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Protein

Carcinoembryonic antigen-related cell adhesion molecule 8

Gene

CEACAM8

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

  • blood coagulation Source: Reactome
  • immune response Source: ProtInc
  • leukocyte migration Source: Reactome
Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-HSA-1566977. Fibronectin matrix formation.
R-HSA-202733. Cell surface interactions at the vascular wall.

Names & Taxonomyi

Protein namesi
Recommended name:
Carcinoembryonic antigen-related cell adhesion molecule 8
Alternative name(s):
CD67 antigen
Carcinoembryonic antigen CGM6
Non-specific cross-reacting antigen NCA-95
CD_antigen: CD66b
Gene namesi
Name:CEACAM8
Synonyms:CGM6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:1820. CEACAM8.

Subcellular locationi

GO - Cellular componenti

  • anchored component of membrane Source: UniProtKB-KW
  • extracellular exosome Source: UniProtKB
  • extracellular space Source: UniProtKB
  • integral component of plasma membrane Source: ProtInc
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26364.

Polymorphism and mutation databases

BioMutaiCEACAM8.
DMDMi6166048.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3434Add
BLAST
Chaini35 – 320286Carcinoembryonic antigen-related cell adhesion molecule 8PRO_0000014572Add
BLAST
Propeptidei321 – 34929Removed in mature formPRO_0000014573Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi104 – 1041N-linked (GlcNAc...)Sequence analysis
Glycosylationi111 – 1111N-linked (GlcNAc...)Sequence analysis
Glycosylationi115 – 1151N-linked (GlcNAc...)Sequence analysis
Glycosylationi152 – 1521N-linked (GlcNAc...)Sequence analysis
Disulfide bondi167 ↔ 215Curated
Glycosylationi173 – 1731N-linked (GlcNAc...)Sequence analysis
Glycosylationi197 – 1971N-linked (GlcNAc...)Sequence analysis
Glycosylationi224 – 2241N-linked (GlcNAc...)Sequence analysis
Glycosylationi256 – 2561N-linked (GlcNAc...)Sequence analysis
Disulfide bondi259 ↔ 299Curated
Glycosylationi274 – 2741N-linked (GlcNAc...)Sequence analysis
Glycosylationi288 – 2881N-linked (GlcNAc...)1 Publication
Glycosylationi309 – 3091N-linked (GlcNAc...)Sequence analysis
Lipidationi320 – 3201GPI-anchor amidated aspartate1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, GPI-anchor, Lipoprotein

Proteomic databases

PaxDbiP31997.
PeptideAtlasiP31997.
PRIDEiP31997.

PTM databases

iPTMnetiP31997.
PhosphoSiteiP31997.

Expressioni

Tissue specificityi

Expressed in leukocytes of chronic myeloid Leukemia patients and bone marrow.

Gene expression databases

BgeeiP31997.
CleanExiHS_CEACAM8.
ExpressionAtlasiP31997. baseline and differential.
GenevisibleiP31997. HS.

Organism-specific databases

HPAiCAB033676.

Interactioni

Protein-protein interaction databases

BioGridi107514. 3 interactions.
IntActiP31997. 3 interactions.
STRINGi9606.ENSP00000244336.

Structurei

Secondary structure

1
349
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi37 – 4610Combined sources
Beta strandi51 – 566Combined sources
Beta strandi64 – 729Combined sources
Helixi75 – 773Combined sources
Beta strandi78 – 836Combined sources
Turni84 – 874Combined sources
Beta strandi88 – 914Combined sources
Beta strandi99 – 1013Combined sources
Beta strandi107 – 1093Combined sources
Helixi114 – 1163Combined sources
Beta strandi118 – 1258Combined sources
Turni127 – 1293Combined sources
Beta strandi131 – 14111Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2DKSNMR-A33-149[»]
4Y88X-ray1.45A34-141[»]
4YIQX-ray1.85A/C34-141[»]
ProteinModelPortaliP31997.
SMRiP31997. Positions 34-316.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP31997.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini35 – 142108Ig-like V-typeAdd
BLAST
Domaini145 – 23288Ig-like C2-type 1Add
BLAST
Domaini237 – 31983Ig-like C2-type 2Add
BLAST

Sequence similaritiesi

Belongs to the immunoglobulin superfamily. CEA family.Curated

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IFE1. Eukaryota.
ENOG410YR1P. LUCA.
HOGENOMiHOG000233417.
HOVERGENiHBG007922.
InParanoidiP31997.
KOiK06499.
OMAiVRMITVS.
OrthoDBiEOG74BJS7.
PhylomeDBiP31997.
TreeFamiTF336859.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF13895. Ig_2. 1 hit.
PF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 3 hits.
SM00408. IGc2. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 3 hits.
PROSITEiPS50835. IG_LIKE. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P31997-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGPISAPSCR WRIPWQGLLL TASLFTFWNP PTTAQLTIEA VPSNAAEGKE
60 70 80 90 100
VLLLVHNLPQ DPRGYNWYKG ETVDANRRII GYVISNQQIT PGPAYSNRET
110 120 130 140 150
IYPNASLLMR NVTRNDTGSY TLQVIKLNLM SEEVTGQFSV HPETPKPSIS
160 170 180 190 200
SNNSNPVEDK DAVAFTCEPE TQNTTYLWWV NGQSLPVSPR LQLSNGNRTL
210 220 230 240 250
TLLSVTRNDV GPYECEIQNP ASANFSDPVT LNVLYGPDAP TISPSDTYYH
260 270 280 290 300
AGVNLNLSCH AASNPPSQYS WSVNGTFQQY TQKLFIPNIT TKNSGSYACH
310 320 330 340
TTNSATGRNR TTVRMITVSD ALVQGSSPGL SARATVSIMI GVLARVALI
Length:349
Mass (Da):38,154
Last modified:July 15, 1999 - v2
Checksum:iAACF74DA1AC839D8
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti17 – 171G → V.
Corresponds to variant rs28367882 [ dbSNP | Ensembl ].
VAR_049849
Natural varianti45 – 451A → V.
Corresponds to variant rs35221575 [ dbSNP | Ensembl ].
VAR_049850
Natural varianti114 – 1141R → K.
Corresponds to variant rs1041997 [ dbSNP | Ensembl ].
VAR_011721
Natural varianti322 – 3221L → V.1 Publication
Corresponds to variant rs45476198 [ dbSNP | Ensembl ].
VAR_049851
Natural varianti340 – 3401I → M.
Corresponds to variant rs8103051 [ dbSNP | Ensembl ].
VAR_049852

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X52378 mRNA. Translation: CAA36604.1.
M33326 mRNA. Translation: AAA59914.1.
D90064 mRNA. Translation: BAA14108.1.
AC004558 Genomic DNA. Translation: AAC13659.1.
BC026263 mRNA. Translation: AAH26263.1.
Z95119 Genomic DNA. Translation: CAB08298.1.
CCDSiCCDS12610.1.
PIRiS13524. A34815.
RefSeqiNP_001807.2. NM_001816.3.
UniGeneiHs.41.

Genome annotation databases

EnsembliENST00000244336; ENSP00000244336; ENSG00000124469.
GeneIDi1088.
KEGGihsa:1088.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X52378 mRNA. Translation: CAA36604.1.
M33326 mRNA. Translation: AAA59914.1.
D90064 mRNA. Translation: BAA14108.1.
AC004558 Genomic DNA. Translation: AAC13659.1.
BC026263 mRNA. Translation: AAH26263.1.
Z95119 Genomic DNA. Translation: CAB08298.1.
CCDSiCCDS12610.1.
PIRiS13524. A34815.
RefSeqiNP_001807.2. NM_001816.3.
UniGeneiHs.41.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2DKSNMR-A33-149[»]
4Y88X-ray1.45A34-141[»]
4YIQX-ray1.85A/C34-141[»]
ProteinModelPortaliP31997.
SMRiP31997. Positions 34-316.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107514. 3 interactions.
IntActiP31997. 3 interactions.
STRINGi9606.ENSP00000244336.

PTM databases

iPTMnetiP31997.
PhosphoSiteiP31997.

Polymorphism and mutation databases

BioMutaiCEACAM8.
DMDMi6166048.

Proteomic databases

PaxDbiP31997.
PeptideAtlasiP31997.
PRIDEiP31997.

Protocols and materials databases

DNASUi1088.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000244336; ENSP00000244336; ENSG00000124469.
GeneIDi1088.
KEGGihsa:1088.

Organism-specific databases

CTDi1088.
GeneCardsiCEACAM8.
HGNCiHGNC:1820. CEACAM8.
HPAiCAB033676.
MIMi615747. gene.
neXtProtiNX_P31997.
PharmGKBiPA26364.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IFE1. Eukaryota.
ENOG410YR1P. LUCA.
HOGENOMiHOG000233417.
HOVERGENiHBG007922.
InParanoidiP31997.
KOiK06499.
OMAiVRMITVS.
OrthoDBiEOG74BJS7.
PhylomeDBiP31997.
TreeFamiTF336859.

Enzyme and pathway databases

ReactomeiR-HSA-1566977. Fibronectin matrix formation.
R-HSA-202733. Cell surface interactions at the vascular wall.

Miscellaneous databases

EvolutionaryTraceiP31997.
GeneWikiiCEACAM8.
GenomeRNAii1088.
NextBioi4526.
PROiP31997.
SOURCEiSearch...

Gene expression databases

BgeeiP31997.
CleanExiHS_CEACAM8.
ExpressionAtlasiP31997. baseline and differential.
GenevisibleiP31997. HS.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF13895. Ig_2. 1 hit.
PF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 3 hits.
SM00408. IGc2. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 3 hits.
PROSITEiPS50835. IG_LIKE. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning of a carcinoembryonic antigen gene family member expressed in leukocytes of chronic myeloid leukemia patients and bone marrow."
    Berling B., Kolbinger F., Grunert F., Thompson J.A., Brombacher F., Buchegger F., Vkleist S., Zimmermann W.
    Cancer Res. 50:6534-6539(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], GPI-ANCHOR AT ASP-320.
    Tissue: Spleen.
  2. "Characterization of a cDNA clone encoding a new species of the nonspecific cross-reacting antigen (NCA), a member of the CEA gene family."
    Arakawa F., Kuroki M., Misumi Y., Oikawa S., Nakazato H., Matsuoka Y.
    Biochem. Biophys. Res. Commun. 166:1063-1071(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT VAL-322.
  3. "Identification of three new genes and estimation of the size of the carcinoembryonic antigen family."
    Khan W.N., Fraengsmyr L., Teglund S., Israelsson A., Bremer K., Hammarstroem S.
    Genomics 14:384-390(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  4. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Lung.
  6. "Mice transgenic for the human CGM6 gene express its product, the granulocyte marker CD66b, exclusively in granulocytes."
    Eades-Perner A., Thompson J., van der Putten H., Zimmermann W.
    Blood 91:663-672(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-21.
  7. "Identification of N-linked glycoproteins in human saliva by glycoprotein capture and mass spectrometry."
    Ramachandran P., Boontheung P., Xie Y., Sondej M., Wong D.T., Loo J.A.
    J. Proteome Res. 5:1493-1503(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-288.
    Tissue: Saliva.
  8. "Solution structure of the first Ig-like domain of human carcinoembryonic antigen related cell adhesion molecule 8."
    RIKEN structural genomics initiative (RSGI)
    Submitted (MAY-2007) to the PDB data bank
    Cited for: STRUCTURE BY NMR OF 33-154.

Entry informationi

Entry nameiCEAM8_HUMAN
AccessioniPrimary (citable) accession number: P31997
Secondary accession number(s): O60399, Q16574
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 15, 1999
Last modified: May 11, 2016
This is version 154 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.