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P32196

- PG3_PIG

UniProt

P32196 - PG3_PIG

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Protein
Protegrin-3
Gene
NPG3
Organism
Sus scrofa (Pig)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Microbicidal activity. Active against E.coli, Listeria monocytogenes and C.albicans, in vitro.

GO - Biological processi

  1. defense response to bacterium Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Antibiotic, Antimicrobial

Names & Taxonomyi

Protein namesi
Recommended name:
Protegrin-3
Short name:
PG-3
Gene namesi
Name:NPG3
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
ProteomesiUP000008227: Unplaced

Subcellular locationi

GO - Cellular componenti

  1. extracellular region Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2929 Reviewed prediction
Add
BLAST
Propeptidei30 – 130101
PRO_0000004748Add
BLAST
Peptidei131 – 14818Protegrin-31 Publication
PRO_0000004749Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi85 ↔ 962 Publications
Disulfide bondi107 ↔ 1242 Publications
Disulfide bondi136 ↔ 145 By similarity
Disulfide bondi138 ↔ 143 By similarity
Modified residuei148 – 1481Arginine amide

Keywords - PTMi

Amidation, Disulfide bond

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi32 – 4817
Beta strandi51 – 6010
Beta strandi74 – 8815
Helixi93 – 953
Beta strandi104 – 1118
Beta strandi121 – 1266

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1KWIX-ray2.19A30-130[»]
1LXEX-ray2.50A30-130[»]
1PFPX-ray2.30A30-130[»]
ProteinModelPortaliP32196.
SMRiP32196. Positions 30-130.

Miscellaneous databases

EvolutionaryTraceiP32196.

Family & Domainsi

Sequence similaritiesi

Belongs to the cathelicidin family.

Keywords - Domaini

Signal

Phylogenomic databases

HOVERGENiHBG006116.

Family and domain databases

InterProiIPR001894. Cathelicidin.
IPR018216. Cathelicidin_CS.
[Graphical view]
PANTHERiPTHR10206. PTHR10206. 1 hit.
PfamiPF00666. Cathelicidins. 1 hit.
[Graphical view]
ProDomiPD001838. Cathelicidin. 1 hit.
[Graphical view] [Entries sharing at least one domain]
PROSITEiPS00946. CATHELICIDINS_1. 1 hit.
PS00947. CATHELICIDINS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P32196-1 [UniParc]FASTAAdd to Basket

« Hide

METQRASLCL GRWSLWLLLL ALVVPSASAQ ALSYREAVLR AVDRLNEQSS    50
EANLYRLLEL DQPPKADEDP GTPKPVSFTV KETVCPRPTR QPPELCDFKE 100
NGRVKQCVGT VTLDQIKDPL DITCNEVQGV RGGGLCYCRR RFCVCVGRG 149
Length:149
Mass (Da):16,578
Last modified:October 1, 1996 - v2
Checksum:i6F4BA98429CD6ED4
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X83267 mRNA. Translation: CAA58240.1.
X84095 Genomic DNA. Translation: CAA58891.1.
PIRiS66285. A53895.
RefSeqiNP_001116622.1. NM_001123150.1.
UniGeneiSsc.420.

Genome annotation databases

GeneIDi100144484.
KEGGissc:100144484.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X83267 mRNA. Translation: CAA58240.1 .
X84095 Genomic DNA. Translation: CAA58891.1 .
PIRi S66285. A53895.
RefSeqi NP_001116622.1. NM_001123150.1.
UniGenei Ssc.420.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1KWI X-ray 2.19 A 30-130 [» ]
1LXE X-ray 2.50 A 30-130 [» ]
1PFP X-ray 2.30 A 30-130 [» ]
ProteinModelPortali P32196.
SMRi P32196. Positions 30-130.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 100144484.
KEGGi ssc:100144484.

Organism-specific databases

CTDi 100144484.

Phylogenomic databases

HOVERGENi HBG006116.

Miscellaneous databases

EvolutionaryTracei P32196.

Family and domain databases

InterProi IPR001894. Cathelicidin.
IPR018216. Cathelicidin_CS.
[Graphical view ]
PANTHERi PTHR10206. PTHR10206. 1 hit.
Pfami PF00666. Cathelicidins. 1 hit.
[Graphical view ]
ProDomi PD001838. Cathelicidin. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
PROSITEi PS00946. CATHELICIDINS_1. 1 hit.
PS00947. CATHELICIDINS_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Identification of a new member of the protegrin family by cDNA cloning."
    Zhao C., Liu L., Lehrer R.I.
    FEBS Lett. 346:285-288(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Bone marrow.
  2. "The structure of porcine protegrin genes."
    Zhao C., Ganz T., Lehrer R.I.
    FEBS Lett. 368:197-202(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: Red Duroc.
  3. "Protegrins: leukocyte antimicrobial peptides that combine features of corticostatic defensins and tachyplesins."
    Kokryakov V.N., Harwig S.S.L., Panyutich E.A., Shevchenko A.A., Aleshina G.M., Shamova O.V., Korneva H.A., Lehrer R.I.
    FEBS Lett. 327:231-236(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 131-148.
    Tissue: Leukocyte.
  4. "Structure of the cathelicidin motif of protegrin-3 precursor: structural insights into the activation mechanism of an antimicrobial protein."
    Sanchez J.F., Hoh F., Strub M.-P., Aumelas A., Dumas C.
    Structure 10:1363-1370(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.19 ANGSTROMS) OF 30-130, DISULFIDE BONDS.
  5. "Selenomethionine and selenocysteine double labeling strategy for crystallographic phasing."
    Strub M.-P., Hoh F., Sanchez J.F., Strub J.-M., Bock A., Aumelas A., Dumas C.
    Structure 11:1359-1367(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS) OF 30-130, DISULFIDE BONDS.

Entry informationi

Entry nameiPG3_PIG
AccessioniPrimary (citable) accession number: P32196
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1996
Last modified: July 24, 2013
This is version 77 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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