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Protein

Putative 2,3-dihydroxypropane-1-sulfonate exporter

Gene

yihP

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Could be involved in the export of 2,3-dihydroxypropane-1-sulfonate (DHPS).1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Symport, Transport

Enzyme and pathway databases

BioCyciEcoCyc:YIHP-MONOMER.
ECOL316407:JW3848-MONOMER.

Protein family/group databases

TCDBi2.A.2.3.9. the glycoside-pentoside-hexuronide (gph):cation symporter family.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative 2,3-dihydroxypropane-1-sulfonate exporter
Gene namesi
Name:yihP
Ordered Locus Names:b3877, JW3848
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11842. yihP.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2020CytoplasmicSequence analysisAdd
BLAST
Transmembranei21 – 4121HelicalSequence analysisAdd
BLAST
Topological domaini42 – 476PeriplasmicSequence analysis
Transmembranei48 – 6821HelicalSequence analysisAdd
BLAST
Topological domaini69 – 9224CytoplasmicSequence analysisAdd
BLAST
Transmembranei93 – 11321HelicalSequence analysisAdd
BLAST
Topological domaini114 – 12310PeriplasmicSequence analysis
Transmembranei124 – 14421HelicalSequence analysisAdd
BLAST
Topological domaini145 – 16218CytoplasmicSequence analysisAdd
BLAST
Transmembranei163 – 18321HelicalSequence analysisAdd
BLAST
Topological domaini184 – 1885PeriplasmicSequence analysis
Transmembranei189 – 20921HelicalSequence analysisAdd
BLAST
Topological domaini210 – 24334CytoplasmicSequence analysisAdd
BLAST
Transmembranei244 – 26421HelicalSequence analysisAdd
BLAST
Topological domaini265 – 27612PeriplasmicSequence analysisAdd
BLAST
Transmembranei277 – 29721HelicalSequence analysisAdd
BLAST
Topological domaini298 – 30811CytoplasmicSequence analysisAdd
BLAST
Transmembranei309 – 32921HelicalSequence analysisAdd
BLAST
Topological domaini330 – 3301PeriplasmicSequence analysis
Transmembranei331 – 35121HelicalSequence analysisAdd
BLAST
Topological domaini352 – 38736CytoplasmicSequence analysisAdd
BLAST
Transmembranei388 – 40821HelicalSequence analysisAdd
BLAST
Topological domaini409 – 41911PeriplasmicSequence analysisAdd
BLAST
Transmembranei420 – 44021HelicalSequence analysisAdd
BLAST
Topological domaini441 – 46121CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 461461Putative 2,3-dihydroxypropane-1-sulfonate exporterPRO_0000170769Add
BLAST

Proteomic databases

PaxDbiP32137.

Interactioni

Protein-protein interaction databases

BioGridi4263257. 216 interactions.
IntActiP32137. 1 interaction.
STRINGi511145.b3877.

Structurei

3D structure databases

ProteinModelPortaliP32137.
SMRiP32137. Positions 12-450.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105CT4. Bacteria.
COG2211. LUCA.
HOGENOMiHOG000222020.
InParanoidiP32137.
KOiK03292.
OMAiAYGMGDL.
OrthoDBiEOG6P5ZFF.
PhylomeDBiP32137.

Family and domain databases

InterProiIPR020846. MFS_dom.
IPR001927. Na/Gal_symport.
IPR018043. Na/Gal_symport_CS.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
TIGRFAMsiTIGR00792. gph. 1 hit.
PROSITEiPS00872. NA_GALACTOSIDE_SYMP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P32137-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSHITTEDPA TLRLPFKEKL SYGIGDLASN ILLDIGTLYL LKFYTDVLGL
60 70 80 90 100
PGTYGGIIFL ISKFFTAFTD MGTGIMLDSR RKIGPKGKFR PFILYASFPV
110 120 130 140 150
TLLAIANFVG TPFDVTGKTV MATILFMLYG LFFSMMNCSY GAMVPAITKN
160 170 180 190 200
PNERASLAAW RQGGATLGLL LCTVGFVPVM NLIEGNQQLG YIFAATLFSL
210 220 230 240 250
FGLLFMWICY SGVKERYVET QPANPAQKPG LLQSFRAIAG NRPLFILCIA
260 270 280 290 300
NLCTLGAFNV KLAIQVYYTQ YVLNDPILLS YMGFFSMGCI FIGVFLMPAS
310 320 330 340 350
VRRFGKKKVY IGGLLIWVLG DLLNYFFGGG SVSFVAFSCL AFFGSAFVNS
360 370 380 390 400
LNWALVSDTV EYGEWRTGVR SEGTVYTGFT FFRKVSQALA GFFPGWMLTQ
410 420 430 440 450
IGYVPNVAQA DHTIEGLRQL IFIYPSALAV VTIVAMGCFY SLNEKMYVRI
460
VEEIEARKRT A
Length:461
Mass (Da):50,982
Last modified:December 15, 1998 - v3
Checksum:iBC0A9A221536967D
GO

Sequence cautioni

The sequence AAB03010.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence BAE77432.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti459 – 4613RTA → AHGVIIINDAAGRYKE in AAB03010 (PubMed:8346018).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L19201 Genomic DNA. Translation: AAB03010.1. Different initiation.
U00096 Genomic DNA. Translation: AAC76874.2.
AP009048 Genomic DNA. Translation: BAE77432.1. Different initiation.
PIRiH65192.
RefSeqiNP_418313.4. NC_000913.3.
WP_000018380.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC76874; AAC76874; b3877.
BAE77432; BAE77432; BAE77432.
GeneIDi948371.
KEGGiecj:JW3848.
eco:b3877.
PATRICi32123257. VBIEscCol129921_3989.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L19201 Genomic DNA. Translation: AAB03010.1. Different initiation.
U00096 Genomic DNA. Translation: AAC76874.2.
AP009048 Genomic DNA. Translation: BAE77432.1. Different initiation.
PIRiH65192.
RefSeqiNP_418313.4. NC_000913.3.
WP_000018380.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP32137.
SMRiP32137. Positions 12-450.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4263257. 216 interactions.
IntActiP32137. 1 interaction.
STRINGi511145.b3877.

Protein family/group databases

TCDBi2.A.2.3.9. the glycoside-pentoside-hexuronide (gph):cation symporter family.

Proteomic databases

PaxDbiP32137.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC76874; AAC76874; b3877.
BAE77432; BAE77432; BAE77432.
GeneIDi948371.
KEGGiecj:JW3848.
eco:b3877.
PATRICi32123257. VBIEscCol129921_3989.

Organism-specific databases

EchoBASEiEB1788.
EcoGeneiEG11842. yihP.

Phylogenomic databases

eggNOGiENOG4105CT4. Bacteria.
COG2211. LUCA.
HOGENOMiHOG000222020.
InParanoidiP32137.
KOiK03292.
OMAiAYGMGDL.
OrthoDBiEOG6P5ZFF.
PhylomeDBiP32137.

Enzyme and pathway databases

BioCyciEcoCyc:YIHP-MONOMER.
ECOL316407:JW3848-MONOMER.

Miscellaneous databases

PROiP32137.

Family and domain databases

InterProiIPR020846. MFS_dom.
IPR001927. Na/Gal_symport.
IPR018043. Na/Gal_symport_CS.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
TIGRFAMsiTIGR00792. gph. 1 hit.
PROSITEiPS00872. NA_GALACTOSIDE_SYMP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Analysis of the Escherichia coli genome. III. DNA sequence of the region from 87.2 to 89.2 minutes."
    Plunkett G. III, Burland V., Daniels D.L., Blattner F.R.
    Nucleic Acids Res. 21:3391-3398(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / MG1655 / ATCC 47076.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], SEQUENCE REVISION TO C-TERMINUS.
    Strain: K12 / MG1655 / ATCC 47076.
  3. "Highly accurate genome sequences of Escherichia coli K-12 strains MG1655 and W3110."
    Hayashi K., Morooka N., Yamamoto Y., Fujita K., Isono K., Choi S., Ohtsubo E., Baba T., Wanner B.L., Mori H., Horiuchi T.
    Mol. Syst. Biol. 2:E1-E5(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: K12 / W3110 / ATCC 27325 / DSM 5911.
  4. "Global topology analysis of the Escherichia coli inner membrane proteome."
    Daley D.O., Rapp M., Granseth E., Melen K., Drew D., von Heijne G.
    Science 308:1321-1323(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: TOPOLOGY [LARGE SCALE ANALYSIS].
    Strain: K12 / MG1655 / ATCC 47076.
  5. "Sulphoglycolysis in Escherichia coli K-12 closes a gap in the biogeochemical sulphur cycle."
    Denger K., Weiss M., Felux A.K., Schneider A., Mayer C., Spiteller D., Huhn T., Cook A.M., Schleheck D.
    Nature 507:114-117(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
    Strain: K12.

Entry informationi

Entry nameiYIHP_ECOLI
AccessioniPrimary (citable) accession number: P32137
Secondary accession number(s): Q2M8H4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: December 15, 1998
Last modified: January 20, 2016
This is version 122 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.