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Protein

Paired box protein Pax-2

Gene

Pax2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Transcription factor that may have a role in kidney cell differentiation.By similarity

GO - Molecular functioni

  • C2H2 zinc finger domain binding Source: UniProtKB
  • core promoter proximal region sequence-specific DNA binding Source: UniProtKB
  • DNA binding Source: MGI
  • RNA polymerase II core promoter proximal region sequence-specific DNA binding Source: NTNU_SB
  • superoxide-generating NADPH oxidase activity Source: UniProtKB
  • transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding Source: NTNU_SB
  • transcription factor activity, sequence-specific DNA binding Source: MGI
  • transcription factor binding Source: MGI
  • transcription regulatory region DNA binding Source: UniProtKB

GO - Biological processi

  • brain morphogenesis Source: DFLAT
  • branching involved in ureteric bud morphogenesis Source: MGI
  • camera-type eye development Source: MGI
  • cell fate determination Source: MGI
  • cellular response to glucose stimulus Source: UniProtKB
  • cellular response to hydrogen peroxide Source: UniProtKB
  • cellular response to mechanical stimulus Source: UniProtKB
  • cellular response to retinoic acid Source: UniProtKB
  • central nervous system development Source: UniProtKB
  • cochlea development Source: DFLAT
  • cochlea morphogenesis Source: DFLAT
  • dopaminergic neuron differentiation Source: ParkinsonsUK-UCL
  • glial cell differentiation Source: DFLAT
  • inner ear morphogenesis Source: DFLAT
  • kidney development Source: MGI
  • mesenchymal to epithelial transition Source: MGI
  • mesenchymal to epithelial transition involved in metanephros morphogenesis Source: UniProtKB
  • mesodermal cell fate specification Source: UniProtKB
  • mesonephric duct development Source: UniProtKB
  • mesonephric tubule development Source: UniProtKB
  • mesonephric tubule formation Source: UniProtKB
  • mesonephros development Source: UniProtKB
  • metanephric collecting duct development Source: UniProtKB
  • metanephric distal convoluted tubule development Source: UniProtKB
  • metanephric epithelium development Source: UniProtKB
  • metanephric mesenchymal cell differentiation Source: UniProtKB
  • metanephric mesenchyme development Source: UniProtKB
  • metanephric nephron tubule formation Source: UniProtKB
  • metanephros development Source: MGI
  • negative regulation of apoptotic process Source: UniProtKB
  • negative regulation of apoptotic process involved in metanephric collecting duct development Source: UniProtKB
  • negative regulation of apoptotic process involved in metanephric nephron tubule development Source: UniProtKB
  • negative regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: UniProtKB
  • negative regulation of cytolysis Source: UniProtKB
  • negative regulation of mesenchymal cell apoptotic process involved in metanephric nephron morphogenesis Source: UniProtKB
  • negative regulation of mesenchymal cell apoptotic process involved in metanephros development Source: UniProtKB
  • negative regulation of programmed cell death Source: MGI
  • negative regulation of reactive oxygen species metabolic process Source: UniProtKB
  • negative regulation of transcription, DNA-templated Source: UniProtKB
  • negative regulation of transcription from RNA polymerase II promoter Source: MGI
  • nephric duct formation Source: UniProtKB
  • neural tube closure Source: DFLAT
  • optic chiasma development Source: DFLAT
  • optic cup morphogenesis involved in camera-type eye development Source: DFLAT
  • optic nerve development Source: DFLAT
  • optic nerve morphogenesis Source: DFLAT
  • optic nerve structural organization Source: DFLAT
  • pancreas development Source: UniProtKB
  • paramesonephric duct development Source: UniProtKB
  • positive regulation of branching involved in ureteric bud morphogenesis Source: UniProtKB
  • positive regulation of epithelial cell proliferation Source: MGI
  • positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis Source: UniProtKB
  • positive regulation of metanephric DCT cell differentiation Source: UniProtKB
  • positive regulation of metanephric glomerulus development Source: UniProtKB
  • positive regulation of optic nerve formation Source: UniProtKB
  • positive regulation of transcription, DNA-templated Source: UniProtKB
  • positive regulation of transcription from RNA polymerase II promoter Source: NTNU_SB
  • pronephric field specification Source: UniProtKB
  • pronephros development Source: UniProtKB
  • protein kinase B signaling Source: UniProtKB
  • reactive oxygen species metabolic process Source: UniProtKB
  • regulation of apoptotic process Source: UniProtKB
  • regulation of metanephric nephron tubule epithelial cell differentiation Source: UniProtKB
  • regulation of metanephros size Source: UniProtKB
  • regulation of programmed cell death Source: MGI
  • renal system development Source: MGI
  • retinal pigment epithelium development Source: DFLAT
  • stem cell differentiation Source: UniProtKB
  • transcription, DNA-templated Source: UniProtKB
  • ureter development Source: UniProtKB
  • ureteric bud development Source: MGI
  • ureter maturation Source: UniProtKB
  • ureter morphogenesis Source: UniProtKB
  • urogenital system development Source: MGI
  • vestibulocochlear nerve formation Source: DFLAT

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processDifferentiation, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Paired box protein Pax-2
Gene namesi
Name:Pax2
Synonyms:Pax-2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:97486. Pax2.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Involvement in diseasei

Defects in Pax2 are a cause of developmental defects of the kidney, brain, ear and eye.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000501761 – 414Paired box protein Pax-2Add BLAST414

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei225PhosphothreonineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiP32114.
PRIDEiP32114.

PTM databases

iPTMnetiP32114.
PhosphoSitePlusiP32114.

Expressioni

Tissue specificityi

Kidney and nephrogenic rests.

Developmental stagei

Expressed in the developing embryo excretory and central nervous systems. In the developing excretory system; expressed in the pronephric tubules and extending nephric duct beginning at day 9 gestation. At 10 dpc, detected in the nephric cord, Wolffian duct and also individual pronephric tubules. At 11 dpc, expressed in the branched ureter and the mesenchymal condensations, at 12 dpc, expression seen in the collecting ducts and condensed mesenchymal cells. At 14-17 dpc, expressed in the perimeter of the growing kidney but expression declines in the more developed glomerular crevices, and at later developmental stages expression in the kidney declines. In the developing CNS; initially expressed in the ventricular zone in two compartments of cells on either side of the sulcus limitans and along the entire rhombencephalon and spinal cord, later is restricted to progeny cells that have migrated to specific regions of the intermediate zone. In the eye, expression is restricted to the ventral half of the optic cup and stalk and later to the optic disk and nerve. In the ear, expression is restricted to regions of the otic vesicle that form neuronal components.1 Publication

Gene expression databases

CleanExiMM_PAX2.

Interactioni

Subunit structurei

Interacts with ELGN3; the interaction targets PAX2 for destruction. Interacts with TLE4.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
Paxip1Q6NZQ43EBI-1395232,EBI-1395317

GO - Molecular functioni

  • C2H2 zinc finger domain binding Source: UniProtKB
  • transcription factor binding Source: MGI

Protein-protein interaction databases

BioGridi202029. 1 interactor.
IntActiP32114. 1 interactor.

Structurei

3D structure databases

ProteinModelPortaliP32114.
SMRiP32114.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini15 – 141PairedPROSITE-ProRule annotationAdd BLAST127

Keywords - Domaini

Paired box

Phylogenomic databases

HOGENOMiHOG000230938.
HOVERGENiHBG009115.
InParanoidiP32114.
KOiK15608.
PhylomeDBiP32114.

Family and domain databases

CDDicd00131. PAX. 1 hit.
Gene3Di1.10.10.10. 2 hits.
InterProiView protein in InterPro
IPR009057. Homeobox-like.
IPR001523. Paired_dom.
IPR022130. Pax2_C.
IPR036388. WH-like_DNA-bd_sf.
PfamiView protein in Pfam
PF00292. PAX. 1 hit.
PF12403. Pax2_C. 1 hit.
PRINTSiPR00027. PAIREDBOX.
SMARTiView protein in SMART
SM00351. PAX. 1 hit.
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiView protein in PROSITE
PS00034. PAIRED_1. 1 hit.
PS51057. PAIRED_2. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform Long (identifier: P32114-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDMHCKADPF SAMHRHGGVN QLGGVFVNGR PLPDVVRQRI VELAHQGVRP
60 70 80 90 100
CDISRQLRVS HGCVSKILGR YYETGSIKPG VIGGSKPKVA TPKVVDKIAE
110 120 130 140 150
YKRQNPTMFA WEIRDRLLAE GICDNDTVPS VSSINRIIRT KVQQPFHPTP
160 170 180 190 200
DGAGTGVTAP GHTIVPSTAS PPVSSASNDP VGSYSINGIL GIPRSNGEKR
210 220 230 240 250
KREEVEVYTD PAHIRGGGGL HLVWTLRDVS EGSVPNGDSQ SGVDSLRKHL
260 270 280 290 300
RADTFTQQQL EALDRVFERP SYPDVFQASE HIKSEQGNEY SLPALTPGLD
310 320 330 340 350
EVKSSLSASA NPELGSNVSG TQTYPVVTGR DMTSTTLPGY PPHVPPTGQG
360 370 380 390 400
SYPTSTLAGM VPGSEFSGNP YSHPQYTAYN EAWRFSNPAL LSSPYYYSAA
410
PRGSAPAAAA YDRH
Length:414
Mass (Da):44,580
Last modified:September 2, 2008 - v2
Checksum:i7BADF256609F4811
GO
Isoform Short (identifier: P32114-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     205-227: Missing.

Show »
Length:391
Mass (Da):42,051
Checksum:iDA826493D7AE910E
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti15R → PG in AAI48233 (PubMed:1516825).Curated1
Sequence conflicti15R → PG in AAI50485 (PubMed:1516825).Curated1
Sequence conflicti115 – 116DR → AQ in CAA39302 (PubMed:1977574).Curated2
Sequence conflicti119A → R in CAA39302 (PubMed:1977574).Curated1
Sequence conflicti344V → L in CAA39302 (PubMed:1977574).Curated1
Sequence conflicti403 – 407GSAPA → SAPAAR in CAA39302 (PubMed:1977574).Curated5
Sequence conflicti410A → AAA in AAI48233 (PubMed:1516825).Curated1
Sequence conflicti410A → AAA in AAI50485 (PubMed:1516825).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_002347205 – 227Missing in isoform Short. 1 PublicationAdd BLAST23

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X55781 Genomic DNA. Translation: CAA39302.1. Sequence problems.
BC148232 mRNA. Translation: AAI48233.1.
BC150484 mRNA. Translation: AAI50485.1.
PIRiA60086.
RefSeqiNP_035167.4. NM_011037.4.
UniGeneiMm.192158.

Genome annotation databases

GeneIDi18504.
KEGGimmu:18504.
UCSCiuc008hqa.2. mouse. [P32114-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiPAX2_MOUSE
AccessioniPrimary (citable) accession number: P32114
Secondary accession number(s): A7E2R6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: September 2, 2008
Last modified: October 25, 2017
This is version 159 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot