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Protein

Lupus La protein homolog

Gene

Ssb

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Binds to the 3' poly(U) terminus of nascent RNA polymerase III transcripts, protecting them from exonuclease digestion and facilitating their folding and maturation.

GO - Molecular functioni

  • nucleotide binding Source: InterPro
  • poly(A) RNA binding Source: MGI
  • RNA binding Source: MGI

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Lupus La protein homolog
Alternative name(s):
La autoantigen homolog
La ribonucleoprotein
Gene namesi
Name:Ssb
Synonyms:Ss-b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:98423. Ssb.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 415415Lupus La protein homologPRO_0000207600Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei92 – 921PhosphoserineBy similarity
Modified residuei94 – 941PhosphoserineBy similarity
Modified residuei116 – 1161N6-acetyllysineBy similarity
Modified residuei120 – 1201PhosphothreonineBy similarity
Modified residuei128 – 1281N6-acetyllysineBy similarity
Modified residuei327 – 3271N6-acetyllysineCombined sources
Modified residuei356 – 3561N6-acetyllysineCombined sources
Modified residuei377 – 3771PhosphothreonineBy similarity

Post-translational modificationi

Phosphorylated.By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP32067.
PaxDbiP32067.
PeptideAtlasiP32067.
PRIDEiP32067.

PTM databases

iPTMnetiP32067.
PhosphoSiteiP32067.

Expressioni

Gene expression databases

BgeeiP32067.
CleanExiMM_SSB.
ExpressionAtlasiP32067. baseline and differential.
GenevisibleiP32067. MM.

Interactioni

Subunit structurei

Interacts with DDX15. May interact with RUFY1 (By similarity).By similarity

Protein-protein interaction databases

BioGridi203508. 4 interactions.
DIPiDIP-37706N.
IntActiP32067. 5 interactions.
MINTiMINT-4100262.
STRINGi10090.ENSMUSP00000088365.

Structurei

3D structure databases

ProteinModelPortaliP32067.
SMRiP32067. Positions 1-185, 224-332.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini7 – 9993HTH La-type RNA-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini111 – 18777RRMPROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 HTH La-type RNA-binding domain.PROSITE-ProRule annotation
Contains 1 RRM (RNA recognition motif) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG410IQXQ. Eukaryota.
COG5193. LUCA.
HOGENOMiHOG000006947.
HOVERGENiHBG001407.
InParanoidiP32067.
KOiK11090.
OMAiTPDQKYK.
OrthoDBiEOG7C5M90.
PhylomeDBiP32067.
TreeFamiTF314476.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
3.30.70.330. 2 hits.
InterProiIPR014886. La_RRM.
IPR002344. Lupus_La.
IPR006630. Lupus_La_RNA-bd.
IPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF05383. La. 1 hit.
PF00076. RRM_1. 1 hit.
PF08777. RRM_3. 1 hit.
[Graphical view]
PRINTSiPR00302. LUPUSLA.
SMARTiSM00715. LA. 1 hit.
SM00360. RRM. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
SSF54928. SSF54928. 2 hits.
PROSITEiPS50961. HTH_LA. 1 hit.
PS50102. RRM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P32067-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAENGDNEKM TALEAKICHQ IEYYFGDFNL PRDKFLKEQI KLDEGWVPLE
60 70 80 90 100
TMIKFNRLNR LTTDFNVIVQ ALSKSKAKLM EVSADKTKIR RSPSRPLPEV
110 120 130 140 150
TDEYKNDVKN RSVYIKGFPT DATLDDIKEW LDDKGQILNI QMRRTLHKTF
160 170 180 190 200
KGSIFAVFDS IQSAKKFVEI PGQKYKDTNL LILFKEDYFA KKNEERKQSK
210 220 230 240 250
VEAKLKAKQE HEGRHKPGST ETRALEGKMG CLLKFSGDLD DQTCREDLHF
260 270 280 290 300
LFSNHGEIKW VDFARGAKEG IILFKEKAKE ALEKARNANN GNLLLRNKKV
310 320 330 340 350
TWKVLEGHAE KEALKKITDD QQESLNKWKS KGGHAGGRFK GSHVFTAARR
360 370 380 390 400
FKGKGKGNRP GYAGAPKGRG QFHGRRTRFD DDDRRRGPMK RGRDGRDREE
410
PASKHKKREN GARDK
Length:415
Mass (Da):47,756
Last modified:October 1, 1993 - v1
Checksum:i2D75197692FDC933
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L00993 mRNA. Translation: AAA39415.1.
BC003820 mRNA. Translation: AAH03820.1.
Y07951 mRNA. Translation: CAA69249.1.
CCDSiCCDS16101.1.
RefSeqiNP_001103615.1. NM_001110145.1.
NP_033304.1. NM_009278.4.
UniGeneiMm.10508.

Genome annotation databases

EnsembliENSMUST00000090852; ENSMUSP00000088365; ENSMUSG00000068882.
ENSMUST00000166411; ENSMUSP00000130313; ENSMUSG00000068882.
GeneIDi20823.
KEGGimmu:20823.
UCSCiuc008jyt.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L00993 mRNA. Translation: AAA39415.1.
BC003820 mRNA. Translation: AAH03820.1.
Y07951 mRNA. Translation: CAA69249.1.
CCDSiCCDS16101.1.
RefSeqiNP_001103615.1. NM_001110145.1.
NP_033304.1. NM_009278.4.
UniGeneiMm.10508.

3D structure databases

ProteinModelPortaliP32067.
SMRiP32067. Positions 1-185, 224-332.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi203508. 4 interactions.
DIPiDIP-37706N.
IntActiP32067. 5 interactions.
MINTiMINT-4100262.
STRINGi10090.ENSMUSP00000088365.

PTM databases

iPTMnetiP32067.
PhosphoSiteiP32067.

Proteomic databases

EPDiP32067.
PaxDbiP32067.
PeptideAtlasiP32067.
PRIDEiP32067.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000090852; ENSMUSP00000088365; ENSMUSG00000068882.
ENSMUST00000166411; ENSMUSP00000130313; ENSMUSG00000068882.
GeneIDi20823.
KEGGimmu:20823.
UCSCiuc008jyt.2. mouse.

Organism-specific databases

CTDi6741.
MGIiMGI:98423. Ssb.

Phylogenomic databases

eggNOGiENOG410IQXQ. Eukaryota.
COG5193. LUCA.
HOGENOMiHOG000006947.
HOVERGENiHBG001407.
InParanoidiP32067.
KOiK11090.
OMAiTPDQKYK.
OrthoDBiEOG7C5M90.
PhylomeDBiP32067.
TreeFamiTF314476.

Miscellaneous databases

ChiTaRSiSsb. mouse.
PROiP32067.
SOURCEiSearch...

Gene expression databases

BgeeiP32067.
CleanExiMM_SSB.
ExpressionAtlasiP32067. baseline and differential.
GenevisibleiP32067. MM.

Family and domain databases

Gene3Di1.10.10.10. 1 hit.
3.30.70.330. 2 hits.
InterProiIPR014886. La_RRM.
IPR002344. Lupus_La.
IPR006630. Lupus_La_RNA-bd.
IPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
IPR011991. WHTH_DNA-bd_dom.
[Graphical view]
PfamiPF05383. La. 1 hit.
PF00076. RRM_1. 1 hit.
PF08777. RRM_3. 1 hit.
[Graphical view]
PRINTSiPR00302. LUPUSLA.
SMARTiSM00715. LA. 1 hit.
SM00360. RRM. 1 hit.
[Graphical view]
SUPFAMiSSF46785. SSF46785. 1 hit.
SSF54928. SSF54928. 2 hits.
PROSITEiPS50961. HTH_LA. 1 hit.
PS50102. RRM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of the mouse autoantigen La (SS-B). Identification of conserved RNA-binding motifs, a putative ATP binding site and reactivity of recombinant protein with poly(U) and human autoantibodies."
    Topfer F., Gordon T., McCluskey J.
    J. Immunol. 150:3091-3100(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Mammary gland.
  3. Groelz D., Bachmann M.
    Submitted (OCT-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-11.
  4. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung, Pancreas, Spleen and Testis.
  5. "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways."
    Park J., Chen Y., Tishkoff D.X., Peng C., Tan M., Dai L., Xie Z., Zhang Y., Zwaans B.M., Skinner M.E., Lombard D.B., Zhao Y.
    Mol. Cell 50:919-930(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-327 AND LYS-356, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic fibroblast.

Entry informationi

Entry nameiLA_MOUSE
AccessioniPrimary (citable) accession number: P32067
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 1, 1993
Last sequence update: October 1, 1993
Last modified: July 6, 2016
This is version 135 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.