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Protein

Growth hormone-releasing hormone receptor

Gene

Ghrhr

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for GRF, coupled to G proteins which activate adenylyl cyclase. Stimulates somatotroph cell growth, growth hormone gene transcription and growth hormone secretion.

GO - Molecular functioni

  • growth factor binding Source: MGI
  • growth hormone-releasing hormone receptor activity Source: MGI
  • peptide hormone binding Source: BHF-UCL

GO - Biological processi

  • activation of adenylate cyclase activity Source: Ensembl
  • adenohypophysis development Source: MGI
  • adenylate cyclase-activating G-protein coupled receptor signaling pathway Source: MGI
  • cAMP-mediated signaling Source: MGI
  • cell maturation Source: MGI
  • cell surface receptor signaling pathway Source: InterPro
  • cellular response to glucose stimulus Source: Ensembl
  • cellular response to insulin stimulus Source: MGI
  • determination of adult lifespan Source: MGI
  • growth hormone secretion Source: MGI
  • hormone metabolic process Source: MGI
  • lactation Source: MGI
  • mammary gland development Source: MGI
  • positive regulation of cAMP biosynthetic process Source: MGI
  • positive regulation of cell proliferation Source: BHF-UCL
  • positive regulation of circadian sleep/wake cycle, non-REM sleep Source: Ensembl
  • positive regulation of growth hormone secretion Source: MGI
  • positive regulation of hormone secretion Source: MGI
  • positive regulation of multicellular organism growth Source: MGI
  • regulation of insulin-like growth factor receptor signaling pathway Source: MGI
  • regulation of intracellular steroid hormone receptor signaling pathway Source: MGI
  • regulation of protein metabolic process Source: MGI
  • response to estrogen Source: MGI
  • response to glucocorticoid Source: MGI
  • response to insulin Source: MGI
  • somatotropin secreting cell development Source: MGI
  • water homeostasis Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-MMU-418555. G alpha (s) signalling events.
R-MMU-420092. Glucagon-type ligand receptors.

Names & Taxonomyi

Protein namesi
Recommended name:
Growth hormone-releasing hormone receptor
Short name:
GHRH receptor
Alternative name(s):
Growth hormone-releasing factor receptor
Short name:
GRF receptor
Short name:
GRFR
Gene namesi
Name:Ghrhr
Synonyms:Grfr
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:95710. Ghrhr.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini23 – 132ExtracellularSequence analysisAdd BLAST110
Transmembranei133 – 152Helical; Name=1Sequence analysisAdd BLAST20
Topological domaini153 – 162CytoplasmicSequence analysis10
Transmembranei163 – 181Helical; Name=2Sequence analysisAdd BLAST19
Topological domaini182 – 204ExtracellularSequence analysisAdd BLAST23
Transmembranei205 – 227Helical; Name=3Sequence analysisAdd BLAST23
Topological domaini228 – 240CytoplasmicSequence analysisAdd BLAST13
Transmembranei241 – 262Helical; Name=4Sequence analysisAdd BLAST22
Topological domaini263 – 280ExtracellularSequence analysisAdd BLAST18
Transmembranei281 – 304Helical; Name=5Sequence analysisAdd BLAST24
Topological domaini305 – 329CytoplasmicSequence analysisAdd BLAST25
Transmembranei330 – 348Helical; Name=6Sequence analysisAdd BLAST19
Topological domaini349 – 361ExtracellularSequence analysisAdd BLAST13
Transmembranei362 – 381Helical; Name=7Sequence analysisAdd BLAST20
Topological domaini382 – 423CytoplasmicSequence analysisAdd BLAST42

GO - Cellular componenti

  • cell surface Source: MGI
  • cytoplasm Source: MGI
  • integral component of membrane Source: MGI
  • nuclear inner membrane Source: MGI
  • nuclear matrix Source: MGI
  • nuclear outer membrane Source: MGI
  • plasma membrane Source: MGI
  • sarcolemma Source: Ensembl
  • secretory granule Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Involvement in diseasei

Little (lit) mice exhibits anterior pituitary hypoplasia.

Keywords - Diseasei

Disease mutation

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_000001282923 – 423Growth hormone-releasing hormone receptorAdd BLAST401

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi41 ↔ 64By similarity
Glycosylationi49N-linked (GlcNAc...)Sequence analysis1
Glycosylationi50N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi55 ↔ 96By similarity
Disulfide bondi78 ↔ 112By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP32082.
PRIDEiP32082.

PTM databases

PhosphoSitePlusiP32082.

Expressioni

Tissue specificityi

Pituitary gland.

Gene expression databases

BgeeiENSMUSG00000004654.
CleanExiMM_GHRHR.
ExpressionAtlasiP32082. baseline and differential.
GenevisibleiP32082. MM.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

BioGridi199917. 1 interactor.
STRINGi10090.ENSMUSP00000068120.

Structurei

3D structure databases

ProteinModelPortaliP32082.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4564. Eukaryota.
ENOG410XRS2. LUCA.
GeneTreeiENSGT00760000118800.
HOGENOMiHOG000008249.
HOVERGENiHBG008318.
InParanoidiP32082.
KOiK04584.
OMAiIHYIIFN.
OrthoDBiEOG091G0NF8.
TreeFamiTF315710.

Family and domain databases

InterProiIPR017981. GPCR_2-like.
IPR001879. GPCR_2_extracellular_dom.
IPR003288. GPCR_2_GHRH_rcpt.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
[Graphical view]
PfamiPF00002. 7tm_2. 1 hit.
PF02793. HRM. 1 hit.
[Graphical view]
PRINTSiPR01352. GHRHRECEPTOR.
PR00249. GPCRSECRETIN.
SMARTiSM00008. HormR. 1 hit.
[Graphical view]
PROSITEiPS00649. G_PROTEIN_RECEP_F2_1. 1 hit.
PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P32082-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDGLMWATRI LCLLSLCGVT LGHLHLECDF ITQLRDDELA CLQAAEGTNN
60 70 80 90 100
TSLGCPGTWD GLLCWPPTGS GQWVSLPCPE FFSHFGSDTG FVKRDCTITG
110 120 130 140 150
WSNPFPPYPV ACPVPLELLT KEKSYFSTVK IIYTTGHSIS IVALCVAIAI
160 170 180 190 200
LVALRRLHCP RNYIHTQLFA TFILKASAVF LKDAAIFQGD STDHCSMSTV
210 220 230 240 250
LCKVSVAISH LATMTNFSWL LAEAVYLSCL LASTSPRSKP AFWWLVLAGW
260 270 280 290 300
GLPVLCTGTW VGCKLAFEDT ECWDLDNSSP CWWIIKGPIV LSVGVNFGLF
310 320 330 340 350
LNIICILLRK LEPAQGGLHT RAQYWRLSKS TLLLIPLFGI HYIIFNFLPD
360 370 380 390 400
SAGLDIRVPL ELGLGSFQGF IVAVLYCFLN QEVRTEISRK WYGHDPELLP
410 420
ARRTCTEWTT PPRSRLKVLT SEC
Length:423
Mass (Da):47,004
Last modified:July 27, 2011 - v2
Checksum:iA2BC658E719A8033
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti265 – 266LA → HS in L07379 (PubMed:1334535).Curated2

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti60D → G in lit. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L07379 mRNA. No translation available.
BC120748 mRNA. Translation: AAI20749.1.
BC120774 mRNA. Translation: AAI20775.1.
CCDSiCCDS20165.1.
PIRiS29753.
RefSeqiNP_001003685.2. NM_001003685.3.
UniGeneiMm.89928.

Genome annotation databases

EnsembliENSMUST00000063578; ENSMUSP00000068120; ENSMUSG00000004654.
GeneIDi14602.
KEGGimmu:14602.
UCSCiuc009cas.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L07379 mRNA. No translation available.
BC120748 mRNA. Translation: AAI20749.1.
BC120774 mRNA. Translation: AAI20775.1.
CCDSiCCDS20165.1.
PIRiS29753.
RefSeqiNP_001003685.2. NM_001003685.3.
UniGeneiMm.89928.

3D structure databases

ProteinModelPortaliP32082.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi199917. 1 interactor.
STRINGi10090.ENSMUSP00000068120.

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSitePlusiP32082.

Proteomic databases

PaxDbiP32082.
PRIDEiP32082.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000063578; ENSMUSP00000068120; ENSMUSG00000004654.
GeneIDi14602.
KEGGimmu:14602.
UCSCiuc009cas.2. mouse.

Organism-specific databases

CTDi2692.
MGIiMGI:95710. Ghrhr.

Phylogenomic databases

eggNOGiKOG4564. Eukaryota.
ENOG410XRS2. LUCA.
GeneTreeiENSGT00760000118800.
HOGENOMiHOG000008249.
HOVERGENiHBG008318.
InParanoidiP32082.
KOiK04584.
OMAiIHYIIFN.
OrthoDBiEOG091G0NF8.
TreeFamiTF315710.

Enzyme and pathway databases

ReactomeiR-MMU-418555. G alpha (s) signalling events.
R-MMU-420092. Glucagon-type ligand receptors.

Miscellaneous databases

PROiP32082.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000004654.
CleanExiMM_GHRHR.
ExpressionAtlasiP32082. baseline and differential.
GenevisibleiP32082. MM.

Family and domain databases

InterProiIPR017981. GPCR_2-like.
IPR001879. GPCR_2_extracellular_dom.
IPR003288. GPCR_2_GHRH_rcpt.
IPR000832. GPCR_2_secretin-like.
IPR017983. GPCR_2_secretin-like_CS.
[Graphical view]
PfamiPF00002. 7tm_2. 1 hit.
PF02793. HRM. 1 hit.
[Graphical view]
PRINTSiPR01352. GHRHRECEPTOR.
PR00249. GPCRSECRETIN.
SMARTiSM00008. HormR. 1 hit.
[Graphical view]
PROSITEiPS00649. G_PROTEIN_RECEP_F2_1. 1 hit.
PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGHRHR_MOUSE
AccessioniPrimary (citable) accession number: P32082
Secondary accession number(s): Q0VB62
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: July 27, 2011
Last modified: November 2, 2016
This is version 137 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.