Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Sulfofructosephosphate aldolase

Gene

yihT

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Cleaves 6-deoxy-6-sulfo-D-fructose 1-phosphate (SFP) to form dihydroxyacetone phosphate (DHAP) and 3-sulfolactaldehyde (SLA).UniRule annotation1 Publication

Catalytic activityi

6-deoxy-6-sulfo-D-fructose 1-phosphate = glycerone phosphate + 2-hydroxy-3-oxopropane-1-sulfonate.UniRule annotation1 Publication

GO - Molecular functioni

  • 6-deoxy-6-sulfofructose-1-phosphate aldolase activity Source: EcoCyc

GO - Biological processi

  • 6-sulfoquinovose(1-) catabolic process Source: EcoCyc
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Enzyme and pathway databases

BioCyciEcoCyc:EG11846-MONOMER.
ECOL316407:JW3852-MONOMER.
MetaCyc:EG11846-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Sulfofructosephosphate aldolaseUniRule annotation (EC:4.1.2.57UniRule annotation)
Short name:
SFP aldolaseUniRule annotation
Gene namesi
Name:yihT
Ordered Locus Names:b3881, JW3852
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11846. yihT.

Pathology & Biotechi

Disruption phenotypei

Mutant fails to grow on sulfoquinovose as a sole carbon source.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 292292Sulfofructosephosphate aldolasePRO_0000203969Add
BLAST

Proteomic databases

PaxDbiP32141.
PRIDEiP32141.

Expressioni

Inductioni

Induced during growth with sulfoquinovose.1 Publication

Interactioni

Protein-protein interaction databases

BioGridi4262639. 8 interactions.
IntActiP32141. 5 interactions.
STRINGi511145.b3881.

Structurei

3D structure databases

ProteinModelPortaliP32141.
SMRiP32141. Positions 1-291.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the aldolase LacD family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105D2M. Bacteria.
COG3684. LUCA.
HOGENOMiHOG000244296.
InParanoidiP32141.
KOiK01671.
OMAiGRAVWQE.
OrthoDBiEOG6SR92W.
PhylomeDBiP32141.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_01912. SFP_aldolase.
InterProiIPR013785. Aldolase_TIM.
IPR002915. DeoC/FbaB/lacD_aldolase.
IPR017291. SFP_aldolase_YihT.
[Graphical view]
PfamiPF01791. DeoC. 1 hit.
[Graphical view]
PIRSFiPIRSF037840. Aldolase_YihT. 1 hit.
SMARTiSM01133. DeoC. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P32141-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNKYTINDIT RASGGFAMLA VDQREAMRMM FAAAGAPAPV ADSVLTDFKV
60 70 80 90 100
NAAKALSPYA SAILVDQQFC YRQVVEQNAI AKSCAMIVAA DEFIPGNGIP
110 120 130 140 150
VDSVVIDRKI NPLQIKQDGG KALKLLVLWR SDEDAQQRLD MVKEFNELCH
160 170 180 190 200
SHGLVSIIEP VVRPPRRGDK FDREQAIIDA AKELGDSGAD LYKVEMPLYG
210 220 230 240 250
KGPQQELLCA SQRLNDHINM PWVILSSGVD EKLFPRAVRV AMTAGASGFL
260 270 280 290
AGRAVWASVV GLPDNELMLR DVCAPKLQQL GDIVDEMMAK RR
Length:292
Mass (Da):31,983
Last modified:October 1, 1993 - v1
Checksum:i4A54012E39FF447F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L19201 Genomic DNA. Translation: AAB03014.1.
U00096 Genomic DNA. Translation: AAD13443.1.
AP009048 Genomic DNA. Translation: BAE77428.1.
PIRiS40825.
RefSeqiNP_418317.1. NC_000913.3.
WP_001046453.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAD13443; AAD13443; b3881.
BAE77428; BAE77428; BAE77428.
GeneIDi948373.
KEGGiecj:JW3852.
eco:b3881.
PATRICi32123265. VBIEscCol129921_3993.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L19201 Genomic DNA. Translation: AAB03014.1.
U00096 Genomic DNA. Translation: AAD13443.1.
AP009048 Genomic DNA. Translation: BAE77428.1.
PIRiS40825.
RefSeqiNP_418317.1. NC_000913.3.
WP_001046453.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP32141.
SMRiP32141. Positions 1-291.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4262639. 8 interactions.
IntActiP32141. 5 interactions.
STRINGi511145.b3881.

Proteomic databases

PaxDbiP32141.
PRIDEiP32141.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAD13443; AAD13443; b3881.
BAE77428; BAE77428; BAE77428.
GeneIDi948373.
KEGGiecj:JW3852.
eco:b3881.
PATRICi32123265. VBIEscCol129921_3993.

Organism-specific databases

EchoBASEiEB1792.
EcoGeneiEG11846. yihT.

Phylogenomic databases

eggNOGiENOG4105D2M. Bacteria.
COG3684. LUCA.
HOGENOMiHOG000244296.
InParanoidiP32141.
KOiK01671.
OMAiGRAVWQE.
OrthoDBiEOG6SR92W.
PhylomeDBiP32141.

Enzyme and pathway databases

BioCyciEcoCyc:EG11846-MONOMER.
ECOL316407:JW3852-MONOMER.
MetaCyc:EG11846-MONOMER.

Miscellaneous databases

PROiP32141.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_01912. SFP_aldolase.
InterProiIPR013785. Aldolase_TIM.
IPR002915. DeoC/FbaB/lacD_aldolase.
IPR017291. SFP_aldolase_YihT.
[Graphical view]
PfamiPF01791. DeoC. 1 hit.
[Graphical view]
PIRSFiPIRSF037840. Aldolase_YihT. 1 hit.
SMARTiSM01133. DeoC. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Analysis of the Escherichia coli genome. III. DNA sequence of the region from 87.2 to 89.2 minutes."
    Plunkett G. III, Burland V., Daniels D.L., Blattner F.R.
    Nucleic Acids Res. 21:3391-3398(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  3. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  4. "Sulphoglycolysis in Escherichia coli K-12 closes a gap in the biogeochemical sulphur cycle."
    Denger K., Weiss M., Felux A.K., Schneider A., Mayer C., Spiteller D., Huhn T., Cook A.M., Schleheck D.
    Nature 507:114-117(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, CATALYTIC ACTIVITY, INDUCTION, DISRUPTION PHENOTYPE, IDENTIFICATION BY MASS SPECTROMETRY.
    Strain: K12.

Entry informationi

Entry nameiSQUT_ECOLI
AccessioniPrimary (citable) accession number: P32141
Secondary accession number(s): Q2M8H8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: May 11, 2016
This is version 112 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.