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Protein

Putative aminopeptidase FrvX

Gene

frvX

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Cofactori

a divalent metal cationBy similarityNote: Binds 2 divalent metal cations per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi61Divalent metal cation 1By similarity1
Metal bindingi175Divalent metal cation 1By similarity1
Metal bindingi175Divalent metal cation 2By similarity1
Active sitei205Proton acceptorBy similarity1
Metal bindingi206Divalent metal cation 2By similarity1
Metal bindingi228Divalent metal cation 1By similarity1
Metal bindingi316Divalent metal cation 2By similarity1

GO - Molecular functioni

Keywordsi

Molecular functionAminopeptidase, Hydrolase, Metalloprotease, Protease
LigandMetal-binding

Enzyme and pathway databases

BioCyciEcoCyc:EG11862-MONOMER

Protein family/group databases

MEROPSiM42.001

Names & Taxonomyi

Protein namesi
Recommended name:
Putative aminopeptidase FrvX (EC:3.4.11.-)
Gene namesi
Name:frvX
Synonyms:yiiI
Ordered Locus Names:b3898, JW3869
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11862 frvX

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000716551 – 356Putative aminopeptidase FrvXAdd BLAST356

Proteomic databases

PaxDbiP32153
PRIDEiP32153

Interactioni

Protein-protein interaction databases

BioGridi4263328, 17 interactors
DIPiDIP-9694N
IntActiP32153, 4 interactors
STRINGi316385.ECDH10B_4088

Structurei

3D structure databases

ProteinModelPortaliP32153
SMRiP32153
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M42 family.Curated

Phylogenomic databases

eggNOGiENOG4105CN9 Bacteria
COG1363 LUCA
HOGENOMiHOG000291973
InParanoidiP32153
KOiK18530
OMAiFMAHMDE
PhylomeDBiP32153

Family and domain databases

Gene3Di2.40.30.40, 1 hit
InterProiView protein in InterPro
IPR008007 Peptidase_M42
IPR023367 Peptidase_M42_dom2
PfamiView protein in Pfam
PF05343 Peptidase_M42, 1 hit
PIRSFiPIRSF001123 PepA_GA, 1 hit

Sequencei

Sequence statusi: Complete.

P32153-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNIELLQQLC EASAVSGDEQ EVRDILINTL EPCVNEITFD GLGSFVARKG
60 70 80 90 100
NKGPKVAVVG HMDEVGFMVT HIDESGFLRF TTIGGWWNQS MLNHRVTIRT
110 120 130 140 150
HKGVKIPGVI GSVAPHALTE KQKQQPLSFD EMFIDIGANS REEVEKRGVE
160 170 180 190 200
IGNFISPEAN FACWGEDKVV GKALDNRIGC AMMAELLQTV NNPEITLYGV
210 220 230 240 250
GSVEEEVGLR GAQTSAEHIK PDVVIVLDTA VAGDVPGIDN IKYPLKLGQG
260 270 280 290 300
PGLMLFDKRY FPNQKLVAAL KSCAAHNDLP LQFSTMKTGA TDGGRYNVMG
310 320 330 340 350
GGRPVVALCL PTRYLHANSG MISKADYEAL LTLIRGFLTT LTAEKVNAFS

QFRQVD
Length:356
Mass (Da):38,733
Last modified:October 1, 1993 - v1
Checksum:i8F399EFDA3ADE353
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L19201 Genomic DNA Translation: AAB03031.1
U00096 Genomic DNA Translation: AAC76880.1
AP009048 Genomic DNA Translation: BAE77411.1
PIRiS40842
RefSeqiNP_418334.1, NC_000913.3
WP_001019484.1, NZ_LN832404.1

Genome annotation databases

EnsemblBacteriaiAAC76880; AAC76880; b3898
BAE77411; BAE77411; BAE77411
GeneIDi948388
KEGGiecj:JW3869
eco:b3898
PATRICifig|1411691.4.peg.2809

Similar proteinsi

Entry informationi

Entry nameiFRVX_ECOLI
AccessioniPrimary (citable) accession number: P32153
Secondary accession number(s): Q2M8J5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: March 28, 2018
This is version 121 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health