ID   ARRB2_HUMAN    STANDARD;      PRT;   409 AA.
AC   P32121; Q2PP19; Q8N7Y2; Q9UEQ6;
DT   01-OCT-1993, integrated into UniProtKB/Swiss-Prot.
DT   05-MAR-2002, sequence version 2.
DT   05-SEP-2006, entry version 56.
DE   Beta-arrestin-2 (Arrestin, beta 2).
GN   Name=ARRB2; Synonyms=ARB2, ARR2;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RC   TISSUE=Thyroid;
RX   MEDLINE=92267237; PubMed=1587386; DOI=10.1016/0303-7207(92)90038-8;
RA   Rapoport B., Kaufman K.D., Chamenbalk G.D.;
RT   "Cloning of a member of the arrestin family from a human thyroid cDNA
RT   library.";
RL   Mol. Cell. Endocrinol. 84:R39-R43(1992).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RC   TISSUE=Brain;
RA   Yu Q.M., Zhou T.H., Wu Y.L., Cheng Z.J., Ma L., Pei G.;
RT   "G-protein coupled receptor interaction with beta-arrestin 2 through
RT   specific agonist stimulation.";
RL   Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC   TISSUE=Testis;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA   Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA   Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA   Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA   Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA   Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA   Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA   Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA   Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA   Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA   Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA   Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA   Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA   Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA   Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA   Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA   Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA   Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA   Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA   Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RG   NHLBI resequencing and genotyping service (RSnG);
RL   Submitted (DEC-2005) to the EMBL/GenBank/DDBJ databases.
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC   TISSUE=Muscle, and Pancreas;
RX   MEDLINE=22388257; PubMed=12477932; DOI=10.1073/pnas.242603899;
RA   Strausberg R.L., Feingold E.A., Grouse L.H., Derge J.G.,
RA   Klausner R.D., Collins F.S., Wagner L., Shenmen C.M., Schuler G.D.,
RA   Altschul S.F., Zeeberg B., Buetow K.H., Schaefer C.F., Bhat N.K.,
RA   Hopkins R.F., Jordan H., Moore T., Max S.I., Wang J., Hsieh F.,
RA   Diatchenko L., Marusina K., Farmer A.A., Rubin G.M., Hong L.,
RA   Stapleton M., Soares M.B., Bonaldo M.F., Casavant T.L., Scheetz T.E.,
RA   Brownstein M.J., Usdin T.B., Toshiyuki S., Carninci P., Prange C.,
RA   Raha S.S., Loquellano N.A., Peters G.J., Abramson R.D., Mullahy S.J.,
RA   Bosak S.A., McEwan P.J., McKernan K.J., Malek J.A., Gunaratne P.H.,
RA   Richards S., Worley K.C., Hale S., Garcia A.M., Gay L.J., Hulyk S.W.,
RA   Villalon D.K., Muzny D.M., Sodergren E.J., Lu X., Gibbs R.A.,
RA   Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A.,
RA   Whiting M., Madan A., Young A.C., Shevchenko Y., Bouffard G.G.,
RA   Blakesley R.W., Touchman J.W., Green E.D., Dickson M.C.,
RA   Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M.,
RA   Butterfield Y.S.N., Krzywinski M.I., Skalska U., Smailus D.E.,
RA   Schnerch A., Schein J.E., Jones S.J.M., Marra M.A.;
RT   "Generation and initial analysis of more than 15,000 full-length human
RT   and mouse cDNA sequences.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:16899-16903(2002).
CC   -!- FUNCTION: Regulates beta-adrenergic receptor function. Beta-
CC       arrestins seem to bind phosphorylated beta-adrenergic receptors,
CC       thereby causing a significant impairment of their capacity to
CC       activate G(S) proteins.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity). Nucleus (By
CC       similarity).
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=P32121-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=P32121-2; Sequence=VSP_008194, VSP_008195;
CC         Note=No experimental confirmation available;
CC   -!- SIMILARITY: Belongs to the arrestin family.
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DR   EMBL; Z11501; CAA77577.1; -; mRNA.
DR   EMBL; AF106941; AAC99468.1; -; mRNA.
DR   EMBL; AK097542; BAC05094.1; -; mRNA.
DR   EMBL; DQ314866; ABC40725.1; -; Genomic_DNA.
DR   EMBL; BC007427; AAH07427.1; -; mRNA.
DR   EMBL; BC067368; AAH67368.1; -; mRNA.
DR   PIR; S18984; S18984.
DR   UniGene; Hs.435811; -.
DR   HSSP; P17870; 1G4M.
DR   Ensembl; ENSG00000141480; Homo sapiens.
DR   H-InvDB; HIX0017258; -.
DR   HGNC; HGNC:712; ARRB2.
DR   MIM; 107941; gene.
DR   ArrayExpress; P32121; -.
DR   RZPD-ProtExp; IOH6100; -.
DR   RZPD-ProtExp; RZPDo834E101; -.
DR   RZPD-ProtExp; U0305; -.
DR   GO; GO:0005737; C:cytoplasm; TAS.
DR   GO; GO:0005886; C:plasma membrane; TAS.
DR   InterPro; IPR000698; Arrestin.
DR   InterPro; IPR011022; Arrestin_C.
DR   InterPro; IPR011021; Arrestin_N.
DR   PANTHER; PTHR11792; Arrestin; 1.
DR   Pfam; PF02752; Arrestin_C; 1.
DR   Pfam; PF00339; Arrestin_N; 1.
DR   PRINTS; PR00309; ARRESTIN.
DR   ProDom; PD002099; Arrestin; 2.
DR   PROSITE; PS00295; ARRESTINS; 1.
KW   Alternative splicing; Nuclear protein; Sensory transduction.
FT   CHAIN         1    409       Beta-arrestin-2.
FT                                /FTId=PRO_0000205199.
FT   MOTIF       389    399       Nuclear export signal (By similarity).
FT   VAR_SEQ      39     53       Missing (in isoform 2).
FT                                /FTId=VSP_008194.
FT   VAR_SEQ     360    360       S -> SAPTPTPPLPVPP (in isoform 2).
FT                                /FTId=VSP_008195.
FT   CONFLICT    189    189       R -> P (in Ref. 1).
SQ   SEQUENCE   409 AA;  46106 MW;  DEEC507D4A7B84FF CRC64;
     MGEKPGTRVF KKSSPNCKLT VYLGKRDFVD HLDKVDPVDG VVLVDPDYLK DRKVFVTLTC
     AFRYGREDLD VLGLSFRKDL FIATYQAFPP VPNPPRPPTR LQDRLLRKLG QHAHPFFFTI
     PQNLPCSVTL QPGPEDTGKA CGVDFEIRAF CAKSLEEKSH KRNSVRLVIR KVQFAPEKPG
     PQPSAETTRH FLMSDRSLHL EASLDKELYY HGEPLNVNVH VTNNSTKTVK KIKVSVRQYA
     DICLFSTAQY KCPVAQLEQD DQVSPSSTFC KVYTITPLLS DNREKRGLAL DGKLKHEDTN
     LASSTIVKEG ANKEVLGILV SYRVKVKLVV SRGGDVSVEL PFVLMHPKPH DHIPLPRPQS
     AAPETDVPVD TNLIEFDTNY ATDDDIVFED FARLRLKGMK DDDYDDQLC
//