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Protein

Daunorubicin/doxorubicin resistance ABC transporter permease protein DrrB

Gene

drrB

Organism
Streptomyces peucetius
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Part of the ABC transporter complex DrrAB involved in daunorubicin and doxorubicin resistance. Probably responsible for the translocation of the substrate across the membrane.2 Publications

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Antibiotic resistance, Transport

Protein family/group databases

TCDBi3.A.1.105.1. the atp-binding cassette (abc) superfamily.

Names & Taxonomyi

Protein namesi
Recommended name:
Daunorubicin/doxorubicin resistance ABC transporter permease protein DrrB
Gene namesi
Name:drrB
OrganismiStreptomyces peucetius
Taxonomic identifieri1950 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaStreptomycetalesStreptomycetaceaeStreptomyces

Subcellular locationi

  • Cell membrane 1 Publication; Multi-pass membrane protein 1 Publication

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 53CytoplasmicSequence analysisAdd BLAST53
Transmembranei54 – 72HelicalSequence analysisAdd BLAST19
Topological domaini73 – 87ExtracellularSequence analysisAdd BLAST15
Transmembranei88 – 106HelicalSequence analysisAdd BLAST19
Topological domaini107 – 119CytoplasmicSequence analysisAdd BLAST13
Transmembranei120 – 138HelicalSequence analysisAdd BLAST19
Topological domaini139 – 141ExtracellularSequence analysis3
Transmembranei142 – 159HelicalSequence analysisAdd BLAST18
Topological domaini160 – 169CytoplasmicSequence analysis10
Transmembranei170 – 188HelicalSequence analysisAdd BLAST19
Topological domaini189 – 199ExtracellularSequence analysisAdd BLAST11
Transmembranei200 – 218HelicalSequence analysisAdd BLAST19
Topological domaini219 – 241CytoplasmicSequence analysisAdd BLAST23
Transmembranei242 – 260HelicalSequence analysisAdd BLAST19
Topological domaini261 – 262ExtracellularSequence analysis2
Transmembranei263 – 280HelicalSequence analysisAdd BLAST18
Topological domaini281 – 283CytoplasmicSequence analysis3

GO - Cellular componenti

  • integral component of plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001829811 – 283Daunorubicin/doxorubicin resistance ABC transporter permease protein DrrBAdd BLAST283

Interactioni

Subunit structurei

The complex is composed of two ATP-binding proteins (DrrA) and two transmembrane proteins (DrrB).1 Publication

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini53 – 280ABC transmembrane type-2PROSITE-ProRule annotationAdd BLAST228

Sequence similaritiesi

Contains 1 ABC transmembrane type-2 domain.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Family and domain databases

InterProiIPR013525. ABC_2_trans.
IPR000412. ABC_2_transport.
[Graphical view]
PfamiPF01061. ABC2_membrane. 1 hit.
[Graphical view]
PIRSFiPIRSF006648. DrrB. 1 hit.
PROSITEiPS51012. ABC_TM2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P32011-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTSPGTVES TTPVSGQLRT VLSAGERPAR ATAVSATLTH LWRAMMAFKH
60 70 80 90 100
FPVQLIDIVL MPLIFLLMFT YLFGGAFADS TEEYLQFYLP GVTVQAVVMM
110 120 130 140 150
TVYTGTSLNT DIHKGVFDRF RTLPFWQPAT LAGSLLGDVL RYVVALATTV
160 170 180 190 200
SLGLLLGFRA DGGFLGVVGA MLVLIVFGFS VSWIFAALGV VASEPERVSG
210 220 230 240 250
TSMIVLYPLL FMSNIFVMPE TMPGWMQAIV DANPMSHAAT ASRELMHGTA
260 270 280
GFWDVGLVLC VSAGLVAVFA PLTMRLYRNK NAH
Length:283
Mass (Da):30,614
Last modified:July 1, 1993 - v1
Checksum:iEC42F07A4D15C07A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M73758 Genomic DNA. Translation: AAA74718.1.
PIRiS27708.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M73758 Genomic DNA. Translation: AAA74718.1.
PIRiS27708.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

TCDBi3.A.1.105.1. the atp-binding cassette (abc) superfamily.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

InterProiIPR013525. ABC_2_trans.
IPR000412. ABC_2_transport.
[Graphical view]
PfamiPF01061. ABC2_membrane. 1 hit.
[Graphical view]
PIRSFiPIRSF006648. DrrB. 1 hit.
PROSITEiPS51012. ABC_TM2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDRRB_STRPE
AccessioniPrimary (citable) accession number: P32011
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: June 24, 2015
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.