ID   ARR2_HUMAN     STANDARD;      PRT;   409 AA.
AC   P32121;
DT   01-OCT-1993 (REL. 27, CREATED)
DT   01-OCT-1993 (REL. 27, LAST SEQUENCE UPDATE)
DT   01-JUN-1994 (REL. 29, LAST ANNOTATION UPDATE)
DE   BETA-ARRESTIN 2.
GN   ARRB2 OR ARB2.
OS   HOMO SAPIENS (HUMAN).
OC   EUKARYOTA; METAZOA; CHORDATA; VERTEBRATA; TETRAPODA; MAMMALIA;
OC   EUTHERIA; PRIMATES.
RN   [1]
RP   SEQUENCE FROM N.A.
RC   TISSUE=THYROID;
RX   MEDLINE; 92267237.
RA   RAPOPORT B., KAUFMAN K.D., CHAMENBALK G.D.;
RL   MOL. CELL. ENDOCRINOL. 84:R39-R43(1992).
CC   -!- FUNCTION: REGULATES BETA-ADRENERGIC RECEPTOR FUNCTION. BETA-
CC       ARRESTINS SEEM TO BIND PHOSPHORYLATED BETA-ADRENERGIC RECEPTORS,
CC       THEREBY CAUSING A SIGNIFICANT IMPAIRMENT OF THEIR CAPACITY TO
CC       ACTIVATE G(S) PROTEINS.
CC   -!- SIMILARITY: SIMILARITY IN THE C-TERMINAL WITH ALPHA-TRANSDUCIN
CC       AND OTHER PURINE NUCLEOTIDE-BINDING PROTEINS.
CC   -!- SIMILARITY: BELONGS TO THE ARRESTIN FAMILY.
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DR   EMBL; Z11501; Z11501.
DR   PIR; S18984; S18984.
DR   MIM; 107941; 11TH EDITION.
DR   PROSITE; PS00295; ARRESTINS.
KW   SENSORY TRANSDUCTION.
SQ   SEQUENCE   409 AA;  46046 MW;  886576 CN;
     MGEKPGTRVF KKSSPNCKLT VYLGKRDFVD HLDKVDPVDG VVLVDPDYLK DRKVFVTLTC
     AFRYGREDLD VLGLSFRKDL FIATYQAFPP VPNPPRPPTR LQDRLLRKLG QHAHPFFFTI
     PQNLPCSVTL QPGPEDTGKA CGVDFEIRAF CAKSLEEKSH KRNSVRLVIR KVQFAPEKPG
     PQPSAETTPH FLMSDRSLHL EASLDKELYY HGEPLNVNVH VTNNSTKTVK KIKVSVRQYA
     DICLFSTAQY KCPVAQLEQD DQVSPSSTFC KVYTITPLLS DNREKRGLAL DGKLKHEDTN
     LASSTIVKEG ANKEVLGILV SYRVKVKLVV SRGGDVSVEL PFVLMHPKPH DHIPLPRPQS
     AAPETDVPVD TNLIEFDTNY ATDDDIVFED FARLRLKGMK DDDYDDQLC
//