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Protein

TATA-box-binding protein

Gene

tbp-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

General transcription factor that functions at the core of the DNA-binding multiprotein factor TFIID. Binding of TFIID to the TATA box is the initial transcriptional step of the pre-initiation complex (PIC), playing a role in the activation of eukaryotic genes transcribed by RNA polymerase II.1 Publication

GO - Molecular functioni

  • AT DNA binding Source: WormBase
  • RNA polymerase III transcription factor activity, sequence-specific DNA binding Source: UniProtKB
  • transcription factor activity, sequence-specific DNA binding Source: WormBase
  • transcription factor binding Source: WormBase

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Transcription

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

ReactomeiR-CEL-674695. RNA Polymerase II Pre-transcription Events.
R-CEL-6807505. RNA polymerase II transcribes snRNA genes.
R-CEL-73776. RNA Polymerase II Promoter Escape.
R-CEL-73779. RNA Polymerase II Transcription Pre-Initiation And Promoter Opening.
R-CEL-75953. RNA Polymerase II Transcription Initiation.
R-CEL-76042. RNA Polymerase II Transcription Initiation And Promoter Clearance.

Names & Taxonomyi

Protein namesi
Recommended name:
TATA-box-binding protein
Alternative name(s):
TATA sequence-binding protein
Short name:
TBP
TATA-binding factor
TATA-box factor
Transcription initiation factor TFIID TBP subunit
Gene namesi
Name:tbp-1
Synonyms:tbp
ORF Names:T20B12.2
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome III

Organism-specific databases

WormBaseiT20B12.2; CE01408; WBGene00006542; tbp-1.

Subcellular locationi

  • Nucleus By similarity

GO - Cellular componenti

  • nucleus Source: WormBase
  • transcription factor TFIID complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001539701 – 340TATA-box-binding proteinAdd BLAST340

Proteomic databases

EPDiP32085.
PaxDbiP32085.
PeptideAtlasiP32085.
PRIDEiP32085.

Expressioni

Gene expression databases

BgeeiWBGene00006542.

Interactioni

Subunit structurei

Belongs to the TFIID complex together with the TBP-associated factors (TAFs). Binds DNA as monomer.1 Publication

GO - Molecular functioni

  • transcription factor binding Source: WormBase

Protein-protein interaction databases

BioGridi41263. 8 interactors.
DIPiDIP-26447N.
IntActiP32085. 8 interactors.
MINTiMINT-1112600.
STRINGi6239.T20B12.2.2.

Structurei

3D structure databases

ProteinModelPortaliP32085.
SMRiP32085.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati168 – 2441Add BLAST77
Repeati258 – 3352Add BLAST78

Sequence similaritiesi

Belongs to the TBP family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG3302. Eukaryota.
COG2101. LUCA.
GeneTreeiENSGT00410000025389.
HOGENOMiHOG000105164.
InParanoidiP32085.
KOiK03120.
OMAiKFTEFMV.
OrthoDBiEOG091G0ENY.
PhylomeDBiP32085.

Family and domain databases

CDDicd04516. TBP_eukaryotes. 1 hit.
Gene3Di3.30.310.10. 2 hits.
HAMAPiMF_00408. TATA_bind_prot_arch. 1 hit.
InterProiIPR012295. Beta2_adaptin/TBP_C_dom.
IPR000814. TBP.
IPR030491. TBP_CS.
IPR033710. TBP_eukaryotic.
[Graphical view]
PANTHERiPTHR10126. PTHR10126. 1 hit.
PfamiPF00352. TBP. 2 hits.
[Graphical view]
PRINTSiPR00686. TIFACTORIID.
PROSITEiPS00351. TFIID. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P32085-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNLNSPAVSM LGGDTPAHGG PNSVLGGQGP SSILTGHGPN SVMGPNSILG
60 70 80 90 100
PGSVLNPQSI QPMQSQQMHS LQGSSMQMHS HLANSNLNLN INPASVGPDR
110 120 130 140 150
NPGSVMHHNL DINPPSVAYQ NLTVPMTPLA YSVYDRDALT HQAPASNIAA
160 170 180 190 200
TMVPATPASQ LDIPMPALQN IVSTVNLGVQ LDLKKIALHA RNAEYNPKRF
210 220 230 240 250
AAVIMRIREP RTTALIFSSG KMVCTGAKSE EASRLAARKY ARIVQKLGFQ
260 270 280 290 300
AKFTEFMVQN MVGSCDVRFP IQLEGLCITH SQFSTYEPEL FPGLIYRMVK
310 320 330 340
PRVVLLIFVS GKVVITGAKT KRDIDEAFGQ IYPILKGFKK
Length:340
Mass (Da):36,647
Last modified:October 1, 1993 - v1
Checksum:iB3127075BC6998CB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L07754 mRNA. Translation: AAA03582.1.
FO081094 Genomic DNA. Translation: CCD69071.1.
AF303249 mRNA. Translation: AAG50207.1.
PIRiA48671.
RefSeqiNP_498635.1. NM_066234.5.
UniGeneiCel.7450.

Genome annotation databases

EnsemblMetazoaiT20B12.2.1; T20B12.2.1; WBGene00006542.
T20B12.2.2; T20B12.2.2; WBGene00006542.
GeneIDi176054.
KEGGicel:CELE_T20B12.2.
UCSCiT20B12.2.1. c. elegans.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L07754 mRNA. Translation: AAA03582.1.
FO081094 Genomic DNA. Translation: CCD69071.1.
AF303249 mRNA. Translation: AAG50207.1.
PIRiA48671.
RefSeqiNP_498635.1. NM_066234.5.
UniGeneiCel.7450.

3D structure databases

ProteinModelPortaliP32085.
SMRiP32085.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi41263. 8 interactors.
DIPiDIP-26447N.
IntActiP32085. 8 interactors.
MINTiMINT-1112600.
STRINGi6239.T20B12.2.2.

Proteomic databases

EPDiP32085.
PaxDbiP32085.
PeptideAtlasiP32085.
PRIDEiP32085.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblMetazoaiT20B12.2.1; T20B12.2.1; WBGene00006542.
T20B12.2.2; T20B12.2.2; WBGene00006542.
GeneIDi176054.
KEGGicel:CELE_T20B12.2.
UCSCiT20B12.2.1. c. elegans.

Organism-specific databases

CTDi176054.
WormBaseiT20B12.2; CE01408; WBGene00006542; tbp-1.

Phylogenomic databases

eggNOGiKOG3302. Eukaryota.
COG2101. LUCA.
GeneTreeiENSGT00410000025389.
HOGENOMiHOG000105164.
InParanoidiP32085.
KOiK03120.
OMAiKFTEFMV.
OrthoDBiEOG091G0ENY.
PhylomeDBiP32085.

Enzyme and pathway databases

ReactomeiR-CEL-674695. RNA Polymerase II Pre-transcription Events.
R-CEL-6807505. RNA polymerase II transcribes snRNA genes.
R-CEL-73776. RNA Polymerase II Promoter Escape.
R-CEL-73779. RNA Polymerase II Transcription Pre-Initiation And Promoter Opening.
R-CEL-75953. RNA Polymerase II Transcription Initiation.
R-CEL-76042. RNA Polymerase II Transcription Initiation And Promoter Clearance.

Miscellaneous databases

PROiP32085.

Gene expression databases

BgeeiWBGene00006542.

Family and domain databases

CDDicd04516. TBP_eukaryotes. 1 hit.
Gene3Di3.30.310.10. 2 hits.
HAMAPiMF_00408. TATA_bind_prot_arch. 1 hit.
InterProiIPR012295. Beta2_adaptin/TBP_C_dom.
IPR000814. TBP.
IPR030491. TBP_CS.
IPR033710. TBP_eukaryotic.
[Graphical view]
PANTHERiPTHR10126. PTHR10126. 1 hit.
PfamiPF00352. TBP. 2 hits.
[Graphical view]
PRINTSiPR00686. TIFACTORIID.
PROSITEiPS00351. TFIID. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTBP_CAEEL
AccessioniPrimary (citable) accession number: P32085
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: November 30, 2016
This is version 126 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Caenorhabditis elegans
    Caenorhabditis elegans: entries, gene names and cross-references to WormBase
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.