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Protein

Tricarboxylate transport protein, mitochondrial

Gene

Slc25a1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Involved in citrate-H+/malate exchange. Important for the bioenergetics of hepatic cells as it provides a carbon source for fatty acid and sterol biosyntheses, and NAD+ for the glycolytic pathway.

GO - Molecular functioni

  • citrate transmembrane transporter activity Source: RGD
  • structural constituent of ribosome Source: GO_Central

GO - Biological processi

  • mitochondrial citrate transport Source: RGD
  • translation Source: GO_Central
Complete GO annotation...

Keywords - Biological processi

Transport

Enzyme and pathway databases

ReactomeiR-RNO-70263. Gluconeogenesis.
R-RNO-75105. Fatty Acyl-CoA Biosynthesis.

Protein family/group databases

TCDBi2.A.29.7.1. the mitochondrial carrier (mc) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Tricarboxylate transport protein, mitochondrial
Alternative name(s):
Citrate transport protein
Short name:
CTP
Solute carrier family 25 member 1
Tricarboxylate carrier protein
Gene namesi
Name:Slc25a1
Synonyms:Slc20a3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 11

Organism-specific databases

RGDi3703. Slc25a1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei29 – 4618Helical; Name=1Sequence analysisAdd
BLAST
Transmembranei86 – 10520Helical; Name=2Sequence analysisAdd
BLAST
Transmembranei129 – 14315Helical; Name=3Sequence analysisAdd
BLAST
Transmembranei183 – 20220Helical; Name=4Sequence analysisAdd
BLAST
Transmembranei224 – 24118Helical; Name=5Sequence analysisAdd
BLAST
Transmembranei278 – 29720Helical; Name=6Sequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 1313Mitochondrion1 PublicationAdd
BLAST
Chaini14 – 311298Tricarboxylate transport protein, mitochondrialPRO_0000019263Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei156 – 1561PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP32089.
PRIDEiP32089.

PTM databases

iPTMnetiP32089.
PhosphoSiteiP32089.

Expressioni

Gene expression databases

BgeeiENSRNOG00000038001.
GenevisibleiP32089. RN.

Interactioni

Protein-protein interaction databases

IntActiP32089. 1 interaction.
STRINGi10116.ENSRNOP00000000306.

Structurei

3D structure databases

ProteinModelPortaliP32089.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati23 – 11189Solcar 1Add
BLAST
Repeati122 – 20887Solcar 2Add
BLAST
Repeati218 – 30386Solcar 3Add
BLAST

Sequence similaritiesi

Contains 3 Solcar repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transit peptide, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0756. Eukaryota.
ENOG410YAYP. LUCA.
GeneTreeiENSGT00550000074856.
HOGENOMiHOG000168307.
HOVERGENiHBG103009.
InParanoidiP32089.
KOiK15100.
OMAiKPKYRGF.
OrthoDBiEOG091G0KE7.
PhylomeDBiP32089.
TreeFamiTF105786.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR002067. Mit_carrier.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
PRINTSiPR00926. MITOCARRIER.
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P32089-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAPRAPRAL TAAAPGSGKA KLTHPGKAIL AGGLAGGIEI CITFPTEYVK
60 70 80 90 100
TQLQLDERAN PPRYRGIGDC VRQTVRSHGV LGLYRGLSSL LYGSIPKAAV
110 120 130 140 150
RFGMFEFLSN HMRDAQGRLD SRRGLLCGLG AGVAEAVVVV CPMETVKVKF
160 170 180 190 200
IHDQTSSNPK YRGFFHGVRE IVREQGLKGT YQGLTATVLK QGSNQAIRFF
210 220 230 240 250
VMTSLRNWYQ GDNPNKPMNP LITGVFGAVA GAASVFGNTP LDVIKTRMQG
260 270 280 290 300
LEAHKYRNTL DCGVQILKNE GPKAFYKGTV PRLGRVCLDV AIVFVIYDEV
310
VKLLNKVWKT D
Length:311
Mass (Da):33,835
Last modified:October 1, 1993 - v1
Checksum:iC7B5B8D82311F6D6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L12016 mRNA. Translation: AAA18899.1.
BC100077 mRNA. Translation: AAI00078.1.
PIRiA46595.
RefSeqiNP_059003.1. NM_017307.3.
UniGeneiRn.8368.

Genome annotation databases

EnsembliENSRNOT00000000306; ENSRNOP00000000306; ENSRNOG00000038001.
GeneIDi29743.
KEGGirno:29743.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L12016 mRNA. Translation: AAA18899.1.
BC100077 mRNA. Translation: AAI00078.1.
PIRiA46595.
RefSeqiNP_059003.1. NM_017307.3.
UniGeneiRn.8368.

3D structure databases

ProteinModelPortaliP32089.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiP32089. 1 interaction.
STRINGi10116.ENSRNOP00000000306.

Protein family/group databases

TCDBi2.A.29.7.1. the mitochondrial carrier (mc) family.

PTM databases

iPTMnetiP32089.
PhosphoSiteiP32089.

Proteomic databases

PaxDbiP32089.
PRIDEiP32089.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000000306; ENSRNOP00000000306; ENSRNOG00000038001.
GeneIDi29743.
KEGGirno:29743.

Organism-specific databases

CTDi6576.
RGDi3703. Slc25a1.

Phylogenomic databases

eggNOGiKOG0756. Eukaryota.
ENOG410YAYP. LUCA.
GeneTreeiENSGT00550000074856.
HOGENOMiHOG000168307.
HOVERGENiHBG103009.
InParanoidiP32089.
KOiK15100.
OMAiKPKYRGF.
OrthoDBiEOG091G0KE7.
PhylomeDBiP32089.
TreeFamiTF105786.

Enzyme and pathway databases

ReactomeiR-RNO-70263. Gluconeogenesis.
R-RNO-75105. Fatty Acyl-CoA Biosynthesis.

Miscellaneous databases

PROiP32089.

Gene expression databases

BgeeiENSRNOG00000038001.
GenevisibleiP32089. RN.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR002067. Mit_carrier.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
PRINTSiPR00926. MITOCARRIER.
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTXTP_RAT
AccessioniPrimary (citable) accession number: P32089
Secondary accession number(s): Q498T8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: September 7, 2016
This is version 123 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.