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P31994 (FCG2B_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 162. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (7) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Low affinity immunoglobulin gamma Fc region receptor II-b

Short name=IgG Fc receptor II-b
Alternative name(s):
CDw32
Fc-gamma RII-b
Short name=Fc-gamma-RIIb
Short name=FcRII-b
CD_antigen=CD32
Gene names
Name:FCGR2B
Synonyms:CD32, FCG2, IGFR2
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length310 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Receptor for the Fc region of complexed or aggregated immunoglobulins gamma. Low affinity receptor. Involved in a variety of effector and regulatory functions such as phagocytosis of immune complexes and modulation of antibody production by B-cells. Binding to this receptor results in down-modulation of previous state of cell activation triggered via antigen receptors on B-cells (BCR), T-cells (TCR) or via another Fc receptor. Isoform IIB1 fails to mediate endocytosis or phagocytosis. Isoform IIB2 does not trigger phagocytosis.

Subunit structure

Isoform IIB1 interacts with measles virus N protein. N protein is released in the blood following lysis of measles infected cells. This interaction presumably block inflammatory immune response. Interacts with INPP5D/SHIP1. Interacts with FGR. Interacts with LYN. Ref.9 Ref.11 Ref.12

Subcellular location

Cell membrane; Single-pass type I membrane protein.

Tissue specificity

Is the most broadly distributed Fc-gamma-receptor. Expressed in monocyte, neutrophils, macrophages, basophils, eosinophils, Langerhans cells, B-cells, platelets cells and placenta (endothelial cells). Not detected in natural killer cells.

Domain

Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases.

Post-translational modification

Phosphorylated by the SRC-type Tyr-kinases LYN and BLK. Ref.10

Polymorphism

Note=FCGR2B polymorphisms can influence susceptibility or resistance to malaria [MIM:611162].

Involvement in disease

A chromosomal aberration involving FCGR2B is found in a follicular lymphoma. Translocation t(1;22)(q22;q11). The translocation leads to the hyperexpression of the receptor. This may play a role in the tumor progression.

Systemic lupus erythematosus (SLE) [MIM:152700]: A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow.
Note: Disease susceptibility is associated with variations affecting the gene represented in this entry. Ref.8 Ref.16

Sequence similarities

Contains 2 Ig-like C2-type (immunoglobulin-like) domains.

Caution

Has sometimes been attributed to correspond to FcR-IIC.

Sequence caution

The sequence CAA35645.1 differs from that shown. Reason: Erroneous initiation.

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]
Isoform IIB1 (identifier: P31994-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform IIB2 (identifier: P31994-2)

The sequence of this isoform differs from the canonical sequence as follows:
     254-272: Missing.
Isoform IIB3 (identifier: P31994-3)

The sequence of this isoform differs from the canonical sequence as follows:
     39-45: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 4242 Potential
Chain43 – 310268Low affinity immunoglobulin gamma Fc region receptor II-b
PRO_0000015147

Regions

Topological domain43 – 217175Extracellular Potential
Transmembrane218 – 24023Helical; Potential
Topological domain241 – 31070Cytoplasmic Potential
Domain48 – 12780Ig-like C2-type 1
Domain131 – 21383Ig-like C2-type 2
Motif290 – 2956ITIM motif

Amino acid modifications

Modified residue2921Phosphotyrosine; by SRC-type Tyr-kinases Ref.10
Glycosylation1061N-linked (GlcNAc...) Potential
Glycosylation1801N-linked (GlcNAc...) Potential
Glycosylation1871N-linked (GlcNAc...) Potential
Disulfide bond71 ↔ 113 Ref.13
Disulfide bond152 ↔ 196 Ref.13

Natural variations

Alternative sequence39 – 457Missing in isoform IIB3.
VSP_002642
Alternative sequence254 – 27219Missing in isoform IIB2.
VSP_002643
Natural variant831Q → P.
Corresponds to variant rs5017567 [ dbSNP | Ensembl ].
VAR_059430
Natural variant2051Y → F. Ref.3
Corresponds to variant rs1050499 [ dbSNP | Ensembl ].
VAR_027045
Natural variant2321I → T Associated with susceptibility to SLE; associated with resistance to malaria; found at an increased frequency in African and Asian populations from areas where malaria is endemic; enhances phagocytosis of Plasmodium falciparum-infected erythrocytes in vitro. Ref.8 Ref.15 Ref.16
Corresponds to variant rs1050501 [ dbSNP | Ensembl ].
VAR_015515
Natural variant2581Y → D. Ref.14
Corresponds to variant rs148534844 [ dbSNP | Ensembl ].
VAR_008798

Experimental info

Sequence conflict461Missing in AAD00637. Ref.1
Sequence conflict461Missing in AAD00638. Ref.1
Sequence conflict461Missing in AAD00639. Ref.1
Sequence conflict461Missing in AAD00644. Ref.1
Sequence conflict1781D → I in CAA35644. Ref.2
Sequence conflict1781D → I in CAA35645. Ref.2
Sequence conflict2301T → I in CAA35644. Ref.2
Sequence conflict2301T → I in CAA35645. Ref.2
Sequence conflict2421V → G in CAA35644. Ref.2
Sequence conflict2421V → G in CAA35645. Ref.2
Sequence conflict2751P → S Ref.2

Secondary structure

........................................ 310
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Isoform IIB1 [UniParc].

Last modified May 30, 2000. Version 2.
Checksum: 2186F8538FF01F36

FASTA31034,044
        10         20         30         40         50         60 
MGILSFLPVL ATESDWADCK SPQPWGHMLL WTAVLFLAPV AGTPAAPPKA VLKLEPQWIN 

        70         80         90        100        110        120 
VLQEDSVTLT CRGTHSPESD SIQWFHNGNL IPTHTQPSYR FKANNNDSGE YTCQTGQTSL 

       130        140        150        160        170        180 
SDPVHLTVLS EWLVLQTPHL EFQEGETIVL RCHSWKDKPL VKVTFFQNGK SKKFSRSDPN 

       190        200        210        220        230        240 
FSIPQANHSH SGDYHCTGNI GYTLYSSKPV TITVQAPSSS PMGIIVAVVT GIAVAAIVAA 

       250        260        270        280        290        300 
VVALIYCRKK RISALPGYPE CREMGETLPE KPANPTNPDE ADKVGAENTI TYSLLMHPDA 

       310 
LEEPDDQNRI 

« Hide

Isoform IIB2 [UniParc].

Checksum: 3B76609541B30962
Show »

FASTA29131,944
Isoform IIB3 [UniParc].

Checksum: B84833348A175687
Show »

FASTA30333,450

References

« Hide 'large scale' references
[1]"Fc-gamma-RIIb nucleotide sequences in SLE and non-SLE humans in vivo derived lymphocytes."
Ng S., Sinclair N.R.S., Anderson C., Bell D.A., Cairns E.
Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS IIB1 AND IIB2).
Tissue: Lymphocyte.
[2]"Human IgG Fc receptor (hFcRII; CD32) exists as multiple isoforms in macrophages, lymphocytes and IgG-transporting placental epithelium."
Stuart S.G., Simister N.E., Clarkson S.B., Kacinski B.M., Shapiro M., Mellman I.
EMBO J. 8:3657-3666(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM IIB2).
Tissue: Placenta.
[3]"Structure and expression of human IgG FcRII(CD32). Functional heterogeneity is encoded by the alternatively spliced products of multiple genes."
Brooks D.G., Qiu W.Q., Luster A.D., Ravetch J.V.
J. Exp. Med. 170:1369-1385(1989) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS IIB1; IIB2 AND IIB3), VARIANT PHE-205.
[4]"Distribution, inducibility and biological function of the cloned and expressed human beta Fc receptor II."
Engelhardt W., Geerds C., Frey J.
Eur. J. Immunol. 20:1367-1377(1990) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM IIB2).
Tissue: Placenta.
[5]"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM IIB2).
[6]"The DNA sequence and biological annotation of human chromosome 1."
Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. expand/collapse author list , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS IIB1 AND IIB2).
Tissue: Skin.
[8]"Fc gamma receptor gene polymorphisms in Japanese patients with systemic lupus erythematosus: contribution of FCGR2B to genetic susceptibility."
Kyogoku C., Dijstelbloem H.M., Tsuchiya N., Hatta Y., Kato H., Yamaguchi A., Fukazawa T., Jansen M.D., Hashimoto H., van de Winkel J.G.J., Kallenberg C.G.M., Tokunaga K.
Arthritis Rheum. 46:1242-1254(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 132-253, INVOLVEMENT IN SLE, VARIANT THR-232.
[9]"Association of immunoglobulin G Fc receptor II with Src-like protein-tyrosine kinase Fgr in neutrophils."
Hamada F., Aoki M., Akiyama T., Toyoshima K.
Proc. Natl. Acad. Sci. U.S.A. 90:6305-6309(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH FGR.
[10]"In vivo and in vitro specificity of protein tyrosine kinases for immunoglobulin G receptor (FcgammaRII) phosphorylation."
Bewarder N., Weinrich V., Budde P., Hartmann D., Flaswinkel H., Reth M., Frey J.
Mol. Cell. Biol. 16:4735-4743(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: PHOSPHORYLATION AT TYR-292.
[11]"Fc gamma receptor type IIb induced recruitment of inositol and protein phosphatases to the signal transductory complex of human B-cell."
Sarmay G., Koncz G., Pecht I., Gergely J.
Immunol. Lett. 57:159-164(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH LYN.
[12]"Measles virus nucleoprotein induces cell-proliferation arrest and apoptosis through NTAIL-NR and NCORE-FcgammaRIIB1 interactions, respectively."
Laine D., Bourhis J.-M., Longhi S., Flacher M., Cassard L., Canard B., Sautes-Fridman C., Rabourdin-Combe C., Valentin H.
J. Gen. Virol. 86:1771-1784(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH MEASLES VIRUS N PROTEIN.
[13]"Crystal structure of the soluble form of the human fcgamma-receptor IIb: a new member of the immunoglobulin superfamily at 1.7 A resolution."
Sondermann P., Huber R., Jacob U.
EMBO J. 18:1095-1103(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (1.74 ANGSTROMS) OF 46-217, DISULFIDE BONDS.
[14]"Interaction of a human Fc gamma RIIb1 (CD32) isoform with murine and human IgG subclasses."
Warmerdam P.A., van den Herik-Oudijk I.E., Parren P.W., Westerdaal N.A., van de Winkel J.G., Capel P.J.
Int. Immunol. 5:239-247(1993) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANT ASP-258.
[15]"Systemic lupus erythematosus-associated defects in the inhibitory receptor FcgammaRIIb reduce susceptibility to malaria."
Clatworthy M.R., Willcocks L., Urban B., Langhorne J., Williams T.N., Peshu N., Watkins N.A., Floto R.A., Smith K.G.
Proc. Natl. Acad. Sci. U.S.A. 104:7169-7174(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: ASSOCIATION OF VARIANT THR-232 WITH RESISTANCE TO MALARIA, CHARACTERIZATION OF VARIANT THR-232.
[16]"A defunctioning polymorphism in FCGR2B is associated with protection against malaria but susceptibility to systemic lupus erythematosus."
Willcocks L.C., Carr E.J., Niederer H.A., Rayner T.F., Williams T.N., Yang W., Scott J.A., Urban B.C., Peshu N., Vyse T.J., Lau Y.L., Lyons P.A., Smith K.G.
Proc. Natl. Acad. Sci. U.S.A. 107:7881-7885(2010) [PubMed] [Europe PMC] [Abstract]
Cited for: ASSOCIATION OF VARIANT THR-232 WITH SUSCEPTIBILITY TO SLE, RESISTANCE TO MALARIA.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U87560 mRNA. Translation: AAD00627.1.
U87561 mRNA. Translation: AAD00628.1.
U87562 mRNA. Translation: AAD00629.1.
U87563 mRNA. Translation: AAD00630.1.
U87564 mRNA. Translation: AAD00631.1.
U87565 mRNA. Translation: AAD00632.1.
U87566 mRNA. Translation: AAD00633.1.
U87567 mRNA. Translation: AAD00634.1.
U87568 mRNA. Translation: AAD00635.1.
U87569 mRNA. Translation: AAD00636.1.
U87570 mRNA. Translation: AAD00637.1.
U87571 mRNA. Translation: AAD00638.1.
U87572 mRNA. Translation: AAD00639.1.
U87573 mRNA. Translation: AAD00640.1.
U87574 mRNA. Translation: AAD00641.1.
U87575 mRNA. Translation: AAD00642.1.
U87576 mRNA. Translation: AAD00643.1.
U87577 mRNA. Translation: AAD00644.1.
X17653 mRNA. Translation: CAA35644.1.
X17653 mRNA. Translation: CAA35645.1. Different initiation.
M31933 mRNA. Translation: AAA35841.1.
M31934 mRNA. Translation: AAA35842.1.
M31935 mRNA. Translation: AAA35843.1.
X52473 mRNA. Translation: CAA36713.1.
CR407635 mRNA. Translation: CAG28563.1.
AL359541 Genomic DNA. No translation available.
BC031992 mRNA. Translation: AAH31992.1.
BC146678 mRNA. Translation: AAI46679.1.
AB050934 mRNA. Translation: BAB92093.1.
PIRJL0119.
RefSeqNP_001002273.1. NM_001002273.2.
NP_001002274.1. NM_001002274.2.
NP_001002275.1. NM_001002275.2.
NP_001177757.1. NM_001190828.1.
NP_003992.3. NM_004001.4.
UniGeneHs.654395.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
2FCBX-ray1.74A46-217[»]
3WJJX-ray2.60C45-217[»]
ProteinModelPortalP31994.
SMRP31994. Positions 50-213.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid108507. 2 interactions.
IntActP31994. 14 interactions.
MINTMINT-1376812.
STRING9606.ENSP00000351497.

Chemistry

DrugBankDB00054. Abciximab.
DB00051. Adalimumab.
DB00092. Alefacept.
DB00087. Alemtuzumab.
DB00074. Basiliximab.
DB00112. Bevacizumab.
DB00002. Cetuximab.
DB00111. Daclizumab.
DB00095. Efalizumab.
DB00005. Etanercept.
DB00056. Gemtuzumab ozogamicin.
DB00078. Ibritumomab.
DB00028. Immune globulin.
DB00075. Muromonab.
DB00108. Natalizumab.
DB00110. Palivizumab.
DB00073. Rituximab.
DB00081. Tositumomab.
DB00072. Trastuzumab.

Protein family/group databases

MEROPSI43.001.

PTM databases

PhosphoSiteP31994.

Polymorphism databases

DMDM8039788.

Proteomic databases

PaxDbP31994.
PRIDEP31994.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000236937; ENSP00000236937; ENSG00000072694. [P31994-2]
ENST00000358671; ENSP00000351497; ENSG00000072694. [P31994-1]
ENST00000367960; ENSP00000356937; ENSG00000072694. [P31994-3]
ENST00000367961; ENSP00000356938; ENSG00000072694. [P31994-3]
ENST00000367962; ENSP00000356939; ENSG00000072694. [P31994-1]
ENST00000403078; ENSP00000386038; ENSG00000072694. [P31994-2]
GeneID2213.
KEGGhsa:2213.
UCSCuc001gay.2. human. [P31994-1]
uc001gba.2. human. [P31994-2]
uc009wun.2. human. [P31994-3]

Organism-specific databases

CTD2213.
GeneCardsGC01P161552.
HGNCHGNC:3618. FCGR2B.
HPACAB007796.
MIM152700. phenotype.
604590. gene.
611162. phenotype.
neXtProtNX_P31994.
Orphanet536. Systemic lupus erythematosus.
PharmGKBPA28064.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG25177.
HOGENOMHOG000251632.
HOVERGENHBG051602.
InParanoidP31994.
KOK12560.
OMAHDYQNHI.
OrthoDBEOG708W0N.
PhylomeDBP31994.
TreeFamTF335097.

Enzyme and pathway databases

ReactomeREACT_6900. Immune System.
SignaLinkP31994.

Gene expression databases

ArrayExpressP31994.
BgeeP31994.
CleanExHS_FCGR2B.
GenevestigatorP31994.

Family and domain databases

Gene3D2.60.40.10. 2 hits.
InterProIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
[Graphical view]
SMARTSM00409. IG. 2 hits.
[Graphical view]
PROSITEPS50835. IG_LIKE. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceP31994.
GeneWikiFCGR2B.
GenomeRNAi2213.
NextBio8967.
PROP31994.
SOURCESearch...

Entry information

Entry nameFCG2B_HUMAN
AccessionPrimary (citable) accession number: P31994
Secondary accession number(s): A6H8N3 expand/collapse secondary AC list , O95649, Q53X85, Q5VXA9, Q8NIA1
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: May 30, 2000
Last modified: April 16, 2014
This is version 162 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 1

Human chromosome 1: entries, gene names and cross-references to MIM

Human cell differentiation molecules

CD nomenclature of surface proteins of human leucocytes and list of entries