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P32044

- KPYK_THEAC

UniProt

P32044 - KPYK_THEAC

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Protein
Pyruvate kinase
Gene
Ta0896
Organism
Thermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + pyruvate = ADP + phosphoenolpyruvate.

Cofactori

Magnesium.
Potassium.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei31 – 311Substrate By similarity
Metal bindingi33 – 331Potassium By similarity
Metal bindingi61 – 611Potassium By similarity
Sitei202 – 2021Transition state stabilizer By similarity
Metal bindingi204 – 2041Magnesium By similarity
Binding sitei227 – 2271Substrate; via amide nitrogen By similarity
Metal bindingi228 – 2281Magnesium By similarity
Binding sitei228 – 2281Substrate; via amide nitrogen By similarity
Binding sitei260 – 2601Substrate By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. magnesium ion binding Source: InterPro
  3. potassium ion binding Source: InterPro
  4. pyruvate kinase activity Source: UniProtKB-EC
Complete GO annotation...

GO - Biological processi

  1. glycolytic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Glycolysis

Keywords - Ligandi

ATP-binding, Magnesium, Metal-binding, Nucleotide-binding, Potassium, Pyruvate

Enzyme and pathway databases

UniPathwayiUPA00109; UER00188.

Names & Taxonomyi

Protein namesi
Recommended name:
Pyruvate kinase (EC:2.7.1.40)
Short name:
PK
Gene namesi
Ordered Locus Names:Ta0896
OrganismiThermoplasma acidophilum (strain ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165)
Taxonomic identifieri273075 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermoplasmataThermoplasmatalesThermoplasmataceaeThermoplasma
ProteomesiUP000001024: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 544544Pyruvate kinase
PRO_0000112129Add
BLAST

Proteomic databases

PRIDEiP32044.

Interactioni

Subunit structurei

Homotetramer.

Protein-protein interaction databases

STRINGi273075.Ta0896.

Structurei

3D structure databases

ProteinModelPortaliP32044.

Family & Domainsi

Sequence similaritiesi

Belongs to the pyruvate kinase family.

Phylogenomic databases

eggNOGiCOG0469.
HOGENOMiHOG000021559.
KOiK00873.
OMAiGTHEEHK.

Family and domain databases

Gene3Di2.40.33.10. 1 hit.
3.20.20.60. 2 hits.
3.40.1380.20. 1 hit.
InterProiIPR001697. Pyr_Knase.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
IPR011037. Pyrv_Knase-like_insert_dom.
IPR015794. Pyrv_Knase_a/b.
IPR015793. Pyrv_Knase_brl.
IPR015795. Pyrv_Knase_C.
IPR015806. Pyrv_Knase_insert_dom.
[Graphical view]
PANTHERiPTHR11817. PTHR11817. 1 hit.
PfamiPF00224. PK. 1 hit.
PF02887. PK_C. 1 hit.
[Graphical view]
PRINTSiPR01050. PYRUVTKNASE.
SUPFAMiSSF50800. SSF50800. 1 hit.
SSF51621. SSF51621. 2 hits.
SSF52935. SSF52935. 1 hit.
TIGRFAMsiTIGR01064. pyruv_kin. 1 hit.

Sequencei

Sequence statusi: Complete.

P32044-1 [UniParc]FASTAAdd to Basket

« Hide

MKTKIVATIG PASSSPEIMK QMIDNGLSLV RINSAHADIK DVSKITQMVR    50
SINRDVGIMI DLKGPELRTG EFAGGTLKIS SGKDYVMGKD IVLNNMNVLS 100
AVQVGDRILM SDGEVSFEVE STDPFTIRAL NDGVLRDRSR VNIPGRFIEL 150
GTITDRDRAF IREGIADGVD FFALSFVQKS ENVDSLRDFV IDSGGDQYII 200
SKIETKSGLD NIEEIVKSSD GIMVARGDLG VELPLKEVVL AQKHIIKTAH 250
EDGDFTIVAT QVLESMVNNS SPTRAEISDI TNAIIDNADA LMLSEESAIG 300
KYPVQAVRTL KEVSDYVEDK VSFDSSYYFK GNTIAYSVAR AAKILSDDIK 350
SDGIVALTHT GSTVRMISSL RPKAMVYAAT VSESLARKLN IYFGVLPLHM 400
EGNAEDLSFS EIMEYIVRSG RFADGSKLVM TSGDPYFTFG GTNDVKVAVV 450
GKFIGRGYSF GDSLSGTATY GTKGDILMSE DGRIPGTDFR AFIFTSDIKP 500
SLMSSLKGKT VVTKARLVRQ IKEGERIYID GNTGIILMAS PDQK 544
Length:544
Mass (Da):59,147
Last modified:December 1, 2000 - v2
Checksum:i7BD8BCAF4706A5B2
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL445065 Genomic DNA. Translation: CAC12025.1.
RefSeqiNP_394355.1. NC_002578.1.
WP_010901306.1. NC_002578.1.

Genome annotation databases

EnsemblBacteriaiCAC12025; CAC12025; CAC12025.
GeneIDi1456432.
KEGGitac:Ta0896.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AL445065 Genomic DNA. Translation: CAC12025.1 .
RefSeqi NP_394355.1. NC_002578.1.
WP_010901306.1. NC_002578.1.

3D structure databases

ProteinModelPortali P32044.
ModBasei Search...

Protein-protein interaction databases

STRINGi 273075.Ta0896.

Proteomic databases

PRIDEi P32044.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai CAC12025 ; CAC12025 ; CAC12025 .
GeneIDi 1456432.
KEGGi tac:Ta0896.

Phylogenomic databases

eggNOGi COG0469.
HOGENOMi HOG000021559.
KOi K00873.
OMAi GTHEEHK.

Enzyme and pathway databases

UniPathwayi UPA00109 ; UER00188 .

Family and domain databases

Gene3Di 2.40.33.10. 1 hit.
3.20.20.60. 2 hits.
3.40.1380.20. 1 hit.
InterProi IPR001697. Pyr_Knase.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
IPR011037. Pyrv_Knase-like_insert_dom.
IPR015794. Pyrv_Knase_a/b.
IPR015793. Pyrv_Knase_brl.
IPR015795. Pyrv_Knase_C.
IPR015806. Pyrv_Knase_insert_dom.
[Graphical view ]
PANTHERi PTHR11817. PTHR11817. 1 hit.
Pfami PF00224. PK. 1 hit.
PF02887. PK_C. 1 hit.
[Graphical view ]
PRINTSi PR01050. PYRUVTKNASE.
SUPFAMi SSF50800. SSF50800. 1 hit.
SSF51621. SSF51621. 2 hits.
SSF52935. SSF52935. 1 hit.
TIGRFAMsi TIGR01064. pyruv_kin. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The genome sequence of the thermoacidophilic scavenger Thermoplasma acidophilum."
    Ruepp A., Graml W., Santos-Martinez M.-L., Koretke K.K., Volker C., Mewes H.-W., Frishman D., Stocker S., Lupas A.N., Baumeister W.
    Nature 407:508-513(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 25905 / DSM 1728 / JCM 9062 / NBRC 15155 / AMRC-C165.
  2. "Purification and properties of pyruvate kinase from Thermoplasma acidophilum."
    Potter S., Fothergill-Gilmore L.A.
    FEMS Microbiol. Lett. 73:235-239(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: CHARACTERIZATION.

Entry informationi

Entry nameiKPYK_THEAC
AccessioniPrimary (citable) accession number: P32044
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: December 1, 2000
Last modified: September 3, 2014
This is version 91 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Caution

1 Publication has published some partial sequence, these sequences do not originate from T.acidophilum, rather they seem to be contaminated with human samples.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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