P32153 (FRVX_ECOLI) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Putative aminopeptidase FrvX
EC=3.4.11.-

Gene names

Name:	frvX
Synonyms:	yiiI
Ordered Locus Names:	b3898, JW3869

Organism

Escherichia coli (strain K12) [Reference proteome] [HAMAP]

Taxonomic identifier

83333 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia › Escherichia coli

Protein attributes

Sequence length	356 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Cofactor	Binds 2 divalent metal cations per subunit By similarity.
Sequence similarities	Belongs to the peptidase M42 family.

Ontologies

Keywords
Ligand	Metal-binding
Molecular function	Aminopeptidase Hydrolase Metalloprotease Protease
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	proteolysis Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	aminopeptidase activity Inferred from electronic annotation. Source: UniProtKB-KW metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW metallopeptidase activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 356	356	Putative aminopeptidase FrvX		PRO_0000071655
Sites
	Active site	205	1	Proton acceptor By similarity
	Metal binding	61	1	Divalent metal cation 1 By similarity
	Metal binding	175	1	Divalent metal cation 1 By similarity
	Metal binding	175	1	Divalent metal cation 2 By similarity
	Metal binding	206	1	Divalent metal cation 2 By similarity
	Metal binding	228	1	Divalent metal cation 1 By similarity
	Metal binding	316	1	Divalent metal cation 2 By similarity

Sequences

	Sequence		Length	Mass (Da)
	P32153 [UniParc]. Last modified October 1, 1993. Version 1. Checksum: 8F399EFDA3ADE353	FASTA	356	38,733
	10 20 30 40 50 60 MNIELLQQLC EASAVSGDEQ EVRDILINTL EPCVNEITFD GLGSFVARKG NKGPKVAVVG 70 80 90 100 110 120 HMDEVGFMVT HIDESGFLRF TTIGGWWNQS MLNHRVTIRT HKGVKIPGVI GSVAPHALTE 130 140 150 160 170 180 KQKQQPLSFD EMFIDIGANS REEVEKRGVE IGNFISPEAN FACWGEDKVV GKALDNRIGC 190 200 210 220 230 240 AMMAELLQTV NNPEITLYGV GSVEEEVGLR GAQTSAEHIK PDVVIVLDTA VAGDVPGIDN 250 260 270 280 290 300 IKYPLKLGQG PGLMLFDKRY FPNQKLVAAL KSCAAHNDLP LQFSTMKTGA TDGGRYNVMG 310 320 330 340 350 GGRPVVALCL PTRYLHANSG MISKADYEAL LTLIRGFLTT LTAEKVNAFS QFRQVD

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Analysis of the Escherichia coli genome. III. DNA sequence of the region from 87.2 to 89.2 minutes." Plunkett G. III, Burland V., Daniels D.L., Blattner F.R. Nucleic Acids Res. 21:3391-3398(1993) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / MG1655 / ATCC 47076.
[2]	"The complete genome sequence of Escherichia coli K-12." Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V., Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F., Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B., Shao Y. Science 277:1453-1474(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / MG1655 / ATCC 47076.
[3]	"Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T. Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
[4]	"Novel phosphotransferase system genes revealed by bacterial genome analysis: unique, putative fructose- and glucoside-specific systems." Reizer J., Michotey V., Reizer A., Saier M.H. Jr. Protein Sci. 3:440-450(1994) [PubMed] [Europe PMC] [Abstract] Cited for: DISCUSSION OF SEQUENCE.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	L19201 Genomic DNA. Translation: AAB03031.1. U00096 Genomic DNA. Translation: AAC76880.1. AP009048 Genomic DNA. Translation: BAE77411.1.
PIR	S40842.
RefSeq	NP_418334.1. NC_000913.2. YP_491552.1. NC_007779.1.
3D structure databases
ProteinModelPortal	P32153.
SMR	P32153. Positions 3-350.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-9694N.
IntAct	P32153. 3 interactions.
STRING	511145.b3898.
Protein family/group databases
MEROPS	M42.001.
Proteomic databases
PaxDb	P32153.
PRIDE	P32153.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAC76880; AAC76880; b3898. BAE77411; BAE77411; BAE77411.
GeneID	12934334. 948388.
KEGG	ecj:Y75_p3288. eco:b3898.
PATRIC	32123305. VBIEscCol129921_4013.
Organism-specific databases
EchoBASE	EB1808.
EcoGene	EG11862. frvX.
Phylogenomic databases
eggNOG	COG1363.
HOGENOM	HOG000291973.
OMA	INWIMEL.
ProtClustDB	PRK09864.
Enzyme and pathway databases
BioCyc	EcoCyc:EG11862-MONOMER. ECOL316407:JW3869-MONOMER.
Gene expression databases
Genevestigator	P32153.
Family and domain databases
Gene3D	2.40.30.40. 1 hit.
InterPro	IPR008007. Peptidase_M42. IPR023367. Peptidase_M42_dom2. [Graphical view]
Pfam	PF05343. Peptidase_M42. 1 hit. [Graphical view]
PIRSF	PIRSF001123. PepA_GA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

FRVX_ECOLI

Accession

Primary (citable) accession number: P32153
Secondary accession number(s): Q2M8J5

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1993
Last sequence update:	October 1, 1993
Last modified:	May 1, 2013
This is version 94 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program