ID   ARR2_HUMAN     STANDARD;      PRT;   409 AA.
AC   P32121;
DT   01-OCT-1993 (Rel. 27, Created)
DT   01-OCT-1993 (Rel. 27, Last sequence update)
DT   01-OCT-2000 (Rel. 40, Last annotation update)
DE   BETA-ARRESTIN 2.
GN   ARRB2 OR ARR2 OR ARB2.
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   SEQUENCE FROM N.A.
RC   TISSUE=Thyroid;
RX   MEDLINE=92267237; PubMed=1587386;
RA   Rapoport B., Kaufman K.D., Chamenbalk G.D.;
RT   "Cloning of a member of the arrestin family from a human thyroid cDNA
RT   library.";
RL   Mol. Cell. Endocrinol. 84:R39-R43(1992).
CC   -!- FUNCTION: REGULATES BETA-ADRENERGIC RECEPTOR FUNCTION. BETA-
CC       ARRESTINS SEEM TO BIND PHOSPHORYLATED BETA-ADRENERGIC RECEPTORS,
CC       THEREBY CAUSING A SIGNIFICANT IMPAIRMENT OF THEIR CAPACITY TO
CC       ACTIVATE G(S) PROTEINS.
CC   -!- SIMILARITY: BELONGS TO THE ARRESTIN FAMILY.
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DR   EMBL; Z11501; CAA77577.1; -.
DR   PIR; S18984; S18984.
DR   MIM; 107941; -.
DR   InterPro; IPR000698; Arrestin.
DR   Pfam; PF00339; arrestin; 1.
DR   PRINTS; PR00309; ARRESTIN.
DR   ProDom; PD002099; -; 1.
DR   PROSITE; PS00295; ARRESTINS; 1.
KW   Sensory transduction.
SQ   SEQUENCE   409 AA;  46046 MW;  B2DB93017D3AD2C8 CRC64;
     MGEKPGTRVF KKSSPNCKLT VYLGKRDFVD HLDKVDPVDG VVLVDPDYLK DRKVFVTLTC
     AFRYGREDLD VLGLSFRKDL FIATYQAFPP VPNPPRPPTR LQDRLLRKLG QHAHPFFFTI
     PQNLPCSVTL QPGPEDTGKA CGVDFEIRAF CAKSLEEKSH KRNSVRLVIR KVQFAPEKPG
     PQPSAETTPH FLMSDRSLHL EASLDKELYY HGEPLNVNVH VTNNSTKTVK KIKVSVRQYA
     DICLFSTAQY KCPVAQLEQD DQVSPSSTFC KVYTITPLLS DNREKRGLAL DGKLKHEDTN
     LASSTIVKEG ANKEVLGILV SYRVKVKLVV SRGGDVSVEL PFVLMHPKPH DHIPLPRPQS
     AAPETDVPVD TNLIEFDTNY ATDDDIVFED FARLRLKGMK DDDYDDQLC
//