P32208
DUT_SWPVK
Deoxyuridine 5'-triphosphate nucleotidohydrolase
dUTPase
3.6.1.23
dUTP pyrophosphatase
DUT
C11L
Swinepox virus (strain Kasza)
SWPV
Viruses
Varidnaviria
Bamfordvirae
Nucleocytoviricota
Pokkesviricetes
Chitovirales
Poxviridae
Chordopoxvirinae
Suipoxvirus
Swinepox virus
Sus scrofa
Pig
DNA sequence analysis of conserved and unique regions of swinepox virus: identification of genetic elements supporting phenotypic observations including a novel G protein-coupled receptor homologue.
NUCLEOTIDE SEQUENCE [GENOMIC DNA]
This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA.
dUTP + H2O = diphosphate + dUMP + H(+)
Mg(2+)
Belongs to the dUTPase family.
Was originally thought to be a protease-like protein (pseudoprotease).
Hydrolase
Magnesium
Metal-binding
Nucleotide metabolism
MSLYVKCVKLSNNAIIPNRSMSGSAGYDLYSAYSYTVKPYNRILVRTDICLMIPDKCYGRISPRSGLSLNYNIDIGGGVIDSDYRGEIGIVFINNGCSDFNIKVGDRIAQIIFERVEYPIMEEVKCLEDTERGNSGFGSSGM
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