Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Protegrin-3

Gene

NPG3

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Microbicidal activity. Active against E.coli, Listeria monocytogenes and C.albicans, in vitro.

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Antibiotic, Antimicrobial

Names & Taxonomyi

Protein namesi
Recommended name:
Protegrin-3
Short name:
PG-3
Gene namesi
Name:NPG3
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 29Sequence analysisAdd BLAST29
PropeptideiPRO_000000474830 – 1301 PublicationAdd BLAST101
PeptideiPRO_0000004749131 – 148Protegrin-3Add BLAST18

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi85 ↔ 96
Disulfide bondi107 ↔ 124
Disulfide bondi136 ↔ 145By similarity
Disulfide bondi138 ↔ 143By similarity
Modified residuei148Arginine amide1

Keywords - PTMi

Amidation, Disulfide bond

Proteomic databases

PaxDbiP32196.
PeptideAtlasiP32196.
PRIDEiP32196.

Interactioni

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000027630.

Structurei

Secondary structure

1149
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi32 – 48Combined sources17
Beta strandi51 – 60Combined sources10
Beta strandi74 – 88Combined sources15
Helixi93 – 95Combined sources3
Beta strandi104 – 111Combined sources8
Beta strandi121 – 126Combined sources6
Beta strandi135 – 139Combined sources5
Beta strandi142 – 147Combined sources6

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1KWIX-ray2.19A30-130[»]
1LXEX-ray2.50A30-130[»]
1PFPX-ray2.30A30-130[»]
2MZ6NMR-A/B131-148[»]
ProteinModelPortaliP32196.
SMRiP32196.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP32196.

Family & Domainsi

Sequence similaritiesi

Belongs to the cathelicidin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J18R. Eukaryota.
ENOG41119S0. LUCA.
HOVERGENiHBG006116.
InParanoidiP32196.

Family and domain databases

InterProiIPR001894. Cathelicidin.
IPR018216. Cathelicidin_CS.
[Graphical view]
PANTHERiPTHR10206. PTHR10206. 1 hit.
PROSITEiPS00946. CATHELICIDINS_1. 1 hit.
PS00947. CATHELICIDINS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P32196-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
METQRASLCL GRWSLWLLLL ALVVPSASAQ ALSYREAVLR AVDRLNEQSS
60 70 80 90 100
EANLYRLLEL DQPPKADEDP GTPKPVSFTV KETVCPRPTR QPPELCDFKE
110 120 130 140
NGRVKQCVGT VTLDQIKDPL DITCNEVQGV RGGGLCYCRR RFCVCVGRG
Length:149
Mass (Da):16,578
Last modified:October 1, 1996 - v2
Checksum:i6F4BA98429CD6ED4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X83267 mRNA. Translation: CAA58240.1.
X84095 Genomic DNA. Translation: CAA58891.1.
PIRiS66285. A53895.
RefSeqiNP_001116622.1. NM_001123150.1.
UniGeneiSsc.420.

Genome annotation databases

GeneIDi100144484.
KEGGissc:100144484.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X83267 mRNA. Translation: CAA58240.1.
X84095 Genomic DNA. Translation: CAA58891.1.
PIRiS66285. A53895.
RefSeqiNP_001116622.1. NM_001123150.1.
UniGeneiSsc.420.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1KWIX-ray2.19A30-130[»]
1LXEX-ray2.50A30-130[»]
1PFPX-ray2.30A30-130[»]
2MZ6NMR-A/B131-148[»]
ProteinModelPortaliP32196.
SMRiP32196.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000027630.

Proteomic databases

PaxDbiP32196.
PeptideAtlasiP32196.
PRIDEiP32196.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100144484.
KEGGissc:100144484.

Organism-specific databases

CTDi100144484.

Phylogenomic databases

eggNOGiENOG410J18R. Eukaryota.
ENOG41119S0. LUCA.
HOVERGENiHBG006116.
InParanoidiP32196.

Miscellaneous databases

EvolutionaryTraceiP32196.

Family and domain databases

InterProiIPR001894. Cathelicidin.
IPR018216. Cathelicidin_CS.
[Graphical view]
PANTHERiPTHR10206. PTHR10206. 1 hit.
PROSITEiPS00946. CATHELICIDINS_1. 1 hit.
PS00947. CATHELICIDINS_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPG3_PIG
AccessioniPrimary (citable) accession number: P32196
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1996
Last modified: November 2, 2016
This is version 92 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.