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P32082

- GHRHR_MOUSE

UniProt

P32082 - GHRHR_MOUSE

Protein

Growth hormone-releasing hormone receptor

Gene

Ghrhr

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 121 (01 Oct 2014)
      Sequence version 2 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    Receptor for GRF, coupled to G proteins which activate adenylyl cyclase. Stimulates somatotroph cell growth, growth hormone gene transcription and growth hormone secretion.

    GO - Molecular functioni

    1. growth hormone-releasing hormone receptor activity Source: MGI
    2. peptide hormone binding Source: BHF-UCL
    3. protein binding Source: MGI

    GO - Biological processi

    1. activation of adenylate cyclase activity Source: Ensembl
    2. adenohypophysis development Source: MGI
    3. adenylate cyclase-activating G-protein coupled receptor signaling pathway Source: MGI
    4. cAMP-mediated signaling Source: Ensembl
    5. cell maturation Source: MGI
    6. cellular response to insulin stimulus Source: MGI
    7. determination of adult lifespan Source: MGI
    8. growth hormone secretion Source: MGI
    9. hormone metabolic process Source: MGI
    10. lactation Source: MGI
    11. mammary gland development Source: MGI
    12. positive regulation of cell proliferation Source: BHF-UCL
    13. positive regulation of growth hormone secretion Source: MGI
    14. positive regulation of hormone secretion Source: MGI
    15. positive regulation of multicellular organism growth Source: MGI
    16. regulation of insulin-like growth factor receptor signaling pathway Source: MGI
    17. regulation of intracellular steroid hormone receptor signaling pathway Source: MGI
    18. regulation of protein metabolic process Source: MGI
    19. response to estrogen Source: Ensembl
    20. response to glucocorticoid Source: Ensembl
    21. somatotropin secreting cell development Source: MGI
    22. water homeostasis Source: MGI

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Growth hormone-releasing hormone receptor
    Short name:
    GHRH receptor
    Alternative name(s):
    Growth hormone-releasing factor receptor
    Short name:
    GRF receptor
    Short name:
    GRFR
    Gene namesi
    Name:Ghrhr
    Synonyms:Grfr
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 6

    Organism-specific databases

    MGIiMGI:95710. Ghrhr.

    Subcellular locationi

    GO - Cellular componenti

    1. cell surface Source: Ensembl
    2. integral component of membrane Source: MGI
    3. nuclear inner membrane Source: Ensembl
    4. nuclear matrix Source: Ensembl
    5. nuclear outer membrane Source: Ensembl
    6. plasma membrane Source: MGI
    7. secretory granule Source: Ensembl

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Involvement in diseasei

    Little (lit) mice exhibits anterior pituitary hypoplasia.

    Keywords - Diseasei

    Disease mutation

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2222Sequence AnalysisAdd
    BLAST
    Chaini23 – 423401Growth hormone-releasing hormone receptorPRO_0000012829Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi41 ↔ 64By similarity
    Glycosylationi49 – 491N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi50 – 501N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi55 ↔ 96By similarity
    Disulfide bondi78 ↔ 112By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiP32082.
    PRIDEiP32082.

    Expressioni

    Tissue specificityi

    Pituitary gland.

    Gene expression databases

    BgeeiP32082.
    CleanExiMM_GHRHR.
    GenevestigatoriP32082.

    Interactioni

    Protein-protein interaction databases

    BioGridi199917. 1 interaction.
    STRINGi10090.ENSMUSP00000068120.

    Structurei

    3D structure databases

    ProteinModelPortaliP32082.
    SMRiP32082. Positions 34-386.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini23 – 132110ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini153 – 16210CytoplasmicSequence Analysis
    Topological domaini182 – 20423ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini228 – 24013CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini263 – 28018ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini305 – 32925CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini349 – 36113ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini382 – 42342CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei133 – 15220Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei163 – 18119Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei205 – 22723Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei241 – 26222Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei281 – 30424Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei330 – 34819Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei362 – 38120Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG249002.
    GeneTreeiENSGT00740000115231.
    HOGENOMiHOG000008249.
    HOVERGENiHBG008318.
    InParanoidiQ0VB62.
    KOiK04584.
    OMAiIHYIIFN.
    OrthoDBiEOG7TF78W.
    TreeFamiTF315710.

    Family and domain databases

    InterProiIPR017981. GPCR_2-like.
    IPR001879. GPCR_2_extracellular_dom.
    IPR003288. GPCR_2_GHRH_rcpt.
    IPR000832. GPCR_2_secretin-like.
    IPR017983. GPCR_2_secretin-like_CS.
    [Graphical view]
    PfamiPF00002. 7tm_2. 1 hit.
    PF02793. HRM. 1 hit.
    [Graphical view]
    PRINTSiPR01352. GHRHRECEPTOR.
    PR00249. GPCRSECRETIN.
    SMARTiSM00008. HormR. 1 hit.
    [Graphical view]
    PROSITEiPS00649. G_PROTEIN_RECEP_F2_1. 1 hit.
    PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
    PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
    PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P32082-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDGLMWATRI LCLLSLCGVT LGHLHLECDF ITQLRDDELA CLQAAEGTNN    50
    TSLGCPGTWD GLLCWPPTGS GQWVSLPCPE FFSHFGSDTG FVKRDCTITG 100
    WSNPFPPYPV ACPVPLELLT KEKSYFSTVK IIYTTGHSIS IVALCVAIAI 150
    LVALRRLHCP RNYIHTQLFA TFILKASAVF LKDAAIFQGD STDHCSMSTV 200
    LCKVSVAISH LATMTNFSWL LAEAVYLSCL LASTSPRSKP AFWWLVLAGW 250
    GLPVLCTGTW VGCKLAFEDT ECWDLDNSSP CWWIIKGPIV LSVGVNFGLF 300
    LNIICILLRK LEPAQGGLHT RAQYWRLSKS TLLLIPLFGI HYIIFNFLPD 350
    SAGLDIRVPL ELGLGSFQGF IVAVLYCFLN QEVRTEISRK WYGHDPELLP 400
    ARRTCTEWTT PPRSRLKVLT SEC 423
    Length:423
    Mass (Da):47,004
    Last modified:July 27, 2011 - v2
    Checksum:iA2BC658E719A8033
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti265 – 2662LA → HS in L07379. (PubMed:1334535)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti60 – 601D → G in lit. 1 Publication

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L07379 mRNA. No translation available.
    BC120748 mRNA. Translation: AAI20749.1.
    BC120774 mRNA. Translation: AAI20775.1.
    CCDSiCCDS20165.1.
    PIRiS29753.
    RefSeqiNP_001003685.2. NM_001003685.3.
    UniGeneiMm.89928.

    Genome annotation databases

    EnsembliENSMUST00000063578; ENSMUSP00000068120; ENSMUSG00000004654.
    GeneIDi14602.
    KEGGimmu:14602.
    UCSCiuc009cas.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    L07379 mRNA. No translation available.
    BC120748 mRNA. Translation: AAI20749.1 .
    BC120774 mRNA. Translation: AAI20775.1 .
    CCDSi CCDS20165.1.
    PIRi S29753.
    RefSeqi NP_001003685.2. NM_001003685.3.
    UniGenei Mm.89928.

    3D structure databases

    ProteinModelPortali P32082.
    SMRi P32082. Positions 34-386.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 199917. 1 interaction.
    STRINGi 10090.ENSMUSP00000068120.

    Chemistry

    GuidetoPHARMACOLOGYi 247.

    Protein family/group databases

    GPCRDBi Search...

    Proteomic databases

    PaxDbi P32082.
    PRIDEi P32082.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000063578 ; ENSMUSP00000068120 ; ENSMUSG00000004654 .
    GeneIDi 14602.
    KEGGi mmu:14602.
    UCSCi uc009cas.2. mouse.

    Organism-specific databases

    CTDi 2692.
    MGIi MGI:95710. Ghrhr.

    Phylogenomic databases

    eggNOGi NOG249002.
    GeneTreei ENSGT00740000115231.
    HOGENOMi HOG000008249.
    HOVERGENi HBG008318.
    InParanoidi Q0VB62.
    KOi K04584.
    OMAi IHYIIFN.
    OrthoDBi EOG7TF78W.
    TreeFami TF315710.

    Miscellaneous databases

    NextBioi 286380.
    PROi P32082.
    SOURCEi Search...

    Gene expression databases

    Bgeei P32082.
    CleanExi MM_GHRHR.
    Genevestigatori P32082.

    Family and domain databases

    InterProi IPR017981. GPCR_2-like.
    IPR001879. GPCR_2_extracellular_dom.
    IPR003288. GPCR_2_GHRH_rcpt.
    IPR000832. GPCR_2_secretin-like.
    IPR017983. GPCR_2_secretin-like_CS.
    [Graphical view ]
    Pfami PF00002. 7tm_2. 1 hit.
    PF02793. HRM. 1 hit.
    [Graphical view ]
    PRINTSi PR01352. GHRHRECEPTOR.
    PR00249. GPCRSECRETIN.
    SMARTi SM00008. HormR. 1 hit.
    [Graphical view ]
    PROSITEi PS00649. G_PROTEIN_RECEP_F2_1. 1 hit.
    PS00650. G_PROTEIN_RECEP_F2_2. 1 hit.
    PS50227. G_PROTEIN_RECEP_F2_3. 1 hit.
    PS50261. G_PROTEIN_RECEP_F2_4. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Pit-1-dependent expression of the receptor for growth hormone releasing factor mediates pituitary cell growth."
      Lin C.R., Lin S.-C., Chang C.P., Rosenfeld M.G.
      Nature 360:765-768(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    3. "Molecular basis of the little mouse phenotype and implications for cell type-specific growth."
      Lin S.-C., Lin C.R., Gukovsky I., Lusis A.J., Sawchenko P.E., Rosenfeld M.G.
      Nature 364:208-213(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT LIT GLY-60.

    Entry informationi

    Entry nameiGHRHR_MOUSE
    AccessioniPrimary (citable) accession number: P32082
    Secondary accession number(s): Q0VB62
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 1, 1993
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 121 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3