Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

TATA-box-binding protein

Gene

tbp-1

Organism
Caenorhabditis elegans
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

General transcription factor that functions at the core of the DNA-binding multiprotein factor TFIID. Binding of TFIID to the TATA box is the initial transcriptional step of the pre-initiation complex (PIC), playing a role in the activation of eukaryotic genes transcribed by RNA polymerase II.1 Publication

GO - Molecular functioni

  • AT DNA binding Source: WormBase
  • DNA binding transcription factor activity Source: WormBase
  • RNA polymerase III transcription factor activity, sequence-specific DNA binding Source: UniProtKB
  • transcription factor binding Source: WormBase

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription

Enzyme and pathway databases

ReactomeiR-CEL-674695 RNA Polymerase II Pre-transcription Events
R-CEL-6807505 RNA polymerase II transcribes snRNA genes
R-CEL-73776 RNA Polymerase II Promoter Escape
R-CEL-73779 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
R-CEL-75953 RNA Polymerase II Transcription Initiation
R-CEL-76042 RNA Polymerase II Transcription Initiation And Promoter Clearance

Names & Taxonomyi

Protein namesi
Recommended name:
TATA-box-binding protein
Alternative name(s):
TATA sequence-binding protein
Short name:
TBP
TATA-binding factor
TATA-box factor
Transcription initiation factor TFIID TBP subunit
Gene namesi
Name:tbp-1
Synonyms:tbp
ORF Names:T20B12.2
OrganismiCaenorhabditis elegans
Taxonomic identifieri6239 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaNematodaChromadoreaRhabditidaRhabditoideaRhabditidaePeloderinaeCaenorhabditis
Proteomesi
  • UP000001940 Componenti: Chromosome III

Organism-specific databases

WormBaseiT20B12.2 ; CE01408 ; WBGene00006542 ; tbp-1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001539701 – 340TATA-box-binding proteinAdd BLAST340

Proteomic databases

EPDiP32085
PaxDbiP32085
PeptideAtlasiP32085
PRIDEiP32085

Expressioni

Gene expression databases

BgeeiWBGene00006542

Interactioni

Subunit structurei

Belongs to the TFIID complex together with the TBP-associated factors (TAFs). Binds DNA as monomer.1 Publication

GO - Molecular functioni

  • transcription factor binding Source: WormBase

Protein-protein interaction databases

BioGridi41263, 8 interactors
DIPiDIP-26447N
IntActiP32085, 9 interactors
STRINGi6239.T20B12.2.2

Structurei

3D structure databases

ProteinModelPortaliP32085
SMRiP32085
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati168 – 2441Add BLAST77
Repeati258 – 3352Add BLAST78

Sequence similaritiesi

Belongs to the TBP family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG3302 Eukaryota
COG2101 LUCA
GeneTreeiENSGT00410000025389
HOGENOMiHOG000105164
InParanoidiP32085
KOiK03120
OMAiKFTEFMV
OrthoDBiEOG091G0ENY
PhylomeDBiP32085

Family and domain databases

CDDicd04516 TBP_eukaryotes, 1 hit
Gene3Di3.30.310.10, 2 hits
HAMAPiMF_00408 TATA_bind_prot_arch, 1 hit
InterProiView protein in InterPro
IPR000814 TBP
IPR030491 TBP_CS
IPR012295 TBP_dom_sf
IPR033710 TBP_eukaryotic
PANTHERiPTHR10126 PTHR10126, 1 hit
PfamiView protein in Pfam
PF00352 TBP, 2 hits
PRINTSiPR00686 TIFACTORIID
PROSITEiView protein in PROSITE
PS00351 TFIID, 2 hits

Sequencei

Sequence statusi: Complete.

P32085-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNLNSPAVSM LGGDTPAHGG PNSVLGGQGP SSILTGHGPN SVMGPNSILG
60 70 80 90 100
PGSVLNPQSI QPMQSQQMHS LQGSSMQMHS HLANSNLNLN INPASVGPDR
110 120 130 140 150
NPGSVMHHNL DINPPSVAYQ NLTVPMTPLA YSVYDRDALT HQAPASNIAA
160 170 180 190 200
TMVPATPASQ LDIPMPALQN IVSTVNLGVQ LDLKKIALHA RNAEYNPKRF
210 220 230 240 250
AAVIMRIREP RTTALIFSSG KMVCTGAKSE EASRLAARKY ARIVQKLGFQ
260 270 280 290 300
AKFTEFMVQN MVGSCDVRFP IQLEGLCITH SQFSTYEPEL FPGLIYRMVK
310 320 330 340
PRVVLLIFVS GKVVITGAKT KRDIDEAFGQ IYPILKGFKK
Length:340
Mass (Da):36,647
Last modified:October 1, 1993 - v1
Checksum:iB3127075BC6998CB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L07754 mRNA Translation: AAA03582.1
FO081094 Genomic DNA Translation: CCD69071.1
AF303249 mRNA Translation: AAG50207.1
PIRiA48671
RefSeqiNP_498635.1, NM_066234.5
UniGeneiCel.7450

Genome annotation databases

EnsemblMetazoaiT20B12.2; T20B12.2; WBGene00006542
GeneIDi176054
KEGGicel:CELE_T20B12.2
UCSCiT20B12.2.1 c. elegans

Similar proteinsi

Entry informationi

Entry nameiTBP_CAEEL
AccessioniPrimary (citable) accession number: P32085
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: March 28, 2018
This is version 134 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programCaenorhabditis annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health