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Protein

Solute carrier family 2, facilitated glucose transporter member 3

Gene

Slc2a3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Facilitative glucose transporter that can also mediate the uptake of various other monosaccharides across the cell membrane. Mediates the uptake of glucose, 2-deoxyglucose, galactose, mannose, xylose and fucose, and probably also dehydroascorbate. Does not mediate fructose transport.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei315MonosaccharideBy similarity1
Binding sitei378MonosaccharideBy similarity1
Binding sitei386MonosaccharideBy similarity1

GO - Molecular functioni

  • dehydroascorbic acid transporter activity Source: UniProtKB
  • D-glucose transmembrane transporter activity Source: UniProtKB
  • glucose binding Source: UniProtKB
  • glucose transmembrane transporter activity Source: MGI

GO - Biological processi

  • dehydroascorbic acid transport Source: UniProtKB
  • glucose transmembrane transport Source: MGI
  • glucose transport Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Sugar transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-196836. Vitamin C (ascorbate) metabolism.
R-MMU-428790. Facilitative Na+-independent glucose transporters.
R-MMU-6798695. Neutrophil degranulation.
R-MMU-70153. Glucose transport.

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 2, facilitated glucose transporter member 3
Alternative name(s):
Glucose transporter type 3, brain
Short name:
GLUT-3
Gene namesi
Name:Slc2a3
Synonyms:Glut-3, Glut3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:95757. Slc2a3.

Subcellular locationi

  • Cell membrane 1 Publication; Multi-pass membrane protein By similarity

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 10CytoplasmicBy similarity10
Transmembranei11 – 32Helical; Name=1Sequence analysisBy similarityAdd BLAST22
Topological domaini33 – 64ExtracellularBy similarityAdd BLAST32
Transmembranei65 – 85Helical; Name=2Sequence analysisBy similarityAdd BLAST21
Topological domaini86 – 90CytoplasmicBy similarity5
Transmembranei91 – 111Helical; Name=3By similarityAdd BLAST21
Topological domaini112 – 118ExtracellularBy similarity7
Transmembranei119 – 142Helical; Name=4Sequence analysisBy similarityAdd BLAST24
Topological domaini143 – 153CytoplasmicBy similarityAdd BLAST11
Transmembranei154 – 174Helical; Name=5Sequence analysisBy similarityAdd BLAST21
Topological domaini175 – 183ExtracellularBy similarity9
Transmembranei184 – 204Helical; Name=6Sequence analysisBy similarityAdd BLAST21
Topological domaini205 – 269CytoplasmicBy similarityAdd BLAST65
Transmembranei270 – 290Helical; Name=7Sequence analysisBy similarityAdd BLAST21
Topological domaini291 – 304ExtracellularBy similarityAdd BLAST14
Transmembranei305 – 325Helical; Name=8Sequence analysisBy similarityAdd BLAST21
Topological domaini326 – 331CytoplasmicBy similarity6
Transmembranei332 – 352Helical; Name=9Sequence analysisBy similarityAdd BLAST21
Topological domaini353 – 363ExtracellularBy similarityAdd BLAST11
Transmembranei364 – 389Helical; Name=10Sequence analysisBy similarityAdd BLAST26
Topological domaini390 – 399CytoplasmicBy similarity10
Transmembranei400 – 420Helical; Name=11Sequence analysisBy similarityAdd BLAST21
Topological domaini421 – 429ExtracellularBy similarity9
Transmembranei430 – 450Helical; Name=12Sequence analysisBy similarityAdd BLAST21
Topological domaini451 – 493CytoplasmicBy similarityAdd BLAST43

GO - Cellular componenti

  • acrosomal membrane Source: MGI
  • cytoplasm Source: UniProtKB
  • extracellular exosome Source: MGI
  • integral component of membrane Source: UniProtKB
  • integral component of plasma membrane Source: UniProtKB
  • plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000503541 – 493Solute carrier family 2, facilitated glucose transporter member 3Add BLAST493

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi43N-linked (GlcNAc...)1 Publication1
Modified residuei232PhosphothreonineCombined sources1
Modified residuei471PhosphoserineCombined sources1
Modified residuei482PhosphoserineBy similarity1
Modified residuei489PhosphothreonineBy similarity1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

EPDiP32037.
PaxDbiP32037.
PeptideAtlasiP32037.
PRIDEiP32037.

PTM databases

iPTMnetiP32037.
PhosphoSitePlusiP32037.

Expressioni

Tissue specificityi

Detected in brain (at protein level). Highly expressed in brain.1 Publication

Gene expression databases

BgeeiENSMUSG00000003153.
ExpressionAtlasiP32037. baseline and differential.
GenevisibleiP32037. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000032476.

Structurei

3D structure databases

ProteinModelPortaliP32037.
SMRiP32037.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni277 – 279Important for selectivity against fructoseBy similarity3
Regioni280 – 286Monosaccharide bindingBy similarity7

Domaini

Transport is mediated via a series of conformation changes, switching between a conformation where the substrate-binding cavity is accessible from the outside, and a another conformation where it is accessible from the cytoplasm.By similarity

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0569. Eukaryota.
COG0477. LUCA.
GeneTreeiENSGT00760000119022.
HOGENOMiHOG000202871.
HOVERGENiHBG014816.
InParanoidiP32037.
KOiK08142.
OMAiMSYICIT.
OrthoDBiEOG091G0A9K.
PhylomeDBiP32037.
TreeFamiTF313762.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR002945. Glc_transpt_3.
IPR020846. MFS_dom.
IPR005828. MFS_sugar_transport-like.
IPR003663. Sugar/inositol_transpt.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamiPF00083. Sugar_tr. 1 hit.
[Graphical view]
PRINTSiPR01192. GLUCTRSPORT3.
PR00171. SUGRTRNSPORT.
SUPFAMiSSF103473. SSF103473. 2 hits.
TIGRFAMsiTIGR00879. SP. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
PS00216. SUGAR_TRANSPORT_1. 1 hit.
PS00217. SUGAR_TRANSPORT_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P32037-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGTTKVTPSL VFAVTVATIG SFQFGYNTGV INAPETILKD FLNYTLEERL
60 70 80 90 100
EDLPSEGLLT ALWSLCVAIF SVGGMIGSFS VGLFVNRFGR RNSMLLVNLL
110 120 130 140 150
AIIAGCLMGF AKIAESVEML ILGRLLIGIF CGLCTGFVPM YIGEVSPTAL
160 170 180 190 200
RGAFGTLNQL GIVVGILVAQ IFGLDFILGS EELWPGLLGL TIIPAILQSA
210 220 230 240 250
ALPFCPESPR FLLINKKEED QATEILQRLW GTSDVVQEIQ EMKDESVRMS
260 270 280 290 300
QEKQVTVLEL FRSPNYVQPL LISIVLQLSQ QLSGINAVFY YSTGIFKDAG
310 320 330 340 350
VQEPIYATIG AGVVNTIFTV VSLFLVERAG RRTLHMIGLG GMAVCSVFMT
360 370 380 390 400
ISLLLKDDYE AMSFVCIVAI LIYVAFFEIG PGPIPWFIVA ELFSQGPRPA
410 420 430 440 450
AIAVAGCCNW TSNFLVGMLF PSAAAYLGAY VFIIFAAFLI FFLIFTFFKV
460 470 480 490
PETKGRTFED IARAFEGQAH SGKGPAGVEL NSMQPVKETP GNA
Length:493
Mass (Da):53,479
Last modified:July 1, 1993 - v1
Checksum:i9090B8DCB8780082
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M75135 mRNA. Translation: AAA37704.1.
X61093 mRNA. Translation: CAA43406.1.
U11853
, U11844, U11845, U11846, U11848, U11849, U11850, U11851, U11852 Genomic DNA. Translation: AAB60666.1.
BC034122 mRNA. Translation: AAH34122.1.
BC058811 mRNA. Translation: AAH58811.1.
CCDSiCCDS20502.1.
PIRiA41751.
RefSeqiNP_035531.3. NM_011401.4.
UniGeneiMm.395108.

Genome annotation databases

EnsembliENSMUST00000032476; ENSMUSP00000032476; ENSMUSG00000003153.
GeneIDi20527.
KEGGimmu:20527.
UCSCiuc009dpq.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M75135 mRNA. Translation: AAA37704.1.
X61093 mRNA. Translation: CAA43406.1.
U11853
, U11844, U11845, U11846, U11848, U11849, U11850, U11851, U11852 Genomic DNA. Translation: AAB60666.1.
BC034122 mRNA. Translation: AAH34122.1.
BC058811 mRNA. Translation: AAH58811.1.
CCDSiCCDS20502.1.
PIRiA41751.
RefSeqiNP_035531.3. NM_011401.4.
UniGeneiMm.395108.

3D structure databases

ProteinModelPortaliP32037.
SMRiP32037.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000032476.

PTM databases

iPTMnetiP32037.
PhosphoSitePlusiP32037.

Proteomic databases

EPDiP32037.
PaxDbiP32037.
PeptideAtlasiP32037.
PRIDEiP32037.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000032476; ENSMUSP00000032476; ENSMUSG00000003153.
GeneIDi20527.
KEGGimmu:20527.
UCSCiuc009dpq.2. mouse.

Organism-specific databases

CTDi6515.
MGIiMGI:95757. Slc2a3.

Phylogenomic databases

eggNOGiKOG0569. Eukaryota.
COG0477. LUCA.
GeneTreeiENSGT00760000119022.
HOGENOMiHOG000202871.
HOVERGENiHBG014816.
InParanoidiP32037.
KOiK08142.
OMAiMSYICIT.
OrthoDBiEOG091G0A9K.
PhylomeDBiP32037.
TreeFamiTF313762.

Enzyme and pathway databases

ReactomeiR-MMU-196836. Vitamin C (ascorbate) metabolism.
R-MMU-428790. Facilitative Na+-independent glucose transporters.
R-MMU-6798695. Neutrophil degranulation.
R-MMU-70153. Glucose transport.

Miscellaneous databases

ChiTaRSiSlc2a3. mouse.
PROiP32037.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000003153.
ExpressionAtlasiP32037. baseline and differential.
GenevisibleiP32037. MM.

Family and domain databases

CDDicd06174. MFS. 1 hit.
InterProiIPR002945. Glc_transpt_3.
IPR020846. MFS_dom.
IPR005828. MFS_sugar_transport-like.
IPR003663. Sugar/inositol_transpt.
IPR005829. Sugar_transporter_CS.
[Graphical view]
PfamiPF00083. Sugar_tr. 1 hit.
[Graphical view]
PRINTSiPR01192. GLUCTRSPORT3.
PR00171. SUGRTRNSPORT.
SUPFAMiSSF103473. SSF103473. 2 hits.
TIGRFAMsiTIGR00879. SP. 1 hit.
PROSITEiPS50850. MFS. 1 hit.
PS00216. SUGAR_TRANSPORT_1. 1 hit.
PS00217. SUGAR_TRANSPORT_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGTR3_MOUSE
AccessioniPrimary (citable) accession number: P32037
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: November 30, 2016
This is version 142 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.