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Protein

60S ribosomal protein L7

Gene

RpL7

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Binds to G-rich structures in 28S rRNA and in mRNAs. Plays a regulatory role in the translation apparatus; inhibits cell-free translation of mRNAs (By similarity).By similarity

GO - Molecular functioni

  • RNA binding Source: UniProtKB-KW
  • structural constituent of ribosome Source: FlyBase

GO - Biological processi

  • centrosome duplication Source: FlyBase
  • cytoplasmic translation Source: FlyBase
  • maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) Source: GO_Central
  • pupariation Source: FlyBase

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein, RNA-binding

Enzyme and pathway databases

ReactomeiR-DME-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-DME-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-DME-72689. Formation of a pool of free 40S subunits.
R-DME-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-DME-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-DME-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosomal protein L7
Gene namesi
Name:RpL7
ORF Names:CG4897
OrganismiDrosophila melanogaster (Fruit fly)
Taxonomic identifieri7227 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000000803 Componenti: Chromosome 2L

Organism-specific databases

FlyBaseiFBgn0005593. RpL7.

Subcellular locationi

GO - Cellular componenti

  • cytosolic large ribosomal subunit Source: FlyBase
  • cytosolic ribosome Source: FlyBase
  • ribosome Source: FlyBase

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001046381 – 25260S ribosomal protein L7Add BLAST252

Proteomic databases

PaxDbiP32100.
PRIDEiP32100.

Expressioni

Gene expression databases

BgeeiFBgn0005593.
ExpressionAtlasiP32100. differential.
GenevisibleiP32100. DM.

Interactioni

Protein-protein interaction databases

BioGridi60443. 17 interactors.
DIPiDIP-18002N.
IntActiP32100. 2 interactors.
STRINGi7227.FBpp0079536.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4V6Welectron microscopy6.00CF1-252[»]
ProteinModelPortaliP32100.
SMRiP32100.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG3184. Eukaryota.
COG1841. LUCA.
InParanoidiP32100.
KOiK02937.
OMAiPTGGWRT.
OrthoDBiEOG091G0IHS.
PhylomeDBiP32100.

Family and domain databases

Gene3Di3.30.1390.20. 2 hits.
InterProiView protein in InterPro
IPR018038. Ribosomal_L30_CS.
IPR016082. Ribosomal_L30_ferredoxin-like.
IPR012988. Ribosomal_L30_N.
IPR005998. Ribosomal_L7_euk.
PfamiView protein in Pfam
PF00327. Ribosomal_L30. 1 hit.
PF08079. Ribosomal_L30_N. 1 hit.
SUPFAMiSSF55129. SSF55129. 1 hit.
TIGRFAMsiTIGR01310. uL30_euk. 1 hit.
PROSITEiView protein in PROSITE
PS00634. RIBOSOMAL_L30. 1 hit.

Sequencei

Sequence statusi: Complete.

P32100-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPAPVVKKPA AKKLPAVPES KLKFSKKQIS KRVAESKRRL KKAAVIALRK
60 70 80 90 100
KENLVRAEKY QNEYIKAEQR EIKLRRLAKK RNQFYVPAEA KLAFVVRIRG
110 120 130 140 150
INKVAPKVRK VLQLFRLRQI NNGVFIKLNK ATINMLRIAE PYITWGYPNL
160 170 180 190 200
KSVRELIYKR GFVKHNRQRV PITDNFVIER KLRQAHQIQC VEDLVHEIFT
210 220 230 240 250
VGPNFKYASN FLWPFKLNTP TGGWRKKANH YVNGGDFGNR EDQINRLLRK

MV
Length:252
Mass (Da):29,552
Last modified:February 21, 2001 - v2
Checksum:i958439D03E83EB44
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014134 Genomic DNA. Translation: AAF52868.1.
AY089648 mRNA. Translation: AAL90386.1.
X15109 mRNA. Translation: CAA33207.1.
PIRiS21500.
RefSeqiNP_001285794.1. NM_001298865.1.
NP_523531.1. NM_078807.3.
UniGeneiDm.3483.

Genome annotation databases

EnsemblMetazoaiFBtr0079946; FBpp0079536; FBgn0005593.
FBtr0343653; FBpp0310250; FBgn0005593.
GeneIDi34352.
KEGGidme:Dmel_CG4897.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE014134 Genomic DNA. Translation: AAF52868.1.
AY089648 mRNA. Translation: AAL90386.1.
X15109 mRNA. Translation: CAA33207.1.
PIRiS21500.
RefSeqiNP_001285794.1. NM_001298865.1.
NP_523531.1. NM_078807.3.
UniGeneiDm.3483.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4V6Welectron microscopy6.00CF1-252[»]
ProteinModelPortaliP32100.
SMRiP32100.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi60443. 17 interactors.
DIPiDIP-18002N.
IntActiP32100. 2 interactors.
STRINGi7227.FBpp0079536.

Proteomic databases

PaxDbiP32100.
PRIDEiP32100.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiFBtr0079946; FBpp0079536; FBgn0005593.
FBtr0343653; FBpp0310250; FBgn0005593.
GeneIDi34352.
KEGGidme:Dmel_CG4897.

Organism-specific databases

CTDi6129.
FlyBaseiFBgn0005593. RpL7.

Phylogenomic databases

eggNOGiKOG3184. Eukaryota.
COG1841. LUCA.
InParanoidiP32100.
KOiK02937.
OMAiPTGGWRT.
OrthoDBiEOG091G0IHS.
PhylomeDBiP32100.

Enzyme and pathway databases

ReactomeiR-DME-156827. L13a-mediated translational silencing of Ceruloplasmin expression.
R-DME-1799339. SRP-dependent cotranslational protein targeting to membrane.
R-DME-72689. Formation of a pool of free 40S subunits.
R-DME-72706. GTP hydrolysis and joining of the 60S ribosomal subunit.
R-DME-975956. Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC).
R-DME-975957. Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC).

Miscellaneous databases

ChiTaRSiRpL7. fly.
GenomeRNAii34352.
PROiPR:P32100.

Gene expression databases

BgeeiFBgn0005593.
ExpressionAtlasiP32100. differential.
GenevisibleiP32100. DM.

Family and domain databases

Gene3Di3.30.1390.20. 2 hits.
InterProiView protein in InterPro
IPR018038. Ribosomal_L30_CS.
IPR016082. Ribosomal_L30_ferredoxin-like.
IPR012988. Ribosomal_L30_N.
IPR005998. Ribosomal_L7_euk.
PfamiView protein in Pfam
PF00327. Ribosomal_L30. 1 hit.
PF08079. Ribosomal_L30_N. 1 hit.
SUPFAMiSSF55129. SSF55129. 1 hit.
TIGRFAMsiTIGR01310. uL30_euk. 1 hit.
PROSITEiView protein in PROSITE
PS00634. RIBOSOMAL_L30. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiRL7_DROME
AccessioniPrimary (citable) accession number: P32100
Secondary accession number(s): Q541C8, Q9VL30
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: February 21, 2001
Last modified: June 7, 2017
This is version 134 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Ribosomal proteins
    Ribosomal proteins families and list of entries
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.