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Protein

Beta-arrestin-2

Gene

ARRB2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Functions in regulating agonist-mediated G-protein coupled receptor (GPCR) signaling by mediating both receptor desensitization and resensitization processes. During homologous desensitization, beta-arrestins bind to the GPRK-phosphorylated receptor and sterically preclude its coupling to the cognate G-protein; the binding appears to require additional receptor determinants exposed only in the active receptor conformation. The beta-arrestins target many receptors for internalization by acting as endocytic adapters (CLASPs, clathrin-associated sorting proteins) and recruiting the GPRCs to the adapter protein 2 complex 2 (AP-2) in clathrin-coated pits (CCPs). However, the extent of beta-arrestin involvement appears to vary significantly depending on the receptor, agonist and cell type. Internalized arrestin-receptor complexes traffic to intracellular endosomes, where they remain uncoupled from G-proteins. Two different modes of arrestin-mediated internalization occur. Class A receptors, like ADRB2, OPRM1, ENDRA, D1AR and ADRA1B dissociate from beta-arrestin at or near the plasma membrane and undergo rapid recycling. Class B receptors, like AVPR2, AGTR1, NTSR1, TRHR and TACR1 internalize as a complex with arrestin and traffic with it to endosomal vesicles, presumably as desensitized receptors, for extended periods of time. Receptor resensitization then requires that receptor-bound arrestin is removed so that the receptor can be dephosphorylated and returned to the plasma membrane. Mediates endocytosis of CCR7 following ligation of CCL19 but not CCL21. Involved in internalization of P2RY1, P2RY4, P2RY6 and P2RY11 and ATP-stimulated internalization of P2RY2. Involved in phosphorylation-dependent internalization of OPRD1 and subsequent recycling or degradation. Involved in ubiquitination of IGF1R. Beta-arrestins function as multivalent adapter proteins that can switch the GPCR from a G-protein signaling mode that transmits short-lived signals from the plasma membrane via small molecule second messengers and ion channels to a beta-arrestin signaling mode that transmits a distinct set of signals that are initiated as the receptor internalizes and transits the intracellular compartment. Acts as signaling scaffold for MAPK pathways such as MAPK1/3 (ERK1/2) and MAPK10 (JNK3). ERK1/2 and JNK3 activated by the beta-arrestin scaffold are largely excluded from the nucleus and confined to cytoplasmic locations such as endocytic vesicles, also called beta-arrestin signalosomes. Acts as signaling scaffold for the AKT1 pathway. GPCRs for which the beta-arrestin-mediated signaling relies on both ARRB1 and ARRB2 (codependent regulation) include ADRB2, F2RL1 and PTH1R. For some GPCRs the beta-arrestin-mediated signaling relies on either ARRB1 or ARRB2 and is inhibited by the other respective beta-arrestin form (reciprocal regulation). Increases ERK1/2 signaling in AGTR1- and AVPR2-mediated activation (reciprocal regulation). Involved in CCR7-mediated ERK1/2 signaling involving ligand CCL19. Is involved in type-1A angiotensin II receptor/AGTR1-mediated ERK activity. Is involved in type-1A angiotensin II receptor/AGTR1-mediated MAPK10 activity. Is involved in dopamine-stimulated AKT1 activity in the striatum by disrupting the association of AKT1 with its negative regulator PP2A. Involved in AGTR1-mediated chemotaxis. Appears to function as signaling scaffold involved in regulation of MIP-1-beta-stimulated CCR5-dependent chemotaxis. Involved in attenuation of NF-kappa-B-dependent transcription in response to GPCR or cytokine stimulation by interacting with and stabilizing CHUK. Suppresses UV-induced NF-kappa-B-dependent activation by interacting with CHUK. The function is promoted by stimulation of ADRB2 and dephosphorylation of ARRB2. Involved in p53/TP53-mediated apoptosis by regulating MDM2 and reducing the MDM2-mediated degradation of p53/TP53. May serve as nuclear messenger for GPCRs. Upon stimulation of OR1D2, may be involved in regulation of gene expression during the early processes of fertilization. Also involved in regulation of receptors other than GPCRs. Involved in endocytosis of TGFBR2 and TGFBR3 and down-regulates TGF-beta signaling such as NF-kappa-B activation. Involved in endocytosis of low-density lipoprotein receptor/LDLR. Involved in endocytosis of smoothened homolog/Smo, which also requires ADRBK1. Involved in endocytosis of SLC9A5. Involved in endocytosis of ENG and subsequent TGF-beta-mediated ERK activation and migration of epithelial cells. Involved in Toll-like receptor and IL-1 receptor signaling through the interaction with TRAF6 which prevents TRAF6 autoubiquitination and oligomerization required for activation of NF-kappa-B and JUN. Involved in insulin resistance by acting as insulin-induced signaling scaffold for SRC, AKT1 and INSR. Involved in regulation of inhibitory signaling of natural killer cells by recruiting PTPN6 and PTPN11 to KIR2DL1. Involved in IL8-mediated granule release in neutrophils. Involved in the internalization of the atypical chemokine receptor ACKR3.29 Publications

GO - Molecular functioni

  • angiotensin receptor binding Source: UniProtKB
  • enzyme binding Source: UniProtKB
  • G-protein coupled receptor binding Source: UniProtKB
  • protein complex scaffold Source: BHF-UCL
  • receptor binding Source: UniProtKB
  • ubiquitin protein ligase binding Source: UniProtKB

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Signal transduction inhibitor

Keywords - Biological processi

Protein transport, Transport

Enzyme and pathway databases

ReactomeiR-HSA-2122948. Activated NOTCH1 Transmits Signal to the Nucleus.
R-HSA-418555. G alpha (s) signalling events.
R-HSA-456926. Thrombin signalling through proteinase activated receptors (PARs).
R-HSA-5099900. WNT5A-dependent internalization of FZD4.
R-HSA-5635838. Activation of SMO.
R-HSA-5674135. MAP2K and MAPK activation.
SignaLinkiP32121.
SIGNORiP32121.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-arrestin-2
Alternative name(s):
Arrestin beta-2
Gene namesi
Name:ARRB2
Synonyms:ARB2, ARR2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:712. ARRB2.

Subcellular locationi

GO - Cellular componenti

  • basolateral plasma membrane Source: Ensembl
  • clathrin-coated pit Source: UniProtKB-SubCell
  • cytoplasm Source: UniProtKB
  • cytoplasmic vesicle Source: UniProtKB
  • cytosol Source: Reactome
  • dendritic spine Source: Ensembl
  • endocytic vesicle Source: UniProtKB
  • nucleus Source: UniProtKB
  • plasma membrane Source: UniProtKB
  • postsynaptic density Source: Ensembl
  • postsynaptic membrane Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Coated pit, Cytoplasm, Cytoplasmic vesicle, Membrane, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi11 – 111K → A: Abolishes interaction with CHUK; when associated with A-12; A-230 and A-231.
Mutagenesisi12 – 121K → A: Abolishes interaction with CHUK; when associated with A-11; A-230 and A-231.
Mutagenesisi54 – 541V → A: Inhibits internalization of CXCR4; no effect on interaction with CXCR4. 1 Publication
Mutagenesisi230 – 2301K → A: Abolishes interaction with CHUK; when associated with A-11; A-12 and A-231.
Mutagenesisi231 – 2311K → A: Abolishes interaction with CHUK; when associated with A-11; A-12 and A-230.
Mutagenesisi360 – 3601S → A or D: Reduces interaction with CHUK; when associated with A-382.
Mutagenesisi382 – 3821T → A or D: Reduces interaction with CHUK; when associated with A-360. 1 Publication
Mutagenesisi382 – 3821T → A: Loss of phosphorylation. 1 Publication

Organism-specific databases

PharmGKBiPA60.

Polymorphism and mutation databases

BioMutaiARRB2.
DMDMi20141230.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 409409Beta-arrestin-2PRO_0000205199Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei48 – 481PhosphotyrosineBy similarity
Modified residuei176 – 1761Hydroxyproline; by PHD21 Publication
Modified residuei181 – 1811Hydroxyproline; by PHD21 Publication
Modified residuei360 – 3601PhosphoserineBy similarity
Modified residuei382 – 3821Phosphothreonine1 Publication

Post-translational modificationi

Phosphorylated at Thr-382 in the cytoplasm; probably dephosphorylated at the plasma membrane. The phosphorylation does not regulate internalization and recycling of ADRB2, interaction with clathrin or AP2B1.1 Publication
The ubiquitination status appears to regulate the formation and trafficking of beta-arrestin-GPCR complexes and signaling. Ubiquitination appears to occurr GPCR-specifc. Ubiquitinated by MDM2; the ubiquitination is required for rapid internalization of ADRB2. Deubiquitinated by USP33; the deubiquitination leads to a dissociation of the beta-arrestin-GPCR complex. Stimulation of a class A GPCR, such as ADRB2, induces transient ubiquitination and subsequently promotes association with USP33. Stimulation of a class B GPCR promotes a sustained ubiquitination.1 Publication
Hydroxylation by PHD2 modulates the rate of internalization by slowing down recruitment to the plasma membrane and inhibiting subsequent co-internalization with class A receptors.1 Publication

Keywords - PTMi

Hydroxylation, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiP32121.
MaxQBiP32121.
PaxDbiP32121.
PeptideAtlasiP32121.
PRIDEiP32121.

PTM databases

iPTMnetiP32121.
PhosphoSiteiP32121.

Expressioni

Gene expression databases

BgeeiENSG00000141480.
CleanExiHS_ARRB2.
ExpressionAtlasiP32121. baseline and differential.
GenevisibleiP32121. HS.

Organism-specific databases

HPAiHPA065681.

Interactioni

Subunit structurei

Homooligomer; the self-association is mediated by InsP6-binding (Probable). Heterooligomer with ARRB1; the association is mediated by InsP6-binding. Interacts with ADRB2 AND CHRM2. Interacts with PDE4A. Interacts with PDE4D. Interacts with MAPK10, MAPK1 and MAPK3. Interacts with DRD2. Interacts with FSHR. Interacts with CLTC. Interacts with HTR2C. Interacts with CCR5. Interacts with CXCR4. Interacts with SRC. Interacts with DUSP16; the interaction is interrupted by stimulation of AGTR1 and activation of MAPK10. Interacts with CHUK; the interaction is enhanced stimulation of ADRB2. Interacts with RELA. Interacts with MDM2; the interaction is enhanced by activation of GPCRs. Interacts with SLC9A5. Interacts with TRAF6. Interacts with IGF1R. Interacts with ENG. Interacts with KIR2DL1, KIR2DL3 and KIR2DL4. Interacts with LDLR. Interacts with AP2B1. Interacts with C5AR1. Interacts with RAF1. Interacts with MAP2K1. Interacts with MAPK1. Interacts with MAPK10; the interaction enhances MAPK10 activation by MAP3K5. Interacts with MAP2K4; the interaction is enhanced by presence of MAP3K5 and MAPK10. Interacts with MAP3K5. Interacts with AKT1. Interacts with IKBKB and MAP3K14. Interacts with SMO (activated). Interacts with GSK3A and GSK3B. Associates with protein phosphatase 2A (PP2A) (By similarity). Interacts with DHX8; the interaction is detected in the nucleus upon OR1D2 stimulation. Interacts with GAPDHS; the interaction is detected in the nucleus upon OR1D2 stimulation. Interacts with H2AFX; the interaction is detected in the nucleus upon OR1D2 stimulation. Interacts with KIF14; the interaction is detected in the nucleus upon OR1D2 stimulation. Interacts with RCC1; the interaction is detected in the nucleus upon OR1D2 stimulation. Interacts with CXCR4; the interaction is dependent on C-terminal phosphorylation of CXCR4 and allows activation of MAPK1 and MAPK3. Interacts with GPR143. Interacts with HCK and CXCR1 (phosphorylated). Interacts with ACKR3 and ACKR4.By similarityCurated22 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
Akt1P317503EBI-714559,EBI-298707From a different organism.
CALM3P621583EBI-714559,EBI-397435
CHUKO151113EBI-714559,EBI-81249
CTNNA1P352213EBI-714559,EBI-701918
CTTNQ142472EBI-714559,EBI-351886
GSNP063963EBI-714559,EBI-351506
HSPA8P111424EBI-714559,EBI-351896
MAP3K1Q132332EBI-714559,EBI-49776
MAP3K5Q996832EBI-714559,EBI-476263
MAPK1P284823EBI-714559,EBI-959949
MAPK9P459845EBI-714559,EBI-713568
NCLP193383EBI-714559,EBI-346967
NOLC1Q149783EBI-714559,EBI-396155
ORFQ9Q2G43EBI-714559,EBI-6248094From a different organism.
PKMP146184EBI-714559,EBI-353408
PPM1AP358133EBI-714559,EBI-989143
PPM1BO756884EBI-714559,EBI-1047039
PRPF4BQ135233EBI-714559,EBI-395940
rlP404174EBI-714559,EBI-867790From a different organism.
S100A9P067022EBI-714559,EBI-1055001
STK38Q152083EBI-714559,EBI-458376
TAB1Q157503EBI-714559,EBI-358643
TCOF1Q134283EBI-714559,EBI-396105
YWHAQP273483EBI-714559,EBI-359854
ZRANB2O952184EBI-714559,EBI-1051583

GO - Molecular functioni

  • angiotensin receptor binding Source: UniProtKB
  • enzyme binding Source: UniProtKB
  • G-protein coupled receptor binding Source: UniProtKB
  • protein complex scaffold Source: BHF-UCL
  • receptor binding Source: UniProtKB
  • ubiquitin protein ligase binding Source: UniProtKB

Protein-protein interaction databases

BioGridi106902. 368 interactions.
DIPiDIP-40089N.
IntActiP32121. 293 interactions.
MINTiMINT-216692.
STRINGi9606.ENSP00000269260.

Structurei

3D structure databases

ProteinModelPortaliP32121.
SMRiP32121. Positions 6-393.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni240 – 409170Interaction with TRAF6Add
BLAST
Regioni363 – 40947Interaction with AP2B1Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi385 – 39511[DE]-X(1,2)-F-X-X-[FL]-X-X-X-R motifAdd
BLAST

Domaini

The [DE]-X(1,2)-F-X-X-[FL]-X-X-X-R motif mediates interaction the AP-2 complex subunit AP2B1.By similarity

Sequence similaritiesi

Belongs to the arrestin family.Curated

Phylogenomic databases

eggNOGiKOG3865. Eukaryota.
ENOG410XR0F. LUCA.
GeneTreeiENSGT00390000013152.
HOGENOMiHOG000231319.
HOVERGENiHBG002399.
InParanoidiP32121.
KOiK04439.
OMAiHDHIPLP.
OrthoDBiEOG091G05M2.
PhylomeDBiP32121.
TreeFamiTF314260.

Family and domain databases

Gene3Di2.60.40.640. 1 hit.
2.60.40.840. 1 hit.
InterProiIPR000698. Arrestin.
IPR011021. Arrestin-like_N.
IPR014752. Arrestin_C.
IPR011022. Arrestin_C-like.
IPR017864. Arrestin_CS.
IPR014753. Arrestin_N.
IPR014756. Ig_E-set.
[Graphical view]
PANTHERiPTHR11792. PTHR11792. 1 hit.
PfamiPF02752. Arrestin_C. 1 hit.
PF00339. Arrestin_N. 1 hit.
[Graphical view]
PRINTSiPR00309. ARRESTIN.
SMARTiSM01017. Arrestin_C. 1 hit.
[Graphical view]
SUPFAMiSSF81296. SSF81296. 2 hits.
PROSITEiPS00295. ARRESTINS. 1 hit.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P32121-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGEKPGTRVF KKSSPNCKLT VYLGKRDFVD HLDKVDPVDG VVLVDPDYLK
60 70 80 90 100
DRKVFVTLTC AFRYGREDLD VLGLSFRKDL FIATYQAFPP VPNPPRPPTR
110 120 130 140 150
LQDRLLRKLG QHAHPFFFTI PQNLPCSVTL QPGPEDTGKA CGVDFEIRAF
160 170 180 190 200
CAKSLEEKSH KRNSVRLVIR KVQFAPEKPG PQPSAETTRH FLMSDRSLHL
210 220 230 240 250
EASLDKELYY HGEPLNVNVH VTNNSTKTVK KIKVSVRQYA DICLFSTAQY
260 270 280 290 300
KCPVAQLEQD DQVSPSSTFC KVYTITPLLS DNREKRGLAL DGKLKHEDTN
310 320 330 340 350
LASSTIVKEG ANKEVLGILV SYRVKVKLVV SRGGDVSVEL PFVLMHPKPH
360 370 380 390 400
DHIPLPRPQS AAPETDVPVD TNLIEFDTNY ATDDDIVFED FARLRLKGMK

DDDYDDQLC
Length:409
Mass (Da):46,106
Last modified:March 5, 2002 - v2
Checksum:iDEEC507D4A7B84FF
GO
Isoform 2 (identifier: P32121-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     360-360: S → SAPTPTPPLPVPP

Show »
Length:421
Mass (Da):47,271
Checksum:i1D5F728967E2BF5D
GO
Isoform 3 (identifier: P32121-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     39-53: Missing.
     360-360: S → SAPTPTPPLPVPP

Note: No experimental confirmation available.
Show »
Length:406
Mass (Da):45,557
Checksum:i2020CE75484DF687
GO
Isoform 4 (identifier: P32121-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     119-119: T → TVRMPLPSEGQGAGAGTVSGVG

Note: No experimental confirmation available.
Show »
Length:430
Mass (Da):48,015
Checksum:iD41C217D16CFD41D
GO
Isoform 5 (identifier: P32121-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     39-53: Missing.

Show »
Length:394
Mass (Da):44,392
Checksum:iEE3C2EC61639E8D5
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti13 – 131S → P in BAG59672 (PubMed:14702039).Curated
Sequence conflicti189 – 1891R → P in CAA77577 (PubMed:1587386).Curated
Sequence conflicti190 – 1901H → R in ABG47460 (Ref. 3) Curated
Sequence conflicti192 – 1921L → P in CAG29306 (Ref. 6) Curated
Sequence conflicti366 – 3661D → G in BAG59672 (PubMed:14702039).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei39 – 5315Missing in isoform 3 and isoform 5. 1 PublicationVSP_008194Add
BLAST
Alternative sequencei119 – 1191T → TVRMPLPSEGQGAGAGTVSG VG in isoform 4. 1 PublicationVSP_044697
Alternative sequencei360 – 3601S → SAPTPTPPLPVPP in isoform 2 and isoform 3. 2 PublicationsVSP_008195

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z11501 mRNA. Translation: CAA77577.1.
AF106941 mRNA. Translation: AAC99468.1.
DQ664180 mRNA. Translation: ABG47460.1.
EU883572 mRNA. Translation: ACG60646.1.
AK097542 mRNA. Translation: BAC05094.1.
AK297181 mRNA. Translation: BAG59672.1.
CR450310 mRNA. Translation: CAG29306.1.
DQ314866 Genomic DNA. Translation: ABC40725.1.
AC091153 Genomic DNA. No translation available.
CH471108 Genomic DNA. Translation: EAW90421.1.
CH471108 Genomic DNA. Translation: EAW90422.1.
BC007427 mRNA. Translation: AAH07427.1.
BC067368 mRNA. Translation: AAH67368.1.
CCDSiCCDS11050.1. [P32121-1]
CCDS11051.1. [P32121-5]
CCDS58504.1. [P32121-4]
CCDS58505.1. [P32121-2]
PIRiS18984.
RefSeqiNP_001244257.1. NM_001257328.1. [P32121-4]
NP_001244258.1. NM_001257329.1.
NP_001244259.1. NM_001257330.1. [P32121-3]
NP_001244260.1. NM_001257331.1. [P32121-2]
NP_004304.1. NM_004313.3. [P32121-1]
NP_945355.1. NM_199004.1. [P32121-5]
UniGeneiHs.435811.

Genome annotation databases

EnsembliENST00000269260; ENSP00000269260; ENSG00000141480. [P32121-1]
ENST00000346341; ENSP00000341895; ENSG00000141480. [P32121-2]
ENST00000381488; ENSP00000370898; ENSG00000141480. [P32121-5]
ENST00000412477; ENSP00000403701; ENSG00000141480. [P32121-4]
GeneIDi409.
KEGGihsa:409.
UCSCiuc002fyj.4. human. [P32121-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Web resourcesi

Wikipedia

Arrestin entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z11501 mRNA. Translation: CAA77577.1.
AF106941 mRNA. Translation: AAC99468.1.
DQ664180 mRNA. Translation: ABG47460.1.
EU883572 mRNA. Translation: ACG60646.1.
AK097542 mRNA. Translation: BAC05094.1.
AK297181 mRNA. Translation: BAG59672.1.
CR450310 mRNA. Translation: CAG29306.1.
DQ314866 Genomic DNA. Translation: ABC40725.1.
AC091153 Genomic DNA. No translation available.
CH471108 Genomic DNA. Translation: EAW90421.1.
CH471108 Genomic DNA. Translation: EAW90422.1.
BC007427 mRNA. Translation: AAH07427.1.
BC067368 mRNA. Translation: AAH67368.1.
CCDSiCCDS11050.1. [P32121-1]
CCDS11051.1. [P32121-5]
CCDS58504.1. [P32121-4]
CCDS58505.1. [P32121-2]
PIRiS18984.
RefSeqiNP_001244257.1. NM_001257328.1. [P32121-4]
NP_001244258.1. NM_001257329.1.
NP_001244259.1. NM_001257330.1. [P32121-3]
NP_001244260.1. NM_001257331.1. [P32121-2]
NP_004304.1. NM_004313.3. [P32121-1]
NP_945355.1. NM_199004.1. [P32121-5]
UniGeneiHs.435811.

3D structure databases

ProteinModelPortaliP32121.
SMRiP32121. Positions 6-393.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi106902. 368 interactions.
DIPiDIP-40089N.
IntActiP32121. 293 interactions.
MINTiMINT-216692.
STRINGi9606.ENSP00000269260.

PTM databases

iPTMnetiP32121.
PhosphoSiteiP32121.

Polymorphism and mutation databases

BioMutaiARRB2.
DMDMi20141230.

Proteomic databases

EPDiP32121.
MaxQBiP32121.
PaxDbiP32121.
PeptideAtlasiP32121.
PRIDEiP32121.

Protocols and materials databases

DNASUi409.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000269260; ENSP00000269260; ENSG00000141480. [P32121-1]
ENST00000346341; ENSP00000341895; ENSG00000141480. [P32121-2]
ENST00000381488; ENSP00000370898; ENSG00000141480. [P32121-5]
ENST00000412477; ENSP00000403701; ENSG00000141480. [P32121-4]
GeneIDi409.
KEGGihsa:409.
UCSCiuc002fyj.4. human. [P32121-1]

Organism-specific databases

CTDi409.
GeneCardsiARRB2.
HGNCiHGNC:712. ARRB2.
HPAiHPA065681.
MIMi107941. gene.
neXtProtiNX_P32121.
PharmGKBiPA60.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3865. Eukaryota.
ENOG410XR0F. LUCA.
GeneTreeiENSGT00390000013152.
HOGENOMiHOG000231319.
HOVERGENiHBG002399.
InParanoidiP32121.
KOiK04439.
OMAiHDHIPLP.
OrthoDBiEOG091G05M2.
PhylomeDBiP32121.
TreeFamiTF314260.

Enzyme and pathway databases

ReactomeiR-HSA-2122948. Activated NOTCH1 Transmits Signal to the Nucleus.
R-HSA-418555. G alpha (s) signalling events.
R-HSA-456926. Thrombin signalling through proteinase activated receptors (PARs).
R-HSA-5099900. WNT5A-dependent internalization of FZD4.
R-HSA-5635838. Activation of SMO.
R-HSA-5674135. MAP2K and MAPK activation.
SignaLinkiP32121.
SIGNORiP32121.

Miscellaneous databases

ChiTaRSiARRB2. human.
GeneWikiiArrestin_beta_2.
GenomeRNAii409.
PROiP32121.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000141480.
CleanExiHS_ARRB2.
ExpressionAtlasiP32121. baseline and differential.
GenevisibleiP32121. HS.

Family and domain databases

Gene3Di2.60.40.640. 1 hit.
2.60.40.840. 1 hit.
InterProiIPR000698. Arrestin.
IPR011021. Arrestin-like_N.
IPR014752. Arrestin_C.
IPR011022. Arrestin_C-like.
IPR017864. Arrestin_CS.
IPR014753. Arrestin_N.
IPR014756. Ig_E-set.
[Graphical view]
PANTHERiPTHR11792. PTHR11792. 1 hit.
PfamiPF02752. Arrestin_C. 1 hit.
PF00339. Arrestin_N. 1 hit.
[Graphical view]
PRINTSiPR00309. ARRESTIN.
SMARTiSM01017. Arrestin_C. 1 hit.
[Graphical view]
SUPFAMiSSF81296. SSF81296. 2 hits.
PROSITEiPS00295. ARRESTINS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiARRB2_HUMAN
AccessioniPrimary (citable) accession number: P32121
Secondary accession number(s): B4DLW0
, B5B0C0, B7WPL3, D3DTK2, H0Y688, Q0Z8D3, Q2PP19, Q6ICT3, Q8N7Y2, Q9UEQ6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: March 5, 2002
Last modified: September 7, 2016
This is version 165 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.