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Protein

Chorismate mutase

Gene

ARO7

Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

Chorismate = prephenate.

Enzyme regulationi

Needs tryptophan for activation and tyrosine is a strong inhibitor. Allosterically regulated.

Pathwayi: prephenate biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes prephenate from chorismate.
Proteins known to be involved in this subpathway in this organism are:
  1. Chorismate mutase (ARO7)
This subpathway is part of the pathway prephenate biosynthesis, which is itself part of Metabolic intermediate biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes prephenate from chorismate, the pathway prephenate biosynthesis and in Metabolic intermediate biosynthesis.

GO - Molecular functioni

  • chorismate mutase activity Source: SGD

GO - Biological processi

  • chorismate metabolic process Source: InterPro
  • L-phenylalanine biosynthetic process Source: SGD
  • tyrosine biosynthetic process Source: SGD

Keywordsi

Molecular functionAllosteric enzyme, Isomerase
Biological processAmino-acid biosynthesis, Aromatic amino acid biosynthesis

Enzyme and pathway databases

BioCyciYEAST:YPR060C-MONOMER
BRENDAi5.4.99.5 984
UniPathwayiUPA00120; UER00203

Names & Taxonomyi

Protein namesi
Recommended name:
Chorismate mutase (EC:5.4.99.5)
Short name:
CM
Gene namesi
Name:ARO7
Synonyms:OSM2
Ordered Locus Names:YPR060C
ORF Names:YP9499.15C
OrganismiSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Taxonomic identifieri559292 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaSaccharomycotinaSaccharomycetesSaccharomycetalesSaccharomycetaceaeSaccharomyces
Proteomesi
  • UP000002311 Componenti: Chromosome XVI

Organism-specific databases

EuPathDBiFungiDB:YPR060C
SGDiS000006264 ARO7

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi226T → I: Constitutively activated and feedback-resistant. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001192041 – 256Chorismate mutaseAdd BLAST256

Proteomic databases

MaxQBiP32178
PaxDbiP32178
PRIDEiP32178

Interactioni

Subunit structurei

Homodimer.

Protein-protein interaction databases

BioGridi36233, 254 interactors
IntActiP32178, 6 interactors
STRINGi4932.YPR060C

Structurei

Secondary structure

1256
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi6 – 9Combined sources4
Helixi12 – 34Combined sources23
Helixi40 – 42Combined sources3
Beta strandi48 – 50Combined sources3
Helixi59 – 73Combined sources15
Helixi76 – 78Combined sources3
Turni87 – 89Combined sources3
Helixi108 – 110Combined sources3
Helixi114 – 124Combined sources11
Helixi126 – 129Combined sources4
Beta strandi130 – 134Combined sources5
Helixi137 – 139Combined sources3
Helixi140 – 159Combined sources20
Helixi161 – 170Combined sources10
Helixi173 – 181Combined sources9
Helixi185 – 191Combined sources7
Helixi195 – 211Combined sources17
Beta strandi212 – 214Combined sources3
Helixi227 – 236Combined sources10
Helixi238 – 251Combined sources14
Turni252 – 254Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1CSMX-ray2.20A/B1-256[»]
2CSMX-ray2.80A1-256[»]
3CSMX-ray3.00A/B1-256[»]
4CSMX-ray2.80A/B1-256[»]
5CSMX-ray2.00A1-256[»]
ProteinModelPortaliP32178
SMRiP32178
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP32178

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini3 – 255Chorismate mutasePROSITE-ProRule annotationAdd BLAST253

Phylogenomic databases

HOGENOMiHOG000176992
InParanoidiP32178
KOiK01850
OMAiLPSINYP
OrthoDBiEOG092C4AF0

Family and domain databases

Gene3Di1.10.590.10, 1 hit
InterProiView protein in InterPro
IPR036263 Chorismate_II_sf
IPR008238 Chorismate_mutase_AroQ_euk
IPR037039 CM_AroQ_sf_eucaryotic
PANTHERiPTHR21145 PTHR21145, 1 hit
PIRSFiPIRSF017318 Chor_mut_AroQ_eu, 1 hit
SUPFAMiSSF48600 SSF48600, 1 hit
TIGRFAMsiTIGR01802 CM_pl-yst, 1 hit
PROSITEiView protein in PROSITE
PS51169 CHORISMATE_MUT_3, 1 hit

Sequencei

Sequence statusi: Complete.

P32178-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDFTKPETVL NLQNIRDELV RMEDSIIFKF IERSHFATCP SVYEANHPGL
60 70 80 90 100
EIPNFKGSFL DWALSNLEIA HSRIRRFESP DETPFFPDKI QKSFLPSINY
110 120 130 140 150
PQILAPYAPE VNYNDKIKKV YIEKIIPLIS KRDGDDKNNF GSVATRDIEC
160 170 180 190 200
LQSLSRRIHF GKFVAEAKFQ SDIPLYTKLI KSKDVEGIMK NITNSAVEEK
210 220 230 240 250
ILERLTKKAE VYGVDPTNES GERRITPEYL VKIYKEIVIP ITKEVEVEYL

LRRLEE
Length:256
Mass (Da):29,747
Last modified:October 1, 1993 - v1
Checksum:i8C6BEBEAA3497E23
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M24517 Genomic DNA Translation: AAB59309.1
Z49219 Genomic DNA Translation: CAA89177.1
Z71255 Genomic DNA Translation: CAA95004.1
AY693179 Genomic DNA Translation: AAT93198.1
BK006949 Genomic DNA Translation: DAA11481.1
PIRiA45921
RefSeqiNP_015385.1, NM_001184157.1

Genome annotation databases

EnsemblFungiiYPR060C; YPR060C; YPR060C
GeneIDi856173
KEGGisce:YPR060C

Similar proteinsi

Entry informationi

Entry nameiCHMU_YEAST
AccessioniPrimary (citable) accession number: P32178
Secondary accession number(s): D6W465
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: March 28, 2018
This is version 160 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
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Main funding by: National Institutes of Health