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Protein

Putative 2,3-dihydroxypropane-1-sulfonate exporter

Gene

yihP

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Could be involved in the export of 2,3-dihydroxypropane-1-sulfonate (DHPS).1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Symport, Transport

Enzyme and pathway databases

BioCyciEcoCyc:YIHP-MONOMER.
ECOL316407:JW3848-MONOMER.

Protein family/group databases

TCDBi2.A.2.3.9. the glycoside-pentoside-hexuronide (gph):cation symporter family.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative 2,3-dihydroxypropane-1-sulfonate exporter
Gene namesi
Name:yihP
Ordered Locus Names:b3877, JW3848
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11842. yihP.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 20CytoplasmicSequence analysisAdd BLAST20
Transmembranei21 – 41HelicalSequence analysisAdd BLAST21
Topological domaini42 – 47PeriplasmicSequence analysis6
Transmembranei48 – 68HelicalSequence analysisAdd BLAST21
Topological domaini69 – 92CytoplasmicSequence analysisAdd BLAST24
Transmembranei93 – 113HelicalSequence analysisAdd BLAST21
Topological domaini114 – 123PeriplasmicSequence analysis10
Transmembranei124 – 144HelicalSequence analysisAdd BLAST21
Topological domaini145 – 162CytoplasmicSequence analysisAdd BLAST18
Transmembranei163 – 183HelicalSequence analysisAdd BLAST21
Topological domaini184 – 188PeriplasmicSequence analysis5
Transmembranei189 – 209HelicalSequence analysisAdd BLAST21
Topological domaini210 – 243CytoplasmicSequence analysisAdd BLAST34
Transmembranei244 – 264HelicalSequence analysisAdd BLAST21
Topological domaini265 – 276PeriplasmicSequence analysisAdd BLAST12
Transmembranei277 – 297HelicalSequence analysisAdd BLAST21
Topological domaini298 – 308CytoplasmicSequence analysisAdd BLAST11
Transmembranei309 – 329HelicalSequence analysisAdd BLAST21
Topological domaini330PeriplasmicSequence analysis1
Transmembranei331 – 351HelicalSequence analysisAdd BLAST21
Topological domaini352 – 387CytoplasmicSequence analysisAdd BLAST36
Transmembranei388 – 408HelicalSequence analysisAdd BLAST21
Topological domaini409 – 419PeriplasmicSequence analysisAdd BLAST11
Transmembranei420 – 440HelicalSequence analysisAdd BLAST21
Topological domaini441 – 461CytoplasmicSequence analysisAdd BLAST21

GO - Cellular componenti

  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001707691 – 461Putative 2,3-dihydroxypropane-1-sulfonate exporterAdd BLAST461

Proteomic databases

PaxDbiP32137.
PRIDEiP32137.

Interactioni

Protein-protein interaction databases

BioGridi4263257. 216 interactors.
IntActiP32137. 1 interactor.
STRINGi511145.b3877.

Structurei

3D structure databases

ProteinModelPortaliP32137.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105CT4. Bacteria.
COG2211. LUCA.
HOGENOMiHOG000222020.
InParanoidiP32137.
KOiK03292.
OMAiAYGMGDL.
PhylomeDBiP32137.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR020846. MFS_dom.
IPR001927. Na/Gal_symport.
IPR018043. Na/Gal_symport_CS.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
TIGRFAMsiTIGR00792. gph. 1 hit.
PROSITEiPS00872. NA_GALACTOSIDE_SYMP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P32137-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSHITTEDPA TLRLPFKEKL SYGIGDLASN ILLDIGTLYL LKFYTDVLGL
60 70 80 90 100
PGTYGGIIFL ISKFFTAFTD MGTGIMLDSR RKIGPKGKFR PFILYASFPV
110 120 130 140 150
TLLAIANFVG TPFDVTGKTV MATILFMLYG LFFSMMNCSY GAMVPAITKN
160 170 180 190 200
PNERASLAAW RQGGATLGLL LCTVGFVPVM NLIEGNQQLG YIFAATLFSL
210 220 230 240 250
FGLLFMWICY SGVKERYVET QPANPAQKPG LLQSFRAIAG NRPLFILCIA
260 270 280 290 300
NLCTLGAFNV KLAIQVYYTQ YVLNDPILLS YMGFFSMGCI FIGVFLMPAS
310 320 330 340 350
VRRFGKKKVY IGGLLIWVLG DLLNYFFGGG SVSFVAFSCL AFFGSAFVNS
360 370 380 390 400
LNWALVSDTV EYGEWRTGVR SEGTVYTGFT FFRKVSQALA GFFPGWMLTQ
410 420 430 440 450
IGYVPNVAQA DHTIEGLRQL IFIYPSALAV VTIVAMGCFY SLNEKMYVRI
460
VEEIEARKRT A
Length:461
Mass (Da):50,982
Last modified:December 15, 1998 - v3
Checksum:iBC0A9A221536967D
GO

Sequence cautioni

The sequence AAB03010 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated
The sequence BAE77432 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti459 – 461RTA → AHGVIIINDAAGRYKE in AAB03010 (PubMed:8346018).Curated3

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L19201 Genomic DNA. Translation: AAB03010.1. Different initiation.
U00096 Genomic DNA. Translation: AAC76874.2.
AP009048 Genomic DNA. Translation: BAE77432.1. Different initiation.
PIRiH65192.
RefSeqiNP_418313.4. NC_000913.3.
WP_000018380.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC76874; AAC76874; b3877.
BAE77432; BAE77432; BAE77432.
GeneIDi948371.
KEGGiecj:JW3848.
eco:b3877.
PATRICi32123257. VBIEscCol129921_3989.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L19201 Genomic DNA. Translation: AAB03010.1. Different initiation.
U00096 Genomic DNA. Translation: AAC76874.2.
AP009048 Genomic DNA. Translation: BAE77432.1. Different initiation.
PIRiH65192.
RefSeqiNP_418313.4. NC_000913.3.
WP_000018380.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP32137.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4263257. 216 interactors.
IntActiP32137. 1 interactor.
STRINGi511145.b3877.

Protein family/group databases

TCDBi2.A.2.3.9. the glycoside-pentoside-hexuronide (gph):cation symporter family.

Proteomic databases

PaxDbiP32137.
PRIDEiP32137.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC76874; AAC76874; b3877.
BAE77432; BAE77432; BAE77432.
GeneIDi948371.
KEGGiecj:JW3848.
eco:b3877.
PATRICi32123257. VBIEscCol129921_3989.

Organism-specific databases

EchoBASEiEB1788.
EcoGeneiEG11842. yihP.

Phylogenomic databases

eggNOGiENOG4105CT4. Bacteria.
COG2211. LUCA.
HOGENOMiHOG000222020.
InParanoidiP32137.
KOiK03292.
OMAiAYGMGDL.
PhylomeDBiP32137.

Enzyme and pathway databases

BioCyciEcoCyc:YIHP-MONOMER.
ECOL316407:JW3848-MONOMER.

Miscellaneous databases

PROiP32137.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR020846. MFS_dom.
IPR001927. Na/Gal_symport.
IPR018043. Na/Gal_symport_CS.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
TIGRFAMsiTIGR00792. gph. 1 hit.
PROSITEiPS00872. NA_GALACTOSIDE_SYMP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiYIHP_ECOLI
AccessioniPrimary (citable) accession number: P32137
Secondary accession number(s): Q2M8H4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: December 15, 1998
Last modified: November 2, 2016
This is version 125 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.