Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Solute carrier family 2, facilitated glucose transporter member 3

Gene

Slc2a3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Facilitative glucose transporter that can also mediate the uptake of various other monosaccharides across the cell membrane. Mediates the uptake of glucose, 2-deoxyglucose, galactose, mannose, xylose and fucose, and probably also dehydroascorbate. Does not mediate fructose transport.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei315MonosaccharideBy similarity1
Binding sitei378MonosaccharideBy similarity1
Binding sitei386MonosaccharideBy similarity1

GO - Molecular functioni

GO - Biological processi

  • dehydroascorbic acid transport Source: UniProtKB
  • glucose transmembrane transport Source: UniProtKB

Keywordsi

Biological processSugar transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-189200 Cellular hexose transport
R-MMU-196836 Vitamin C (ascorbate) metabolism
R-MMU-6798695 Neutrophil degranulation

Names & Taxonomyi

Protein namesi
Recommended name:
Solute carrier family 2, facilitated glucose transporter member 3
Alternative name(s):
Glucose transporter type 3, brain
Short name:
GLUT-3
Gene namesi
Name:Slc2a3
Synonyms:Glut-3, Glut3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:95757 Slc2a3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 10CytoplasmicBy similarity10
Transmembranei11 – 32Helical; Name=1Sequence analysisBy similarityAdd BLAST22
Topological domaini33 – 64ExtracellularBy similarityAdd BLAST32
Transmembranei65 – 85Helical; Name=2Sequence analysisBy similarityAdd BLAST21
Topological domaini86 – 90CytoplasmicBy similarity5
Transmembranei91 – 111Helical; Name=3By similarityAdd BLAST21
Topological domaini112 – 118ExtracellularBy similarity7
Transmembranei119 – 142Helical; Name=4Sequence analysisBy similarityAdd BLAST24
Topological domaini143 – 153CytoplasmicBy similarityAdd BLAST11
Transmembranei154 – 174Helical; Name=5Sequence analysisBy similarityAdd BLAST21
Topological domaini175 – 183ExtracellularBy similarity9
Transmembranei184 – 204Helical; Name=6Sequence analysisBy similarityAdd BLAST21
Topological domaini205 – 269CytoplasmicBy similarityAdd BLAST65
Transmembranei270 – 290Helical; Name=7Sequence analysisBy similarityAdd BLAST21
Topological domaini291 – 304ExtracellularBy similarityAdd BLAST14
Transmembranei305 – 325Helical; Name=8Sequence analysisBy similarityAdd BLAST21
Topological domaini326 – 331CytoplasmicBy similarity6
Transmembranei332 – 352Helical; Name=9Sequence analysisBy similarityAdd BLAST21
Topological domaini353 – 363ExtracellularBy similarityAdd BLAST11
Transmembranei364 – 389Helical; Name=10Sequence analysisBy similarityAdd BLAST26
Topological domaini390 – 399CytoplasmicBy similarity10
Transmembranei400 – 420Helical; Name=11Sequence analysisBy similarityAdd BLAST21
Topological domaini421 – 429ExtracellularBy similarity9
Transmembranei430 – 450Helical; Name=12Sequence analysisBy similarityAdd BLAST21
Topological domaini451 – 493CytoplasmicBy similarityAdd BLAST43

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000503541 – 493Solute carrier family 2, facilitated glucose transporter member 3Add BLAST493

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi43N-linked (GlcNAc...) asparagine1 Publication1
Modified residuei232PhosphothreonineCombined sources1
Modified residuei471PhosphoserineCombined sources1
Modified residuei482PhosphoserineBy similarity1
Modified residuei489PhosphothreonineBy similarity1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

EPDiP32037
PaxDbiP32037
PeptideAtlasiP32037
PRIDEiP32037

PTM databases

iPTMnetiP32037
PhosphoSitePlusiP32037

Expressioni

Tissue specificityi

Detected in brain (at protein level). Highly expressed in brain.1 Publication

Gene expression databases

BgeeiENSMUSG00000003153
ExpressionAtlasiP32037 baseline and differential
GenevisibleiP32037 MM

Interactioni

Protein-protein interaction databases

BioGridi203306, 1 interactor
STRINGi10090.ENSMUSP00000032476

Structurei

3D structure databases

ProteinModelPortaliP32037
SMRiP32037
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni277 – 279Important for selectivity against fructoseBy similarity3
Regioni280 – 286Monosaccharide bindingBy similarity7

Domaini

Transport is mediated via a series of conformation changes, switching between a conformation where the substrate-binding cavity is accessible from the outside, and a another conformation where it is accessible from the cytoplasm.By similarity

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0569 Eukaryota
COG0477 LUCA
GeneTreeiENSGT00760000119022
HOGENOMiHOG000202871
HOVERGENiHBG014816
InParanoidiP32037
KOiK08142
OMAiCCNWTAN
OrthoDBiEOG091G0A9K
PhylomeDBiP32037
TreeFamiTF313762

Family and domain databases

CDDicd06174 MFS, 1 hit
InterProiView protein in InterPro
IPR002945 Glc_transpt_3
IPR020846 MFS_dom
IPR005828 MFS_sugar_transport-like
IPR036259 MFS_trans_sf
IPR003663 Sugar/inositol_transpt
IPR005829 Sugar_transporter_CS
PfamiView protein in Pfam
PF00083 Sugar_tr, 1 hit
PRINTSiPR01192 GLUCTRSPORT3
PR00171 SUGRTRNSPORT
SUPFAMiSSF103473 SSF103473, 2 hits
TIGRFAMsiTIGR00879 SP, 1 hit
PROSITEiView protein in PROSITE
PS50850 MFS, 1 hit
PS00216 SUGAR_TRANSPORT_1, 1 hit
PS00217 SUGAR_TRANSPORT_2, 1 hit

Sequencei

Sequence statusi: Complete.

P32037-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGTTKVTPSL VFAVTVATIG SFQFGYNTGV INAPETILKD FLNYTLEERL
60 70 80 90 100
EDLPSEGLLT ALWSLCVAIF SVGGMIGSFS VGLFVNRFGR RNSMLLVNLL
110 120 130 140 150
AIIAGCLMGF AKIAESVEML ILGRLLIGIF CGLCTGFVPM YIGEVSPTAL
160 170 180 190 200
RGAFGTLNQL GIVVGILVAQ IFGLDFILGS EELWPGLLGL TIIPAILQSA
210 220 230 240 250
ALPFCPESPR FLLINKKEED QATEILQRLW GTSDVVQEIQ EMKDESVRMS
260 270 280 290 300
QEKQVTVLEL FRSPNYVQPL LISIVLQLSQ QLSGINAVFY YSTGIFKDAG
310 320 330 340 350
VQEPIYATIG AGVVNTIFTV VSLFLVERAG RRTLHMIGLG GMAVCSVFMT
360 370 380 390 400
ISLLLKDDYE AMSFVCIVAI LIYVAFFEIG PGPIPWFIVA ELFSQGPRPA
410 420 430 440 450
AIAVAGCCNW TSNFLVGMLF PSAAAYLGAY VFIIFAAFLI FFLIFTFFKV
460 470 480 490
PETKGRTFED IARAFEGQAH SGKGPAGVEL NSMQPVKETP GNA
Length:493
Mass (Da):53,479
Last modified:July 1, 1993 - v1
Checksum:i9090B8DCB8780082
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M75135 mRNA Translation: AAA37704.1
X61093 mRNA Translation: CAA43406.1
U11853
, U11844, U11845, U11846, U11848, U11849, U11850, U11851, U11852 Genomic DNA Translation: AAB60666.1
BC034122 mRNA Translation: AAH34122.1
BC058811 mRNA Translation: AAH58811.1
CCDSiCCDS20502.1
PIRiA41751
RefSeqiNP_035531.3, NM_011401.4
UniGeneiMm.395108

Genome annotation databases

EnsembliENSMUST00000032476; ENSMUSP00000032476; ENSMUSG00000003153
GeneIDi20527
KEGGimmu:20527
UCSCiuc009dpq.2 mouse

Similar proteinsi

Entry informationi

Entry nameiGTR3_MOUSE
AccessioniPrimary (citable) accession number: P32037
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: April 25, 2018
This is version 153 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health