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Protein

Putative frv operon regulatory protein

Gene

frvR

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Could be involved in the regulation of the transcription of the FRV operon.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi20 – 3920H-T-H motifBy similarityAdd
BLAST

GO - Molecular functioni

GO - Biological processi

  • regulation of transcription, DNA-templated Source: UniProtKB-KW
  • transcription, DNA-templated Source: EcoCyc
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciEcoCyc:EG11861-MONOMER.
ECOL316407:JW3868-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative frv operon regulatory protein
Including the following 1 domains:
Putative phosphotransferase EIIA component (EC:2.7.1.-)
Alternative name(s):
Putative PTS system EIIA component
Gene namesi
Name:frvR
Synonyms:yiiH
Ordered Locus Names:b3897, JW3868
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11861. frvR.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 582582Putative frv operon regulatory proteinPRO_0000087349Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei505 – 5051Phosphohistidine; by HPrBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP32152.
PRIDEiP32152.

Interactioni

Protein-protein interaction databases

BioGridi4263326. 6 interactions.
IntActiP32152. 1 interaction.
STRINGi511145.b3897.

Structurei

3D structure databases

ProteinModelPortaliP32152.
SMRiP32152. Positions 81-137.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini443 – 582140PTS EIIA type-2PROSITE-ProRule annotationAdd
BLAST

Domaini

The PTS EIIA type-2 domain may serve a regulatory function, through its phosphorylation activity.

Sequence similaritiesi

Contains 1 PTS EIIA type-2 domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG4106C3V. Bacteria.
COG1762. LUCA.
COG3711. LUCA.
HOGENOMiHOG000009657.
InParanoidiP32152.
KOiK18531.
OMAiEIINHVL.
OrthoDBiEOG644ZM8.
PhylomeDBiP32152.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
3.40.930.10. 1 hit.
InterProiIPR013196. HTH_11.
IPR016152. PTrfase/Anion_transptr.
IPR002178. PTS_EIIA_type-2_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF08279. HTH_11. 1 hit.
PF00359. PTS_EIIA_2. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
SSF55804. SSF55804. 1 hit.
PROSITEiPS51094. PTS_EIIA_TYPE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P32152-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLNERQLKIV DLLEQQPRTP GELAQQTGVS GRTILRDIDY LNFTLNGKAR
60 70 80 90 100
IFASGSAGYQ LEIFERRSFF QLLQKHDNDD RLLALLLLNT FTPRAQLASA
110 120 130 140 150
LNLPETWVAE RLPRLKQRYE RTCCLASRPG LGHFIDETEE KRVILLANLL
160 170 180 190 200
RKDPFLIPLA GITRDNLQHL STACDNQHRW PLMQGDYLSS LILAIYALRN
210 220 230 240 250
QLTDEWPQYP GDEIKQIVEH SGLFLGDNAV RTLTGLIEKQ HQQAQVISAD
260 270 280 290 300
NVQGLLQRVP GIASLNIIDA QLVENITGHL LRCLAAPVWI AEHRQSSMNN
310 320 330 340 350
LKAAWPAAFD MSLHFITLLR EQLDIPLFDS DLIGLYFACA LERHQNERQP
360 370 380 390 400
IILLSDQNAI ATINQLAIER DVLNCRVIIA RSLSELVAIR EEIEPLLIIN
410 420 430 440 450
NSHYLLDDAV NNYITVKNII TAAGIEQIKH FLATAFIRQQ PERFFSAPGS
460 470 480 490 500
FHYSNVRGES WQHITRQICA QLVAQHHITA DEAQRIIARE GEGENLIVNR
510 520 530 540 550
LAIPHCWSEQ ERRFRGFFIT LAQPVEVNNE VINHVLIACA AADARHELKI
560 570 580
FSYLASILCQ HPAEIIAGLT GYEAFMELLH KG
Length:582
Mass (Da):66,000
Last modified:October 1, 1993 - v1
Checksum:i96F37F10C58C2A10
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L19201 Genomic DNA. Translation: AAB03030.1.
U00096 Genomic DNA. Translation: AAC76879.1.
AP009048 Genomic DNA. Translation: BAE77412.1.
PIRiS40841.
RefSeqiNP_418333.1. NC_000913.3.
WP_000931299.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC76879; AAC76879; b3897.
BAE77412; BAE77412; BAE77412.
GeneIDi948389.
KEGGiecj:JW3868.
eco:b3897.
PATRICi32123303. VBIEscCol129921_4012.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L19201 Genomic DNA. Translation: AAB03030.1.
U00096 Genomic DNA. Translation: AAC76879.1.
AP009048 Genomic DNA. Translation: BAE77412.1.
PIRiS40841.
RefSeqiNP_418333.1. NC_000913.3.
WP_000931299.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP32152.
SMRiP32152. Positions 81-137.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4263326. 6 interactions.
IntActiP32152. 1 interaction.
STRINGi511145.b3897.

Proteomic databases

PaxDbiP32152.
PRIDEiP32152.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC76879; AAC76879; b3897.
BAE77412; BAE77412; BAE77412.
GeneIDi948389.
KEGGiecj:JW3868.
eco:b3897.
PATRICi32123303. VBIEscCol129921_4012.

Organism-specific databases

EchoBASEiEB1807.
EcoGeneiEG11861. frvR.

Phylogenomic databases

eggNOGiENOG4106C3V. Bacteria.
COG1762. LUCA.
COG3711. LUCA.
HOGENOMiHOG000009657.
InParanoidiP32152.
KOiK18531.
OMAiEIINHVL.
OrthoDBiEOG644ZM8.
PhylomeDBiP32152.

Enzyme and pathway databases

BioCyciEcoCyc:EG11861-MONOMER.
ECOL316407:JW3868-MONOMER.

Miscellaneous databases

PROiP32152.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
3.40.930.10. 1 hit.
InterProiIPR013196. HTH_11.
IPR016152. PTrfase/Anion_transptr.
IPR002178. PTS_EIIA_type-2_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF08279. HTH_11. 1 hit.
PF00359. PTS_EIIA_2. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
SSF55804. SSF55804. 1 hit.
PROSITEiPS51094. PTS_EIIA_TYPE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Analysis of the Escherichia coli genome. III. DNA sequence of the region from 87.2 to 89.2 minutes."
    Plunkett G. III, Burland V., Daniels D.L., Blattner F.R.
    Nucleic Acids Res. 21:3391-3398(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  3. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  4. "Novel phosphotransferase system genes revealed by bacterial genome analysis: unique, putative fructose- and glucoside-specific systems."
    Reizer J., Michotey V., Reizer A., Saier M.H. Jr.
    Protein Sci. 3:440-450(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: DISCUSSION OF SEQUENCE.

Entry informationi

Entry nameiFRVR_ECOLI
AccessioniPrimary (citable) accession number: P32152
Secondary accession number(s): Q2M8J4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: January 20, 2016
This is version 115 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.