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Protein

Inner membrane protein YihN

Gene

yihN

Organism
Escherichia coli (strain K12)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

BioCyciEcoCyc:YIHN-MONOMER.
ECOL316407:JW3845-MONOMER.

Protein family/group databases

TCDBi2.A.1.52.1. the major facilitator superfamily (mfs).

Names & Taxonomyi

Protein namesi
Recommended name:
Inner membrane protein YihNCurated
Gene namesi
Name:yihN
Ordered Locus Names:b3874, JW3845
OrganismiEscherichia coli (strain K12)
Taxonomic identifieri83333 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesEnterobacteriaceaeEscherichia
Proteomesi
  • UP000000318 Componenti: Chromosome
  • UP000000625 Componenti: Chromosome

Organism-specific databases

EcoGeneiEG11840. yihN.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 44PeriplasmicCuratedAdd BLAST44
Transmembranei45 – 65HelicalSequence analysisAdd BLAST21
Topological domaini66 – 73CytoplasmicCurated8
Transmembranei74 – 91HelicalSequence analysisAdd BLAST18
Topological domaini92 – 95PeriplasmicCurated4
Transmembranei96 – 118HelicalSequence analysisAdd BLAST23
Topological domaini119 – 146CytoplasmicCuratedAdd BLAST28
Transmembranei147 – 167HelicalSequence analysisAdd BLAST21
Topological domaini168PeriplasmicCurated1
Transmembranei169 – 189HelicalSequence analysisAdd BLAST21
Topological domaini190 – 220CytoplasmicCuratedAdd BLAST31
Transmembranei221 – 241HelicalSequence analysisAdd BLAST21
Transmembranei242 – 262HelicalSequence analysisAdd BLAST21
Topological domaini263 – 288CytoplasmicCuratedAdd BLAST26
Transmembranei289 – 309HelicalSequence analysisAdd BLAST21
Transmembranei310 – 330HelicalSequence analysisAdd BLAST21
Topological domaini331 – 354CytoplasmicCuratedAdd BLAST24
Transmembranei355 – 375HelicalSequence analysisAdd BLAST21
Topological domaini376 – 385PeriplasmicCurated10
Transmembranei386 – 406HelicalSequence analysisAdd BLAST21
Topological domaini407 – 421Cytoplasmic1 PublicationAdd BLAST15

GO - Cellular componenti

  • integral component of membrane Source: GO_Central
  • plasma membrane Source: EcoCyc
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001696761 – 421Inner membrane protein YihNAdd BLAST421

Proteomic databases

PaxDbiP32135.
PRIDEiP32135.

Expressioni

Inductioni

Down-regulated by cystine.1 Publication

Interactioni

Protein-protein interaction databases

BioGridi4262634. 179 interactors.
DIPiDIP-12495N.
IntActiP32135. 1 interactor.
MINTiMINT-1286054.
STRINGi511145.b3874.

Structurei

3D structure databases

ProteinModelPortaliP32135.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the major facilitator superfamily.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105R9B. Bacteria.
ENOG410XQHZ. LUCA.
HOGENOMiHOG000127507.
OMAiCDMLNWP.
PhylomeDBiP32135.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR011701. MFS.
IPR020846. MFS_dom.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P32135-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLTKKKWALF SLLTLCGGTI YKLPSLKDAF YIPMQEYFHL TNGQIGNAMS
60 70 80 90 100
VNSFVTTVGF FLSIYFADKL PRRYTMSFSL IATGLLGVYL TTMPGYWGIL
110 120 130 140 150
FVWALFGVTC DMMNWPVLLK SVSRLGNSEQ QGRLFGFFET GRGIVDTVVA
160 170 180 190 200
FSALAVFTWF GSGLLGFKAG IWFYSLIVIA VGIIIFFVLN DKEEAPSVEV
210 220 230 240 250
KKEDGASKNT SMTSVLKDKT IWLIAFNVFF VYAVYCGLTF FIPFLKNIYL
260 270 280 290 300
LPVALVGAYG IINQYCLKMI GGPIGGMISD KILKSPSKYL CYTFIISTAA
310 320 330 340 350
LVLLIMLPHE SMPVYLGMAC TLGFGAIVFT QRAVFFAPIG EAKIAENKTG
360 370 380 390 400
AAMALGSFIG YAPAMFCFSL YGYILDLNPG IIGYKIVFGI MACFAFSGAV
410 420
VSVMLVKRIS QRKKEMLAAE A
Length:421
Mass (Da):46,335
Last modified:October 1, 1993 - v1
Checksum:i4FD9FAAA33A8E846
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L19201 Genomic DNA. Translation: AAB03008.1.
U00096 Genomic DNA. Translation: AAC76871.1.
AP009048 Genomic DNA. Translation: BAE77435.1.
PIRiS40819.
RefSeqiNP_418310.1. NC_000913.3.
WP_000956313.1. NZ_LN832404.1.

Genome annotation databases

EnsemblBacteriaiAAC76871; AAC76871; b3874.
BAE77435; BAE77435; BAE77435.
GeneIDi948365.
KEGGiecj:JW3845.
eco:b3874.
PATRICi32123251. VBIEscCol129921_3986.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L19201 Genomic DNA. Translation: AAB03008.1.
U00096 Genomic DNA. Translation: AAC76871.1.
AP009048 Genomic DNA. Translation: BAE77435.1.
PIRiS40819.
RefSeqiNP_418310.1. NC_000913.3.
WP_000956313.1. NZ_LN832404.1.

3D structure databases

ProteinModelPortaliP32135.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi4262634. 179 interactors.
DIPiDIP-12495N.
IntActiP32135. 1 interactor.
MINTiMINT-1286054.
STRINGi511145.b3874.

Protein family/group databases

TCDBi2.A.1.52.1. the major facilitator superfamily (mfs).

Proteomic databases

PaxDbiP32135.
PRIDEiP32135.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAC76871; AAC76871; b3874.
BAE77435; BAE77435; BAE77435.
GeneIDi948365.
KEGGiecj:JW3845.
eco:b3874.
PATRICi32123251. VBIEscCol129921_3986.

Organism-specific databases

EchoBASEiEB1786.
EcoGeneiEG11840. yihN.

Phylogenomic databases

eggNOGiENOG4105R9B. Bacteria.
ENOG410XQHZ. LUCA.
HOGENOMiHOG000127507.
OMAiCDMLNWP.
PhylomeDBiP32135.

Enzyme and pathway databases

BioCyciEcoCyc:YIHN-MONOMER.
ECOL316407:JW3845-MONOMER.

Miscellaneous databases

PROiP32135.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR011701. MFS.
IPR020846. MFS_dom.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiYIHN_ECOLI
AccessioniPrimary (citable) accession number: P32135
Secondary accession number(s): Q2M8H1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: November 2, 2016
This is version 124 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Escherichia coli
    Escherichia coli (strain K12): entries and cross-references to EcoGene
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.