ID ARRB2_HUMAN Reviewed; 409 AA. AC P32121; Q0Z8D3; Q2PP19; Q6ICT3; Q8N7Y2; Q9UEQ6; DT 01-OCT-1993, integrated into UniProtKB/Swiss-Prot. DT 05-MAR-2002, sequence version 2. DT 03-MAR-2009, entry version 86. DE RecName: Full=Beta-arrestin-2; DE AltName: Full=Arrestin beta-2; GN Name=ARRB2; Synonyms=ARB2, ARR2; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; OC Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; OC Catarrhini; Hominidae; Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). RC TISSUE=Thyroid; RX MEDLINE=92267237; PubMed=1587386; DOI=10.1016/0303-7207(92)90038-8; RA Rapoport B., Kaufman K.D., Chamenbalk G.D.; RT "Cloning of a member of the arrestin family from a human thyroid cDNA RT library."; RL Mol. Cell. Endocrinol. 84:R39-R43(1992). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). RC TISSUE=Brain; RA Yu Q.M., Zhou T.H., Wu Y.L., Cheng Z.J., Ma L., Pei G.; RT "G-protein coupled receptor interaction with beta-arrestin 2 through RT specific agonist stimulation."; RL Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases. RN [3] RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2). RA Sanchez-Laorden B.L., Jimenez-Cervantes C., Garcia-Borron J.C.; RT "A new splice-variant of beta-arrestin 2 is involved in agonist- RT induced MC1R endocytosis."; RL Submitted (MAY-2006) to the EMBL/GenBank/DDBJ databases. RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3). RC TISSUE=Testis; RX PubMed=14702039; DOI=10.1038/ng1285; RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S., RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., RA Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., RA Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., RA Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., RA Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., RA Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., RA Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., RA Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., RA Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., RA Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., RA Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., RA Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., RA Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., RA Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., RA Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., RA Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., RA Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., RA Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., RA Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., RA Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.; RT "Complete sequencing and characterization of 21,243 full-length human RT cDNAs."; RL Nat. Genet. 36:40-45(2004). RN [5] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). RA Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.; RT "Cloning of human full open reading frames in Gateway(TM) system entry RT vector (pDONR201)."; RL Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases. RN [6] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA]. RG NHLBI resequencing and genotyping service (RS&G); RL Submitted (DEC-2005) to the EMBL/GenBank/DDBJ databases. RN [7] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). RC TISSUE=Muscle, and Pancreas; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA RT project: the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). CC -!- FUNCTION: Regulates beta-adrenergic receptor function. Beta- CC arrestins seem to bind phosphorylated beta-adrenergic receptors, CC thereby causing a significant impairment of their capacity to CC activate G(S) proteins. CC -!- INTERACTION: CC O00203:AP3B1; NbExp=1; IntAct=EBI-714559, EBI-1044383; CC P49407:ARRB1; NbExp=1; IntAct=EBI-714559, EBI-743313; CC Q14137:BOP1; NbExp=1; IntAct=EBI-714559, EBI-1050828; CC P62158:CALM1; NbExp=1; IntAct=EBI-714559, EBI-397435; CC Q96GQ7:DDX27; NbExp=1; IntAct=EBI-714559, EBI-722051; CC P22087:FBL; NbExp=1; IntAct=EBI-714559, EBI-358318; CC P06396:GSN; NbExp=1; IntAct=EBI-714559, EBI-351506; CC P11142:HSPA8; NbExp=1; IntAct=EBI-714559, EBI-351896; CC O00505:KPNA3; NbExp=1; IntAct=EBI-714559, EBI-358297; CC O00629:KPNA4; NbExp=1; IntAct=EBI-714559, EBI-396343; CC Q8N983:MRPL43; NbExp=1; IntAct=EBI-714559, EBI-1043145; CC Q9H9J2:MRPL44; NbExp=1; IntAct=EBI-714559, EBI-713619; CC P19338:NCL; NbExp=1; IntAct=EBI-714559, EBI-352553; CC Q14978:NOLC1; NbExp=2; IntAct=EBI-714559, EBI-396155; CC O00541:PES1; NbExp=1; IntAct=EBI-714559, EBI-1053271; CC P14618:PKM2; NbExp=1; IntAct=EBI-714559, EBI-353408; CC P35813:PPM1A; NbExp=1; IntAct=EBI-714559, EBI-989143; CC O75688:PPM1B; NbExp=1; IntAct=EBI-714559, EBI-1047039; CC Q13523:PRPF4B; NbExp=1; IntAct=EBI-714559, EBI-395940; CC P51148:RAB5C; NbExp=1; IntAct=EBI-714559, EBI-1054923; CC Q6DKI1:RPL7L1; NbExp=1; IntAct=EBI-714559, EBI-1052408; CC P06702:S100A9; NbExp=1; IntAct=EBI-714559, EBI-1055001; CC Q15208:STK38; NbExp=1; IntAct=EBI-714559, EBI-458376; CC Q13428:TCOF1; NbExp=2; IntAct=EBI-714559, EBI-396105; CC P27348:YWHAQ; NbExp=1; IntAct=EBI-714559, EBI-359854; CC O95218:ZRANB2; NbExp=1; IntAct=EBI-714559, EBI-1051583; CC -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity). Nucleus (By CC similarity). CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=3; CC Name=1; CC IsoId=P32121-1; Sequence=Displayed; CC Name=2; CC IsoId=P32121-3; Sequence=VSP_008195; CC Name=3; CC IsoId=P32121-2; Sequence=VSP_008194, VSP_008195; CC Note=No experimental confirmation available; CC -!- SIMILARITY: Belongs to the arrestin family. CC -!- WEB RESOURCE: Name=Wikipedia; Note=Arrestin entry; CC URL="http://en.wikipedia.org/wiki/Arrestin"; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; Z11501; CAA77577.1; -; mRNA. DR EMBL; AF106941; AAC99468.1; -; mRNA. DR EMBL; DQ664180; ABG47460.1; -; mRNA. DR EMBL; AK097542; BAC05094.1; -; mRNA. DR EMBL; CR450310; CAG29306.1; -; mRNA. DR EMBL; DQ314866; ABC40725.1; -; Genomic_DNA. DR EMBL; BC007427; AAH07427.1; -; mRNA. DR EMBL; BC067368; AAH67368.1; -; mRNA. DR IPI; IPI00180375; -. DR IPI; IPI00783893; -. DR IPI; IPI00786904; -. DR PIR; S18984; S18984. DR RefSeq; NP_004304.1; -. DR RefSeq; NP_945355.1; -. DR UniGene; Hs.435811; -. DR HSSP; P17870; 1G4M. DR IntAct; P32121; 276. DR PhosphoSite; P32121; -. DR PRIDE; P32121; -. DR Ensembl; ENSG00000141480; Homo sapiens. DR GeneID; 409; -. DR KEGG; hsa:409; -. DR GeneCards; GC17P004560; -. DR HGNC; HGNC:712; ARRB2. DR MIM; 107941; gene. DR PharmGKB; PA60; -. DR HOVERGEN; P32121; -. DR Pathway_Interaction_DB; arf6_traffickingpathway; Arf6 trafficking events. DR Pathway_Interaction_DB; arf6arrestinpathway; Arf6 mediated densensitization of LHCGR. DR Pathway_Interaction_DB; arf6cyclingpathway; Arf6 signaling events. DR Pathway_Interaction_DB; hedgehog_2pathway; Signaling events mediated by the Hedgehog family. DR Pathway_Interaction_DB; hedgehog_glipathway; Hedgehog signaling events mediated by Gli proteins. DR Pathway_Interaction_DB; nfkappabatypicalpathway; Atypical NF-kappaB pathway. DR Pathway_Interaction_DB; tgfbrpathway; TGF-beta receptor signaling. DR Pathway_Interaction_DB; txa2pathway; Thromboxane A2 receptor signaling. DR NextBio; 1719; -. DR ArrayExpress; P32121; -. DR Bgee; P32121; -. DR CleanEx; HS_ARRB2; -. DR GermOnline; ENSG00000141480; Homo sapiens. DR GO; GO:0031410; C:cytoplasmic vesicle; IDA:UniProtKB. DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW. DR GO; GO:0005886; C:plasma membrane; TAS:ProtInc. DR GO; GO:0005515; F:protein binding; IPI:IntAct. DR GO; GO:0031623; P:receptor internalization; IDA:UniProtKB. DR GO; GO:0050896; P:response to stimulus; IEA:UniProtKB-KW. DR GO; GO:0007600; P:sensory perception; IEA:InterPro. DR GO; GO:0007179; P:transforming growth factor beta receptor si...; IDA:UniProtKB. DR InterPro; IPR000698; Arrestin. DR InterPro; IPR011022; Arrestin-like_C. DR InterPro; IPR011021; Arrestin-like_N. DR InterPro; IPR014752; Arrestin_C. DR InterPro; IPR017864; Arrestin_CS. DR InterPro; IPR014753; Arrestin_N. DR Gene3D; G3DSA:2.60.40.640; Arrestin_C; 1. DR Gene3D; G3DSA:2.60.40.840; Arrestin_N; 1. DR PANTHER; PTHR11792; Arrestin; 1. DR Pfam; PF02752; Arrestin_C; 1. DR Pfam; PF00339; Arrestin_N; 1. DR PRINTS; PR00309; ARRESTIN. DR ProDom; PD002099; Arrestin; 2. DR PROSITE; PS00295; ARRESTINS; 1. PE 1: Evidence at protein level; KW Alternative splicing; Cytoplasm; Nucleus; Phosphoprotein; KW Sensory transduction. FT CHAIN 1 409 Beta-arrestin-2. FT /FTId=PRO_0000205199. FT MOTIF 389 399 Nuclear export signal (By similarity). FT MOD_RES 48 48 Phosphotyrosine (By similarity). FT VAR_SEQ 39 53 Missing (in isoform 3). FT /FTId=VSP_008194. FT VAR_SEQ 360 360 S -> SAPTPTPPLPVPP (in isoform 2 and FT isoform 3). FT /FTId=VSP_008195. FT CONFLICT 189 189 R -> P (in Ref. 1; CAA77577). FT CONFLICT 190 190 H -> R (in Ref. 3; ABG47460). FT CONFLICT 192 192 L -> P (in Ref. 5; CAG29306). SQ SEQUENCE 409 AA; 46106 MW; DEEC507D4A7B84FF CRC64; MGEKPGTRVF KKSSPNCKLT VYLGKRDFVD HLDKVDPVDG VVLVDPDYLK DRKVFVTLTC AFRYGREDLD VLGLSFRKDL FIATYQAFPP VPNPPRPPTR LQDRLLRKLG QHAHPFFFTI PQNLPCSVTL QPGPEDTGKA CGVDFEIRAF CAKSLEEKSH KRNSVRLVIR KVQFAPEKPG PQPSAETTRH FLMSDRSLHL EASLDKELYY HGEPLNVNVH VTNNSTKTVK KIKVSVRQYA DICLFSTAQY KCPVAQLEQD DQVSPSSTFC KVYTITPLLS DNREKRGLAL DGKLKHEDTN LASSTIVKEG ANKEVLGILV SYRVKVKLVV SRGGDVSVEL PFVLMHPKPH DHIPLPRPQS AAPETDVPVD TNLIEFDTNY ATDDDIVFED FARLRLKGMK DDDYDDQLC //