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P32190

- GLPK_YEAST

UniProt

P32190 - GLPK_YEAST

Protein

Glycerol kinase

Gene

GUT1

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 124 (01 Oct 2014)
      Sequence version 1 (01 Oct 1993)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + glycerol = ADP + sn-glycerol 3-phosphate.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei56 – 561SubstrateBy similarity
    Binding sitei60 – 601ATPBy similarity
    Binding sitei201 – 2011SubstrateBy similarity
    Binding sitei258 – 2581SubstrateBy similarity
    Binding sitei386 – 3861SubstrateBy similarity
    Binding sitei408 – 4081ATPBy similarity
    Binding sitei463 – 4631ATP; via carbonyl oxygenBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi584 – 5885ATPBy similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. glycerol kinase activity Source: SGD

    GO - Biological processi

    1. glycerol-3-phosphate metabolic process Source: InterPro
    2. glycerol catabolic process Source: UniProtKB-UniPathway
    3. glycerol metabolic process Source: SGD

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    Glycerol metabolism

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciYEAST:YHL032C-MONOMER.
    UniPathwayiUPA00618; UER00672.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glycerol kinase (EC:2.7.1.30)
    Short name:
    GK
    Short name:
    Glycerokinase
    Alternative name(s):
    ATP:glycerol 3-phosphotransferase
    Gene namesi
    Name:GUT1
    Ordered Locus Names:YHL032C
    OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
    Taxonomic identifieri559292 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
    ProteomesiUP000002311: Chromosome VIII

    Organism-specific databases

    CYGDiYHL032c.
    SGDiS000001024. GUT1.

    Subcellular locationi

    GO - Cellular componenti

    1. mitochondrion Source: SGD

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 709709Glycerol kinasePRO_0000059542Add
    BLAST

    Proteomic databases

    MaxQBiP32190.
    PaxDbiP32190.

    Expressioni

    Gene expression databases

    GenevestigatoriP32190.

    Interactioni

    Protein-protein interaction databases

    BioGridi36390. 27 interactions.
    DIPiDIP-6761N.
    IntActiP32190. 3 interactions.
    MINTiMINT-641670.
    STRINGi4932.YHL032C.

    Structurei

    3D structure databases

    ProteinModelPortaliP32190.
    SMRiP32190. Positions 147-696.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the FGGY kinase family.Curated

    Phylogenomic databases

    eggNOGiCOG0554.
    GeneTreeiENSGT00530000063143.
    HOGENOMiHOG000222134.
    KOiK00864.
    OMAiMRETTIL.
    OrthoDBiEOG7DRJBQ.

    Family and domain databases

    InterProiIPR018485. Carb_kinase_FGGY_C.
    IPR018483. Carb_kinase_FGGY_CS.
    IPR018484. Carb_kinase_FGGY_N.
    IPR005999. Glycerol_kin.
    [Graphical view]
    PfamiPF02782. FGGY_C. 1 hit.
    PF00370. FGGY_N. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR01311. glycerol_kin. 1 hit.
    PROSITEiPS00933. FGGY_KINASES_1. 1 hit.
    PS00445. FGGY_KINASES_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P32190-1 [UniParc]FASTAAdd to Basket

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    MFPSLFRLVV FSKRYIFRSS QRLYTSLKQE QSRMSKIMED LRSDYVPLIA    50
    SIDVGTTSSR CILFNRWGQD VSKHQIEYST SASKGKIGVS GLRRPSTAPA 100
    RETPNAGDIK TSGKPIFSAE GYAIQETKFL KIEELDLDFH NEPTLKFPKP 150
    GWVECHPQKL LVNVVQCLAS SLLSLQTINS ERVANGLPPY KVICMGIANM 200
    RETTILWSRR TGKPIVNYGI VWNDTRTIKI VRDKWQNTSV DRQLQLRQKT 250
    GLPLLSTYFS CSKLRWFLDN EPLCTKAYEE NDLMFGTVDT WLIYQLTKQK 300
    AFVSDVTNAS RTGFMNLSTL KYDNELLEFW GIDKNLIHMP EIVSSSQYYG 350
    DFGIPDWIME KLHDSPKTVL RDLVKRNLPI QGCLGDQSAS MVGQLAYKPG 400
    AAKCTYGTGC FLLYNTGTKK LISQHGALTT LAFWFPHLQE YGGQKPELSK 450
    PHFALEGSVA VAGAVVQWLR DNLRLIDKSE DVGPIASTVP DSGGVVFVPA 500
    FSGLFAPYWD PDARATIMGM SQFTTASHIA RAAVEGVCFQ ARAILKAMSS 550
    DAFGEGSKDR DFLEEISDVT YEKSPLSVLA VDGGMSRSNE VMQIQADILG 600
    PCVKVRRSPT AECTALGAAI AANMAFKDVN ERPLWKDLHD VKKWVFYNGM 650
    EKNEQISPEA HPNLKIFRSE SDDAERRKHW KYWEVAVERS KGWLKDIEGE 700
    HEQVLENFQ 709
    Length:709
    Mass (Da):79,824
    Last modified:October 1, 1993 - v1
    Checksum:i12B42C4DABE49FF6
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X69049 Genomic DNA. Translation: CAA48791.1.
    U11583 Genomic DNA. Translation: AAB65044.1.
    BK006934 Genomic DNA. Translation: DAA06653.1.
    PIRiS33907.
    RefSeqiNP_011831.1. NM_001179112.1.

    Genome annotation databases

    EnsemblFungiiYHL032C; YHL032C; YHL032C.
    GeneIDi856353.
    KEGGisce:YHL032C.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X69049 Genomic DNA. Translation: CAA48791.1 .
    U11583 Genomic DNA. Translation: AAB65044.1 .
    BK006934 Genomic DNA. Translation: DAA06653.1 .
    PIRi S33907.
    RefSeqi NP_011831.1. NM_001179112.1.

    3D structure databases

    ProteinModelPortali P32190.
    SMRi P32190. Positions 147-696.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 36390. 27 interactions.
    DIPi DIP-6761N.
    IntActi P32190. 3 interactions.
    MINTi MINT-641670.
    STRINGi 4932.YHL032C.

    Proteomic databases

    MaxQBi P32190.
    PaxDbi P32190.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblFungii YHL032C ; YHL032C ; YHL032C .
    GeneIDi 856353.
    KEGGi sce:YHL032C.

    Organism-specific databases

    CYGDi YHL032c.
    SGDi S000001024. GUT1.

    Phylogenomic databases

    eggNOGi COG0554.
    GeneTreei ENSGT00530000063143.
    HOGENOMi HOG000222134.
    KOi K00864.
    OMAi MRETTIL.
    OrthoDBi EOG7DRJBQ.

    Enzyme and pathway databases

    UniPathwayi UPA00618 ; UER00672 .
    BioCyci YEAST:YHL032C-MONOMER.

    Miscellaneous databases

    NextBioi 981796.
    PROi P32190.

    Gene expression databases

    Genevestigatori P32190.

    Family and domain databases

    InterProi IPR018485. Carb_kinase_FGGY_C.
    IPR018483. Carb_kinase_FGGY_CS.
    IPR018484. Carb_kinase_FGGY_N.
    IPR005999. Glycerol_kin.
    [Graphical view ]
    Pfami PF02782. FGGY_C. 1 hit.
    PF00370. FGGY_N. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR01311. glycerol_kin. 1 hit.
    PROSITEi PS00933. FGGY_KINASES_1. 1 hit.
    PS00445. FGGY_KINASES_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The glycerol kinase (GUT1) gene of Saccharomyces cerevisiae: cloning and characterization."
      Pavlik P., Simon M., Schuster T., Ruis H.
      Curr. Genet. 24:21-25(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: ATCC 204511 / S288c / AB972.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 204508 / S288c.
    3. Cited for: GENOME REANNOTATION.
      Strain: ATCC 204508 / S288c.

    Entry informationi

    Entry nameiGLPK_YEAST
    AccessioniPrimary (citable) accession number: P32190
    Secondary accession number(s): D3DKT6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1993
    Last sequence update: October 1, 1993
    Last modified: October 1, 2014
    This is version 124 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families
    3. Yeast
      Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD
    4. Yeast chromosome VIII
      Yeast (Saccharomyces cerevisiae) chromosome VIII: entries and gene names

    External Data

    Dasty 3