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Protein

Putative aminopeptidase FrvX

Gene

frvX

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Cofactori

a divalent metal cationBy similarityNote: Binds 2 divalent metal cations per subunit.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi61 – 611Divalent metal cation 1By similarity
Metal bindingi175 – 1751Divalent metal cation 1By similarity
Metal bindingi175 – 1751Divalent metal cation 2By similarity
Active sitei205 – 2051Proton acceptorBy similarity
Metal bindingi206 – 2061Divalent metal cation 2By similarity
Metal bindingi228 – 2281Divalent metal cation 1By similarity
Metal bindingi316 – 3161Divalent metal cation 2By similarity

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Aminopeptidase, Hydrolase, Metalloprotease, Protease

Keywords - Ligandi

Metal-binding

Enzyme and pathway databases

BioCyciEcoCyc:EG11862-MONOMER.
ECOL316407:JW3869-MONOMER.

Protein family/group databases

MEROPSiM42.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative aminopeptidase FrvX (EC:3.4.11.-)
Gene namesi
Name:frvX
Synonyms:yiiI
Ordered Locus Names:b3898, JW3869
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11862. frvX.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 356356Putative aminopeptidase FrvXPRO_0000071655Add
BLAST

Proteomic databases

PaxDbiP32153.
PRIDEiP32153.

Interactioni

Protein-protein interaction databases

BioGridi4263328. 12 interactions.
DIPiDIP-9694N.
IntActiP32153. 3 interactions.
STRINGi511145.b3898.

Structurei

3D structure databases

ProteinModelPortaliP32153.
SMRiP32153. Positions 3-350.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M42 family.Curated

Phylogenomic databases

eggNOGiENOG4105CN9. Bacteria.
COG1363. LUCA.
HOGENOMiHOG000291973.
InParanoidiP32153.
KOiK18530.
OMAiFTVMNNE.
OrthoDBiEOG6V4GDH.
PhylomeDBiP32153.

Family and domain databases

Gene3Di2.40.30.40. 1 hit.
InterProiIPR008007. Peptidase_M42.
IPR023367. Peptidase_M42_dom2.
[Graphical view]
PfamiPF05343. Peptidase_M42. 1 hit.
[Graphical view]
PIRSFiPIRSF001123. PepA_GA. 1 hit.

Sequencei

Sequence statusi: Complete.

P32153-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNIELLQQLC EASAVSGDEQ EVRDILINTL EPCVNEITFD GLGSFVARKG
60 70 80 90 100
NKGPKVAVVG HMDEVGFMVT HIDESGFLRF TTIGGWWNQS MLNHRVTIRT
110 120 130 140 150
HKGVKIPGVI GSVAPHALTE KQKQQPLSFD EMFIDIGANS REEVEKRGVE
160 170 180 190 200
IGNFISPEAN FACWGEDKVV GKALDNRIGC AMMAELLQTV NNPEITLYGV
210 220 230 240 250
GSVEEEVGLR GAQTSAEHIK PDVVIVLDTA VAGDVPGIDN IKYPLKLGQG
260 270 280 290 300
PGLMLFDKRY FPNQKLVAAL KSCAAHNDLP LQFSTMKTGA TDGGRYNVMG
310 320 330 340 350
GGRPVVALCL PTRYLHANSG MISKADYEAL LTLIRGFLTT LTAEKVNAFS

QFRQVD
Length:356
Mass (Da):38,733
Last modified:October 1, 1993 - v1
Checksum:i8F399EFDA3ADE353
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L19201 Genomic DNA. Translation: AAB03031.1.
U00096 Genomic DNA. Translation: AAC76880.1.
AP009048 Genomic DNA. Translation: BAE77411.1.
PIRiS40842.
RefSeqiNP_418334.1. NC_000913.3.
WP_001019484.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC76880; AAC76880; b3898.
BAE77411; BAE77411; BAE77411.
GeneIDi948388.
KEGGiecj:JW3869.
eco:b3898.
PATRICi32123305. VBIEscCol129921_4013.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L19201 Genomic DNA. Translation: AAB03031.1.
U00096 Genomic DNA. Translation: AAC76880.1.
AP009048 Genomic DNA. Translation: BAE77411.1.
PIRiS40842.
RefSeqiNP_418334.1. NC_000913.3.
WP_001019484.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP32153.
SMRiP32153. Positions 3-350.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4263328. 12 interactions.
DIPiDIP-9694N.
IntActiP32153. 3 interactions.
STRINGi511145.b3898.

Protein family/group databases

MEROPSiM42.001.

Proteomic databases

PaxDbiP32153.
PRIDEiP32153.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC76880; AAC76880; b3898.
BAE77411; BAE77411; BAE77411.
GeneIDi948388.
KEGGiecj:JW3869.
eco:b3898.
PATRICi32123305. VBIEscCol129921_4013.

Organism-specific databases

EchoBASEiEB1808.
EcoGeneiEG11862. frvX.

Phylogenomic databases

eggNOGiENOG4105CN9. Bacteria.
COG1363. LUCA.
HOGENOMiHOG000291973.
InParanoidiP32153.
KOiK18530.
OMAiFTVMNNE.
OrthoDBiEOG6V4GDH.
PhylomeDBiP32153.

Enzyme and pathway databases

BioCyciEcoCyc:EG11862-MONOMER.
ECOL316407:JW3869-MONOMER.

Miscellaneous databases

PROiP32153.

Family and domain databases

Gene3Di2.40.30.40. 1 hit.
InterProiIPR008007. Peptidase_M42.
IPR023367. Peptidase_M42_dom2.
[Graphical view]
PfamiPF05343. Peptidase_M42. 1 hit.
[Graphical view]
PIRSFiPIRSF001123. PepA_GA. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Analysis of the Escherichia coli genome. III. DNA sequence of the region from 87.2 to 89.2 minutes."
    Plunkett G. III, Burland V., Daniels D.L., Blattner F.R.
    Nucleic Acids Res. 21:3391-3398(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  3. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  4. "Novel phosphotransferase system genes revealed by bacterial genome analysis: unique, putative fructose- and glucoside-specific systems."
    Reizer J., Michotey V., Reizer A., Saier M.H. Jr.
    Protein Sci. 3:440-450(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: DISCUSSION OF SEQUENCE.

Entry informationi

Entry nameiFRVX_ECOLI
AccessioniPrimary (citable) accession number: P32153
Secondary accession number(s): Q2M8J5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: January 20, 2016
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.