ID   ARR2_HUMAN     STANDARD;      PRT;   409 AA.
AC   P32121; Q9UEQ6;
DT   01-OCT-1993 (Rel. 27, Created)
DT   28-FEB-2003 (Rel. 41, Last sequence update)
DT   15-SEP-2003 (Rel. 42, Last annotation update)
DE   Beta-arrestin 2 (Arrestin, beta 2).
GN   ARRB2 OR ARR2 OR ARB2.
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   SEQUENCE FROM N.A.
RC   TISSUE=Thyroid;
RX   MEDLINE=92267237; PubMed=1587386;
RA   Rapoport B., Kaufman K.D., Chamenbalk G.D.;
RT   "Cloning of a member of the arrestin family from a human thyroid cDNA
RT   library.";
RL   Mol. Cell. Endocrinol. 84:R39-R43(1992).
RN   [2]
RP   SEQUENCE FROM N.A.
RC   TISSUE=Brain;
RA   Yu Q.M., Zhou T.H., Wu Y.L., Cheng Z.J., Ma L., Pei G.;
RT   "G-protein coupled receptor interaction with beta-arrestin 2 through
RT   specific agonist stimulation.";
RL   Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases.
RN   [3]
RP   SEQUENCE FROM N.A.
RC   TISSUE=Muscle;
RX   MEDLINE=22388257; PubMed=12477932;
RA   Strausberg R.L., Feingold E.A., Grouse L.H., Derge J.G.,
RA   Klausner R.D., Collins F.S., Wagner L., Shenmen C.M., Schuler G.D.,
RA   Altschul S.F., Zeeberg B., Buetow K.H., Schaefer C.F., Bhat N.K.,
RA   Hopkins R.F., Jordan H., Moore T., Max S.I., Wang J., Hsieh F.,
RA   Diatchenko L., Marusina K., Farmer A.A., Rubin G.M., Hong L.,
RA   Stapleton M., Soares M.B., Bonaldo M.F., Casavant T.L., Scheetz T.E.,
RA   Brownstein M.J., Usdin T.B., Toshiyuki S., Carninci P., Prange C.,
RA   Raha S.S., Loquellano N.A., Peters G.J., Abramson R.D., Mullahy S.J.,
RA   Bosak S.A., McEwan P.J., McKernan K.J., Malek J.A., Gunaratne P.H.,
RA   Richards S., Worley K.C., Hale S., Garcia A.M., Gay L.J., Hulyk S.W.,
RA   Villalon D.K., Muzny D.M., Sodergren E.J., Lu X., Gibbs R.A.,
RA   Fahey J., Helton E., Ketteman M., Madan A., Rodrigues S., Sanchez A.,
RA   Whiting M., Madan A., Young A.C., Shevchenko Y., Bouffard G.G.,
RA   Blakesley R.W., Touchman J.W., Green E.D., Dickson M.C.,
RA   Rodriguez A.C., Grimwood J., Schmutz J., Myers R.M., Butterfield Y.S.,
RA   Krzywinski M.I., Skalska U., Smailus D.E., Schnerch A., Schein J.E.,
RA   Jones S.J., Marra M.A.;
RT   "Generation and initial analysis of more than 15,000 full-length
RT   human and mouse cDNA sequences.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:16899-16903(2002).
CC   -!- FUNCTION: REGULATES BETA-ADRENERGIC RECEPTOR FUNCTION. BETA-
CC       ARRESTINS SEEM TO BIND PHOSPHORYLATED BETA-ADRENERGIC RECEPTORS,
CC       THEREBY CAUSING A SIGNIFICANT IMPAIRMENT OF THEIR CAPACITY TO
CC       ACTIVATE G(S) PROTEINS.
CC   -!- SIMILARITY: BELONGS TO THE ARRESTIN FAMILY.
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DR   EMBL; Z11501; CAA77577.1; -.
DR   EMBL; AF106941; AAC99468.1; -.
DR   EMBL; BC007427; AAH07427.1; -.
DR   PIR; S18984; S18984.
DR   HSSP; P08168; 1CF1.
DR   Genew; HGNC:712; ARRB2.
DR   MIM; 107941; -.
DR   GO; GO:0005737; C:cytoplasm; TAS.
DR   GO; GO:0005886; C:plasma membrane; TAS.
DR   InterPro; IPR000698; Arrestin.
DR   Pfam; PF00339; arrestin; 1.
DR   Pfam; PF02752; arrestin_C; 1.
DR   PRINTS; PR00309; ARRESTIN.
DR   ProDom; PD002099; Arrestin; 1.
DR   PROSITE; PS00295; ARRESTINS; 1.
KW   Sensory transduction.
FT   CONFLICT    189    189       R -> P (IN REF. 1).
SQ   SEQUENCE   409 AA;  46105 MW;  DEEC507D4A7B84FF CRC64;
     MGEKPGTRVF KKSSPNCKLT VYLGKRDFVD HLDKVDPVDG VVLVDPDYLK DRKVFVTLTC
     AFRYGREDLD VLGLSFRKDL FIATYQAFPP VPNPPRPPTR LQDRLLRKLG QHAHPFFFTI
     PQNLPCSVTL QPGPEDTGKA CGVDFEIRAF CAKSLEEKSH KRNSVRLVIR KVQFAPEKPG
     PQPSAETTRH FLMSDRSLHL EASLDKELYY HGEPLNVNVH VTNNSTKTVK KIKVSVRQYA
     DICLFSTAQY KCPVAQLEQD DQVSPSSTFC KVYTITPLLS DNREKRGLAL DGKLKHEDTN
     LASSTIVKEG ANKEVLGILV SYRVKVKLVV SRGGDVSVEL PFVLMHPKPH DHIPLPRPQS
     AAPETDVPVD TNLIEFDTNY ATDDDIVFED FARLRLKGMK DDDYDDQLC
//