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P32043 (HXC5_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 116. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Homeobox protein Hox-C5
Alternative name(s):
Homeobox protein Hox-3.4
Homeobox protein Hox-6.2
Gene names
Name:Hoxc5
Synonyms:Hox-3.4, Hoxc-5
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length222 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Subcellular location

Nucleus.

Sequence similarities

Belongs to the Antp homeobox family.

Contains 1 homeobox DNA-binding domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 222222Homeobox protein Hox-C5
PRO_0000200170

Regions

DNA binding155 – 21460Homeobox
Motif140 – 1456Antp-type hexapeptide

Experimental info

Sequence conflict861L → P in AAA79876. Ref.1
Sequence conflict1251T → R in AAA79876. Ref.1

Sequences

Sequence LengthMass (Da)Tools
P32043 [UniParc].

Last modified September 5, 2006. Version 3.
Checksum: 95D763BF5E4E7AC7

FASTA22224,992
        10         20         30         40         50         60 
MSSYVANSFY KQSPNIPAYN MQTCGNYGSA SEVQASRYCY GGLDLSITFP PPAPSNSLHG 

        70         80         90        100        110        120 
VDMAANPRAH PDRPACSAAA APGHALGRDE AAPLNPGMYS QKAARPALEE RAKSSGEIKE 

       130        140        150        160        170        180 
EQAQTGQPAG LSQPPAPPQI YPWMTKLHMS HETDGKRSRT SYTRYQTLEL EKEFHFNRYL 

       190        200        210        220 
TRRRRIEIAN NLCLNERQIK IWFQNRRMKW KKDSKMKSKE AL 

« Hide

References

« Hide 'large scale' references
[1]"Characterization of the murine Hoxc-5 gene."
Geada A.M., Coletta P.L., Sharpe P.T.
Mamm. Genome 7:81-84(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Strain: C57BL/6J.
Tissue: Muellerian duct.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]"Mouse Hox-3.4: homeobox sequence and embryonic expression patterns compared with other members of the Hox gene network."
Gaunt S.J., Coletta P.L., Pravtcheva D., Sharpe P.T.
Development 109:329-339(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 152-222.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U28071 Genomic DNA. Translation: AAA79876.1.
AK078527 mRNA. Translation: BAC37324.1.
BC115551 mRNA. Translation: AAI15552.1.
BC115552 mRNA. Translation: AAI15553.1.
CCDSCCDS27896.1.
PIRA60084.
RefSeqNP_783857.1. NM_175730.5.
UniGeneMm.103825.

3D structure databases

ProteinModelPortalP32043.
SMRP32043. Positions 159-214.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid200387. 3 interactions.
STRING10090.ENSMUSP00000001709.

PTM databases

PhosphoSiteP32043.

Proteomic databases

PRIDEP32043.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000001709; ENSMUSP00000001709; ENSMUSG00000022485.
GeneID15424.
KEGGmmu:15424.
UCSCuc007xxe.1. mouse.

Organism-specific databases

CTD3222.
MGIMGI:96196. Hoxc5.

Phylogenomic databases

eggNOGNOG286013.
GeneTreeENSGT00750000117269.
HOGENOMHOG000231178.
HOVERGENHBG016849.
InParanoidP32043.
KOK09305.
OMACYSGLDL.
OrthoDBEOG780RP4.
PhylomeDBP32043.
TreeFamTF316310.

Gene expression databases

BgeeP32043.
CleanExMM_HOXC5.
GenevestigatorP32043.

Family and domain databases

Gene3D1.10.10.60. 1 hit.
InterProIPR017995. Homeobox_antennapedia.
IPR001827. Homeobox_Antennapedia_CS.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSPR00025. ANTENNAPEDIA.
PR00024. HOMEOBOX.
SMARTSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMSSF46689. SSF46689. 1 hit.
PROSITEPS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio288170.
PROP32043.
SOURCESearch...

Entry information

Entry nameHXC5_MOUSE
AccessionPrimary (citable) accession number: P32043
Secondary accession number(s): Q8BJW4
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: September 5, 2006
Last modified: July 9, 2014
This is version 116 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

Vertebrate homeotic Hox proteins

Nomenclature of vertebrate homeotic Hox proteins and list of entries