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P32038

- CFAD_RAT

UniProt

P32038 - CFAD_RAT

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Protein

Complement factor D

Gene
Cfd, Adn, Df
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Factor D cleaves factor B when the latter is complexed with factor C3b, activating the C3bbb complex, which then becomes the C3 convertase of the alternate pathway. Its function is homologous to that of C1s in the classical pathway.

Catalytic activityi

Selective cleavage of Arg-|-Lys bond in complement factor B when in complex with complement subcomponent C3b or with cobra venom factor.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei66 – 661Charge relay system
Active sitei115 – 1151Charge relay system
Active sitei209 – 2091Charge relay system

GO - Molecular functioni

  1. endopeptidase activity Source: RGD
  2. serine-type endopeptidase activity Source: RGD

GO - Biological processi

  1. complement activation, alternative pathway Source: UniProtKB-KW
  2. Notch signaling pathway Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine protease

Keywords - Biological processi

Complement alternate pathway, Immunity, Innate immunity

Protein family/group databases

MEROPSiS01.191.

Names & Taxonomyi

Protein namesi
Recommended name:
Complement factor D (EC:3.4.21.46)
Alternative name(s):
Adipsin
C3 convertase activator
Endogenous vascular elastase
Properdin factor D
Gene namesi
Name:Cfd
Synonyms:Adn, Df
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi2498. Cfd.

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020 Reviewed predictionAdd
BLAST
Propeptidei21 – 255Activation peptidePRO_0000027566
Chaini26 – 263238Complement factor DPRO_0000027567Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi46 – 461N-linked (GlcNAc...)
Disulfide bondi51 ↔ 67 By similarity
Disulfide bondi149 ↔ 215 By similarity
Disulfide bondi180 ↔ 196 By similarity
Disulfide bondi205 ↔ 230 By similarity

Post-translational modificationi

N-glycosylated.

Keywords - PTMi

Disulfide bond, Glycoprotein, Zymogen

Proteomic databases

PaxDbiP32038.
PRIDEiP32038.

Expressioni

Gene expression databases

GenevestigatoriP32038.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000015029.

Structurei

3D structure databases

ProteinModelPortaliP32038.
SMRiP32038. Positions 26-254.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini26 – 254229Peptidase S1Add
BLAST

Sequence similaritiesi

Belongs to the peptidase S1 family.

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiCOG5640.
HOGENOMiHOG000251820.
HOVERGENiHBG013304.
InParanoidiP32038.
KOiK01334.
PhylomeDBiP32038.

Family and domain databases

InterProiIPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view]
PfamiPF00089. Trypsin. 1 hit.
[Graphical view]
PRINTSiPR00722. CHYMOTRYPSIN.
SMARTiSM00020. Tryp_SPc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P32038-1 [UniParc]FASTAAdd to Basket

« Hide

MHSSVYLVAL VVLEAAVCVA QPRGRILGGQ EAMAHARPYM ASVQVNGTHV    50
CGGTLVDEQW VLSAAHCMDG VTKDEVVQVL LGAHSLSSPE PYKHLYDVQS 100
VVLHPGSRPD SVEDDLMLFK LSHNASLGPH VRPLPLQRED REVKPGTLCD 150
VAGWGVVTHA GRRPDVLQQL TVSIMDRNTC NLRTYHDGAI TKNMMCAESN 200
RRDTCRGDSG GPLVCGDAVE AVVTWGSRVC GNRRKPGVFT RVATYVPWIE 250
NVLSGNVSVN VTA 263
Length:263
Mass (Da):28,442
Last modified:November 1, 1997 - v2
Checksum:iD573133568A31CE0
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
S73894 mRNA. Translation: AAB31922.1.
PIRiI55608.
RefSeqiNP_001071110.1. NM_001077642.1.
UniGeneiRn.16172.

Genome annotation databases

GeneIDi54249.
KEGGirno:54249.
UCSCiRGD:2498. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
S73894 mRNA. Translation: AAB31922.1 .
PIRi I55608.
RefSeqi NP_001071110.1. NM_001077642.1.
UniGenei Rn.16172.

3D structure databases

ProteinModelPortali P32038.
SMRi P32038. Positions 26-254.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000015029.

Protein family/group databases

MEROPSi S01.191.

Proteomic databases

PaxDbi P32038.
PRIDEi P32038.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 54249.
KEGGi rno:54249.
UCSCi RGD:2498. rat.

Organism-specific databases

CTDi 1675.
RGDi 2498. Cfd.

Phylogenomic databases

eggNOGi COG5640.
HOGENOMi HOG000251820.
HOVERGENi HBG013304.
InParanoidi P32038.
KOi K01334.
PhylomeDBi P32038.

Miscellaneous databases

NextBioi 610740.
PROi P32038.

Gene expression databases

Genevestigatori P32038.

Family and domain databases

InterProi IPR001254. Peptidase_S1.
IPR018114. Peptidase_S1_AS.
IPR001314. Peptidase_S1A.
IPR009003. Trypsin-like_Pept_dom.
[Graphical view ]
Pfami PF00089. Trypsin. 1 hit.
[Graphical view ]
PRINTSi PR00722. CHYMOTRYPSIN.
SMARTi SM00020. Tryp_SPc. 1 hit.
[Graphical view ]
SUPFAMi SSF50494. SSF50494. 1 hit.
PROSITEi PS50240. TRYPSIN_DOM. 1 hit.
PS00134. TRYPSIN_HIS. 1 hit.
PS00135. TRYPSIN_SER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The endogenous vascular elastase that governs development and progression of monocrotaline-induced pulmonary hypertension in rats is a novel enzyme related to the serine proteinase adipsin."
    Zhu L., Wigle D., Hinek A., Kobayashi J., Ye C., Zuker M., Dodo H., Keeley F.W., Rabinovitch M.
    J. Clin. Invest. 94:1163-1171(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Purification and partial characterization of rat factor D."
    Baker B.C., Campbell C.J., Grinham C.J., Turcatti G.
    Biochem. J. 279:775-779(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 26-55.

Entry informationi

Entry nameiCFAD_RAT
AccessioniPrimary (citable) accession number: P32038
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: November 1, 1997
Last modified: May 14, 2014
This is version 104 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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