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Protein

ADP/ATP translocase 3

Gene

SLC25A6

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalyzes the exchange of cytoplasmic ADP with mitochondrial ATP across the mitochondrial inner membrane. May participate in the formation of the permeability transition pore complex (PTPC) responsible for the release of mitochondrial products that triggers apoptosis (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei80ADPBy similarity1
Binding sitei92ADPBy similarity1
Binding sitei235ADPBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processApoptosis, Transport

Enzyme and pathway databases

ReactomeiR-BTA-1268020 Mitochondrial protein import
R-BTA-422356 Regulation of insulin secretion

Names & Taxonomyi

Protein namesi
Recommended name:
ADP/ATP translocase 3
Alternative name(s):
ADP,ATP carrier protein 3
ADP,ATP carrier protein, isoform T2
Short name:
ANT 2
Adenine nucleotide translocator 3
Short name:
ANT 3
Solute carrier family 25 member 6
Cleaved into the following chain:
Gene namesi
Name:SLC25A6
Synonyms:ANT3
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Organism-specific databases

VGNCiVGNC:49967 SLC25A6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei8 – 37Helical; Name=1By similarityAdd BLAST30
Transmembranei75 – 99Helical; Name=2By similarityAdd BLAST25
Transmembranei110 – 130Helical; Name=3By similarityAdd BLAST21
Transmembranei179 – 199Helical; Name=4By similarityAdd BLAST21
Transmembranei211 – 231Helical; Name=5By similarityAdd BLAST21
Transmembranei274 – 291Helical; Name=6By similarityAdd BLAST18

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004257801 – 298ADP/ATP translocase 3Add BLAST298
Initiator methionineiRemoved; alternateBy similarity
ChainiPRO_00000905832 – 298ADP/ATP translocase 3, N-terminally processedAdd BLAST297

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1
Modified residuei2N-acetylthreonine; in ADP/ATP translocase 3, N-terminally processedBy similarity1
Modified residuei52N6,N6,N6-trimethyllysineBy similarity1
Modified residuei105N6-acetyllysineBy similarity1
Modified residuei268N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation, Methylation

Proteomic databases

PaxDbiP32007
PeptideAtlasiP32007
PRIDEiP32007

Expressioni

Gene expression databases

BgeeiENSBTAG00000047418

Interactioni

Subunit structurei

Homodimer. Found in a complex with ARL2, ARL2BP and SLC25A6.1 Publication

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000055370

Structurei

3D structure databases

ProteinModelPortaliP32007
SMRiP32007
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati6 – 98Solcar 1Add BLAST93
Repeati111 – 201Solcar 2Add BLAST91
Repeati212 – 297Solcar 3Add BLAST86

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni235 – 240Important for transport activityBy similarity6

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi235 – 240Nucleotide carrier signature motifBy similarity6

Domaini

The transmembrane helices are not perpendicular to the plane of the membrane, but cross the membrane at an angle. Odd-numbered transmembrane helices exhibit a sharp kink, due to the presence of a conserved proline residue.By similarity

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0749 Eukaryota
ENOG410XNW0 LUCA
GeneTreeiENSGT00390000011543
HOVERGENiHBG108348
InParanoidiP32007
KOiK05863
OMAiNGKRQFK
OrthoDBiEOG091G0ULB
TreeFamiTF300743

Family and domain databases

Gene3Di1.50.40.10, 1 hit
InterProiView protein in InterPro
IPR002113 Aden_trnslctor
IPR002067 Mit_carrier
IPR018108 Mitochondrial_sb/sol_carrier
IPR023395 Mt_carrier_dom_sf
PfamiView protein in Pfam
PF00153 Mito_carr, 3 hits
PRINTSiPR00927 ADPTRNSLCASE
PR00926 MITOCARRIER
SUPFAMiSSF103506 SSF103506, 1 hit
PROSITEiView protein in PROSITE
PS50920 SOLCAR, 3 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P32007-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTEQAISFAK DFLAGGIAAA ISKTAVAPIE RVKLLLQVQH ASKQIAADKQ
60 70 80 90 100
YKGIVDCIVR IPKEQGVLSF WRGNLANVIR YFPTQALNFA FKDKYKQIFL
110 120 130 140 150
GGVDKRTQFW RYFAGNLASG GAAGATSLCF VYPLDFARTR LAADVGKSGS
160 170 180 190 200
EREFRGLGDC LVKITKSDGI RGLYQGFNVS VQGIIIYRAA YFGIYDTAKG
210 220 230 240 250
MLPDPKNTHI VVSWMIAQTV TAVAGVVSYP FDTVRRRMMM QSGRKGADIM
260 270 280 290
YKGTVDCWRK ILKDEGGKAF FKGAWSNVLR GMGGAFVLVL YDELKKVI
Length:298
Mass (Da):32,877
Last modified:January 23, 2007 - v3
Checksum:i1C34E7DF6EDE4061
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M24103 mRNA Translation: AAA30769.1
BT029910 mRNA Translation: ABM06156.1
BC150034 mRNA Translation: AAI50035.1
PIRiB43646
RefSeqiNP_777085.1, NM_174660.2
UniGeneiBt.5176

Genome annotation databases

EnsembliENSBTAT00000063682; ENSBTAP00000055370; ENSBTAG00000047418
GeneIDi282480
KEGGibta:282480

Similar proteinsi

Entry informationi

Entry nameiADT3_BOVIN
AccessioniPrimary (citable) accession number: P32007
Secondary accession number(s): A1L5C3, A6QQX7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: January 23, 2007
Last modified: June 20, 2018
This is version 130 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

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