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P32196

- PG3_PIG

UniProt

P32196 - PG3_PIG

Protein

Protegrin-3

Gene

NPG3

Organism
Sus scrofa (Pig)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Microbicidal activity. Active against E.coli, Listeria monocytogenes and C.albicans, in vitro.

    GO - Biological processi

    1. defense response to bacterium Source: UniProtKB-KW

    Keywords - Molecular functioni

    Antibiotic, Antimicrobial

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protegrin-3
    Short name:
    PG-3
    Gene namesi
    Name:NPG3
    OrganismiSus scrofa (Pig)
    Taxonomic identifieri9823 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
    ProteomesiUP000008227: Unplaced

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular region Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2929Sequence AnalysisAdd
    BLAST
    Propeptidei30 – 1301011 PublicationPRO_0000004748Add
    BLAST
    Peptidei131 – 14818Protegrin-3PRO_0000004749Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi85 ↔ 96
    Disulfide bondi107 ↔ 124
    Disulfide bondi136 ↔ 145By similarity
    Disulfide bondi138 ↔ 143By similarity
    Modified residuei148 – 1481Arginine amide

    Keywords - PTMi

    Amidation, Disulfide bond

    Structurei

    Secondary structure

    1
    149
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi32 – 4817
    Beta strandi51 – 6010
    Beta strandi74 – 8815
    Helixi93 – 953
    Beta strandi104 – 1118
    Beta strandi121 – 1266

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1KWIX-ray2.19A30-130[»]
    1LXEX-ray2.50A30-130[»]
    1PFPX-ray2.30A30-130[»]
    ProteinModelPortaliP32196.
    SMRiP32196. Positions 30-130.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP32196.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cathelicidin family.Curated

    Keywords - Domaini

    Signal

    Phylogenomic databases

    HOVERGENiHBG006116.

    Family and domain databases

    InterProiIPR001894. Cathelicidin.
    IPR018216. Cathelicidin_CS.
    [Graphical view]
    PANTHERiPTHR10206. PTHR10206. 1 hit.
    PfamiPF00666. Cathelicidins. 1 hit.
    [Graphical view]
    ProDomiPD001838. Cathelicidin. 1 hit.
    [Graphical view] [Entries sharing at least one domain]
    PROSITEiPS00946. CATHELICIDINS_1. 1 hit.
    PS00947. CATHELICIDINS_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P32196-1 [UniParc]FASTAAdd to Basket

    « Hide

    METQRASLCL GRWSLWLLLL ALVVPSASAQ ALSYREAVLR AVDRLNEQSS    50
    EANLYRLLEL DQPPKADEDP GTPKPVSFTV KETVCPRPTR QPPELCDFKE 100
    NGRVKQCVGT VTLDQIKDPL DITCNEVQGV RGGGLCYCRR RFCVCVGRG 149
    Length:149
    Mass (Da):16,578
    Last modified:October 1, 1996 - v2
    Checksum:i6F4BA98429CD6ED4
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X83267 mRNA. Translation: CAA58240.1.
    X84095 Genomic DNA. Translation: CAA58891.1.
    PIRiS66285. A53895.
    RefSeqiNP_001116622.1. NM_001123150.1.
    UniGeneiSsc.420.

    Genome annotation databases

    GeneIDi100144484.
    KEGGissc:100144484.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X83267 mRNA. Translation: CAA58240.1 .
    X84095 Genomic DNA. Translation: CAA58891.1 .
    PIRi S66285. A53895.
    RefSeqi NP_001116622.1. NM_001123150.1.
    UniGenei Ssc.420.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1KWI X-ray 2.19 A 30-130 [» ]
    1LXE X-ray 2.50 A 30-130 [» ]
    1PFP X-ray 2.30 A 30-130 [» ]
    ProteinModelPortali P32196.
    SMRi P32196. Positions 30-130.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 100144484.
    KEGGi ssc:100144484.

    Organism-specific databases

    CTDi 100144484.

    Phylogenomic databases

    HOVERGENi HBG006116.

    Miscellaneous databases

    EvolutionaryTracei P32196.

    Family and domain databases

    InterProi IPR001894. Cathelicidin.
    IPR018216. Cathelicidin_CS.
    [Graphical view ]
    PANTHERi PTHR10206. PTHR10206. 1 hit.
    Pfami PF00666. Cathelicidins. 1 hit.
    [Graphical view ]
    ProDomi PD001838. Cathelicidin. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    PROSITEi PS00946. CATHELICIDINS_1. 1 hit.
    PS00947. CATHELICIDINS_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of a new member of the protegrin family by cDNA cloning."
      Zhao C., Liu L., Lehrer R.I.
      FEBS Lett. 346:285-288(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Bone marrow.
    2. "The structure of porcine protegrin genes."
      Zhao C., Ganz T., Lehrer R.I.
      FEBS Lett. 368:197-202(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: Red Duroc.
    3. "Protegrins: leukocyte antimicrobial peptides that combine features of corticostatic defensins and tachyplesins."
      Kokryakov V.N., Harwig S.S.L., Panyutich E.A., Shevchenko A.A., Aleshina G.M., Shamova O.V., Korneva H.A., Lehrer R.I.
      FEBS Lett. 327:231-236(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 131-148.
      Tissue: Leukocyte.
    4. "Structure of the cathelicidin motif of protegrin-3 precursor: structural insights into the activation mechanism of an antimicrobial protein."
      Sanchez J.F., Hoh F., Strub M.-P., Aumelas A., Dumas C.
      Structure 10:1363-1370(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.19 ANGSTROMS) OF 30-130, DISULFIDE BONDS.
    5. "Selenomethionine and selenocysteine double labeling strategy for crystallographic phasing."
      Strub M.-P., Hoh F., Sanchez J.F., Strub J.-M., Bock A., Aumelas A., Dumas C.
      Structure 11:1359-1367(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS) OF 30-130, DISULFIDE BONDS.

    Entry informationi

    Entry nameiPG3_PIG
    AccessioniPrimary (citable) accession number: P32196
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1993
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 78 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3