ID   HXC5_MOUSE              Reviewed;         222 AA.
AC   P32043; Q8BJW4;
DT   01-JUL-1993, integrated into UniProtKB/Swiss-Prot.
DT   05-SEP-2006, sequence version 3.
DT   27-MAR-2024, entry version 165.
DE   RecName: Full=Homeobox protein Hox-C5;
DE   AltName: Full=Homeobox protein Hox-3.4;
DE   AltName: Full=Homeobox protein Hox-6.2;
GN   Name=Hoxc5; Synonyms=Hox-3.4, Hoxc-5;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=8903739; DOI=10.1007/s003359900021;
RA   Geada A.M., Coletta P.L., Sharpe P.T.;
RT   "Characterization of the murine Hoxc-5 gene.";
RL   Mamm. Genome 7:81-84(1996).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Muellerian duct;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 152-222.
RX   PubMed=1976088; DOI=10.1242/dev.109.2.329;
RA   Gaunt S.J., Coletta P.L., Pravtcheva D., Sharpe P.T.;
RT   "Mouse Hox-3.4: homeobox sequence and embryonic expression patterns
RT   compared with other members of the Hox gene network.";
RL   Development 109:329-339(1990).
CC   -!- FUNCTION: Sequence-specific transcription factor which is part of a
CC       developmental regulatory system that provides cells with specific
CC       positional identities on the anterior-posterior axis.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- SIMILARITY: Belongs to the Antp homeobox family. {ECO:0000305}.
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DR   EMBL; U28071; AAA79876.1; -; Genomic_DNA.
DR   EMBL; AK078527; BAC37324.1; -; mRNA.
DR   EMBL; BC115551; AAI15552.1; -; mRNA.
DR   EMBL; BC115552; AAI15553.1; -; mRNA.
DR   CCDS; CCDS27896.1; -.
DR   PIR; A60084; A60084.
DR   RefSeq; NP_783857.1; NM_175730.5.
DR   AlphaFoldDB; P32043; -.
DR   SMR; P32043; -.
DR   BioGRID; 200387; 3.
DR   IntAct; P32043; 3.
DR   STRING; 10090.ENSMUSP00000001709; -.
DR   PhosphoSitePlus; P32043; -.
DR   MaxQB; P32043; -.
DR   PaxDb; 10090-ENSMUSP00000001709; -.
DR   ProteomicsDB; 266934; -.
DR   Antibodypedia; 27321; 145 antibodies from 20 providers.
DR   DNASU; 15424; -.
DR   Ensembl; ENSMUST00000001709.3; ENSMUSP00000001709.3; ENSMUSG00000022485.4.
DR   GeneID; 15424; -.
DR   KEGG; mmu:15424; -.
DR   UCSC; uc007xxe.1; mouse.
DR   AGR; MGI:96196; -.
DR   CTD; 3222; -.
DR   MGI; MGI:96196; Hoxc5.
DR   VEuPathDB; HostDB:ENSMUSG00000022485; -.
DR   eggNOG; KOG0489; Eukaryota.
DR   GeneTree; ENSGT00940000161023; -.
DR   HOGENOM; CLU_061398_2_1_1; -.
DR   InParanoid; P32043; -.
DR   OMA; HISHESD; -.
DR   OrthoDB; 728401at2759; -.
DR   PhylomeDB; P32043; -.
DR   TreeFam; TF316310; -.
DR   BioGRID-ORCS; 15424; 3 hits in 77 CRISPR screens.
DR   PRO; PR:P32043; -.
DR   Proteomes; UP000000589; Chromosome 15.
DR   RNAct; P32043; Protein.
DR   Bgee; ENSMUSG00000022485; Expressed in thoracic region of vertebral column and 95 other cell types or tissues.
DR   GO; GO:0030054; C:cell junction; ISO:MGI.
DR   GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0009952; P:anterior/posterior pattern specification; IGI:MGI.
DR   GO; GO:0048706; P:embryonic skeletal system development; IGI:MGI.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   CDD; cd00086; homeodomain; 1.
DR   Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017995; Homeobox_antennapedia.
DR   InterPro; IPR001827; Homeobox_Antennapedia_CS.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR020479; Homeobox_metazoa.
DR   PANTHER; PTHR45659; HOMEOBOX PROTEIN HOX; 1.
DR   PANTHER; PTHR45659:SF5; HOMEOBOX PROTEIN HOX-C5; 1.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00025; ANTENNAPEDIA.
DR   PRINTS; PR00024; HOMEOBOX.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; Homeodomain-like; 1.
DR   PROSITE; PS00032; ANTENNAPEDIA; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
DR   Genevisible; P32043; MM.
PE   2: Evidence at transcript level;
KW   Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..222
FT                   /note="Homeobox protein Hox-C5"
FT                   /id="PRO_0000200170"
FT   DNA_BIND        155..214
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          68..141
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           140..145
FT                   /note="Antp-type hexapeptide"
FT   CONFLICT        86
FT                   /note="L -> P (in Ref. 1; AAA79876)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        125
FT                   /note="T -> R (in Ref. 1; AAA79876)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   222 AA;  24992 MW;  95D763BF5E4E7AC7 CRC64;
     MSSYVANSFY KQSPNIPAYN MQTCGNYGSA SEVQASRYCY GGLDLSITFP PPAPSNSLHG
     VDMAANPRAH PDRPACSAAA APGHALGRDE AAPLNPGMYS QKAARPALEE RAKSSGEIKE
     EQAQTGQPAG LSQPPAPPQI YPWMTKLHMS HETDGKRSRT SYTRYQTLEL EKEFHFNRYL
     TRRRRIEIAN NLCLNERQIK IWFQNRRMKW KKDSKMKSKE AL
//