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Protein

PTS system fructose-like EIIA component

Gene

frvA

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II FrvAB PTS system is involved in fructose transport.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei64Tele-phosphohistidine intermediatePROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinase, Transferase
Biological processPhosphotransferase system, Sugar transport, Transport

Enzyme and pathway databases

BioCyciEcoCyc:FRVA-MONOMER
MetaCyc:FRVA-MONOMER

Protein family/group databases

TCDBi4.A.2.1.25 the pts fructose-mannitol (fru) family

Names & Taxonomyi

Protein namesi
Recommended name:
PTS system fructose-like EIIA component1 Publication
Alternative name(s):
Fructose-like phosphotransferase enzyme IIA component1 Publication
Gene namesi
Name:frvA1 Publication
Synonyms:yiiK
Ordered Locus Names:b3900, JW3871
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11864 frvA

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001865001 – 148PTS system fructose-like EIIA componentAdd BLAST148

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei64Phosphohistidine; by HPrCurated1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP32155
PRIDEiP32155

Interactioni

Protein-protein interaction databases

BioGridi4261599, 7 interactors
IntActiP32155, 1 interactor
STRINGi316407.85676159

Structurei

3D structure databases

ProteinModelPortaliP32155
SMRiP32155
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 145PTS EIIA type-2PROSITE-ProRule annotationAdd BLAST144

Domaini

The PTS EIIA type-2 domain is phosphorylated by phospho-HPr on a histidyl residue. Then, it transfers the phosphoryl group to the PTS EIIB type-2 domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG41064BA Bacteria
COG1762 LUCA
HOGENOMiHOG000227561
KOiK11201
OMAiPIECSFI
PhylomeDBiP32155

Family and domain databases

Gene3Di3.40.930.10, 1 hit
InterProiView protein in InterPro
IPR016152 PTrfase/Anion_transptr
IPR002178 PTS_EIIA_type-2_dom
IPR004715 PTS_IIA_fruc
PfamiView protein in Pfam
PF00359 PTS_EIIA_2, 1 hit
SUPFAMiSSF55804 SSF55804, 1 hit
TIGRFAMsiTIGR00848 fruA, 1 hit
PROSITEiView protein in PROSITE
PS51094 PTS_EIIA_TYPE_2, 1 hit
PS00372 PTS_EIIA_TYPE_2_HIS, 1 hit

Sequencei

Sequence statusi: Complete.

P32155-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAALTASCID LNIQGNGAYS VLKQLATIAL QNGFITDSHQ FLQTLLLREK
60 70 80 90 100
MHSTGFGSGV AVPHGKSACV KQPFVLFARK AQAIDWKASD GEDVNCWICL
110 120 130 140
GVPQSGEEDQ VKIIGTLCRK IIHKEFIHQL QQGDTDQVLA LLNQTLSS
Length:148
Mass (Da):16,094
Last modified:February 1, 1994 - v2
Checksum:i04AE87B9084BA1C6
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti81A → G in AAB03033 (PubMed:8346018).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X60472 Genomic DNA Translation: CAA43004.1
L19201 Genomic DNA Translation: AAB03033.2
U00096 Genomic DNA Translation: AAC76882.1
AP009048 Genomic DNA Translation: BAE77409.1
PIRiD48649
RefSeqiNP_418336.1, NC_000913.3
WP_000729595.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC76882; AAC76882; b3900
BAE77409; BAE77409; BAE77409
GeneIDi948391
KEGGiecj:JW3871
eco:b3900
PATRICifig|1411691.4.peg.2807

Similar proteinsi

Entry informationi

Entry nameiPTFLA_ECOLI
AccessioniPrimary (citable) accession number: P32155
Secondary accession number(s): P76776, Q2M8J7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: February 1, 1994
Last modified: March 28, 2018
This is version 138 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health