SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

P32191

- GPDM_YEAST

UniProt

P32191 - GPDM_YEAST

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Glycerol-3-phosphate dehydrogenase, mitochondrial

Gene
GUT2, YIL155C
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at protein leveli

Functioni

Catalytic activityi

sn-glycerol 3-phosphate + a quinone = glycerone phosphate + a quinol.

Cofactori

FAD.

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi69 – 9729FAD Reviewed predictionAdd
BLAST

GO - Molecular functioni

  1. glycerol-3-phosphate dehydrogenase activity Source: SGD
  2. sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity Source: UniProtKB-EC

GO - Biological processi

  1. glycerol-3-phosphate metabolic process Source: InterPro
  2. glycerol catabolic process Source: UniProtKB-UniPathway
  3. glycerol metabolic process Source: SGD
  4. NADH oxidation Source: SGD
  5. replicative cell aging Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

FAD, Flavoprotein

Enzyme and pathway databases

BioCyciYEAST:YIL155C-MONOMER.
SABIO-RKP32191.
UniPathwayiUPA00618; UER00673.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycerol-3-phosphate dehydrogenase, mitochondrial (EC:1.1.5.3)
Short name:
GPD-M
Short name:
GPDH-M
Gene namesi
Name:GUT2
Ordered Locus Names:YIL155C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome IX

Organism-specific databases

CYGDiYIL155c.
SGDiS000001417. GUT2.

Subcellular locationi

Mitochondrion inner membrane 1 Publication

GO - Cellular componenti

  1. glycerol-3-phosphate dehydrogenase complex Source: InterPro
  2. integral component of mitochondrial outer membrane Source: SGD
  3. mitochondrial inner membrane Source: UniProtKB-SubCell
  4. mitochondrion Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini? – 649Glycerol-3-phosphate dehydrogenase, mitochondrialPRO_0000010434
Transit peptidei1 – ?Mitochondrion Reviewed prediction

Proteomic databases

MaxQBiP32191.
PaxDbiP32191.
PeptideAtlasiP32191.
PRIDEiP32191.

Expressioni

Gene expression databases

GenevestigatoriP32191.

Interactioni

Protein-protein interaction databases

BioGridi34837. 34 interactions.
MINTiMINT-4490257.
STRINGi4932.YIL155C.

Structurei

3D structure databases

ProteinModelPortaliP32191.
SMRiP32191. Positions 63-638.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG0578.
GeneTreeiENSGT00390000001718.
HOGENOMiHOG000004813.
KOiK00111.
OMAiGLESEXV.
OrthoDBiEOG7NSBB6.

Family and domain databases

InterProiIPR006076. FAD-dep_OxRdtase.
IPR000447. G3P_DH_FAD-dep.
[Graphical view]
PfamiPF01266. DAO. 1 hit.
[Graphical view]
PRINTSiPR01001. FADG3PDH.
PROSITEiPS00977. FAD_G3PDH_1. 1 hit.
PS00978. FAD_G3PDH_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P32191-1 [UniParc]FASTAAdd to Basket

« Hide

MFSVTRRRAA GAAAAMATAT GTLYWMTSQG DRPLVHNDPS YMVQFPTAAP    50
PQVSRRDLLD RLAKTHQFDV LIIGGGATGT GCALDAATRG LNVALVEKGD 100
FASGTSSKST KMIHGGVRYL EKAFWEFSKA QLDLVIEALN ERKHLINTAP 150
HLCTVLPILI PIYSTWQVPY IYMGCKFYDF FAGSQNLKKS YLLSKSATVE 200
KAPMLTTDNL KASLVYHDGS FNDSRLNATL AITAVENGAT VLNYVEVQKL 250
IKDPTSGKVI GAEARDVETN ELVRINAKCV VNATGPYSDA ILQMDRNPSG 300
LPDSPLNDNS KIKSTFNQIA VMDPKMVIPS IGVHIVLPSF YCPKDMGLLD 350
VRTSDGRVMF FLPWQGKVLA GTTDIPLKQV PENPMPTEAD IQDILKELQH 400
YIEFPVKRED VLSAWAGVRP LVRDPRTIPA DGKKGSATQG VVRSHFLFTS 450
DNGLITIAGG KWTTYRQMAE ETVDKVVEVG GFHNLKPCHT RDIKLAGAEE 500
WTQNYVALLA QNYHLSSKMS NYLVQNYGTR SSIICEFFKE SMENKLPLSL 550
ADKENNVIYS SEENNLVNFD TFRYPFTIGE LKYSMQYEYC RTPLDFLLRR 600
TRFAFLDAKE ALNAVHATVK VMGDEFNWSE KKRQWELEKT VNFIKTFGV 649
Length:649
Mass (Da):72,389
Last modified:February 1, 1995 - v2
Checksum:iFE6B25F5B21EF8DA
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti1 – 5151MFSVT…TAAPP → MTRATWCNSPPPLHR1 PublicationAdd
BLAST
Sequence conflicti63 – 631A → D in CAA50652. 1 Publication
Sequence conflicti182 – 1821A → G in CAA50652. 1 Publication
Sequence conflicti234 – 2341A → G in CAA50652. 1 Publication
Sequence conflicti243 – 2431N → I in CAA50652. 1 Publication
Sequence conflicti249 – 2491K → R in AAT92886. 1 Publication
Sequence conflicti320 – 3201A → S in CAA50652. 1 Publication
Sequence conflicti342 – 3421C → S in CAA50652. 1 Publication
Sequence conflicti645 – 6462KT → QGR in CAA50652. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z38059 Genomic DNA. Translation: CAA86123.1.
X71660 Genomic DNA. Translation: CAA50652.1.
AY692867 Genomic DNA. Translation: AAT92886.1.
BK006942 Genomic DNA. Translation: DAA08398.1.
PIRiS38190. S48379.
RefSeqiNP_012111.1. NM_001179503.1.

Genome annotation databases

EnsemblFungiiYIL155C; YIL155C; YIL155C.
GeneIDi854651.
KEGGisce:YIL155C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Z38059 Genomic DNA. Translation: CAA86123.1 .
X71660 Genomic DNA. Translation: CAA50652.1 .
AY692867 Genomic DNA. Translation: AAT92886.1 .
BK006942 Genomic DNA. Translation: DAA08398.1 .
PIRi S38190. S48379.
RefSeqi NP_012111.1. NM_001179503.1.

3D structure databases

ProteinModelPortali P32191.
SMRi P32191. Positions 63-638.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 34837. 34 interactions.
MINTi MINT-4490257.
STRINGi 4932.YIL155C.

Proteomic databases

MaxQBi P32191.
PaxDbi P32191.
PeptideAtlasi P32191.
PRIDEi P32191.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YIL155C ; YIL155C ; YIL155C .
GeneIDi 854651.
KEGGi sce:YIL155C.

Organism-specific databases

CYGDi YIL155c.
SGDi S000001417. GUT2.

Phylogenomic databases

eggNOGi COG0578.
GeneTreei ENSGT00390000001718.
HOGENOMi HOG000004813.
KOi K00111.
OMAi GLESEXV.
OrthoDBi EOG7NSBB6.

Enzyme and pathway databases

UniPathwayi UPA00618 ; UER00673 .
BioCyci YEAST:YIL155C-MONOMER.
SABIO-RK P32191.

Miscellaneous databases

NextBioi 977202.
PROi P32191.

Gene expression databases

Genevestigatori P32191.

Family and domain databases

InterProi IPR006076. FAD-dep_OxRdtase.
IPR000447. G3P_DH_FAD-dep.
[Graphical view ]
Pfami PF01266. DAO. 1 hit.
[Graphical view ]
PRINTSi PR01001. FADG3PDH.
PROSITEi PS00977. FAD_G3PDH_1. 1 hit.
PS00978. FAD_G3PDH_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "GUT2, a gene for mitochondrial glycerol 3-phosphate dehydrogenase of Saccharomyces cerevisiae."
    Roennow B., Kielland-Brandt M.C.
    Yeast 9:1121-1130(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: S288c / GRF88.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  5. "Yeast mitochondrial dehydrogenases are associated in a supramolecular complex."
    Grandier-Vazeille X., Bathany K., Chaignepain S., Camougrand N., Manon S., Schmitter J.-M.
    Biochemistry 40:9758-9769(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
  6. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiGPDM_YEAST
AccessioniPrimary (citable) accession number: P32191
Secondary accession number(s): D6VVD2, E9P8Y2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: February 1, 1995
Last modified: June 11, 2014
This is version 126 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 1670 molecules/cell in log phase SD medium.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome IX
    Yeast (Saccharomyces cerevisiae) chromosome IX: entries and gene names

External Data

Dasty 3

Similar proteinsi