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Protein

Genome polyprotein

Gene
N/A
Organism
Lettuce mosaic virus (strain 0 / isolate French) (LMV)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Capsid protein: involved in aphid transmission, cell-to-cell and systemis movement, encapsidation of the viral RNA and in the regulation of viral RNA amplification.
Nuclear inclusion protein B: an RNA-dependent RNA polymerase that plays an essential role in the virus replication.
Helper component proteinase: required for aphid transmission and also has proteolytic activity. Only cleaves a Gly-Gly dipeptide at its own C-terminus. Interacts with virions and aphid stylets. Acts as a suppressor of RNA-mediated gene silencing, also known as post-transcriptional gene silencing (PTGS), a mechanism of plant viral defense that limits the accumulation of viral RNAs. May have RNA-binding activity (By similarity).By similarity
Cytoplasmic inclusion protein: has helicase activity. It may be involved in replication.
Both 6K peptides are indispensable for virus replication.By similarity
Nuclear inclusion protein A: has RNA-binding and proteolytic activities.

Catalytic activityi

Hydrolyzes glutaminyl bonds, and activity is further restricted by preferences for the amino acids in P6 - P1' that vary with the species of potyvirus, e.g. Glu-Xaa-Xaa-Tyr-Xaa-Gln-|-(Ser or Gly) for the enzyme from tobacco etch virus. The natural substrate is the viral polyprotein, but other proteins and oligopeptides containing the appropriate consensus sequence are also cleaved.
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).PROSITE-ProRule annotation
Hydrolyzes a Gly-|-Gly bond at its own C-terminus, commonly in the sequence -Tyr-Xaa-Val-Gly-|-Gly, in the processing of the potyviral polyprotein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei345For P1 proteinase activityBy similarity1
Active sitei354For P1 proteinase activitySequence analysis1
Active sitei388For P1 proteinase activityBy similarity1
Active sitei781For helper component proteinase activityPROSITE-ProRule annotation1
Active sitei854For helper component proteinase activityPROSITE-ProRule annotation1
Active sitei2260For nuclear inclusion protein A activityPROSITE-ProRule annotation1
Active sitei2295For nuclear inclusion protein A activityPROSITE-ProRule annotation1
Active sitei2365For nuclear inclusion protein A activityPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi1410 – 1417ATPPROSITE-ProRule annotation8

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Helicase, Hydrolase, Nucleotidyltransferase, Protease, RNA-directed RNA polymerase, Suppressor of RNA silencing, Thiol protease, Transferase

Keywords - Biological processi

Viral RNA replication

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Genome polyprotein
Cleaved into the following 10 chains:
Alternative name(s):
N-terminal protein
Helper component proteinase (EC:3.4.22.45)
Short name:
HC-pro
6 kDa protein 1
Short name:
6K1
6 kDa protein 2
Short name:
6K2
Alternative name(s):
VPg
Nuclear inclusion protein A (EC:3.4.22.44)
Short name:
NI-a
Short name:
NIa
Alternative name(s):
49 kDa proteinase
Short name:
49 kDa-Pro
NIa-pro
Nuclear inclusion protein B (EC:2.7.7.48)
Short name:
NI-b
Short name:
NIb
Alternative name(s):
RNA-directed RNA polymerase
Capsid protein
Short name:
CP
Alternative name(s):
Coat protein
OrganismiLettuce mosaic virus (strain 0 / isolate French) (LMV)
Taxonomic identifieri117132 [NCBI]
Taxonomic lineageiVirusesssRNA virusesssRNA positive-strand viruses, no DNA stagePotyviridaePotyvirus
Virus hostiCarthamus tinctorius (Safflower) [TaxID: 4222]
Cicer arietinum (Chickpea) (Garbanzo) [TaxID: 3827]
Cichorium endivia (Endive) [TaxID: 114280]
Cichorium intybus (Chicory) [TaxID: 13427]
Eustoma exaltatum subsp. russellianum (Bluebells) (Eustoma grandiflorum) [TaxID: 52518]
Lactuca [TaxID: 4235]
Pisum sativum (Garden pea) [TaxID: 3888]
Spinacia oleracea (Spinach) [TaxID: 3562]
Proteomesi
  • UP000008377 Componenti: Genome

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Capsid protein, Helical capsid protein, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004199991 – 3255Genome polyproteinAdd BLAST3255
ChainiPRO_00000402691 – 437P1 proteinaseSequence analysisAdd BLAST437
ChainiPRO_0000040270438 – 895Helper component proteinaseSequence analysisAdd BLAST458
ChainiPRO_0000040271896 – 1273Protein P3By similarityAdd BLAST378
ChainiPRO_00000402721274 – 13256 kDa protein 1By similarityAdd BLAST52
ChainiPRO_00000402731326 – 1968Cytoplasmic inclusion proteinBy similarityAdd BLAST643
ChainiPRO_00000402741969 – 20216 kDa protein 2By similarityAdd BLAST53
ChainiPRO_00000402752022 – 2214Viral genome-linked proteinBy similarityAdd BLAST193
ChainiPRO_00000402762215 – 2457Nuclear inclusion protein ABy similarityAdd BLAST243
ChainiPRO_00000402772458 – 2977Nuclear inclusion protein BBy similarityAdd BLAST520
ChainiPRO_00000402782978 – 3255Capsid proteinBy similarityAdd BLAST278

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2084O-(5'-phospho-RNA)-tyrosineBy similarity1

Post-translational modificationi

VPg is uridylylated by the polymerase and is covalently attached to the 5'-end of the genomic RNA. This uridylylated form acts as a nucleotide-peptide primer for the polymerase (By similarity).By similarity
Potyviral RNA is expressed as two polyproteins which undergo post-translational proteolytic processing. Genome polyprotein is processed by NIa-pro, P1 and HC-pro proteinases resulting in the production of at least ten individual proteins. P3N-PIPO polyprotein is cleaved by P1 and HC-pro proteinases resulting in the production of three individual proteins. The P1 proteinase and the HC-pro cleave only their respective C-termini autocatalytically. 6K1 is essential for proper proteolytic separation of P3 from CI (By similarity).By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei437 – 438Cleavage; by P1 proteinaseSequence analysis2
Sitei895 – 896Cleavage; by autolysisPROSITE-ProRule annotation2
Sitei1273 – 1274Cleavage; by NIa-proBy similarity2
Sitei1325 – 1326Cleavage; by NIa-proBy similarity2
Sitei1968 – 1969Cleavage; by NIa-proBy similarity2
Sitei2021 – 2022Cleavage; by NIa-proBy similarity2
Sitei2214 – 2215Cleavage; by NIa-proBy similarity2
Sitei2457 – 2458Cleavage; by NIa-proBy similarity2
Sitei2977 – 2978Cleavage; by NIa-proBy similarity2

Keywords - PTMi

Covalent protein-RNA linkage, Phosphoprotein

Structurei

3D structure databases

ProteinModelPortaliP31999.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini773 – 895Peptidase C6PROSITE-ProRule annotationAdd BLAST123
Domaini1397 – 1549Helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST153
Domaini1568 – 1727Helicase C-terminalPROSITE-ProRule annotationAdd BLAST160
Domaini2215 – 2433Peptidase C4PROSITE-ProRule annotationAdd BLAST219
Domaini2699 – 2823RdRp catalyticPROSITE-ProRule annotationAdd BLAST125

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi489 – 492Involved in interaction with stylet and aphid transmissionBy similarity4
Motifi747 – 749Involved in virions binding and aphid transmissionBy similarity3
Motifi1499 – 1502DECH box4
Motifi2062 – 2069Nuclear localization signalSequence analysis8

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi1266 – 1271Poly-Glu6
Compositional biasi2965 – 2972Poly-Asp8

Domaini

The N-terminus of helper component proteinase is involved in interaction with stylets. The central part is involved in interaction with virions and the C-terminus is involved in cell-to cell movement of the virus.

Sequence similaritiesi

Contains 1 helicase ATP-binding domain.PROSITE-ProRule annotation
Contains 1 helicase C-terminal domain.PROSITE-ProRule annotation
Contains 1 peptidase C4 domain.PROSITE-ProRule annotation
Contains 1 peptidase C6 domain.PROSITE-ProRule annotationCurated
Contains 1 peptidase S30 domain.Curated
Contains 1 RdRp catalytic domain.PROSITE-ProRule annotation

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR011545. DEAD/DEAH_box_helicase_dom.
IPR001456. HC-pro.
IPR031159. HC_PRO_CPD_dom.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR002540. Pept_S30_P1_potyvir.
IPR009003. Peptidase_S1_PA.
IPR001592. Poty_coat.
IPR001730. Potyv_NIa-pro_dom.
IPR013648. PP_Potyviridae.
IPR001205. RNA-dir_pol_C.
IPR007094. RNA-dir_pol_PSvirus.
[Graphical view]
PfamiPF00270. DEAD. 1 hit.
PF00271. Helicase_C. 1 hit.
PF00863. Peptidase_C4. 1 hit.
PF00851. Peptidase_C6. 1 hit.
PF01577. Peptidase_S30. 1 hit.
PF00767. Poty_coat. 1 hit.
PF08440. Poty_PP. 1 hit.
PF00680. RdRP_1. 1 hit.
[Graphical view]
PRINTSiPR00966. NIAPOTYPTASE.
SMARTiSM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
SSF52540. SSF52540. 2 hits.
PROSITEiPS51744. HC_PRO_CPD. 1 hit.
PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS51436. POTYVIRUS_NIA_PRO. 1 hit.
PS50507. RDRP_SSRNA_POS. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by ribosomal frameshifting. AlignAdd to basket

Isoform Genome polyprotein (identifier: P31999-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MATLDNCTQV HHMFAYNREH GTNYTRNHFR RYLAAQRIGF YYDWDDDVYE
60 70 80 90 100
CPTCEAIYHS LDDIKNWHEC DPPAFDLNDF ITDARLKSAP VPDLGPVIIE
110 120 130 140 150
IPKAEEKQEL NFFAATPAPE VSQWKCRGLQ FGSFTELETS EPVASAPEPK
160 170 180 190 200
CEEPARTIAK PEESVEQETR GDGKRLLQAQ MEVDKAEQDL AFACLNASLK
210 220 230 240 250
PRLEGRTTAT IARRRDGCLV YKTKPSWSQR RRAKKTLKVD TLACENPYIP
260 270 280 290 300
AIVDKISIAG GSSASVMHEQ QKPKTLHTTP SRKVATHYKR TVMNQQTLMA
310 320 330 340 350
FINQVGTILL NAEKEFEVVG CRKQKVTGKG TRHNGVRLVK LKTAHEEGHR
360 370 380 390 400
RRVDIRIPNG LRPIVMRISA RGGWHRTWTD SELSPGSSGY VLNSSKIIGK
410 420 430 440 450
FGLRRHSIFV VRGRVDGEVI DSQSKVTHSI THRMVQYSDV ARNFWNGYST
460 470 480 490 500
CFMHNTPKDI LHTCTSDFDV KECGTVAALL TQTLFQFGKI TCEKCAIEYK
510 520 530 540 550
NLTRDELATR VNKEIDGTII SIQTQHPRFV HVLNFLRLIK QVLNAKNGNF
560 570 580 590 600
GAFQETERII GDRMDAPFSH VNKLNAIVIK GNQATSDEMA QASNHVLEIA
610 620 630 640 650
RYLKNRTENI QKGSLKSFRN KISGKAHLNP SLMCDNQLDK NGGFEWGQRS
660 670 680 690 700
YHAKRFFDGY FETIDPSDGY SKYTIRRNPN GHRKLAIGNL IVSTNFESHR
710 720 730 740 750
RSMIGESIED PGLTNQCVSK EGDTFIYPCC CVTDEYGKPT LSEIKMPTKH
760 770 780 790 800
HLVLGNAGDP KYVDLPKEAE GKMFVTKDGY CYINIFLAML VDVPEDQAKD
810 820 830 840 850
FTKMAREIAV KQLGEWPSMM DVATACNILA TFHPDTRRSE LPRILVDHAT
860 870 880 890 900
KTFHVIDSYG SITTGFHILK ANTVTQLVKF AHESLESEMQ HYRVGGEPDK
910 920 930 940 950
APRKPAGSVP TLGISDLRDL GVELENEEHS IRPNLQRLIK AIYRPRMMRS
960 970 980 990 1000
LLTEEPYLLI LSIVSPGVLM ALYNSGSLER TMHEFLQTDQ RLSATAQILK
1010 1020 1030 1040 1050
HLAKKVSLAK TLTIQNAILE GGAGSLNEIL DAPAGRSLSY RLAKQTVEVM
1060 1070 1080 1090 1100
MARSDMDKEL VDVGFSVLRD QKNELIEKSY LMDLEDSWHA LPLCGKLSAM
1110 1120 1130 1140 1150
RASRRWRDTS TPEVIPTGAA DLKGRYSISV GSVSKSAILH LKGICSGAVK
1160 1170 1180 1190 1200
RVRDKWVGVQ VQGVKWLAKS VHYMIPELTN ILNVGTLLLT LISLGVAFRN
1210 1220 1230 1240 1250
LTGQFKEMKH KETLAKEEEL RKRIRTYNST YYEIHGKHAD AKQITKFITH
1260 1270 1280 1290 1300
HDPKLLEVVE FYEGPEEEEV EHQAKREDQA NLERIIAFTA LVMMMFDSER
1310 1320 1330 1340 1350
SDCVYRSLSK LKSLVSTCED DVRHQSVDEI IDLFDEKKET IDFEIEGKEL
1360 1370 1380 1390 1400
YSSRVVDSTF SKWWDNQLVR GNTMAHYRTE GHFMTFTRET AASVAAEIAH
1410 1420 1430 1440 1450
NEYRDILLQG GVGSGKSTGL PFHLHRKGGV LLIEPTRPLA QNVYKQLGSS
1460 1470 1480 1490 1500
PFHLSPNLRM RGSCKFGSSQ VTVATSGYAL HFIANNAQSL KAYDFIIFDE
1510 1520 1530 1540 1550
CHVLDASAMA FRCLLQEFEY QGKIIKVSAT PPGRKLDFKP MHMVDIATEN
1560 1570 1580 1590 1600
ELSIQQFVQG QGTGVNCDAT KKGDNILVYV SSYNEVDMLS KMLNDKGYKV
1610 1620 1630 1640 1650
TKVDGRTMKL GSVEVETVGT PQRKHFVVAT NIIENGVTLD VDVVVDFGQK
1660 1670 1680 1690 1700
VVPILDSEHR MIRYTKKSIT YGERIQRVGR VGRNKAGSAI RIGSTEMGTE
1710 1720 1730 1740 1750
EIPASIATEA AFLCFTYGLP VMTSNVSTSV LGNCTVRQAR TMQKFELSPF
1760 1770 1780 1790 1800
FMVDLVHHDG TIHPAINSLL KQFKLKESDI KLSTLAIPNA VTTFWKSARE
1810 1820 1830 1840 1850
YNSLGARTTI DDAAKIPFMI KDVPEHLQEK LWETIQQYKG DAGFGRCTSA
1860 1870 1880 1890 1900
NACKIAYTLS VSPFMIPATI NKIDALMAEE RQKMEYFQTV TANTCTISNF
1910 1920 1930 1940 1950
SISSIGDMIR SRYSTNHSRE NLQKLQAVRD TIINFECQAG TGDGGSFDME
1960 1970 1980 1990 2000
TAQKLAEEYG CIDVIYHQSK EALSKRLGLK GRWNQSLICK DLLVFCGVAI
2010 2020 2030 2040 2050
GGTWMMFQSF KDGMADAVRH QGKGKRQRQK LRYRQARDNK VGIEVYGDDA
2060 2070 2080 2090 2100
TMEHYFGAAY TEKGKKSGKT KGMGTKNRRF VNMYGYNPED FSFIRFLDPL
2110 2120 2130 2140 2150
TGKTMDEQVF SDISLVQDAF SKERLKLLSE GEIESEHMRN GIRAYLVKNL
2160 2170 2180 2190 2200
TTAALEIDMT PHNSCQLGAK TNNIAGYVDR EYELRQTGEA RVVAPALIPK
2210 2220 2230 2240 2250
DNPITDEDIP VKHESKTLFR GLRDYNPIAA AICLLTNESD GMKETMYGIG
2260 2270 2280 2290 2300
FGNTIITNQH LFRRNNGVLR VQSRHGEYVL PNTTQLKVLP CEGRDIMVII
2310 2320 2330 2340 2350
LTPDFPPFPQ KLKFRPPIKG EKICLVGSLF QDKSITSTVS ETSVTTPVDN
2360 2370 2380 2390 2400
SFLWKHWITT KDGHCGLPLV SSNDGYIVGI HSATSSRQTQ NYHAAMPEDF
2410 2420 2430 2440 2450
HQTHLIDPAS KSWVKHWKYN PDNMVWGGIN LINSTPREPF KINKLVTDLF
2460 2470 2480 2490 2500
GDAVQFQSKQ DEWFASQLKG NLKAVGKSTS QLVTKHTVKG KCMMFELYLQ
2510 2520 2530 2540 2550
THEEEKEFFK PLMGAYQKSR LNREAFTKDI MKYSTPITVG IVDCDTFLKA
2560 2570 2580 2590 2600
EEGVIKRLER LGFSGCEYVT DEEAIFQALN MKAAVGALYS GKKRDYFEGY
2610 2620 2630 2640 2650
GPEEKENILR ESCKRLYTGK FGVWNGSLKS ELRPMEKVMA NKTRVFTAAP
2660 2670 2680 2690 2700
LDTLLAGKVC VDDFNNYFYS KNIEAPWTVG MTKFYGGWNE LLTKLPDGWV
2710 2720 2730 2740 2750
YCDADGSQFD SSLSPFLINS VLRIRLKFME DWDLGEQMLK NLYTEIVYTA
2760 2770 2780 2790 2800
ILTPDSTIVK KFKGNNSGQP STVVDNTLMV VLAMTYTLHK LGFEDEEQDS
2810 2820 2830 2840 2850
MCKYFVNGDD LIIAIKPEHE SLLDQFQHCF KSLGLNYDFN SRTRKKEELW
2860 2870 2880 2890 2900
FMSHCGIKKD GIFIPKLEPE RIVSILEWDR SDQPVHRLEA ICAAMIESWG
2910 2920 2930 2940 2950
YDKLTHEIRK FYKWCLEQAP YADLAKAGKA PYIAECALKR LYTSKEASEA
2960 2970 2980 2990 3000
ELEKYMEAIR SLVNDEDDDD MDEVYHQVDA KLDAGQGSKT DDKQKNSADP
3010 3020 3030 3040 3050
KDNIITEKGS GSGQMKKDDD INAGLHGKHT IPRTKAITQK MKLPMIRGKV
3060 3070 3080 3090 3100
ALNLDHLLEY EPNQRDISNT RATQKQYESW YDGVKNDYDV DDSGMQLILN
3110 3120 3130 3140 3150
GLMVWCIENG TSPNINGTWV MMDGEEQVEY ALKPIIEHAK PTFRQIMAHF
3160 3170 3180 3190 3200
SDAAEAYIEM RNKKKPYMPR YGRLRGLNDM GLARYAFDFY ETTSATPNRA
3210 3220 3230 3240 3250
REAHNQMKAA ALVGTQNRLF GMDGGGSTQE ENTERHTAAD VNQNMHTLLG

VRGLH
Note: Produced by conventional translation.
Length:3,255
Mass (Da):367,571
Last modified:June 6, 2002 - v3
Checksum:i763F676F95876A12
GO
Isoform P3N-PIPO polyprotein (identifier: P0CJ97-1) [UniParc]FASTAAdd to basket
The sequence of this isoform can be found in the external entry P0CJ97.
Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.
Note: Produced by -1 ribosomal frameshifting in P3 ORF.
Length:1,152
Mass (Da):130,214
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X97704 mRNA. Translation: CAA66280.2.
X65652 Genomic RNA. Translation: CAA46602.1.
PIRiS70859.

Keywords - Coding sequence diversityi

Ribosomal frameshifting

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X97704 mRNA. Translation: CAA66280.2.
X65652 Genomic RNA. Translation: CAA46602.1.
PIRiS70859.

3D structure databases

ProteinModelPortaliP31999.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR011545. DEAD/DEAH_box_helicase_dom.
IPR001456. HC-pro.
IPR031159. HC_PRO_CPD_dom.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR002540. Pept_S30_P1_potyvir.
IPR009003. Peptidase_S1_PA.
IPR001592. Poty_coat.
IPR001730. Potyv_NIa-pro_dom.
IPR013648. PP_Potyviridae.
IPR001205. RNA-dir_pol_C.
IPR007094. RNA-dir_pol_PSvirus.
[Graphical view]
PfamiPF00270. DEAD. 1 hit.
PF00271. Helicase_C. 1 hit.
PF00863. Peptidase_C4. 1 hit.
PF00851. Peptidase_C6. 1 hit.
PF01577. Peptidase_S30. 1 hit.
PF00767. Poty_coat. 1 hit.
PF08440. Poty_PP. 1 hit.
PF00680. RdRP_1. 1 hit.
[Graphical view]
PRINTSiPR00966. NIAPOTYPTASE.
SMARTiSM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view]
SUPFAMiSSF50494. SSF50494. 1 hit.
SSF52540. SSF52540. 2 hits.
PROSITEiPS51744. HC_PRO_CPD. 1 hit.
PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS51436. POTYVIRUS_NIA_PRO. 1 hit.
PS50507. RDRP_SSRNA_POS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPOLG_LMV0
AccessioniPrimary (citable) accession number: P31999
Secondary accession number(s): P90263
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: June 6, 2002
Last modified: October 5, 2016
This is version 129 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.