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P32043

- HXC5_MOUSE

UniProt

P32043 - HXC5_MOUSE

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Protein
Homeobox protein Hox-C5
Gene
Hoxc5, Hox-3.4, Hoxc-5
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi155 – 21460Homeobox
Add
BLAST

GO - Molecular functioni

  1. sequence-specific DNA binding Source: InterPro
  2. sequence-specific DNA binding transcription factor activity Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. anterior/posterior pattern specification Source: MGI
  2. embryonic skeletal system development Source: MGI
  3. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Hox-C5
Alternative name(s):
Homeobox protein Hox-3.4
Homeobox protein Hox-6.2
Gene namesi
Name:Hoxc5
Synonyms:Hox-3.4, Hoxc-5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 15

Organism-specific databases

MGIiMGI:96196. Hoxc5.

Subcellular locationi

GO - Cellular componenti

  1. cell junction Source: Ensembl
  2. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 222222Homeobox protein Hox-C5
PRO_0000200170Add
BLAST

Proteomic databases

PRIDEiP32043.

PTM databases

PhosphoSiteiP32043.

Expressioni

Gene expression databases

BgeeiP32043.
CleanExiMM_HOXC5.
GenevestigatoriP32043.

Interactioni

Protein-protein interaction databases

BioGridi200387. 3 interactions.
STRINGi10090.ENSMUSP00000001709.

Structurei

3D structure databases

ProteinModelPortaliP32043.
SMRiP32043. Positions 159-214.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi140 – 1456Antp-type hexapeptide

Sequence similaritiesi

Belongs to the Antp homeobox family.

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG286013.
GeneTreeiENSGT00750000117269.
HOGENOMiHOG000231178.
HOVERGENiHBG016849.
InParanoidiP32043.
KOiK09305.
OMAiCYSGLDL.
OrthoDBiEOG780RP4.
PhylomeDBiP32043.
TreeFamiTF316310.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017995. Homeobox_antennapedia.
IPR001827. Homeobox_Antennapedia_CS.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00025. ANTENNAPEDIA.
PR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P32043-1 [UniParc]FASTAAdd to Basket

« Hide

MSSYVANSFY KQSPNIPAYN MQTCGNYGSA SEVQASRYCY GGLDLSITFP    50
PPAPSNSLHG VDMAANPRAH PDRPACSAAA APGHALGRDE AAPLNPGMYS 100
QKAARPALEE RAKSSGEIKE EQAQTGQPAG LSQPPAPPQI YPWMTKLHMS 150
HETDGKRSRT SYTRYQTLEL EKEFHFNRYL TRRRRIEIAN NLCLNERQIK 200
IWFQNRRMKW KKDSKMKSKE AL 222
Length:222
Mass (Da):24,992
Last modified:September 5, 2006 - v3
Checksum:i95D763BF5E4E7AC7
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti86 – 861L → P in AAA79876. 1 Publication
Sequence conflicti125 – 1251T → R in AAA79876. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U28071 Genomic DNA. Translation: AAA79876.1.
AK078527 mRNA. Translation: BAC37324.1.
BC115551 mRNA. Translation: AAI15552.1.
BC115552 mRNA. Translation: AAI15553.1.
CCDSiCCDS27896.1.
PIRiA60084.
RefSeqiNP_783857.1. NM_175730.5.
UniGeneiMm.103825.

Genome annotation databases

EnsembliENSMUST00000001709; ENSMUSP00000001709; ENSMUSG00000022485.
GeneIDi15424.
KEGGimmu:15424.
UCSCiuc007xxe.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U28071 Genomic DNA. Translation: AAA79876.1 .
AK078527 mRNA. Translation: BAC37324.1 .
BC115551 mRNA. Translation: AAI15552.1 .
BC115552 mRNA. Translation: AAI15553.1 .
CCDSi CCDS27896.1.
PIRi A60084.
RefSeqi NP_783857.1. NM_175730.5.
UniGenei Mm.103825.

3D structure databases

ProteinModelPortali P32043.
SMRi P32043. Positions 159-214.
ModBasei Search...

Protein-protein interaction databases

BioGridi 200387. 3 interactions.
STRINGi 10090.ENSMUSP00000001709.

PTM databases

PhosphoSitei P32043.

Proteomic databases

PRIDEi P32043.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000001709 ; ENSMUSP00000001709 ; ENSMUSG00000022485 .
GeneIDi 15424.
KEGGi mmu:15424.
UCSCi uc007xxe.1. mouse.

Organism-specific databases

CTDi 3222.
MGIi MGI:96196. Hoxc5.

Phylogenomic databases

eggNOGi NOG286013.
GeneTreei ENSGT00750000117269.
HOGENOMi HOG000231178.
HOVERGENi HBG016849.
InParanoidi P32043.
KOi K09305.
OMAi CYSGLDL.
OrthoDBi EOG780RP4.
PhylomeDBi P32043.
TreeFami TF316310.

Miscellaneous databases

NextBioi 288170.
PROi P32043.
SOURCEi Search...

Gene expression databases

Bgeei P32043.
CleanExi MM_HOXC5.
Genevestigatori P32043.

Family and domain databases

Gene3Di 1.10.10.60. 1 hit.
InterProi IPR017995. Homeobox_antennapedia.
IPR001827. Homeobox_Antennapedia_CS.
IPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view ]
Pfami PF00046. Homeobox. 1 hit.
[Graphical view ]
PRINTSi PR00025. ANTENNAPEDIA.
PR00024. HOMEOBOX.
SMARTi SM00389. HOX. 1 hit.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 1 hit.
PROSITEi PS00032. ANTENNAPEDIA. 1 hit.
PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of the murine Hoxc-5 gene."
    Geada A.M., Coletta P.L., Sharpe P.T.
    Mamm. Genome 7:81-84(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Muellerian duct.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "Mouse Hox-3.4: homeobox sequence and embryonic expression patterns compared with other members of the Hox gene network."
    Gaunt S.J., Coletta P.L., Pravtcheva D., Sharpe P.T.
    Development 109:329-339(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 152-222.

Entry informationi

Entry nameiHXC5_MOUSE
AccessioniPrimary (citable) accession number: P32043
Secondary accession number(s): Q8BJW4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: September 5, 2006
Last modified: July 9, 2014
This is version 116 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Vertebrate homeotic Hox proteins
    Nomenclature of vertebrate homeotic Hox proteins and list of entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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