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P32038

- CFAD_RAT

UniProt

P32038 - CFAD_RAT

Protein

Complement factor D

Gene

Cfd

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 105 (01 Oct 2014)
      Sequence version 2 (01 Nov 1997)
      Previous versions | rss
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    Functioni

    Factor D cleaves factor B when the latter is complexed with factor C3b, activating the C3bbb complex, which then becomes the C3 convertase of the alternate pathway. Its function is homologous to that of C1s in the classical pathway.

    Catalytic activityi

    Selective cleavage of Arg-|-Lys bond in complement factor B when in complex with complement subcomponent C3b or with cobra venom factor.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei66 – 661Charge relay system
    Active sitei115 – 1151Charge relay system
    Active sitei209 – 2091Charge relay system

    GO - Molecular functioni

    1. endopeptidase activity Source: RGD
    2. serine-type endopeptidase activity Source: RGD

    GO - Biological processi

    1. complement activation, alternative pathway Source: UniProtKB-KW
    2. Notch signaling pathway Source: RGD

    Keywords - Molecular functioni

    Hydrolase, Protease, Serine protease

    Keywords - Biological processi

    Complement alternate pathway, Immunity, Innate immunity

    Protein family/group databases

    MEROPSiS01.191.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Complement factor D (EC:3.4.21.46)
    Alternative name(s):
    Adipsin
    C3 convertase activator
    Endogenous vascular elastase
    Properdin factor D
    Gene namesi
    Name:Cfd
    Synonyms:Adn, Df
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi2498. Cfd.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular space Source: RGD

    Keywords - Cellular componenti

    Secreted

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2020Sequence AnalysisAdd
    BLAST
    Propeptidei21 – 255Activation peptide1 PublicationPRO_0000027566
    Chaini26 – 263238Complement factor DPRO_0000027567Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi46 – 461N-linked (GlcNAc...)
    Disulfide bondi51 ↔ 67PROSITE-ProRule annotation
    Disulfide bondi149 ↔ 215PROSITE-ProRule annotation
    Disulfide bondi180 ↔ 196PROSITE-ProRule annotation
    Disulfide bondi205 ↔ 230PROSITE-ProRule annotation

    Post-translational modificationi

    N-glycosylated.

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Zymogen

    Proteomic databases

    PaxDbiP32038.
    PRIDEiP32038.

    Expressioni

    Gene expression databases

    GenevestigatoriP32038.

    Interactioni

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000015029.

    Structurei

    3D structure databases

    ProteinModelPortaliP32038.
    SMRiP32038. Positions 26-254.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini26 – 254229Peptidase S1PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the peptidase S1 family.PROSITE-ProRule annotation
    Contains 1 peptidase S1 domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal

    Phylogenomic databases

    eggNOGiCOG5640.
    HOGENOMiHOG000251820.
    HOVERGENiHBG013304.
    InParanoidiP32038.
    KOiK01334.
    PhylomeDBiP32038.

    Family and domain databases

    InterProiIPR001254. Peptidase_S1.
    IPR018114. Peptidase_S1_AS.
    IPR001314. Peptidase_S1A.
    IPR009003. Trypsin-like_Pept_dom.
    [Graphical view]
    PfamiPF00089. Trypsin. 1 hit.
    [Graphical view]
    PRINTSiPR00722. CHYMOTRYPSIN.
    SMARTiSM00020. Tryp_SPc. 1 hit.
    [Graphical view]
    SUPFAMiSSF50494. SSF50494. 1 hit.
    PROSITEiPS50240. TRYPSIN_DOM. 1 hit.
    PS00134. TRYPSIN_HIS. 1 hit.
    PS00135. TRYPSIN_SER. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P32038-1 [UniParc]FASTAAdd to Basket

    « Hide

    MHSSVYLVAL VVLEAAVCVA QPRGRILGGQ EAMAHARPYM ASVQVNGTHV    50
    CGGTLVDEQW VLSAAHCMDG VTKDEVVQVL LGAHSLSSPE PYKHLYDVQS 100
    VVLHPGSRPD SVEDDLMLFK LSHNASLGPH VRPLPLQRED REVKPGTLCD 150
    VAGWGVVTHA GRRPDVLQQL TVSIMDRNTC NLRTYHDGAI TKNMMCAESN 200
    RRDTCRGDSG GPLVCGDAVE AVVTWGSRVC GNRRKPGVFT RVATYVPWIE 250
    NVLSGNVSVN VTA 263
    Length:263
    Mass (Da):28,442
    Last modified:November 1, 1997 - v2
    Checksum:iD573133568A31CE0
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S73894 mRNA. Translation: AAB31922.1.
    PIRiI55608.
    RefSeqiNP_001071110.1. NM_001077642.1.
    UniGeneiRn.16172.

    Genome annotation databases

    GeneIDi54249.
    KEGGirno:54249.
    UCSCiRGD:2498. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    S73894 mRNA. Translation: AAB31922.1 .
    PIRi I55608.
    RefSeqi NP_001071110.1. NM_001077642.1.
    UniGenei Rn.16172.

    3D structure databases

    ProteinModelPortali P32038.
    SMRi P32038. Positions 26-254.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000015029.

    Protein family/group databases

    MEROPSi S01.191.

    Proteomic databases

    PaxDbi P32038.
    PRIDEi P32038.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 54249.
    KEGGi rno:54249.
    UCSCi RGD:2498. rat.

    Organism-specific databases

    CTDi 1675.
    RGDi 2498. Cfd.

    Phylogenomic databases

    eggNOGi COG5640.
    HOGENOMi HOG000251820.
    HOVERGENi HBG013304.
    InParanoidi P32038.
    KOi K01334.
    PhylomeDBi P32038.

    Miscellaneous databases

    NextBioi 610740.
    PROi P32038.

    Gene expression databases

    Genevestigatori P32038.

    Family and domain databases

    InterProi IPR001254. Peptidase_S1.
    IPR018114. Peptidase_S1_AS.
    IPR001314. Peptidase_S1A.
    IPR009003. Trypsin-like_Pept_dom.
    [Graphical view ]
    Pfami PF00089. Trypsin. 1 hit.
    [Graphical view ]
    PRINTSi PR00722. CHYMOTRYPSIN.
    SMARTi SM00020. Tryp_SPc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50494. SSF50494. 1 hit.
    PROSITEi PS50240. TRYPSIN_DOM. 1 hit.
    PS00134. TRYPSIN_HIS. 1 hit.
    PS00135. TRYPSIN_SER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The endogenous vascular elastase that governs development and progression of monocrotaline-induced pulmonary hypertension in rats is a novel enzyme related to the serine proteinase adipsin."
      Zhu L., Wigle D., Hinek A., Kobayashi J., Ye C., Zuker M., Dodo H., Keeley F.W., Rabinovitch M.
      J. Clin. Invest. 94:1163-1171(1994) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Purification and partial characterization of rat factor D."
      Baker B.C., Campbell C.J., Grinham C.J., Turcatti G.
      Biochem. J. 279:775-779(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 26-55.

    Entry informationi

    Entry nameiCFAD_RAT
    AccessioniPrimary (citable) accession number: P32038
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 1993
    Last sequence update: November 1, 1997
    Last modified: October 1, 2014
    This is version 105 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3