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P32191

- GPDM_YEAST

UniProt

P32191 - GPDM_YEAST

Protein

Glycerol-3-phosphate dehydrogenase, mitochondrial

Gene

GUT2

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 127 (01 Oct 2014)
      Sequence version 2 (01 Feb 1995)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    sn-glycerol 3-phosphate + a quinone = glycerone phosphate + a quinol.

    Cofactori

    FAD.

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi69 – 9729FADSequence AnalysisAdd
    BLAST

    GO - Molecular functioni

    1. glycerol-3-phosphate dehydrogenase activity Source: SGD
    2. sn-glycerol-3-phosphate:ubiquinone-8 oxidoreductase activity Source: UniProtKB-EC

    GO - Biological processi

    1. glycerol-3-phosphate metabolic process Source: InterPro
    2. glycerol catabolic process Source: UniProtKB-UniPathway
    3. glycerol metabolic process Source: SGD
    4. NADH oxidation Source: SGD
    5. replicative cell aging Source: SGD

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    FAD, Flavoprotein

    Enzyme and pathway databases

    BioCyciYEAST:YIL155C-MONOMER.
    SABIO-RKP32191.
    UniPathwayiUPA00618; UER00673.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glycerol-3-phosphate dehydrogenase, mitochondrial (EC:1.1.5.3)
    Short name:
    GPD-M
    Short name:
    GPDH-M
    Gene namesi
    Name:GUT2
    Ordered Locus Names:YIL155C
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome IX

    Organism-specific databases

    CYGDiYIL155c.
    SGDiS000001417. GUT2.

    Subcellular locationi

    Mitochondrion inner membrane 1 Publication

    GO - Cellular componenti

    1. glycerol-3-phosphate dehydrogenase complex Source: InterPro
    2. integral component of mitochondrial outer membrane Source: SGD
    3. mitochondrial inner membrane Source: UniProtKB-SubCell
    4. mitochondrion Source: SGD

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini? – 649Glycerol-3-phosphate dehydrogenase, mitochondrialPRO_0000010434
    Transit peptidei1 – ?MitochondrionSequence Analysis

    Proteomic databases

    MaxQBiP32191.
    PaxDbiP32191.
    PeptideAtlasiP32191.
    PRIDEiP32191.

    Expressioni

    Gene expression databases

    GenevestigatoriP32191.

    Interactioni

    Protein-protein interaction databases

    BioGridi34837. 34 interactions.
    MINTiMINT-4490257.
    STRINGi4932.YIL155C.

    Structurei

    3D structure databases

    ProteinModelPortaliP32191.
    SMRiP32191. Positions 63-638.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiCOG0578.
    GeneTreeiENSGT00390000001718.
    HOGENOMiHOG000004813.
    KOiK00111.
    OMAiGLESEXV.
    OrthoDBiEOG7NSBB6.

    Family and domain databases

    InterProiIPR006076. FAD-dep_OxRdtase.
    IPR000447. G3P_DH_FAD-dep.
    [Graphical view]
    PfamiPF01266. DAO. 1 hit.
    [Graphical view]
    PRINTSiPR01001. FADG3PDH.
    PROSITEiPS00977. FAD_G3PDH_1. 1 hit.
    PS00978. FAD_G3PDH_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P32191-1 [UniParc]FASTAAdd to Basket

    « Hide

    MFSVTRRRAA GAAAAMATAT GTLYWMTSQG DRPLVHNDPS YMVQFPTAAP    50
    PQVSRRDLLD RLAKTHQFDV LIIGGGATGT GCALDAATRG LNVALVEKGD 100
    FASGTSSKST KMIHGGVRYL EKAFWEFSKA QLDLVIEALN ERKHLINTAP 150
    HLCTVLPILI PIYSTWQVPY IYMGCKFYDF FAGSQNLKKS YLLSKSATVE 200
    KAPMLTTDNL KASLVYHDGS FNDSRLNATL AITAVENGAT VLNYVEVQKL 250
    IKDPTSGKVI GAEARDVETN ELVRINAKCV VNATGPYSDA ILQMDRNPSG 300
    LPDSPLNDNS KIKSTFNQIA VMDPKMVIPS IGVHIVLPSF YCPKDMGLLD 350
    VRTSDGRVMF FLPWQGKVLA GTTDIPLKQV PENPMPTEAD IQDILKELQH 400
    YIEFPVKRED VLSAWAGVRP LVRDPRTIPA DGKKGSATQG VVRSHFLFTS 450
    DNGLITIAGG KWTTYRQMAE ETVDKVVEVG GFHNLKPCHT RDIKLAGAEE 500
    WTQNYVALLA QNYHLSSKMS NYLVQNYGTR SSIICEFFKE SMENKLPLSL 550
    ADKENNVIYS SEENNLVNFD TFRYPFTIGE LKYSMQYEYC RTPLDFLLRR 600
    TRFAFLDAKE ALNAVHATVK VMGDEFNWSE KKRQWELEKT VNFIKTFGV 649
    Length:649
    Mass (Da):72,389
    Last modified:February 1, 1995 - v2
    Checksum:iFE6B25F5B21EF8DA
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti1 – 5151MFSVT…TAAPP → MTRATWCNSPPPLHR(PubMed:8256521)CuratedAdd
    BLAST
    Sequence conflicti63 – 631A → D in CAA50652. (PubMed:8256521)Curated
    Sequence conflicti182 – 1821A → G in CAA50652. (PubMed:8256521)Curated
    Sequence conflicti234 – 2341A → G in CAA50652. (PubMed:8256521)Curated
    Sequence conflicti243 – 2431N → I in CAA50652. (PubMed:8256521)Curated
    Sequence conflicti249 – 2491K → R in AAT92886. (PubMed:17322287)Curated
    Sequence conflicti320 – 3201A → S in CAA50652. (PubMed:8256521)Curated
    Sequence conflicti342 – 3421C → S in CAA50652. (PubMed:8256521)Curated
    Sequence conflicti645 – 6462KT → QGR in CAA50652. (PubMed:8256521)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z38059 Genomic DNA. Translation: CAA86123.1.
    X71660 Genomic DNA. Translation: CAA50652.1.
    AY692867 Genomic DNA. Translation: AAT92886.1.
    BK006942 Genomic DNA. Translation: DAA08398.1.
    PIRiS38190. S48379.
    RefSeqiNP_012111.1. NM_001179503.1.

    Genome annotation databases

    EnsemblFungiiYIL155C; YIL155C; YIL155C.
    GeneIDi854651.
    KEGGisce:YIL155C.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Z38059 Genomic DNA. Translation: CAA86123.1 .
    X71660 Genomic DNA. Translation: CAA50652.1 .
    AY692867 Genomic DNA. Translation: AAT92886.1 .
    BK006942 Genomic DNA. Translation: DAA08398.1 .
    PIRi S38190. S48379.
    RefSeqi NP_012111.1. NM_001179503.1.

    3D structure databases

    ProteinModelPortali P32191.
    SMRi P32191. Positions 63-638.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 34837. 34 interactions.
    MINTi MINT-4490257.
    STRINGi 4932.YIL155C.

    Proteomic databases

    MaxQBi P32191.
    PaxDbi P32191.
    PeptideAtlasi P32191.
    PRIDEi P32191.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YIL155C ; YIL155C ; YIL155C .
    GeneIDi 854651.
    KEGGi sce:YIL155C.

    Organism-specific databases

    CYGDi YIL155c.
    SGDi S000001417. GUT2.

    Phylogenomic databases

    eggNOGi COG0578.
    GeneTreei ENSGT00390000001718.
    HOGENOMi HOG000004813.
    KOi K00111.
    OMAi GLESEXV.
    OrthoDBi EOG7NSBB6.

    Enzyme and pathway databases

    UniPathwayi UPA00618 ; UER00673 .
    BioCyci YEAST:YIL155C-MONOMER.
    SABIO-RK P32191.

    Miscellaneous databases

    NextBioi 977202.
    PROi P32191.

    Gene expression databases

    Genevestigatori P32191.

    Family and domain databases

    InterProi IPR006076. FAD-dep_OxRdtase.
    IPR000447. G3P_DH_FAD-dep.
    [Graphical view ]
    Pfami PF01266. DAO. 1 hit.
    [Graphical view ]
    PRINTSi PR01001. FADG3PDH.
    PROSITEi PS00977. FAD_G3PDH_1. 1 hit.
    PS00978. FAD_G3PDH_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "GUT2, a gene for mitochondrial glycerol 3-phosphate dehydrogenase of Saccharomyces cerevisiae."
      Roennow B., Kielland-Brandt M.C.
      Yeast 9:1121-1130(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: S288c / GRF88.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    3. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.
    4. Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    5. "Yeast mitochondrial dehydrogenases are associated in a supramolecular complex."
      Grandier-Vazeille X., Bathany K., Chaignepain S., Camougrand N., Manon S., Schmitter J.-M.
      Biochemistry 40:9758-9769(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION.
    6. Cited for: LEVEL OF PROTEIN EXPRESSION [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiGPDM_YEAST
    AccessioniPrimary (citable) accession number: P32191
    Secondary accession number(s): D6VVD2, E9P8Y2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1993
    Last sequence update: February 1, 1995
    Last modified: October 1, 2014
    This is version 127 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Present with 1670 molecules/cell in log phase SD medium.1 Publication

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families
    3. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    4. Yeast chromosome IX
      Yeast (Saccharomyces cerevisiae) chromosome IX: entries and gene names

    External Data

    Dasty 3