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Protein

ADP/ATP translocase 3

Gene

SLC25A6

Organism
Bos taurus (Bovine)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the exchange of cytoplasmic ADP with mitochondrial ATP across the mitochondrial inner membrane. May participate in the formation of the permeability transition pore complex (PTPC) responsible for the release of mitochondrial products that triggers apoptosis (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei80 – 801NucleotideBy similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Apoptosis, Transport

Enzyme and pathway databases

ReactomeiR-BTA-1268020. Mitochondrial protein import.
R-BTA-422356. Regulation of insulin secretion.

Names & Taxonomyi

Protein namesi
Recommended name:
ADP/ATP translocase 3
Alternative name(s):
ADP,ATP carrier protein 3
ADP,ATP carrier protein, isoform T2
Short name:
ANT 2
Adenine nucleotide translocator 3
Short name:
ANT 3
Solute carrier family 25 member 6
Cleaved into the following chain:
Gene namesi
Name:SLC25A6
Synonyms:ANT3
OrganismiBos taurus (Bovine)
Taxonomic identifieri9913 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaRuminantiaPecoraBovidaeBovinaeBos
Proteomesi
  • UP000009136 Componenti: Unplaced

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei5 – 3935Helical; Name=1By similarityAdd
BLAST
Transmembranei75 – 10026Helical; Name=2By similarityAdd
BLAST
Transmembranei109 – 14335Helical; Name=3By similarityAdd
BLAST
Transmembranei176 – 20227Helical; Name=4By similarityAdd
BLAST
Transmembranei207 – 24135Helical; Name=5By similarityAdd
BLAST
Transmembranei273 – 29826Helical; Name=6By similarityAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 298298ADP/ATP translocase 3PRO_0000090583Add
BLAST
Initiator methionineiRemoved; alternateBy similarity
Chaini2 – 298297ADP/ATP translocase 3, N-terminally processedPRO_0000425780Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity
Modified residuei2 – 21N-acetylthreonine; in ADP/ATP translocase 3, N-terminally processedBy similarity
Modified residuei43 – 431N6-succinyllysineBy similarity
Modified residuei105 – 1051N6-acetyllysine; alternateBy similarity
Modified residuei105 – 1051N6-succinyllysine; alternateBy similarity
Modified residuei147 – 1471N6-acetyllysine; alternateBy similarity
Modified residuei147 – 1471N6-succinyllysine; alternateBy similarity
Modified residuei163 – 1631N6-acetyllysineBy similarity
Modified residuei166 – 1661N6-acetyllysineBy similarity
Modified residuei268 – 2681N6-acetyllysine; alternateBy similarity
Modified residuei268 – 2681N6-succinyllysine; alternateBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiP32007.
PeptideAtlasiP32007.
PRIDEiP32007.

Interactioni

Subunit structurei

Homodimer. Found in a complex with ARL2, ARL2BP and SLC25A6.1 Publication

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000055370.

Structurei

3D structure databases

ProteinModelPortaliP32007.
SMRiP32007. Positions 2-294.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati6 – 9893Solcar 1Add
BLAST
Repeati111 – 20191Solcar 2Add
BLAST
Repeati212 – 29786Solcar 3Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi235 – 2406Substrate recognitionBy similarity

Sequence similaritiesi

Contains 3 Solcar repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0749. Eukaryota.
ENOG410XNW0. LUCA.
GeneTreeiENSGT00390000011543.
HOVERGENiHBG108348.
InParanoidiP32007.
KOiK05863.
OMAiTRSHVIN.
OrthoDBiEOG7T1RBR.
TreeFamiTF300743.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR002113. Aden_trnslctor.
IPR002067. Mit_carrier.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
PRINTSiPR00927. ADPTRNSLCASE.
PR00926. MITOCARRIER.
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P32007-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTEQAISFAK DFLAGGIAAA ISKTAVAPIE RVKLLLQVQH ASKQIAADKQ
60 70 80 90 100
YKGIVDCIVR IPKEQGVLSF WRGNLANVIR YFPTQALNFA FKDKYKQIFL
110 120 130 140 150
GGVDKRTQFW RYFAGNLASG GAAGATSLCF VYPLDFARTR LAADVGKSGS
160 170 180 190 200
EREFRGLGDC LVKITKSDGI RGLYQGFNVS VQGIIIYRAA YFGIYDTAKG
210 220 230 240 250
MLPDPKNTHI VVSWMIAQTV TAVAGVVSYP FDTVRRRMMM QSGRKGADIM
260 270 280 290
YKGTVDCWRK ILKDEGGKAF FKGAWSNVLR GMGGAFVLVL YDELKKVI
Length:298
Mass (Da):32,877
Last modified:January 23, 2007 - v3
Checksum:i1C34E7DF6EDE4061
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M24103 mRNA. Translation: AAA30769.1.
BT029910 mRNA. Translation: ABM06156.1.
BC150034 mRNA. Translation: AAI50035.1.
PIRiB43646.
RefSeqiNP_777085.1. NM_174660.2.
UniGeneiBt.5176.

Genome annotation databases

EnsembliENSBTAT00000063682; ENSBTAP00000055370; ENSBTAG00000047418.
GeneIDi282480.
KEGGibta:282480.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M24103 mRNA. Translation: AAA30769.1.
BT029910 mRNA. Translation: ABM06156.1.
BC150034 mRNA. Translation: AAI50035.1.
PIRiB43646.
RefSeqiNP_777085.1. NM_174660.2.
UniGeneiBt.5176.

3D structure databases

ProteinModelPortaliP32007.
SMRiP32007. Positions 2-294.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9913.ENSBTAP00000055370.

Proteomic databases

PaxDbiP32007.
PeptideAtlasiP32007.
PRIDEiP32007.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSBTAT00000063682; ENSBTAP00000055370; ENSBTAG00000047418.
GeneIDi282480.
KEGGibta:282480.

Organism-specific databases

CTDi293.

Phylogenomic databases

eggNOGiKOG0749. Eukaryota.
ENOG410XNW0. LUCA.
GeneTreeiENSGT00390000011543.
HOVERGENiHBG108348.
InParanoidiP32007.
KOiK05863.
OMAiTRSHVIN.
OrthoDBiEOG7T1RBR.
TreeFamiTF300743.

Enzyme and pathway databases

ReactomeiR-BTA-1268020. Mitochondrial protein import.
R-BTA-422356. Regulation of insulin secretion.

Family and domain databases

Gene3Di1.50.40.10. 1 hit.
InterProiIPR002113. Aden_trnslctor.
IPR002067. Mit_carrier.
IPR018108. Mitochondrial_sb/sol_carrier.
IPR023395. Mt_carrier_dom.
[Graphical view]
PfamiPF00153. Mito_carr. 3 hits.
[Graphical view]
PRINTSiPR00927. ADPTRNSLCASE.
PR00926. MITOCARRIER.
SUPFAMiSSF103506. SSF103506. 1 hit.
PROSITEiPS50920. SOLCAR. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Two bovine genes for mitochondrial ADP/ATP translocase expressed differences in various tissues."
    Powell S.J., Medd S.M., Runswick M.J., Walker J.E.
    Biochemistry 28:866-873(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. NIH - Mammalian Gene Collection (MGC) project
    Submitted (JUL-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: Hereford.
    Tissue: Ovary.
  4. "ARL2 and BART enter mitochondria and bind the adenine nucleotide transporter."
    Sharer J.D., Shern J.F., Van Valkenburgh H., Wallace D.C., Kahn R.A.
    Mol. Biol. Cell 13:71-83(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 3-9; 35-43; 65-80 AND 274-280, IDENTIFICATION IN A COMPLEX WITH ARL2 AND ARL2BP, TISSUE SPECIFICITY.

Entry informationi

Entry nameiADT3_BOVIN
AccessioniPrimary (citable) accession number: P32007
Secondary accession number(s): A1L5C3, A6QQX7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: January 23, 2007
Last modified: July 6, 2016
This is version 117 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

The transmembrane helices are not perpendicular to the plane of the membrane, but cross the membrane at an angle. Odd-numbered transmembrane helices exhibit a sharp kink, due to the presence of a conserved proline residue (By similarity).By similarity

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.