-diphosphate reductase small chain
PRO_0000190500Add
BLAST

Proteomic databases

PRIDEiP32209.

Interactioni

Subunit structurei

Heterodimer of a large and a small chain.

Structurei

3D structure databases

ProteinModelPortaliP32209.
SMRiP32209. Positions 2-270.

Family & Domainsi

Sequence similaritiesi

Family and domain databases

Gene3Di1.10.620.20. 1 hit.
InterProiIPR009078. Ferritin-like_SF.
IPR012348. RNR-rel.
IPR000358. RNR_small.
[Graphical view]
PANTHERiPTHR23409. PTHR23409. 1 hit.
PfamiPF00268. Ribonuc_red_sm. 1 hit.
[Graphical view]
SUPFAMiSSF47240. SSF47240. 1 hit.
PROSITEiPS00368. RIBORED_SMALL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P32209-1 [UniParc]FASTAAdd to Basket

« Hide

MEPILQESDS RFVIFPIKYH DIWKMYKQSV ASFWTVEEVD LSKDLDDWDK    50
LTKDEKYFIK HILAFFASSD GIVNENLAER FYVDVQCSEA RCFYGFQIAM 100
ENIHSEMYSL LIDTYVRDNI EKMHLFNAIE TMECVKKKAD WARKWISSNK 150
VYGERVVAFA AVEGIFFSGS FAAIFWIKKR GLMPGLTFSN ELISRDEGLH 200
CDFACLMFKH LLHPPSKEVI TSIIIDAVNI EKEFLTVAIP VDLIGMNCCL 250
MSQYIEFVAD RLLTELGCEK SQCI 274
Length:274
Mass (Da):31,753
Last modified:October 1, 1993 - v1
Checksum:iF6F1A309EC75F411
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L22013 Unassigned RNA. Translation: AAC37857.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L22013 Unassigned RNA. Translation: AAC37857.1 .

3D structure databases

ProteinModelPortali P32209.
SMRi P32209. Positions 2-270.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PRIDEi P32209.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Enzyme and pathway databases

UniPathwayi UPA00326 .

Family and domain databases

Gene3Di 1.10.620.20. 1 hit.
InterProi IPR009078. Ferritin-like_SF.
IPR012348. RNR-rel.
IPR000358. RNR_small.
[Graphical view ]
PANTHERi PTHR23409. PTHR23409. 1 hit.
Pfami PF00268. Ribonuc_red_sm. 1 hit.
[Graphical view ]
SUPFAMi SSF47240. SSF47240. 1 hit.
PROSITEi PS00368. RIBORED_SMALL. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "DNA sequence analysis of conserved and unique regions of swinepox virus: identification of genetic elements supporting phenotypic observations including a novel G protein-coupled receptor homologue."
    Massung R.F., Jayarama V., Moyer R.W.
    Virology 197:511-528(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.

Entry informationi

Entry nameiRIR2_SWPVK
AccessioniPrimary (citable) accession number: P32209
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: December 11, 2013
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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