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P32191

- GPDM_YEAST

UniProt

P32191 - GPDM_YEAST

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Protein

Glycerol-3-phosphate dehydrogenase, mitochondrial

Gene

GUT2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Catalytic activityi

sn-glycerol 3-phosphate + a quinone = glycerone phosphate + a quinol.

Cofactori

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi69 – 9729FADSequence AnalysisAdd
BLAST

GO - Molecular functioni

  1. glycerol-3-phosphate dehydrogenase activity Source: SGD
  2. sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity Source: UniProtKB-EC

GO - Biological processi

  1. glycerol-3-phosphate metabolic process Source: InterPro
  2. glycerol catabolic process Source: UniProtKB-UniPathway
  3. glycerol metabolic process Source: SGD
  4. NADH oxidation Source: SGD
  5. replicative cell aging Source: SGD
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

FAD, Flavoprotein

Enzyme and pathway databases

BioCyciYEAST:YIL155C-MONOMER.
ReactomeiREACT_248072. Fatty acid, triacylglycerol, and ketone body metabolism.
SABIO-RKP32191.
UniPathwayiUPA00618; UER00673.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycerol-3-phosphate dehydrogenase, mitochondrial (EC:1.1.5.3)
Short name:
GPD-M
Short name:
GPDH-M
Gene namesi
Name:GUT2
Ordered Locus Names:YIL155C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome IX

Organism-specific databases

CYGDiYIL155c.
SGDiS000001417. GUT2.

Subcellular locationi

Mitochondrion inner membrane 1 Publication

GO - Cellular componenti

  1. glycerol-3-phosphate dehydrogenase complex Source: InterPro
  2. integral component of mitochondrial outer membrane Source: SGD
  3. mitochondrial inner membrane Source: UniProtKB-KW
  4. mitochondrion Source: SGD
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini? – 649Glycerol-3-phosphate dehydrogenase, mitochondrialPRO_0000010434
Transit peptidei1 – ?MitochondrionSequence Analysis

Proteomic databases

MaxQBiP32191.
PaxDbiP32191.
PeptideAtlasiP32191.
PRIDEiP32191.

Expressioni

Gene expression databases

GenevestigatoriP32191.

Interactioni

Protein-protein interaction databases

BioGridi34837. 34 interactions.
MINTiMINT-4490257.
STRINGi4932.YIL155C.

Structurei

3D structure databases

ProteinModelPortaliP32191.
SMRiP32191. Positions 67-638.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG0578.
GeneTreeiENSGT00390000001718.
HOGENOMiHOG000004813.
InParanoidiP32191.
KOiK00111.
OMAiGLESEXV.
OrthoDBiEOG7NSBB6.

Family and domain databases

InterProiIPR006076. FAD-dep_OxRdtase.
IPR000447. G3P_DH_FAD-dep.
[Graphical view]
PfamiPF01266. DAO. 1 hit.
[Graphical view]
PRINTSiPR01001. FADG3PDH.
PROSITEiPS00977. FAD_G3PDH_1. 1 hit.
PS00978. FAD_G3PDH_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P32191-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MFSVTRRRAA GAAAAMATAT GTLYWMTSQG DRPLVHNDPS YMVQFPTAAP
60 70 80 90 100
PQVSRRDLLD RLAKTHQFDV LIIGGGATGT GCALDAATRG LNVALVEKGD
110 120 130 140 150
FASGTSSKST KMIHGGVRYL EKAFWEFSKA QLDLVIEALN ERKHLINTAP
160 170 180 190 200
HLCTVLPILI PIYSTWQVPY IYMGCKFYDF FAGSQNLKKS YLLSKSATVE
210 220 230 240 250
KAPMLTTDNL KASLVYHDGS FNDSRLNATL AITAVENGAT VLNYVEVQKL
260 270 280 290 300
IKDPTSGKVI GAEARDVETN ELVRINAKCV VNATGPYSDA ILQMDRNPSG
310 320 330 340 350
LPDSPLNDNS KIKSTFNQIA VMDPKMVIPS IGVHIVLPSF YCPKDMGLLD
360 370 380 390 400
VRTSDGRVMF FLPWQGKVLA GTTDIPLKQV PENPMPTEAD IQDILKELQH
410 420 430 440 450
YIEFPVKRED VLSAWAGVRP LVRDPRTIPA DGKKGSATQG VVRSHFLFTS
460 470 480 490 500
DNGLITIAGG KWTTYRQMAE ETVDKVVEVG GFHNLKPCHT RDIKLAGAEE
510 520 530 540 550
WTQNYVALLA QNYHLSSKMS NYLVQNYGTR SSIICEFFKE SMENKLPLSL
560 570 580 590 600
ADKENNVIYS SEENNLVNFD TFRYPFTIGE LKYSMQYEYC RTPLDFLLRR
610 620 630 640
TRFAFLDAKE ALNAVHATVK VMGDEFNWSE KKRQWELEKT VNFIKTFGV
Length:649
Mass (Da):72,389
Last modified:February 1, 1995 - v2
Checksum:iFE6B25F5B21EF8DA
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti1 – 5151MFSVT…TAAPP → MTRATWCNSPPPLHR(PubMed:8256521)CuratedAdd
BLAST
Sequence conflicti63 – 631A → D in CAA50652. (PubMed:8256521)Curated
Sequence conflicti182 – 1821A → G in CAA50652. (PubMed:8256521)Curated
Sequence conflicti234 – 2341A → G in CAA50652. (PubMed:8256521)Curated
Sequence conflicti243 – 2431N → I in CAA50652. (PubMed:8256521)Curated
Sequence conflicti249 – 2491K → R in AAT92886. (PubMed:17322287)Curated
Sequence conflicti320 – 3201A → S in CAA50652. (PubMed:8256521)Curated
Sequence conflicti342 – 3421C → S in CAA50652. (PubMed:8256521)Curated
Sequence conflicti645 – 6462KT → QGR in CAA50652. (PubMed:8256521)Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z38059 Genomic DNA. Translation: CAA86123.1.
X71660 Genomic DNA. Translation: CAA50652.1.
AY692867 Genomic DNA. Translation: AAT92886.1.
BK006942 Genomic DNA. Translation: DAA08398.1.
PIRiS38190. S48379.
RefSeqiNP_012111.1. NM_001179503.1.

Genome annotation databases

EnsemblFungiiYIL155C; YIL155C; YIL155C.
GeneIDi854651.
KEGGisce:YIL155C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z38059 Genomic DNA. Translation: CAA86123.1 .
X71660 Genomic DNA. Translation: CAA50652.1 .
AY692867 Genomic DNA. Translation: AAT92886.1 .
BK006942 Genomic DNA. Translation: DAA08398.1 .
PIRi S38190. S48379.
RefSeqi NP_012111.1. NM_001179503.1.

3D structure databases

ProteinModelPortali P32191.
SMRi P32191. Positions 67-638.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 34837. 34 interactions.
MINTi MINT-4490257.
STRINGi 4932.YIL155C.

Proteomic databases

MaxQBi P32191.
PaxDbi P32191.
PeptideAtlasi P32191.
PRIDEi P32191.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YIL155C ; YIL155C ; YIL155C .
GeneIDi 854651.
KEGGi sce:YIL155C.

Organism-specific databases

CYGDi YIL155c.
SGDi S000001417. GUT2.

Phylogenomic databases

eggNOGi COG0578.
GeneTreei ENSGT00390000001718.
HOGENOMi HOG000004813.
InParanoidi P32191.
KOi K00111.
OMAi GLESEXV.
OrthoDBi EOG7NSBB6.

Enzyme and pathway databases

UniPathwayi UPA00618 ; UER00673 .
BioCyci YEAST:YIL155C-MONOMER.
Reactomei REACT_248072. Fatty acid, triacylglycerol, and ketone body metabolism.
SABIO-RK P32191.

Miscellaneous databases

NextBioi 977202.
PROi P32191.

Gene expression databases

Genevestigatori P32191.

Family and domain databases

InterProi IPR006076. FAD-dep_OxRdtase.
IPR000447. G3P_DH_FAD-dep.
[Graphical view ]
Pfami PF01266. DAO. 1 hit.
[Graphical view ]
PRINTSi PR01001. FADG3PDH.
PROSITEi PS00977. FAD_G3PDH_1. 1 hit.
PS00978. FAD_G3PDH_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "GUT2, a gene for mitochondrial glycerol 3-phosphate dehydrogenase of Saccharomyces cerevisiae."
    Roennow B., Kielland-Brandt M.C.
    Yeast 9:1121-1130(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: S288c / GRF88.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.
  4. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  5. "Yeast mitochondrial dehydrogenases are associated in a supramolecular complex."
    Grandier-Vazeille X., Bathany K., Chaignepain S., Camougrand N., Manon S., Schmitter J.-M.
    Biochemistry 40:9758-9769(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
  6. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiGPDM_YEAST
AccessioniPrimary (citable) accession number: P32191
Secondary accession number(s): D6VVD2, E9P8Y2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: February 1, 1995
Last modified: November 26, 2014
This is version 129 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Miscellaneous

Present with 1670 molecules/cell in log phase SD medium.1 Publication

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome IX
    Yeast (Saccharomyces cerevisiae) chromosome IX: entries and gene names

External Data

Dasty 3