Skip Header

Contribute Send feedback
Read comments (?) or add your own

P32137 (YIHP_ECOLI) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 103. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Inner membrane symporter YihP
Gene names
Name:yihP
Ordered Locus Names:b3877, JW3848
OrganismEscherichia coli (strain K12) [Reference proteome] [HAMAP]
Taxonomic identifier83333 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Escherichia ›

Protein attributes

Sequence length461 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Subcellular location

Cell inner membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the sodium:galactoside symporter (TC 2.A.2) family. [View classification]

Sequence caution

The sequence AAB03010.1 differs from that shown. Reason: Erroneous initiation.

The sequence BAE77432.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Biological processSymport
Transport
   Cellular componentCell inner membrane
Cell membrane
Membrane
   DomainTransmembrane
Transmembrane helix
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processsodium ion transport

Inferred from electronic annotation. Source: InterPro

   Cellular_componentintegral to membrane

Inferred from electronic annotation. Source: UniProtKB-KW

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionsymporter activity

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 461461Inner membrane symporter YihP
PRO_0000170769

Regions

Topological domain1 – 2020Cytoplasmic Potential
Transmembrane21 – 4121Helical; Potential
Topological domain42 – 476Periplasmic Potential
Transmembrane48 – 6821Helical; Potential
Topological domain69 – 9224Cytoplasmic Potential
Transmembrane93 – 11321Helical; Potential
Topological domain114 – 12310Periplasmic Potential
Transmembrane124 – 14421Helical; Potential
Topological domain145 – 16218Cytoplasmic Potential
Transmembrane163 – 18321Helical; Potential
Topological domain184 – 1885Periplasmic Potential
Transmembrane189 – 20921Helical; Potential
Topological domain210 – 24334Cytoplasmic Potential
Transmembrane244 – 26421Helical; Potential
Topological domain265 – 27612Periplasmic Potential
Transmembrane277 – 29721Helical; Potential
Topological domain298 – 30811Cytoplasmic Potential
Transmembrane309 – 32921Helical; Potential
Topological domain3301Periplasmic Potential
Transmembrane331 – 35121Helical; Potential
Topological domain352 – 38736Cytoplasmic Potential
Transmembrane388 – 40821Helical; Potential
Topological domain409 – 41911Periplasmic Potential
Transmembrane420 – 44021Helical; Potential
Topological domain441 – 46121Cytoplasmic Potential

Experimental info

Sequence conflict459 – 4613RTA → AHGVIIINDAAGRYKE in AAB03010. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P32137 [UniParc].

Last modified December 15, 1998. Version 3.
Checksum: BC0A9A221536967D

FASTA46150,982
        10         20         30         40         50         60 
MSHITTEDPA TLRLPFKEKL SYGIGDLASN ILLDIGTLYL LKFYTDVLGL PGTYGGIIFL 

        70         80         90        100        110        120 
ISKFFTAFTD MGTGIMLDSR RKIGPKGKFR PFILYASFPV TLLAIANFVG TPFDVTGKTV 

       130        140        150        160        170        180 
MATILFMLYG LFFSMMNCSY GAMVPAITKN PNERASLAAW RQGGATLGLL LCTVGFVPVM 

       190        200        210        220        230        240 
NLIEGNQQLG YIFAATLFSL FGLLFMWICY SGVKERYVET QPANPAQKPG LLQSFRAIAG 

       250        260        270        280        290        300 
NRPLFILCIA NLCTLGAFNV KLAIQVYYTQ YVLNDPILLS YMGFFSMGCI FIGVFLMPAS 

       310        320        330        340        350        360 
VRRFGKKKVY IGGLLIWVLG DLLNYFFGGG SVSFVAFSCL AFFGSAFVNS LNWALVSDTV 

       370        380        390        400        410        420 
EYGEWRTGVR SEGTVYTGFT FFRKVSQALA GFFPGWMLTQ IGYVPNVAQA DHTIEGLRQL 

       430        440        450        460 
IFIYPSALAV VTIVAMGCFY SLNEKMYVRI VEEIEARKRT A

« Hide

References

[1]"Analysis of the Escherichia coli genome. III. DNA sequence of the region from 87.2 to 89.2 minutes."
Plunkett G. III, Burland V., Daniels D.L., Blattner F.R.
Nucleic Acids Res. 21:3391-3398(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: K12 / MG1655 / ATCC 47076.
[2]"The complete genome sequence of Escherichia coli K-12."
Blattner F.R., Plunkett G. III, Bloch C.A., Perna N.T., Burland V., Riley M., Collado-Vides J., Glasner J.D., Rode C.K., Mayhew G.F., Gregor J., Davis N.W., Kirkpatrick H.A., Goeden M.A., Rose D.J., Mau B., Shao Y.
Science 277:1453-1474(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], SEQUENCE REVISION TO C-TERMINUS.
Strain: K12 / MG1655 / ATCC 47076.
[3]"Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
[4]"Global topology analysis of the Escherichia coli inner membrane proteome."
Daley D.O., Rapp M., Granseth E., Melen K., Drew D., von Heijne G.
Science 308:1321-1323(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
Strain: K12 / MG1655 / ATCC 47076.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		L19201 Genomic DNA. Translation: AAB03010.1. Different initiation.
U00096 Genomic DNA. Translation: AAC76874.2.
AP009048 Genomic DNA. Translation: BAE77432.1. Different initiation.
PIRH65192.
RefSeqNP_418313.4. NC_000913.2.
YP_491573.1. NC_007779.1.

3D structure databases

ProteinModelPortalP32137.
ModBaseSearch...

Protein-protein interaction databases

STRING511145.b3877.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAC76874; AAC76874; b3877.
BAE77432; BAE77432; BAE77432.
GeneID12934263.
948371.
KEGGecj:Y75_p3309.
eco:b3877.
PATRIC32123257. VBIEscCol129921_3989.

Organism-specific databases

EchoBASEEB1788.
EcoGeneEG11842. yihP.

Phylogenomic databases

eggNOGCOG2211.
HOGENOMHOG000222020.
KOK03292.
OMAMATVLFM.
ProtClustDBCLSK880801.

Enzyme and pathway databases

BioCycEcoCyc:YIHP-MONOMER.
ECOL316407:JW3848-MONOMER.

Gene expression databases

GenevestigatorP32137.

Family and domain databases

InterProIPR016196. MFS_dom_general_subst_transpt.
IPR001927. Na/Gal_symport.
IPR018043. Na/Gal_symport_CS.
[Graphical view]
SUPFAMSSF103473. MFS_gen_substrate_transporter. 1 hit.
TIGRFAMsTIGR00792. gph. 1 hit.
PROSITEPS00872. NA_GALACTOSIDE_SYMP. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameYIHP_ECOLI
AccessionPrimary (citable) accession number: P32137
Secondary accession number(s): Q2M8H4
Entry history
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: December 15, 1998
Last modified: May 1, 2013
This is version 103 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

Escherichia coli

Escherichia coli (strain K12): entries and cross-references to EcoGene

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents