Reviewed, UniProtKB/Swiss-Prot P32152 (FRVR_ECOLI)

Names and origin

Protein names

Recommended name:
    Putative frv operon regulatory protein
Including the following 1 domains:
    1- Recommended name:
            Putative phosphotransferase EIIA component
              EC=2.7.1.-
        Alternative name(s):
            Putative PTS system EIIA component

Gene names

Name:	frvR
Synonyms:	yiiH
Ordered Locus Names:	b3897, JW3868

Organism

Escherichia coli (strain K12) [Complete proteome] [HAMAP]

Taxonomic identifier

83333 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia

Protein attributes

Sequence length	582 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Could be involved in the regulation of the transcription of the FRV operon.
Domain	The PTS EIIA type-2 domain may serve a regulatory function, through its phosphorylation activity.
Sequence similarities	Contains 1 PTS EIIA type-2 domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Ligand	DNA-binding
Molecular function	Kinase Transferase
PTM	Phosphoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	phosphoenolpyruvate-dependent sugar phosphotransferase system Inferred from electronic annotation. Source: InterPro regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW transcription Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	DNA binding Inferred from electronic annotation. Source: UniProtKB-KW kinase activity Inferred from electronic annotation. Source: UniProtKB-KW protein binding Inferred from physical interaction. Source: IntAct sugar:hydrogen symporter activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
groL	P0A6F5	1	EBI-1133981,EBI-543750

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 582	582	Putative frv operon regulatory protein		PRO_0000087349
Regions
	Domain	443 – 582	140	PTS EIIA type-2
	DNA binding	20 – 39	20	H-T-H motif By similarity
Amino acid modifications
	Modified residue	505	1	Phosphohistidine; by HPr By similarity

Sequences

	Sequence		Length	Mass (Da)
	P32152-1 [UniParc]. Last modified October 1, 1993. Version 1. Checksum: 96F37F10C58C2A10	FASTA	582	66,000
	10 20 30 40 50 60 MLNERQLKIV DLLEQQPRTP GELAQQTGVS GRTILRDIDY LNFTLNGKAR IFASGSAGYQ 70 80 90 100 110 120 LEIFERRSFF QLLQKHDNDD RLLALLLLNT FTPRAQLASA LNLPETWVAE RLPRLKQRYE 130 140 150 160 170 180 RTCCLASRPG LGHFIDETEE KRVILLANLL RKDPFLIPLA GITRDNLQHL STACDNQHRW 190 200 210 220 230 240 PLMQGDYLSS LILAIYALRN QLTDEWPQYP GDEIKQIVEH SGLFLGDNAV RTLTGLIEKQ 250 260 270 280 290 300 HQQAQVISAD NVQGLLQRVP GIASLNIIDA QLVENITGHL LRCLAAPVWI AEHRQSSMNN 310 320 330 340 350 360 LKAAWPAAFD MSLHFITLLR EQLDIPLFDS DLIGLYFACA LERHQNERQP IILLSDQNAI 370 380 390 400 410 420 ATINQLAIER DVLNCRVIIA RSLSELVAIR EEIEPLLIIN NSHYLLDDAV NNYITVKNII 430 440 450 460 470 480 TAAGIEQIKH FLATAFIRQQ PERFFSAPGS FHYSNVRGES WQHITRQICA QLVAQHHITA 490 500 510 520 530 540 DEAQRIIARE GEGENLIVNR LAIPHCWSEQ ERRFRGFFIT LAQPVEVNNE VINHVLIACA 550 560 570 580 AADARHELKI FSYLASILCQ HPAEIIAGLT GYEAFMELLH KG

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Analysis of the Escherichia coli genome. III. DNA sequence of the region from 87.2 to 89.2 minutes." Plunkett G. III, Burland V., Daniels D.L., Blattner F.R. Nucleic Acids Res. 21:3391-3398(1993) [PubMed: 8346018] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / MG1655 / ATCC 47076.
[2]	"The complete genome sequence of Escherichia coli K-12." Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V., Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F., Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B., Shao Y. Science 277:1453-1474(1997) [PubMed: 9278503] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / MG1655 / ATCC 47076.
[3]	"Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110." Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T. Mol. Syst. Biol. 2:E1-E5(2006) [PubMed: 16738553] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
[4]	"Novel phosphotransferase system genes revealed by bacterial genome analysis: unique, putative fructose- and glucoside-specific systems." Reizer J., Michotey V., Reizer A., Saier M.H. Jr. Protein Sci. 3:440-450(1994) [PubMed: 8019415] [Abstract] Cited for: DISCUSSION OF SEQUENCE.

Cross-references

Sequence databases
EMBLGenBankDDBJ	L19201 Genomic DNA. Translation: AAB03030.1. U00096 Genomic DNA. Translation: AAC76879.1. AP009048 Genomic DNA. Translation: BAE77412.1.
PIR	S40841.
RefSeq	AP_003911.1. NP_418333.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	P32152. 1 interaction.
Genome annotation databases
GeneID	948389.
GenomeReviews	Gene locus JW3868 in contig AP009048_GR. Gene locus b3897 in contig U00096_GR.
KEGG	ecj:JW3868. eco:b3897.
Organism-specific databases
EchoBASE	EB1807.
EcoGene	EG11861. frvR.
CMR	Search...
Phylogenomic databases
HOGENOM	P32152.
OMA	P32152. VEQSGMF.
Enzyme and pathway databases
BioCyc	EcoCyc:EG11861-MON.
Family and domain databases
InterPro	IPR013196. HTH_11. IPR002178. PTS_EIIA_2. [Graphical view]
Gene3D	G3DSA:3.40.930.10. PTS_EIIA_2. 1 hit.
Pfam	PF08279. HTH_11. 1 hit. PF00359. PTS_EIIA_2. 1 hit. [Graphical view]
PROSITE	PS51094. PTS_EIIA_TYPE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

FRVR_ECOLI

Accession

Primary (citable) accession number: P32152
Secondary accession number(s): Q2M8J4

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 1, 1993
Last sequence update:	October 1, 1993
Last modified:	June 16, 2009
This is version 58 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)