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P32190 (GLPK_YEAST) Reviewed, UniProtKB/Swiss-Prot

Last modified March 19, 2014. Version 121. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glycerol kinase

Short name=GK
Short name=Glycerokinase
EC=2.7.1.30
Alternative name(s):
ATP:glycerol 3-phosphotransferase
Gene names
Name:GUT1
Ordered Locus Names:YHL032C
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) [Reference proteome]
Taxonomic identifier559292 [NCBI]
Taxonomic lineageEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces

Protein attributes

Sequence length709 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + glycerol = ADP + sn-glycerol 3-phosphate.

Pathway

Polyol metabolism; glycerol degradation via glycerol kinase pathway; sn-glycerol 3-phosphate from glycerol: step 1/1.

Sequence similarities

Belongs to the FGGY kinase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 709709Glycerol kinase
PRO_0000059542

Regions

Nucleotide binding584 – 5885ATP By similarity

Sites

Binding site561Substrate By similarity
Binding site601ATP By similarity
Binding site2011Substrate By similarity
Binding site2581Substrate By similarity
Binding site3861Substrate By similarity
Binding site4081ATP By similarity
Binding site4631ATP; via carbonyl oxygen By similarity

Sequences

Sequence LengthMass (Da)Tools
P32190 [UniParc].

Last modified October 1, 1993. Version 1.
Checksum: 12B42C4DABE49FF6

FASTA70979,824
        10         20         30         40         50         60 
MFPSLFRLVV FSKRYIFRSS QRLYTSLKQE QSRMSKIMED LRSDYVPLIA SIDVGTTSSR 

        70         80         90        100        110        120 
CILFNRWGQD VSKHQIEYST SASKGKIGVS GLRRPSTAPA RETPNAGDIK TSGKPIFSAE 

       130        140        150        160        170        180 
GYAIQETKFL KIEELDLDFH NEPTLKFPKP GWVECHPQKL LVNVVQCLAS SLLSLQTINS 

       190        200        210        220        230        240 
ERVANGLPPY KVICMGIANM RETTILWSRR TGKPIVNYGI VWNDTRTIKI VRDKWQNTSV 

       250        260        270        280        290        300 
DRQLQLRQKT GLPLLSTYFS CSKLRWFLDN EPLCTKAYEE NDLMFGTVDT WLIYQLTKQK 

       310        320        330        340        350        360 
AFVSDVTNAS RTGFMNLSTL KYDNELLEFW GIDKNLIHMP EIVSSSQYYG DFGIPDWIME 

       370        380        390        400        410        420 
KLHDSPKTVL RDLVKRNLPI QGCLGDQSAS MVGQLAYKPG AAKCTYGTGC FLLYNTGTKK 

       430        440        450        460        470        480 
LISQHGALTT LAFWFPHLQE YGGQKPELSK PHFALEGSVA VAGAVVQWLR DNLRLIDKSE 

       490        500        510        520        530        540 
DVGPIASTVP DSGGVVFVPA FSGLFAPYWD PDARATIMGM SQFTTASHIA RAAVEGVCFQ 

       550        560        570        580        590        600 
ARAILKAMSS DAFGEGSKDR DFLEEISDVT YEKSPLSVLA VDGGMSRSNE VMQIQADILG 

       610        620        630        640        650        660 
PCVKVRRSPT AECTALGAAI AANMAFKDVN ERPLWKDLHD VKKWVFYNGM EKNEQISPEA 

       670        680        690        700 
HPNLKIFRSE SDDAERRKHW KYWEVAVERS KGWLKDIEGE HEQVLENFQ 

« Hide

References

« Hide 'large scale' references
[1]"The glycerol kinase (GUT1) gene of Saccharomyces cerevisiae: cloning and characterization."
Pavlik P., Simon M., Schuster T., Ruis H.
Curr. Genet. 24:21-25(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: ATCC 204511 / S288c / AB972.
[2]"Complete nucleotide sequence of Saccharomyces cerevisiae chromosome VIII."
Johnston M., Andrews S., Brinkman R., Cooper J., Ding H., Dover J., Du Z., Favello A., Fulton L., Gattung S., Geisel C., Kirsten J., Kucaba T., Hillier L.W., Jier M., Johnston L., Langston Y., Latreille P. expand/collapse author list , Louis E.J., Macri C., Mardis E., Menezes S., Mouser L., Nhan M., Rifkin L., Riles L., St Peter H., Trevaskis E., Vaughan K., Vignati D., Wilcox L., Wohldman P., Waterston R., Wilson R., Vaudin M.
Science 265:2077-2082(1994) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 204508 / S288c.
[3]Saccharomyces Genome Database
Submitted (DEC-2009) to the EMBL/GenBank/DDBJ databases
Cited for: GENOME REANNOTATION.
Strain: ATCC 204508 / S288c.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X69049 Genomic DNA. Translation: CAA48791.1.
U11583 Genomic DNA. Translation: AAB65044.1.
BK006934 Genomic DNA. Translation: DAA06653.1.
PIRS33907.
RefSeqNP_011831.1. NM_001179112.1.

3D structure databases

ProteinModelPortalP32190.
SMRP32190. Positions 48-696.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid36390. 27 interactions.
DIPDIP-6761N.
IntActP32190. 3 interactions.
MINTMINT-641670.
STRING4932.YHL032C.

Proteomic databases

PaxDbP32190.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblFungiYHL032C; YHL032C; YHL032C.
GeneID856353.
KEGGsce:YHL032C.

Organism-specific databases

CYGDYHL032c.
SGDS000001024. GUT1.

Phylogenomic databases

eggNOGCOG0554.
GeneTreeENSGT00530000063143.
HOGENOMHOG000222134.
KOK00864.
OMAMRETTIL.
OrthoDBEOG7DRJBQ.

Enzyme and pathway databases

BioCycYEAST:YHL032C-MONOMER.
UniPathwayUPA00618; UER00672.

Gene expression databases

GenevestigatorP32190.

Family and domain databases

InterProIPR018485. Carb_kinase_FGGY_C.
IPR018483. Carb_kinase_FGGY_CS.
IPR018484. Carb_kinase_FGGY_N.
IPR005999. Glycerol_kin.
[Graphical view]
PfamPF02782. FGGY_C. 1 hit.
PF00370. FGGY_N. 1 hit.
[Graphical view]
TIGRFAMsTIGR01311. glycerol_kin. 1 hit.
PROSITEPS00933. FGGY_KINASES_1. 1 hit.
PS00445. FGGY_KINASES_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio981796.
PROP32190.

Entry information

Entry nameGLPK_YEAST
AccessionPrimary (citable) accession number: P32190
Secondary accession number(s): D3DKT6
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: March 19, 2014
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Relevant documents

Yeast chromosome VIII

Yeast (Saccharomyces cerevisiae) chromosome VIII: entries and gene names

Yeast

Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways