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P32196

- PG3_PIG

UniProt

P32196 - PG3_PIG

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Protein

Protegrin-3

Gene

NPG3

Organism
Sus scrofa (Pig)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Microbicidal activity. Active against E.coli, Listeria monocytogenes and C.albicans, in vitro.

GO - Biological processi

  1. defense response to bacterium Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Antibiotic, Antimicrobial

Names & Taxonomyi

Protein namesi
Recommended name:
Protegrin-3
Short name:
PG-3
Gene namesi
Name:NPG3
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
ProteomesiUP000008227: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2929Sequence AnalysisAdd
BLAST
Propeptidei30 – 1301011 PublicationPRO_0000004748Add
BLAST
Peptidei131 – 14818Protegrin-3PRO_0000004749Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi85 ↔ 96
Disulfide bondi107 ↔ 124
Disulfide bondi136 ↔ 145By similarity
Disulfide bondi138 ↔ 143By similarity
Modified residuei148 – 1481Arginine amide

Keywords - PTMi

Amidation, Disulfide bond

Structurei

Secondary structure

1
149
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi32 – 4817
Beta strandi51 – 6010
Beta strandi74 – 8815
Helixi93 – 953
Beta strandi104 – 1118
Beta strandi121 – 1266

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1KWIX-ray2.19A30-130[»]
1LXEX-ray2.50A30-130[»]
1PFPX-ray2.30A30-130[»]
ProteinModelPortaliP32196.
SMRiP32196. Positions 30-130.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP32196.

Family & Domainsi

Sequence similaritiesi

Belongs to the cathelicidin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

HOVERGENiHBG006116.
InParanoidiP32196.

Family and domain databases

InterProiIPR001894. Cathelicidin.
IPR018216. Cathelicidin_CS.
[Graphical view]
PANTHERiPTHR10206. PTHR10206. 1 hit.
PfamiPF00666. Cathelicidins. 1 hit.
[Graphical view]
ProDomiPD001838. Cathelicidin. 1 hit.
[Graphical view] [Entries sharing at least one domain]
PROSITEiPS00946. CATHELICIDINS_1. 1 hit.
PS00947. CATHELICIDINS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P32196-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
METQRASLCL GRWSLWLLLL ALVVPSASAQ ALSYREAVLR AVDRLNEQSS
60 70 80 90 100
EANLYRLLEL DQPPKADEDP GTPKPVSFTV KETVCPRPTR QPPELCDFKE
110 120 130 140
NGRVKQCVGT VTLDQIKDPL DITCNEVQGV RGGGLCYCRR RFCVCVGRG
Length:149
Mass (Da):16,578
Last modified:October 1, 1996 - v2
Checksum:i6F4BA98429CD6ED4
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X83267 mRNA. Translation: CAA58240.1.
X84095 Genomic DNA. Translation: CAA58891.1.
PIRiS66285. A53895.
RefSeqiNP_001116622.1. NM_001123150.1.
UniGeneiSsc.420.

Genome annotation databases

GeneIDi100144484.
KEGGissc:100144484.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X83267 mRNA. Translation: CAA58240.1 .
X84095 Genomic DNA. Translation: CAA58891.1 .
PIRi S66285. A53895.
RefSeqi NP_001116622.1. NM_001123150.1.
UniGenei Ssc.420.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1KWI X-ray 2.19 A 30-130 [» ]
1LXE X-ray 2.50 A 30-130 [» ]
1PFP X-ray 2.30 A 30-130 [» ]
ProteinModelPortali P32196.
SMRi P32196. Positions 30-130.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 100144484.
KEGGi ssc:100144484.

Organism-specific databases

CTDi 100144484.

Phylogenomic databases

HOVERGENi HBG006116.
InParanoidi P32196.

Miscellaneous databases

EvolutionaryTracei P32196.

Family and domain databases

InterProi IPR001894. Cathelicidin.
IPR018216. Cathelicidin_CS.
[Graphical view ]
PANTHERi PTHR10206. PTHR10206. 1 hit.
Pfami PF00666. Cathelicidins. 1 hit.
[Graphical view ]
ProDomi PD001838. Cathelicidin. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
PROSITEi PS00946. CATHELICIDINS_1. 1 hit.
PS00947. CATHELICIDINS_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Identification of a new member of the protegrin family by cDNA cloning."
    Zhao C., Liu L., Lehrer R.I.
    FEBS Lett. 346:285-288(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Bone marrow.
  2. "The structure of porcine protegrin genes."
    Zhao C., Ganz T., Lehrer R.I.
    FEBS Lett. 368:197-202(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: Red Duroc.
  3. "Protegrins: leukocyte antimicrobial peptides that combine features of corticostatic defensins and tachyplesins."
    Kokryakov V.N., Harwig S.S.L., Panyutich E.A., Shevchenko A.A., Aleshina G.M., Shamova O.V., Korneva H.A., Lehrer R.I.
    FEBS Lett. 327:231-236(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 131-148.
    Tissue: Leukocyte.
  4. "Structure of the cathelicidin motif of protegrin-3 precursor: structural insights into the activation mechanism of an antimicrobial protein."
    Sanchez J.F., Hoh F., Strub M.-P., Aumelas A., Dumas C.
    Structure 10:1363-1370(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.19 ANGSTROMS) OF 30-130, DISULFIDE BONDS.
  5. "Selenomethionine and selenocysteine double labeling strategy for crystallographic phasing."
    Strub M.-P., Hoh F., Sanchez J.F., Strub J.-M., Bock A., Aumelas A., Dumas C.
    Structure 11:1359-1367(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS) OF 30-130, DISULFIDE BONDS.

Entry informationi

Entry nameiPG3_PIG
AccessioniPrimary (citable) accession number: P32196
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1996
Last modified: October 29, 2014
This is version 79 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3