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Protein

Protegrin-2

Gene

NPG2

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Microbicidal activity. Active against E.coli, Listeria monocytogenes and C.albicans, in vitro.

GO - Biological processi

Keywordsi

Molecular functionAntibiotic, Antimicrobial

Names & Taxonomyi

Protein namesi
Recommended name:
Protegrin-2
Short name:
PG-2
Gene namesi
Name:NPG2
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Unplaced

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 29Sequence analysisAdd BLAST29
PropeptideiPRO_000000474630 – 1301 PublicationAdd BLAST101
PeptideiPRO_0000004747131 – 146Protegrin-2Add BLAST16

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi85 ↔ 96By similarity
Disulfide bondi107 ↔ 124By similarity
Disulfide bondi136 ↔ 145By similarity
Disulfide bondi138 ↔ 143By similarity
Modified residuei146Valine amide1 Publication1

Keywords - PTMi

Amidation, Disulfide bond

Proteomic databases

PaxDbiP32195.
PeptideAtlasiP32195.
PRIDEiP32195.

Structurei

Secondary structure

1147
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi136 – 139Combined sources4
Beta strandi142 – 145Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2MUHNMR-A131-146[»]
ProteinModelPortaliP32195.
SMRiP32195.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cathelicidin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J18R. Eukaryota.
ENOG41119S0. LUCA.
HOVERGENiHBG006116.
InParanoidiP32195.

Family and domain databases

InterProiView protein in InterPro
IPR001894. Cathelicidin.
IPR018216. Cathelicidin_CS.
PANTHERiPTHR10206. PTHR10206. 1 hit.
PROSITEiView protein in PROSITE
PS00946. CATHELICIDINS_1. 1 hit.
PS00947. CATHELICIDINS_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P32195-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
METQRASLCL GRWSLWLLLL ALVVPSASAQ ALSYREAVLR AVDRLNEQSS
60 70 80 90 100
EANLYRLLEL DQPPKADEDP GTPKPVSFTV KETVCPRPTR QPPELCDFKE
110 120 130 140
NGRVKQCVGT VTLDQIKDPL DITCNEVQGV RGGRLCYCRR RFCICVG
Length:147
Mass (Da):16,478
Last modified:October 1, 1996 - v2
Checksum:i698429DFFEC40466
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L24745 mRNA. Translation: AAA31061.1.
PIRiJN0900.
RefSeqiNP_001123438.1. NM_001129966.1.
UniGeneiSsc.420.

Genome annotation databases

GeneIDi100170125.

Similar proteinsi

Entry informationi

Entry nameiPG2_PIG
AccessioniPrimary (citable) accession number: P32195
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1996
Last modified: October 25, 2017
This is version 90 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families