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Protein

Hepatocyte nuclear factor 3-gamma

Gene

Foxa3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcription factor that is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites (By similarity). Originally described as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis. Involved in regulation of neuronal-specific transcription. May be involved in regulation of spermatogenesis (By similarity).By similarity1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi118 – 209Fork-headPROSITE-ProRule annotationAdd BLAST92

GO - Molecular functioni

GO - Biological processi

  • anatomical structure morphogenesis Source: GO_Central
  • cell differentiation Source: UniProtKB-KW
  • cellular glucose homeostasis Source: UniProtKB
  • chromatin organization Source: UniProtKB-KW
  • multicellular organism development Source: UniProtKB-KW
  • negative regulation of cell proliferation Source: RGD
  • positive regulation of hepatocyte differentiation Source: RGD
  • positive regulation of transcription by RNA polymerase II Source: UniProtKB
  • regulation of transcription, DNA-templated Source: RGD
  • response to nutrient levels Source: RGD
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Molecular functionActivator, Chromatin regulator, Developmental protein, DNA-binding
Biological processDifferentiation, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Hepatocyte nuclear factor 3-gamma
Short name:
HNF-3-gamma
Short name:
HNF-3G
Alternative name(s):
Forkhead box protein A3
Gene namesi
Name:Foxa3
Synonyms:Hnf3g, Tcf-3g, Tcf3g
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi2809 Foxa3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000918021 – 354Hepatocyte nuclear factor 3-gammaAdd BLAST354

Proteomic databases

PaxDbiP32183
PRIDEiP32183

Expressioni

Tissue specificityi

Liver.

Interactioni

Subunit structurei

Interacts with FOXA2.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000019219

Structurei

3D structure databases

ProteinModelPortaliP32183
SMRiP32183
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

eggNOGiKOG3563 Eukaryota
COG5025 LUCA
HOGENOMiHOG000231817
HOVERGENiHBG006621
InParanoidiP32183
KOiK08038
PhylomeDBiP32183

Family and domain databases

CDDicd00059 FH, 1 hit
Gene3Di1.10.10.10, 1 hit
InterProiView protein in InterPro
IPR013638 Fork-head_N
IPR001766 Fork_head_dom
IPR018533 Forkhead_box_C
IPR018122 TF_fork_head_CS_1
IPR030456 TF_fork_head_CS_2
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF00250 Forkhead, 1 hit
PF08430 Forkhead_N, 1 hit
PF09354 HNF_C, 1 hit
PRINTSiPR00053 FORKHEAD
SMARTiView protein in SMART
SM00339 FH, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
PROSITEiView protein in PROSITE
PS00657 FORK_HEAD_1, 1 hit
PS00658 FORK_HEAD_2, 1 hit
PS50039 FORK_HEAD_3, 1 hit

Sequencei

Sequence statusi: Complete.

P32183-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLGSVKMEAH DLAEWSYYPE AGEVYSPVNP VPTMAPLNSY MSLNPLSSPY
60 70 80 90 100
PPGGLQASPL PTGPLAPPAP TAPLGPTFPG LGAGSGTGGS ASGYGAPGPG
110 120 130 140 150
LVHGKEMAKG YRRPLTHAKP PYSYISLITM AIQQAPGKML TLSEIYQWIM
160 170 180 190 200
DLFPYYRENQ QRWQNSIRHS LSFNDCFVKV ARSPDKPGKG SYWALHPSSG
210 220 230 240 250
NMFENGCYLR RQKRFKLEEK AKKGNSATSA TRNGTVGSAT SATTTAATAV
260 270 280 290 300
TSPAQPQPTP PSEPEAQSGE DVGGLDCASP PSSAPYFTGL ELPGELKLDA
310 320 330 340 350
PYNFNHPFSI NNLMSEQTST PSKLDVGFGG YGAESGEPGV YYQSLYSRSL

LNAS
Length:354
Mass (Da):37,652
Last modified:October 1, 1993 - v1
Checksum:i318B01ECCE7C365C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L09648 mRNA Translation: AAA41339.1
PIRiS35090
RefSeqiNP_058773.1, NM_017077.2
UniGeneiRn.10949

Genome annotation databases

GeneIDi25100
KEGGirno:25100

Similar proteinsi

Entry informationi

Entry nameiFOXA3_RAT
AccessioniPrimary (citable) accession number: P32183
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: May 23, 2018
This is version 140 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health