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Protein

Fructose-like phosphotransferase enzyme IIA component

Gene

frvA

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane.By similarity

Catalytic activityi

Protein EIIA N(pi)-phospho-L-histidine + protein EIIB = protein EIIA + protein EIIB N(pi)-phospho-L-histidine/cysteine.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei64 – 641Tele-phosphohistidine intermediatePROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Phosphotransferase system, Sugar transport, Transport

Enzyme and pathway databases

BioCyciEcoCyc:FRVA-MONOMER.
ECOL316407:JW3871-MONOMER.

Protein family/group databases

TCDBi4.A.2.1.25. the pts fructose-mannitol (fru) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Fructose-like phosphotransferase enzyme IIA component (EC:2.7.1.-)
Alternative name(s):
PTS system fructose-like EIIA component
Gene namesi
Name:frvA
Synonyms:yiiK
Ordered Locus Names:b3900, JW3871
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11864. frvA.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 148148Fructose-like phosphotransferase enzyme IIA componentPRO_0000186500Add
BLAST

Proteomic databases

PaxDbiP32155.

Interactioni

Protein-protein interaction databases

BioGridi4261599. 7 interactions.
IntActiP32155. 1 interaction.
STRINGi511145.b3900.

Structurei

3D structure databases

ProteinModelPortaliP32155.
SMRiP32155. Positions 45-144.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini2 – 145144PTS EIIA type-2PROSITE-ProRule annotationAdd
BLAST

Domaini

The EIIA domain is phosphorylated by phospho-HPr on a histidyl residue. Then, it transfers the phosphoryl group to the EIIB domain.

Sequence similaritiesi

Contains 1 PTS EIIA type-2 domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG41064BA. Bacteria.
COG1762. LUCA.
HOGENOMiHOG000227561.
KOiK11201.
OMAiWQASDGE.
PhylomeDBiP32155.

Family and domain databases

Gene3Di3.40.930.10. 1 hit.
InterProiIPR016152. PTrfase/Anion_transptr.
IPR002178. PTS_EIIA_type-2_dom.
IPR004715. PTS_IIA_fruc.
[Graphical view]
PfamiPF00359. PTS_EIIA_2. 1 hit.
[Graphical view]
SUPFAMiSSF55804. SSF55804. 1 hit.
TIGRFAMsiTIGR00848. fruA. 1 hit.
PROSITEiPS51094. PTS_EIIA_TYPE_2. 1 hit.
PS00372. PTS_EIIA_TYPE_2_HIS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P32155-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAALTASCID LNIQGNGAYS VLKQLATIAL QNGFITDSHQ FLQTLLLREK
60 70 80 90 100
MHSTGFGSGV AVPHGKSACV KQPFVLFARK AQAIDWKASD GEDVNCWICL
110 120 130 140
GVPQSGEEDQ VKIIGTLCRK IIHKEFIHQL QQGDTDQVLA LLNQTLSS
Length:148
Mass (Da):16,094
Last modified:February 1, 1994 - v2
Checksum:i04AE87B9084BA1C6
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti81 – 811A → G in AAB03033 (PubMed:8346018).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X60472 Genomic DNA. Translation: CAA43004.1.
L19201 Genomic DNA. Translation: AAB03033.2.
U00096 Genomic DNA. Translation: AAC76882.1.
AP009048 Genomic DNA. Translation: BAE77409.1.
PIRiD48649.
RefSeqiNP_418336.1. NC_000913.3.
WP_000729595.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC76882; AAC76882; b3900.
BAE77409; BAE77409; BAE77409.
GeneIDi948391.
KEGGiecj:JW3871.
eco:b3900.
PATRICi32123309. VBIEscCol129921_4015.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X60472 Genomic DNA. Translation: CAA43004.1.
L19201 Genomic DNA. Translation: AAB03033.2.
U00096 Genomic DNA. Translation: AAC76882.1.
AP009048 Genomic DNA. Translation: BAE77409.1.
PIRiD48649.
RefSeqiNP_418336.1. NC_000913.3.
WP_000729595.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP32155.
SMRiP32155. Positions 45-144.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4261599. 7 interactions.
IntActiP32155. 1 interaction.
STRINGi511145.b3900.

Protein family/group databases

TCDBi4.A.2.1.25. the pts fructose-mannitol (fru) family.

Proteomic databases

PaxDbiP32155.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC76882; AAC76882; b3900.
BAE77409; BAE77409; BAE77409.
GeneIDi948391.
KEGGiecj:JW3871.
eco:b3900.
PATRICi32123309. VBIEscCol129921_4015.

Organism-specific databases

EchoBASEiEB1810.
EcoGeneiEG11864. frvA.

Phylogenomic databases

eggNOGiENOG41064BA. Bacteria.
COG1762. LUCA.
HOGENOMiHOG000227561.
KOiK11201.
OMAiWQASDGE.
PhylomeDBiP32155.

Enzyme and pathway databases

BioCyciEcoCyc:FRVA-MONOMER.
ECOL316407:JW3871-MONOMER.

Miscellaneous databases

PROiP32155.

Family and domain databases

Gene3Di3.40.930.10. 1 hit.
InterProiIPR016152. PTrfase/Anion_transptr.
IPR002178. PTS_EIIA_type-2_dom.
IPR004715. PTS_IIA_fruc.
[Graphical view]
PfamiPF00359. PTS_EIIA_2. 1 hit.
[Graphical view]
SUPFAMiSSF55804. SSF55804. 1 hit.
TIGRFAMsiTIGR00848. fruA. 1 hit.
PROSITEiPS51094. PTS_EIIA_TYPE_2. 1 hit.
PS00372. PTS_EIIA_TYPE_2_HIS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPTFA_ECOLI
AccessioniPrimary (citable) accession number: P32155
Secondary accession number(s): P76776, Q2M8J7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: February 1, 1994
Last modified: September 7, 2016
This is version 130 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.