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P32190

- GLPK_YEAST

UniProt

P32190 - GLPK_YEAST

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Protein
Glycerol kinase
Gene
GUT1, YHL032C
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + glycerol = ADP + sn-glycerol 3-phosphate.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei56 – 561Substrate By similarity
Binding sitei60 – 601ATP By similarity
Binding sitei201 – 2011Substrate By similarity
Binding sitei258 – 2581Substrate By similarity
Binding sitei386 – 3861Substrate By similarity
Binding sitei408 – 4081ATP By similarity
Binding sitei463 – 4631ATP; via carbonyl oxygen By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi584 – 5885ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. glycerol kinase activity Source: SGD

GO - Biological processi

  1. glycerol catabolic process Source: UniProtKB-UniPathway
  2. glycerol metabolic process Source: SGD
  3. glycerol-3-phosphate metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Glycerol metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciYEAST:YHL032C-MONOMER.
UniPathwayiUPA00618; UER00672.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycerol kinase (EC:2.7.1.30)
Short name:
GK
Short name:
Glycerokinase
Alternative name(s):
ATP:glycerol 3-phosphotransferase
Gene namesi
Name:GUT1
Ordered Locus Names:YHL032C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
ProteomesiUP000002311: Chromosome VIII

Organism-specific databases

CYGDiYHL032c.
SGDiS000001024. GUT1.

Subcellular locationi

GO - Cellular componenti

  1. mitochondrion Source: SGD
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 709709Glycerol kinase
PRO_0000059542Add
BLAST

Proteomic databases

MaxQBiP32190.
PaxDbiP32190.

Expressioni

Gene expression databases

GenevestigatoriP32190.

Interactioni

Protein-protein interaction databases

BioGridi36390. 27 interactions.
DIPiDIP-6761N.
IntActiP32190. 3 interactions.
MINTiMINT-641670.
STRINGi4932.YHL032C.

Structurei

3D structure databases

ProteinModelPortaliP32190.
SMRiP32190. Positions 147-696.

Family & Domainsi

Sequence similaritiesi

Belongs to the FGGY kinase family.

Phylogenomic databases

eggNOGiCOG0554.
GeneTreeiENSGT00530000063143.
HOGENOMiHOG000222134.
KOiK00864.
OMAiMRETTIL.
OrthoDBiEOG7DRJBQ.

Family and domain databases

InterProiIPR018485. Carb_kinase_FGGY_C.
IPR018483. Carb_kinase_FGGY_CS.
IPR018484. Carb_kinase_FGGY_N.
IPR005999. Glycerol_kin.
[Graphical view]
PfamiPF02782. FGGY_C. 1 hit.
PF00370. FGGY_N. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01311. glycerol_kin. 1 hit.
PROSITEiPS00933. FGGY_KINASES_1. 1 hit.
PS00445. FGGY_KINASES_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P32190-1 [UniParc]FASTAAdd to Basket

« Hide

MFPSLFRLVV FSKRYIFRSS QRLYTSLKQE QSRMSKIMED LRSDYVPLIA    50
SIDVGTTSSR CILFNRWGQD VSKHQIEYST SASKGKIGVS GLRRPSTAPA 100
RETPNAGDIK TSGKPIFSAE GYAIQETKFL KIEELDLDFH NEPTLKFPKP 150
GWVECHPQKL LVNVVQCLAS SLLSLQTINS ERVANGLPPY KVICMGIANM 200
RETTILWSRR TGKPIVNYGI VWNDTRTIKI VRDKWQNTSV DRQLQLRQKT 250
GLPLLSTYFS CSKLRWFLDN EPLCTKAYEE NDLMFGTVDT WLIYQLTKQK 300
AFVSDVTNAS RTGFMNLSTL KYDNELLEFW GIDKNLIHMP EIVSSSQYYG 350
DFGIPDWIME KLHDSPKTVL RDLVKRNLPI QGCLGDQSAS MVGQLAYKPG 400
AAKCTYGTGC FLLYNTGTKK LISQHGALTT LAFWFPHLQE YGGQKPELSK 450
PHFALEGSVA VAGAVVQWLR DNLRLIDKSE DVGPIASTVP DSGGVVFVPA 500
FSGLFAPYWD PDARATIMGM SQFTTASHIA RAAVEGVCFQ ARAILKAMSS 550
DAFGEGSKDR DFLEEISDVT YEKSPLSVLA VDGGMSRSNE VMQIQADILG 600
PCVKVRRSPT AECTALGAAI AANMAFKDVN ERPLWKDLHD VKKWVFYNGM 650
EKNEQISPEA HPNLKIFRSE SDDAERRKHW KYWEVAVERS KGWLKDIEGE 700
HEQVLENFQ 709
Length:709
Mass (Da):79,824
Last modified:October 1, 1993 - v1
Checksum:i12B42C4DABE49FF6
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X69049 Genomic DNA. Translation: CAA48791.1.
U11583 Genomic DNA. Translation: AAB65044.1.
BK006934 Genomic DNA. Translation: DAA06653.1.
PIRiS33907.
RefSeqiNP_011831.1. NM_001179112.1.

Genome annotation databases

EnsemblFungiiYHL032C; YHL032C; YHL032C.
GeneIDi856353.
KEGGisce:YHL032C.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X69049 Genomic DNA. Translation: CAA48791.1 .
U11583 Genomic DNA. Translation: AAB65044.1 .
BK006934 Genomic DNA. Translation: DAA06653.1 .
PIRi S33907.
RefSeqi NP_011831.1. NM_001179112.1.

3D structure databases

ProteinModelPortali P32190.
SMRi P32190. Positions 147-696.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 36390. 27 interactions.
DIPi DIP-6761N.
IntActi P32190. 3 interactions.
MINTi MINT-641670.
STRINGi 4932.YHL032C.

Proteomic databases

MaxQBi P32190.
PaxDbi P32190.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblFungii YHL032C ; YHL032C ; YHL032C .
GeneIDi 856353.
KEGGi sce:YHL032C.

Organism-specific databases

CYGDi YHL032c.
SGDi S000001024. GUT1.

Phylogenomic databases

eggNOGi COG0554.
GeneTreei ENSGT00530000063143.
HOGENOMi HOG000222134.
KOi K00864.
OMAi MRETTIL.
OrthoDBi EOG7DRJBQ.

Enzyme and pathway databases

UniPathwayi UPA00618 ; UER00672 .
BioCyci YEAST:YHL032C-MONOMER.

Miscellaneous databases

NextBioi 981796.
PROi P32190.

Gene expression databases

Genevestigatori P32190.

Family and domain databases

InterProi IPR018485. Carb_kinase_FGGY_C.
IPR018483. Carb_kinase_FGGY_CS.
IPR018484. Carb_kinase_FGGY_N.
IPR005999. Glycerol_kin.
[Graphical view ]
Pfami PF02782. FGGY_C. 1 hit.
PF00370. FGGY_N. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR01311. glycerol_kin. 1 hit.
PROSITEi PS00933. FGGY_KINASES_1. 1 hit.
PS00445. FGGY_KINASES_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The glycerol kinase (GUT1) gene of Saccharomyces cerevisiae: cloning and characterization."
    Pavlik P., Simon M., Schuster T., Ruis H.
    Curr. Genet. 24:21-25(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 204511 / S288c / AB972.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 204508 / S288c.
  3. Cited for: GENOME REANNOTATION.
    Strain: ATCC 204508 / S288c.

Entry informationi

Entry nameiGLPK_YEAST
AccessioniPrimary (citable) accession number: P32190
Secondary accession number(s): D3DKT6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: June 11, 2014
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
  3. Yeast
    Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
  4. Yeast chromosome VIII
    Yeast (Saccharomyces cerevisiae) chromosome VIII: entries and gene names

External Data

Dasty 3

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