ID   ARR2_HUMAN     STANDARD;      PRT;   409 AA.
AC   P32121; Q8N7Y2; Q9UEQ6;
DT   01-OCT-1993 (Rel. 27, Created)
DT   28-FEB-2003 (Rel. 41, Last sequence update)
DT   05-JUL-2004 (Rel. 44, Last annotation update)
DE   Beta-arrestin 2 (Arrestin, beta 2).
GN   Name=ARRB2; Synonyms=ARB2, ARR2;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   SEQUENCE FROM N.A. (ISOFORM 1).
RC   TISSUE=Thyroid;
RX   MEDLINE=92267237; PubMed=1587386; DOI=10.1016/0303-7207(92)90038-8;
RA   Rapoport B., Kaufman K.D., Chamenbalk G.D.;
RT   "Cloning of a member of the arrestin family from a human thyroid cDNA
RT   library.";
RL   Mol. Cell. Endocrinol. 84:R39-R43(1992).
RN   [2]
RP   SEQUENCE FROM N.A. (ISOFORM 1).
RC   TISSUE=Brain;
RA   Yu Q.M., Zhou T.H., Wu Y.L., Cheng Z.J., Ma L., Pei G.;
RT   "G-protein coupled receptor interaction with beta-arrestin 2 through
RT   specific agonist stimulation.";
RL   Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   SEQUENCE FROM N.A. (ISOFORM 2).
RC   TISSUE=Testis;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J.-I., Saito K., Kawai Y., Isono Y., Nakamura Y.,
RA   Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M.,
RA   Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H.,
RA   Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E.,
RA   Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M.,
RA   Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K.,
RA   Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y.,
RA   Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T.,
RA   Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O.,
RA   Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M.,
RA   Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA   Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA   Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA   Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA   Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA   Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA   Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA   Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA   Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA   Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA   Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [4]
RP   SEQUENCE FROM N.A. (ISOFORM 1).
RC   TISSUE=Muscle;
RX   MEDLINE=22388257; PubMed=12477932; DOI=10.1073/pnas.242603899;
RA   Strausberg R.L., Feingold E.A., Grouse L.H., Derge J.G.,
RA   Klausner R.D., Collins F.S., Wagner L., Shenmen C.M., Schuler G.D.,
RA   Altschul S.F., Zeeberg B., Buetow K.H., Schaefer C.F., Bhat N.K.,
RA   Hopkins R.F., Jordan H., Moore T., Max S.I., Wang J., Hsieh F.,
RA   Diatchenko L., Marusina K., Farmer A.A., Rubin G.M., Hong L.,
RA   Stapleton M., Soares M.B., Bonaldo M.F., Casavant T.L., Scheetz T.E.,
RA   Brownstein M.J., Usdin T.B., Toshiyuki S., Carninci P., Prange C.,
RA   Raha S.S., Loquellano N.A., Peters G.J., Abramson R.D., Mullahy S.J.,
RA   Bosak S.A., McEwan P.J., McKernan K.J., Malek J.A., Gunaratne P.H.,
RA   Richards S., Worley K.C., Hale S., Garcia A.M., Gay L.J., Hulyk S.W.,
RA   Villalon D.K., Muzny D.M., Sodergren E.J., Lu X., Gibbs R.A.,
RA   Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A.,
RA   Whiting M., Madan A., Young A.C., Shevchenko Y., Bouffard G.G.,
RA   Blakesley R.W., Touchman J.W., Green E.D., Dickson M.C.,
RA   Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M.,
RA   Butterfield Y.S.N., Krzywinski M.I., Skalska U., Smailus D.E.,
RA   Schnerch A., Schein J.E., Jones S.J.M., Marra M.A.;
RT   "Generation and initial analysis of more than 15,000 full-length human
RT   and mouse cDNA sequences.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:16899-16903(2002).
CC   -!- FUNCTION: Regulates beta-adrenergic receptor function. Beta-
CC       arrestins seem to bind phosphorylated beta-adrenergic receptors,
CC       thereby causing a significant impairment of their capacity to
CC       activate G(S) proteins.
CC   -!- SUBCELLULAR LOCATION: Cytoplasmic and nuclear (By similarity).
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC       Name=1;
CC         IsoId=P32121-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=P32121-2; Sequence=VSP_008194, VSP_008195;
CC         Note=No experimental confirmation available;
CC   -!- SIMILARITY: Belongs to the arrestin family.
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DR   EMBL; Z11501; CAA77577.1; -.
DR   EMBL; AF106941; AAC99468.1; -.
DR   EMBL; AK097542; BAC05094.1; -.
DR   EMBL; BC007427; AAH07427.1; -.
DR   PIR; S18984; S18984.
DR   HSSP; P17870; 1G4M.
DR   Genew; HGNC:712; ARRB2.
DR   H-InvDB; HIX0017258; -.
DR   MIM; 107941; -.
DR   GO; GO:0005737; C:cytoplasm; TAS.
DR   GO; GO:0005886; C:plasma membrane; TAS.
DR   InterPro; IPR000698; Arrestin.
DR   InterPro; IPR011022; Arrestin_C.
DR   InterPro; IPR011021; Arrestin_N.
DR   Pfam; PF02752; Arrestin_C; 1.
DR   Pfam; PF00339; Arrestin_N; 1.
DR   PRINTS; PR00309; ARRESTIN.
DR   ProDom; PD002099; Arrestin; 2.
DR   PROSITE; PS00295; ARRESTINS; 1.
KW   Alternative splicing; Nuclear protein; Sensory transduction.
FT   DOMAIN      389    399       Nuclear export signal (By similarity).
FT   VARSPLIC     39     53       Missing (in isoform 2).
FT                                /FTId=VSP_008194.
FT   VARSPLIC    360    360       S -> SAPTPTPPLPVPP (in isoform 2).
FT                                /FTId=VSP_008195.
FT   CONFLICT    189    189       R -> P (in Ref. 1).
SQ   SEQUENCE   409 AA;  46105 MW;  DEEC507D4A7B84FF CRC64;
     MGEKPGTRVF KKSSPNCKLT VYLGKRDFVD HLDKVDPVDG VVLVDPDYLK DRKVFVTLTC
     AFRYGREDLD VLGLSFRKDL FIATYQAFPP VPNPPRPPTR LQDRLLRKLG QHAHPFFFTI
     PQNLPCSVTL QPGPEDTGKA CGVDFEIRAF CAKSLEEKSH KRNSVRLVIR KVQFAPEKPG
     PQPSAETTRH FLMSDRSLHL EASLDKELYY HGEPLNVNVH VTNNSTKTVK KIKVSVRQYA
     DICLFSTAQY KCPVAQLEQD DQVSPSSTFC KVYTITPLLS DNREKRGLAL DGKLKHEDTN
     LASSTIVKEG ANKEVLGILV SYRVKVKLVV SRGGDVSVEL PFVLMHPKPH DHIPLPRPQS
     AAPETDVPVD TNLIEFDTNY ATDDDIVFED FARLRLKGMK DDDYDDQLC
//