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Protein

Hepatocyte nuclear factor 3-gamma

Gene

Foxa3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Transcription factor that is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites (By similarity). Originally described as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis. Involved in regulation of neuronal-specific transcription. May be involved in regulation of spermatogenesis (By similarity).By similarity1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi118 – 20992Fork-headPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  • DNA binding Source: RGD
  • sequence-specific DNA binding Source: InterPro
  • transcription factor activity, sequence-specific DNA binding Source: RGD

GO - Biological processi

  • cell differentiation Source: UniProtKB-KW
  • cellular glucose homeostasis Source: UniProtKB
  • chromatin modification Source: UniProtKB-KW
  • multicellular organism development Source: UniProtKB-KW
  • negative regulation of cell proliferation Source: RGD
  • positive regulation of hepatocyte differentiation Source: RGD
  • positive regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  • regulation of transcription, DNA-templated Source: RGD
  • response to nutrient levels Source: RGD
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator, Chromatin regulator, Developmental protein

Keywords - Biological processi

Differentiation, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Hepatocyte nuclear factor 3-gamma
Short name:
HNF-3-gamma
Short name:
HNF-3G
Alternative name(s):
Forkhead box protein A3
Gene namesi
Name:Foxa3
Synonyms:Hnf3g, Tcf-3g, Tcf3g
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi2809. Foxa3.

Subcellular locationi

GO - Cellular componenti

  • nucleus Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 354354Hepatocyte nuclear factor 3-gammaPRO_0000091802Add
BLAST

Proteomic databases

PaxDbiP32183.
PRIDEiP32183.

Expressioni

Tissue specificityi

Liver.

Interactioni

Subunit structurei

Interacts with FOXA2.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000019219.

Structurei

3D structure databases

ProteinModelPortaliP32183.
SMRiP32183. Positions 119-209.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Contains 1 fork-head DNA-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG3563. Eukaryota.
COG5025. LUCA.
HOGENOMiHOG000231817.
HOVERGENiHBG006621.
InParanoidiP32183.
KOiK08038.
PhylomeDBiP32183.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR013638. Fork-head_N.
IPR001766. Fork_head_dom.
IPR018533. Forkhead_box_C.
IPR018122. TF_fork_head_CS_1.
IPR030456. TF_fork_head_CS_2.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00250. Forkhead. 1 hit.
PF08430. Forkhead_N. 1 hit.
PF09354. HNF_C. 1 hit.
[Graphical view]
PRINTSiPR00053. FORKHEAD.
SMARTiSM00339. FH. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiPS00657. FORK_HEAD_1. 1 hit.
PS00658. FORK_HEAD_2. 1 hit.
PS50039. FORK_HEAD_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P32183-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLGSVKMEAH DLAEWSYYPE AGEVYSPVNP VPTMAPLNSY MSLNPLSSPY
60 70 80 90 100
PPGGLQASPL PTGPLAPPAP TAPLGPTFPG LGAGSGTGGS ASGYGAPGPG
110 120 130 140 150
LVHGKEMAKG YRRPLTHAKP PYSYISLITM AIQQAPGKML TLSEIYQWIM
160 170 180 190 200
DLFPYYRENQ QRWQNSIRHS LSFNDCFVKV ARSPDKPGKG SYWALHPSSG
210 220 230 240 250
NMFENGCYLR RQKRFKLEEK AKKGNSATSA TRNGTVGSAT SATTTAATAV
260 270 280 290 300
TSPAQPQPTP PSEPEAQSGE DVGGLDCASP PSSAPYFTGL ELPGELKLDA
310 320 330 340 350
PYNFNHPFSI NNLMSEQTST PSKLDVGFGG YGAESGEPGV YYQSLYSRSL

LNAS
Length:354
Mass (Da):37,652
Last modified:October 1, 1993 - v1
Checksum:i318B01ECCE7C365C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L09648 mRNA. Translation: AAA41339.1.
PIRiS35090.
RefSeqiNP_058773.1. NM_017077.2.
UniGeneiRn.10949.

Genome annotation databases

GeneIDi25100.
KEGGirno:25100.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L09648 mRNA. Translation: AAA41339.1.
PIRiS35090.
RefSeqiNP_058773.1. NM_017077.2.
UniGeneiRn.10949.

3D structure databases

ProteinModelPortaliP32183.
SMRiP32183. Positions 119-209.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000019219.

Proteomic databases

PaxDbiP32183.
PRIDEiP32183.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi25100.
KEGGirno:25100.

Organism-specific databases

CTDi3171.
RGDi2809. Foxa3.

Phylogenomic databases

eggNOGiKOG3563. Eukaryota.
COG5025. LUCA.
HOGENOMiHOG000231817.
HOVERGENiHBG006621.
InParanoidiP32183.
KOiK08038.
PhylomeDBiP32183.

Miscellaneous databases

NextBioi605413.
PROiP32183.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
InterProiIPR013638. Fork-head_N.
IPR001766. Fork_head_dom.
IPR018533. Forkhead_box_C.
IPR018122. TF_fork_head_CS_1.
IPR030456. TF_fork_head_CS_2.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF00250. Forkhead. 1 hit.
PF08430. Forkhead_N. 1 hit.
PF09354. HNF_C. 1 hit.
[Graphical view]
PRINTSiPR00053. FORKHEAD.
SMARTiSM00339. FH. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
PROSITEiPS00657. FORK_HEAD_1. 1 hit.
PS00658. FORK_HEAD_2. 1 hit.
PS50039. FORK_HEAD_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Hepatocyte nuclear factor 3 alpha belongs to a gene family in mammals that is homologous to the Drosophila homeotic gene fork head."
    Lai E., Prezioso V.R., Tao W.F., Chen W.S., Darnell J.E. Jr.
    Genes Dev. 5:416-427(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The role of HNF1alpha, HNF3gamma, and cyclic AMP in glucose-6-phosphatase gene activation."
    Lin B., Morris D.W., Chou J.Y.
    Biochemistry 36:14096-14106(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  3. "Co-crystal structure of the HNF-3/fork head DNA-recognition motif resembles histone H5."
    Clark K.L., Halay E.D., Lai E., Burley S.K.
    Nature 364:412-420(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR OF 107-223.

Entry informationi

Entry nameiFOXA3_RAT
AccessioniPrimary (citable) accession number: P32183
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: May 11, 2016
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.