Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Carcinoembryonic antigen-related cell adhesion molecule 8

Gene

CEACAM8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

  • immune response Source: ProtInc
  • leukocyte migration Source: Reactome
Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000124469-MONOMER.
ReactomeiR-HSA-1566977. Fibronectin matrix formation.
R-HSA-202733. Cell surface interactions at the vascular wall.
R-HSA-6798695. Neutrophil degranulation.

Names & Taxonomyi

Protein namesi
Recommended name:
Carcinoembryonic antigen-related cell adhesion molecule 8
Alternative name(s):
CD67 antigen
Carcinoembryonic antigen CGM6
Non-specific cross-reacting antigen NCA-95
CD_antigen: CD66b
Gene namesi
Name:CEACAM8
Synonyms:CGM6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:1820. CEACAM8.

Subcellular locationi

GO - Cellular componenti

  • anchored component of membrane Source: UniProtKB-KW
  • extracellular exosome Source: UniProtKB
  • extracellular space Source: UniProtKB
  • integral component of plasma membrane Source: ProtInc
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi1088.
OpenTargetsiENSG00000124469.
PharmGKBiPA26364.

Polymorphism and mutation databases

BioMutaiCEACAM8.
DMDMi6166048.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 34Add BLAST34
ChainiPRO_000001457235 – 320Carcinoembryonic antigen-related cell adhesion molecule 8Add BLAST286
PropeptideiPRO_0000014573321 – 349Removed in mature formAdd BLAST29

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi104N-linked (GlcNAc...)Sequence analysis1
Glycosylationi111N-linked (GlcNAc...)Sequence analysis1
Glycosylationi115N-linked (GlcNAc...)Sequence analysis1
Glycosylationi152N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi167 ↔ 215Curated
Glycosylationi173N-linked (GlcNAc...)Sequence analysis1
Glycosylationi197N-linked (GlcNAc...)Sequence analysis1
Glycosylationi224N-linked (GlcNAc...)Sequence analysis1
Glycosylationi256N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi259 ↔ 299Curated
Glycosylationi274N-linked (GlcNAc...)Sequence analysis1
Glycosylationi288N-linked (GlcNAc...)1 Publication1
Glycosylationi309N-linked (GlcNAc...)Sequence analysis1
Lipidationi320GPI-anchor amidated aspartate1 Publication1

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

PaxDbiP31997.
PeptideAtlasiP31997.
PRIDEiP31997.

PTM databases

iPTMnetiP31997.
PhosphoSitePlusiP31997.

Expressioni

Tissue specificityi

Expressed in leukocytes of chronic myeloid Leukemia patients and bone marrow.

Gene expression databases

BgeeiENSG00000124469.
CleanExiHS_CEACAM8.
ExpressionAtlasiP31997. baseline and differential.
GenevisibleiP31997. HS.

Organism-specific databases

HPAiCAB033676.

Interactioni

Protein-protein interaction databases

BioGridi107514. 3 interactors.
IntActiP31997. 3 interactors.
STRINGi9606.ENSP00000244336.

Structurei

Secondary structure

1349
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi37 – 46Combined sources10
Beta strandi51 – 56Combined sources6
Beta strandi64 – 72Combined sources9
Helixi75 – 77Combined sources3
Beta strandi78 – 83Combined sources6
Turni84 – 87Combined sources4
Beta strandi88 – 91Combined sources4
Beta strandi99 – 101Combined sources3
Beta strandi107 – 109Combined sources3
Helixi114 – 116Combined sources3
Beta strandi118 – 125Combined sources8
Turni127 – 129Combined sources3
Beta strandi131 – 141Combined sources11

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2DKSNMR-A33-149[»]
4WTZX-ray2.52G/H/I/J/K/L34-141[»]
4Y88X-ray1.45A34-141[»]
4YIQX-ray1.85A/C34-141[»]
ProteinModelPortaliP31997.
SMRiP31997.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP31997.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini35 – 142Ig-like V-typeAdd BLAST108
Domaini145 – 232Ig-like C2-type 1Add BLAST88
Domaini237 – 319Ig-like C2-type 2Add BLAST83

Sequence similaritiesi

Belongs to the immunoglobulin superfamily. CEA family.Curated

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IFE1. Eukaryota.
ENOG410YR1P. LUCA.
GeneTreeiENSGT00760000119187.
HOGENOMiHOG000233417.
HOVERGENiHBG007922.
InParanoidiP31997.
KOiK06499.
OMAiQFSVHPE.
OrthoDBiEOG091G0AMM.
PhylomeDBiP31997.
TreeFamiTF336859.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF13895. Ig_2. 1 hit.
PF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 3 hits.
SM00408. IGc2. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 3 hits.
PROSITEiPS50835. IG_LIKE. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P31997-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGPISAPSCR WRIPWQGLLL TASLFTFWNP PTTAQLTIEA VPSNAAEGKE
60 70 80 90 100
VLLLVHNLPQ DPRGYNWYKG ETVDANRRII GYVISNQQIT PGPAYSNRET
110 120 130 140 150
IYPNASLLMR NVTRNDTGSY TLQVIKLNLM SEEVTGQFSV HPETPKPSIS
160 170 180 190 200
SNNSNPVEDK DAVAFTCEPE TQNTTYLWWV NGQSLPVSPR LQLSNGNRTL
210 220 230 240 250
TLLSVTRNDV GPYECEIQNP ASANFSDPVT LNVLYGPDAP TISPSDTYYH
260 270 280 290 300
AGVNLNLSCH AASNPPSQYS WSVNGTFQQY TQKLFIPNIT TKNSGSYACH
310 320 330 340
TTNSATGRNR TTVRMITVSD ALVQGSSPGL SARATVSIMI GVLARVALI
Length:349
Mass (Da):38,154
Last modified:July 15, 1999 - v2
Checksum:iAACF74DA1AC839D8
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04984917G → V.Corresponds to variant rs28367882dbSNPEnsembl.1
Natural variantiVAR_04985045A → V.Corresponds to variant rs35221575dbSNPEnsembl.1
Natural variantiVAR_011721114R → K.Corresponds to variant rs1041997dbSNPEnsembl.1
Natural variantiVAR_049851322L → V.1 PublicationCorresponds to variant rs45476198dbSNPEnsembl.1
Natural variantiVAR_049852340I → M.Corresponds to variant rs8103051dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X52378 mRNA. Translation: CAA36604.1.
M33326 mRNA. Translation: AAA59914.1.
D90064 mRNA. Translation: BAA14108.1.
AC004558 Genomic DNA. Translation: AAC13659.1.
BC026263 mRNA. Translation: AAH26263.1.
Z95119 Genomic DNA. Translation: CAB08298.1.
CCDSiCCDS12610.1.
PIRiS13524. A34815.
RefSeqiNP_001807.2. NM_001816.3.
XP_016881684.1. XM_017026195.1.
UniGeneiHs.41.

Genome annotation databases

EnsembliENST00000244336; ENSP00000244336; ENSG00000124469.
GeneIDi1088.
KEGGihsa:1088.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X52378 mRNA. Translation: CAA36604.1.
M33326 mRNA. Translation: AAA59914.1.
D90064 mRNA. Translation: BAA14108.1.
AC004558 Genomic DNA. Translation: AAC13659.1.
BC026263 mRNA. Translation: AAH26263.1.
Z95119 Genomic DNA. Translation: CAB08298.1.
CCDSiCCDS12610.1.
PIRiS13524. A34815.
RefSeqiNP_001807.2. NM_001816.3.
XP_016881684.1. XM_017026195.1.
UniGeneiHs.41.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2DKSNMR-A33-149[»]
4WTZX-ray2.52G/H/I/J/K/L34-141[»]
4Y88X-ray1.45A34-141[»]
4YIQX-ray1.85A/C34-141[»]
ProteinModelPortaliP31997.
SMRiP31997.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107514. 3 interactors.
IntActiP31997. 3 interactors.
STRINGi9606.ENSP00000244336.

PTM databases

iPTMnetiP31997.
PhosphoSitePlusiP31997.

Polymorphism and mutation databases

BioMutaiCEACAM8.
DMDMi6166048.

Proteomic databases

PaxDbiP31997.
PeptideAtlasiP31997.
PRIDEiP31997.

Protocols and materials databases

DNASUi1088.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000244336; ENSP00000244336; ENSG00000124469.
GeneIDi1088.
KEGGihsa:1088.

Organism-specific databases

CTDi1088.
DisGeNETi1088.
GeneCardsiCEACAM8.
HGNCiHGNC:1820. CEACAM8.
HPAiCAB033676.
MIMi615747. gene.
neXtProtiNX_P31997.
OpenTargetsiENSG00000124469.
PharmGKBiPA26364.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IFE1. Eukaryota.
ENOG410YR1P. LUCA.
GeneTreeiENSGT00760000119187.
HOGENOMiHOG000233417.
HOVERGENiHBG007922.
InParanoidiP31997.
KOiK06499.
OMAiQFSVHPE.
OrthoDBiEOG091G0AMM.
PhylomeDBiP31997.
TreeFamiTF336859.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000124469-MONOMER.
ReactomeiR-HSA-1566977. Fibronectin matrix formation.
R-HSA-202733. Cell surface interactions at the vascular wall.
R-HSA-6798695. Neutrophil degranulation.

Miscellaneous databases

EvolutionaryTraceiP31997.
GeneWikiiCEACAM8.
GenomeRNAii1088.
PROiP31997.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000124469.
CleanExiHS_CEACAM8.
ExpressionAtlasiP31997. baseline and differential.
GenevisibleiP31997. HS.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF13895. Ig_2. 1 hit.
PF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 3 hits.
SM00408. IGc2. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 3 hits.
PROSITEiPS50835. IG_LIKE. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCEAM8_HUMAN
AccessioniPrimary (citable) accession number: P31997
Secondary accession number(s): O60399, Q16574
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 15, 1999
Last modified: November 30, 2016
This is version 160 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.