P31995 (FCG2C_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Low affinity immunoglobulin gamma Fc region receptor II-c
Short name=IgG Fc receptor II-c

Alternative name(s):
CDw32
Fc-gamma RII-c
Short name=Fc-gamma-RIIc
Short name=FcRII-c
CD_antigen=CD32

Gene names

Name:	FCGR2C
Synonyms:	CD32, FCG2, IGFR2

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	323 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Receptor for the Fc region of complexed immunoglobulins gamma. Low affinity receptor. Involved in a variety of effector and regulatory functions such as phagocytosis of immune complexes and modulation of antibody production by B-cells.
Subcellular location	Isoform IIC4: Cytoplasm Probable. Isoform IIC3: Cell membrane; Single-pass type I membrane protein. Isoform IIC2: Cell membrane; Single-pass type I membrane protein. Isoform IIC1: Cell membrane; Single-pass type I membrane protein.
Tissue specificity	Isoform IIC1 is detected in monocytes, macrophages, polymorphonuclear cells and natural killer cells.
Domain	Contains an intracytoplasmic twice repeated motif referred as immunoreceptor tyrosine-based activator motif (ITAM). These motifs are involved in triggering cell activation upon receptors aggregation.
Post-translational modification	Phosphorylated by SRC-type Tyr-kinases such as LYN, BLK, FYN and SYK. Ref.3
Sequence similarities	Contains 2 Ig-like C2-type (immunoglobulin-like) domains.
Caution	Has sometimes been attributed to correspond to FcR-IIB.
Sequence caution	The sequence CAA35643.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Cellular component	Cell membrane Cytoplasm Membrane
Coding sequence diversity	Alternative splicing
Domain	Immunoglobulin domain Repeat Signal Transmembrane Transmembrane helix
Ligand	IgG-binding protein
Molecular function	Receptor
PTM	Disulfide bond Glycoprotein Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	immune response Non-traceable author statement Ref.1. Source: UniProtKB
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell integral to membrane Non-traceable author statement Ref.1. Source: UniProtKB plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	transmembrane signaling receptor activity Non-traceable author statement Ref.1. Source: UniProtKB
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
CRP	P02741	2	EBI-1396036,EBI-1395983
NCK1	P16333	2	EBI-1396036,EBI-389883

Alternative products

This entry describes 4 isoforms produced by alternative splicing. [Align] [Select]

Isoform IIC1 (identifier: P31995-1)

Also known as: C1;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform IIC2 (identifier: P31995-2)

The sequence of this isoform differs from the canonical sequence as follows:
     267-323: PPGRQMIAIRKRQPEETNNDYETADGGYMTLNPRAPTDDDKNIYLTLPPNDHVNSNN → MLSCSHLDVK

Isoform IIC3 (identifier: P31995-3)

The sequence of this isoform differs from the canonical sequence as follows:
     255-323: NSTDPVKAAQ...PPNDHVNSNN → TWTSNDCHQKETT

Isoform IIC4 (identifier: P31995-4)

The sequence of this isoform differs from the canonical sequence as follows:
     216-323: APSSSPMGII...PPNDHVNSNN → GPRLRTAAKQSSLVGAEVP

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 42	42	Potential
	Chain	43 – 323	281	Low affinity immunoglobulin gamma Fc region receptor II-c		PRO_0000015148
Regions
	Topological domain	43 – 223	181	Extracellular Potential
	Transmembrane	224 – 246	23	Helical; Potential
	Topological domain	247 – 323	77	Cytoplasmic Potential
	Domain	48 – 127	80	Ig-like C2-type 1
	Domain	131 – 213	83	Ig-like C2-type 2
Amino acid modifications
	Modified residue	294	1	Phosphotyrosine; by SRC-type Tyr-kinases Ref.3
	Modified residue	310	1	Phosphotyrosine; by SRC-type Tyr-kinases Ref.3
	Glycosylation	106	1	N-linked (GlcNAc...) Potential
	Glycosylation	180	1	N-linked (GlcNAc...) Potential
	Glycosylation	187	1	N-linked (GlcNAc...) Potential
	Disulfide bond	71 ↔ 113		By similarity
	Disulfide bond	152 ↔ 196		By similarity
Natural variations
	Alternative sequence	216 – 323	108	APSSS…VNSNN → GPRLRTAAKQSSLVGAEVP in isoform IIC4.		VSP_002644
	Alternative sequence	255 – 323	69	NSTDP…VNSNN → TWTSNDCHQKETT in isoform IIC3.		VSP_002645
	Alternative sequence	267 – 323	57	PPGRQ…VNSNN → MLSCSHLDVK in isoform IIC2.		VSP_002646
Experimental info
	Sequence conflict	151	1	R → K in AAC12810. Ref.2
	Sequence conflict	164	1	T → I in AAC12809. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Isoform IIC1 (C1) [UniParc]. Last modified July 1, 1993. Version 1. Checksum: DC4C1A22A0DE4572	FASTA	323	35,578
	10 20 30 40 50 60 MGILSFLPVL ATESDWADCK SPQPWGHMLL WTAVLFLAPV AGTPAAPPKA VLKLEPQWIN 70 80 90 100 110 120 VLQEDSVTLT CRGTHSPESD SIQWFHNGNL IPTHTQPSYR FKANNNDSGE YTCQTGQTSL 130 140 150 160 170 180 SDPVHLTVLS EWLVLQTPHL EFQEGETIVL RCHSWKDKPL VKVTFFQNGK SKKFSRSDPN 190 200 210 220 230 240 FSIPQANHSH SGDYHCTGNI GYTLYSSKPV TITVQAPSSS PMGIIVAVVT GIAVAAIVAA 250 260 270 280 290 300 VVALIYCRKK RISANSTDPV KAAQFEPPGR QMIAIRKRQP EETNNDYETA DGGYMTLNPR 310 320 APTDDDKNIY LTLPPNDHVN SNN
	Isoform IIC2 [UniParc]. Checksum: 395960C5B26197F5	FASTA	276	30,241
	10 20 30 40 50 60 MGILSFLPVL ATESDWADCK SPQPWGHMLL WTAVLFLAPV AGTPAAPPKA VLKLEPQWIN 70 80 90 100 110 120 VLQEDSVTLT CRGTHSPESD SIQWFHNGNL IPTHTQPSYR FKANNNDSGE YTCQTGQTSL 130 140 150 160 170 180 SDPVHLTVLS EWLVLQTPHL EFQEGETIVL RCHSWKDKPL VKVTFFQNGK SKKFSRSDPN 190 200 210 220 230 240 FSIPQANHSH SGDYHCTGNI GYTLYSSKPV TITVQAPSSS PMGIIVAVVT GIAVAAIVAA 250 260 270 VVALIYCRKK RISANSTDPV KAAQFEMLSC SHLDVK
	Isoform IIC3 [UniParc]. Checksum: AD2C3AB385122162	FASTA	267	29,370
	10 20 30 40 50 60 MGILSFLPVL ATESDWADCK SPQPWGHMLL WTAVLFLAPV AGTPAAPPKA VLKLEPQWIN 70 80 90 100 110 120 VLQEDSVTLT CRGTHSPESD SIQWFHNGNL IPTHTQPSYR FKANNNDSGE YTCQTGQTSL 130 140 150 160 170 180 SDPVHLTVLS EWLVLQTPHL EFQEGETIVL RCHSWKDKPL VKVTFFQNGK SKKFSRSDPN 190 200 210 220 230 240 FSIPQANHSH SGDYHCTGNI GYTLYSSKPV TITVQAPSSS PMGIIVAVVT GIAVAAIVAA 250 260 VVALIYCRKK RISATWTSND CHQKETT
	Isoform IIC4 [UniParc]. Checksum: E593027A497A89B3	FASTA	234	25,907
	10 20 30 40 50 60 MGILSFLPVL ATESDWADCK SPQPWGHMLL WTAVLFLAPV AGTPAAPPKA VLKLEPQWIN 70 80 90 100 110 120 VLQEDSVTLT CRGTHSPESD SIQWFHNGNL IPTHTQPSYR FKANNNDSGE YTCQTGQTSL 130 140 150 160 170 180 SDPVHLTVLS EWLVLQTPHL EFQEGETIVL RCHSWKDKPL VKVTFFQNGK SKKFSRSDPN 190 200 210 220 230 FSIPQANHSH SGDYHCTGNI GYTLYSSKPV TITVQGPRLR TAAKQSSLVG AEVP

References

[1]	"Human IgG Fc receptor (hFcRII; CD32) exists as multiple isoforms in macrophages, lymphocytes and IgG-transporting placental epithelium." Stuart S.G., Simister N.E., Clarkson S.B., Kacinski B.M., Shapiro M., Mellman I. EMBO J. 8:3657-3666(1989) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM IIC1). Tissue: Placenta.
[2]	"Expression of functional CD32 molecules on human NK cells is determined by an allelic polymorphism of the FcgammaRIIC gene." Metes D., Ernst L.K., Chambers W.H., Sulica A., Herberman R.B., Morel P.A. Blood 91:2369-2380(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS IIC1; IIC2; IIC3 AND IIC4). Tissue: Natural killer cell.
[3]	"In vivo and in vitro specificity of protein tyrosine kinases for immunoglobulin G receptor (FcgammaRII) phosphorylation." Bewarder N., Weinrich V., Budde P., Hartmann D., Flaswinkel H., Reth M., Frey J. Mol. Cell. Biol. 16:4735-4743(1996) [PubMed] [Europe PMC] [Abstract] Cited for: PHOSPHORYLATION AT TYR-294 AND TYR-310.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X17652 mRNA. Translation: CAA35642.1. X17652 mRNA. Translation: CAA35643.1. Different initiation. U90938 mRNA. Translation: AAC12807.1. U90939 mRNA. Translation: AAC12808.1. U90940 mRNA. Translation: AAC12809.1. U90941 mRNA. Translation: AAC12810.1.
IPI	IPI00013971. IPI00215903. IPI00215904. IPI00215905.
PIR	S06946.
UniGene	Hs.656750.
3D structure databases
ProteinModelPortal	P31995.
ModBase	Search...
Protein-protein interaction databases
IntAct	P31995. 7 interactions.
MINT	MINT-7241761.
STRING	9606.ENSP00000420811.
PTM databases
PhosphoSite	P31995.
Polymorphism databases
DMDM	399478.
Proteomic databases
PRIDE	P31995.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
UCSC	uc009wum.2. human.
Organism-specific databases
GeneCards	GC01P161551.
H-InvDB	HIX0056771.
HGNC	HGNC:15626. FCGR2C.
MIM	612169. gene.
neXtProt	NX_P31995.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	HBG051602.
Gene expression databases
CleanEx	HS_FCGR2C.
Genevestigator	P31995.
GermOnline	ENSG00000203746. Homo sapiens.
Family and domain databases
Gene3D	2.60.40.10. 2 hits.
InterPro	IPR007110. Ig-like_dom. IPR013783. Ig-like_fold. IPR003599. Ig_sub. [Graphical view]
SMART	SM00409. IG. 2 hits. [Graphical view]
PROSITE	PS50835. IG_LIKE. 2 hits. [Graphical view]
ProtoNet	Search...
Other
DrugBank	DB00054. Abciximab. DB00051. Adalimumab. DB00092. Alefacept. DB00087. Alemtuzumab. DB00074. Basiliximab. DB00112. Bevacizumab. DB00002. Cetuximab. DB00111. Daclizumab. DB00095. Efalizumab. DB00005. Etanercept. DB00056. Gemtuzumab ozogamicin. DB00078. Ibritumomab. DB00028. Immune globulin. DB00075. Muromonab. DB00108. Natalizumab. DB00110. Palivizumab. DB00073. Rituximab. DB00081. Tositumomab. DB00072. Trastuzumab.
SOURCE	Search...

Entry information

Entry name

FCG2C_HUMAN

Accession

Primary (citable) accession number: P31995
Secondary accession number(s): O00523, O00524, O00525

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 1, 1993
Last sequence update:	July 1, 1993
Last modified:	May 1, 2013
This is version 121 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.