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Protein

Lupus La protein homolog

Gene

Ssb

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds to the 3' poly(U) terminus of nascent RNA polymerase III transcripts, protecting them from exonuclease digestion and facilitating their folding and maturation.

GO - Molecular functioni

  • poly(U) RNA binding Source: MGI
  • RNA binding Source: MGI
  • sequence-specific mRNA binding Source: MGI
  • tRNA binding Source: MGI

GO - Biological processi

Keywordsi

Molecular functionRNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Lupus La protein homolog
Alternative name(s):
La autoantigen homolog
La ribonucleoprotein
Gene namesi
Name:Ssb
Synonyms:Ss-b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:98423 Ssb

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002076001 – 415Lupus La protein homologAdd BLAST415

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei92PhosphoserineBy similarity1
Modified residuei94PhosphoserineBy similarity1
Modified residuei116N6-acetyllysineBy similarity1
Modified residuei120PhosphothreonineBy similarity1
Modified residuei128N6-acetyllysineBy similarity1
Modified residuei327N6-acetyllysineCombined sources1
Modified residuei356N6-acetyllysineCombined sources1
Modified residuei377PhosphothreonineBy similarity1

Post-translational modificationi

Phosphorylated.By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP32067
PaxDbiP32067
PeptideAtlasiP32067
PRIDEiP32067

PTM databases

iPTMnetiP32067
PhosphoSitePlusiP32067
SwissPalmiP32067

Expressioni

Gene expression databases

BgeeiENSMUSG00000068882
CleanExiMM_SSB
ExpressionAtlasiP32067 baseline and differential
GenevisibleiP32067 MM

Interactioni

Subunit structurei

Interacts with DDX15. May interact with RUFY1 (By similarity).By similarity

Protein-protein interaction databases

BioGridi203508, 4 interactors
DIPiDIP-37706N
IntActiP32067, 6 interactors
MINTiP32067
STRINGi10090.ENSMUSP00000088365

Structurei

3D structure databases

ProteinModelPortaliP32067
SMRiP32067
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini7 – 99HTH La-type RNA-bindingPROSITE-ProRule annotationAdd BLAST93
Domaini111 – 187RRMPROSITE-ProRule annotationAdd BLAST77

Phylogenomic databases

eggNOGiENOG410IQXQ Eukaryota
COG5193 LUCA
GeneTreeiENSGT00830000128380
HOGENOMiHOG000006947
HOVERGENiHBG001407
InParanoidiP32067
KOiK11090
OMAiPEHNEER
OrthoDBiEOG091G0K95
PhylomeDBiP32067
TreeFamiTF314476

Family and domain databases

Gene3Di1.10.10.10, 1 hit
3.30.70.330, 2 hits
InterProiView protein in InterPro
IPR006630 La_HTH
IPR014886 La_RRM
IPR002344 Lupus_La
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF05383 La, 1 hit
PF00076 RRM_1, 1 hit
PF08777 RRM_3, 1 hit
PRINTSiPR00302 LUPUSLA
SMARTiView protein in SMART
SM00715 LA, 1 hit
SM00360 RRM, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
SSF54928 SSF54928, 2 hits
PROSITEiView protein in PROSITE
PS50961 HTH_LA, 1 hit
PS50102 RRM, 1 hit

Sequencei

Sequence statusi: Complete.

P32067-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAENGDNEKM TALEAKICHQ IEYYFGDFNL PRDKFLKEQI KLDEGWVPLE
60 70 80 90 100
TMIKFNRLNR LTTDFNVIVQ ALSKSKAKLM EVSADKTKIR RSPSRPLPEV
110 120 130 140 150
TDEYKNDVKN RSVYIKGFPT DATLDDIKEW LDDKGQILNI QMRRTLHKTF
160 170 180 190 200
KGSIFAVFDS IQSAKKFVEI PGQKYKDTNL LILFKEDYFA KKNEERKQSK
210 220 230 240 250
VEAKLKAKQE HEGRHKPGST ETRALEGKMG CLLKFSGDLD DQTCREDLHF
260 270 280 290 300
LFSNHGEIKW VDFARGAKEG IILFKEKAKE ALEKARNANN GNLLLRNKKV
310 320 330 340 350
TWKVLEGHAE KEALKKITDD QQESLNKWKS KGGHAGGRFK GSHVFTAARR
360 370 380 390 400
FKGKGKGNRP GYAGAPKGRG QFHGRRTRFD DDDRRRGPMK RGRDGRDREE
410
PASKHKKREN GARDK
Length:415
Mass (Da):47,756
Last modified:October 1, 1993 - v1
Checksum:i2D75197692FDC933
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L00993 mRNA Translation: AAA39415.1
BC003820 mRNA Translation: AAH03820.1
Y07951 mRNA Translation: CAA69249.1
CCDSiCCDS16101.1
RefSeqiNP_001103615.1, NM_001110145.1
NP_033304.1, NM_009278.4
UniGeneiMm.10508

Genome annotation databases

EnsembliENSMUST00000090852; ENSMUSP00000088365; ENSMUSG00000068882
ENSMUST00000166411; ENSMUSP00000130313; ENSMUSG00000068882
GeneIDi20823
KEGGimmu:20823
UCSCiuc008jyt.2 mouse

Similar proteinsi

Entry informationi

Entry nameiLA_MOUSE
AccessioniPrimary (citable) accession number: P32067
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: May 23, 2018
This is version 146 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health