Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Low affinity immunoglobulin gamma Fc region receptor II-b

Gene

FCGR2B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for the Fc region of complexed or aggregated immunoglobulins gamma. Low affinity receptor. Involved in a variety of effector and regulatory functions such as phagocytosis of immune complexes and modulation of antibody production by B-cells. Binding to this receptor results in down-modulation of previous state of cell activation triggered via antigen receptors on B-cells (BCR), T-cells (TCR) or via another Fc receptor. Isoform IIB1 fails to mediate endocytosis or phagocytosis. Isoform IIB2 does not trigger phagocytosis.

GO - Molecular functioni

  • amyloid-beta binding Source: ARUK-UCL
  • IgG binding Source: ARUK-UCL
  • low-affinity IgG receptor activity Source: ARUK-UCL
  • macromolecular complex binding Source: ARUK-UCL

GO - Biological processi

  • antigen processing and presentation of exogenous peptide antigen via MHC class II Source: ARUK-UCL
  • cellular response to amyloid-beta Source: ARUK-UCL
  • cellular response to molecule of bacterial origin Source: ARUK-UCL
  • cerebellum development Source: BHF-UCL
  • defense response Source: ARUK-UCL
  • Fc-gamma receptor signaling pathway involved in phagocytosis Source: ARUK-UCL
  • follicular B cell differentiation Source: ARUK-UCL
  • follicular dendritic cell activation Source: ARUK-UCL
  • immune complex clearance by monocytes and macrophages Source: ARUK-UCL
  • immune response Source: ProtInc
  • immunoglobulin mediated immune response Source: ARUK-UCL
  • inflammatory response Source: ARUK-UCL
  • mature B cell differentiation involved in immune response Source: ARUK-UCL
  • negative regulation of acute inflammatory response to antigenic stimulus Source: ARUK-UCL
  • negative regulation of antibody-dependent cellular cytotoxicity Source: ARUK-UCL
  • negative regulation of B cell activation Source: ARUK-UCL
  • negative regulation of B cell proliferation Source: ARUK-UCL
  • negative regulation of cytokine secretion Source: ARUK-UCL
  • negative regulation of cytotoxic T cell degranulation Source: ARUK-UCL
  • negative regulation of dendritic cell antigen processing and presentation Source: ARUK-UCL
  • negative regulation of dendritic cell differentiation Source: ARUK-UCL
  • negative regulation of humoral immune response mediated by circulating immunoglobulin Source: ARUK-UCL
  • negative regulation of immune response Source: ARUK-UCL
  • negative regulation of immunoglobulin production Source: ARUK-UCL
  • negative regulation of interleukin-10 production Source: ARUK-UCL
  • negative regulation of macrophage activation Source: ARUK-UCL
  • negative regulation of neutrophil activation Source: ARUK-UCL
  • negative regulation of phagocytosis Source: ARUK-UCL
  • negative regulation of type I hypersensitivity Source: ARUK-UCL
  • phagocytosis, engulfment Source: ARUK-UCL
  • positive regulation of humoral immune response Source: ARUK-UCL
  • positive regulation of JNK cascade Source: ARUK-UCL
  • positive regulation of neuron death Source: ARUK-UCL
  • positive regulation of phagocytosis Source: ARUK-UCL
  • positive regulation of response to endoplasmic reticulum stress Source: ARUK-UCL
  • receptor-mediated endocytosis Source: ARUK-UCL
  • regulation of adaptive immune response Source: ARUK-UCL
  • regulation of B cell antigen processing and presentation Source: ARUK-UCL
  • regulation of dendritic spine maintenance Source: ARUK-UCL
  • regulation of immune complex clearance by monocytes and macrophages Source: ARUK-UCL
  • regulation of immune response Source: Reactome
  • regulation of innate immune response Source: ARUK-UCL
  • regulation of receptor activity Source: ARUK-UCL
  • response to bacterium Source: ARUK-UCL
  • signal transduction Source: ProtInc
  • viral process Source: UniProtKB-KW

Keywordsi

Molecular functionIgG-binding protein, Receptor
Biological processHost-virus interaction

Enzyme and pathway databases

ReactomeiR-HSA-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
SignaLinkiP31994.
SIGNORiP31994.

Protein family/group databases

MEROPSiI43.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Low affinity immunoglobulin gamma Fc region receptor II-b
Short name:
IgG Fc receptor II-b
Alternative name(s):
CDw32
Fc-gamma RII-b
Short name:
Fc-gamma-RIIb
Short name:
FcRII-b
CD_antigen: CD32
Gene namesi
Name:FCGR2B
Synonyms:CD32, FCG2, IGFR2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000072694.19.
HGNCiHGNC:3618. FCGR2B.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini43 – 217ExtracellularSequence analysisAdd BLAST175
Transmembranei218 – 240HelicalSequence analysisAdd BLAST23
Topological domaini241 – 310CytoplasmicSequence analysisAdd BLAST70

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Involvement in diseasei

Systemic lupus erythematosus (SLE)2 Publications
Disease susceptibility is associated with variations affecting the gene represented in this entry.
Disease descriptionA chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow.
See also OMIM:152700
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_015515232I → T Associated with susceptibility to SLE; associated with resistance to malaria; found at an increased frequency in African and Asian populations from areas where malaria is endemic; enhances phagocytosis of Plasmodium falciparum-infected erythrocytes in vitro. 4 PublicationsCorresponds to variant dbSNP:rs1050501Ensembl.1

Keywords - Diseasei

Proto-oncogene, Systemic lupus erythematosus

Organism-specific databases

DisGeNETi2213.
9103.
MalaCardsiFCGR2B.
MIMi152700. phenotype.
611162. phenotype.
OpenTargetsiENSG00000072694.
Orphaneti536. Systemic lupus erythematosus.
PharmGKBiPA28064.

Chemistry databases

DrugBankiDB00054. Abciximab.
DB00051. Adalimumab.
DB00092. Alefacept.
DB00087. Alemtuzumab.
DB00098. Anti-thymocyte Globulin (Rabbit).
DB00074. Basiliximab.
DB00112. Bevacizumab.
DB00002. Cetuximab.
DB00111. Daclizumab.
DB00095. Efalizumab.
DB00005. Etanercept.
DB00056. Gemtuzumab ozogamicin.
DB00078. Ibritumomab tiuxetan.
DB00028. Immune Globulin Human.
DB00075. Muromonab.
DB00108. Natalizumab.
DB00110. Palivizumab.
DB00073. Rituximab.
DB00081. Tositumomab.
DB00072. Trastuzumab.

Polymorphism and mutation databases

BioMutaiFCGR2B.
DMDMi8039788.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 42Sequence analysisAdd BLAST42
ChainiPRO_000001514743 – 310Low affinity immunoglobulin gamma Fc region receptor II-bAdd BLAST268

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi71 ↔ 113PROSITE-ProRule annotation1 Publication
Glycosylationi106N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi152 ↔ 196PROSITE-ProRule annotation1 Publication
Glycosylationi180N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi187N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei292Phosphotyrosine; by SRC-type Tyr-kinases1 Publication1

Post-translational modificationi

Phosphorylated by the SRC-type Tyr-kinases LYN and BLK.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiP31994.
PaxDbiP31994.
PeptideAtlasiP31994.
PRIDEiP31994.

PTM databases

iPTMnetiP31994.
PhosphoSitePlusiP31994.

Expressioni

Tissue specificityi

Is the most broadly distributed Fc-gamma-receptor. Expressed in monocyte, neutrophils, macrophages, basophils, eosinophils, Langerhans cells, B-cells, platelets cells and placenta (endothelial cells). Not detected in natural killer cells.

Gene expression databases

BgeeiENSG00000072694.
CleanExiHS_FCGR2B.
GenevisibleiP31994. HS.

Organism-specific databases

HPAiCAB007796.
HPA014730.

Interactioni

Subunit structurei

Isoform IIB1 interacts with measles virus N protein. N protein is released in the blood following lysis of measles infected cells. This interaction presumably block inflammatory immune response. Interacts with INPP5D/SHIP1. Interacts with FGR. Interacts with LYN.3 Publications

Binary interactionsi

Show more details

GO - Molecular functioni

  • IgG binding Source: ARUK-UCL

Protein-protein interaction databases

BioGridi108507. 5 interactors.
DIPiDIP-36638N.
ELMiP31994.
IntActiP31994. 15 interactors.
MINTiMINT-1376812.
STRINGi9606.ENSP00000351497.

Structurei

Secondary structure

1310
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi51 – 56Combined sources6
Beta strandi59 – 62Combined sources4
Beta strandi66 – 72Combined sources7
Beta strandi83 – 86Combined sources4
Beta strandi96 – 102Combined sources7
Helixi105 – 107Combined sources3
Beta strandi109 – 114Combined sources6
Beta strandi116 – 118Combined sources3
Beta strandi124 – 129Combined sources6
Beta strandi131 – 136Combined sources6
Beta strandi140 – 142Combined sources3
Beta strandi148 – 154Combined sources7
Helixi155 – 157Combined sources3
Beta strandi161 – 167Combined sources7
Beta strandi170 – 177Combined sources8
Beta strandi180 – 183Combined sources4
Helixi188 – 190Combined sources3
Beta strandi192 – 200Combined sources9
Beta strandi203 – 206Combined sources4
Beta strandi210 – 214Combined sources5

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2FCBX-ray1.74A46-217[»]
3WJJX-ray2.60C45-217[»]
ProteinModelPortaliP31994.
SMRiP31994.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP31994.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini48 – 127Ig-like C2-type 1Add BLAST80
Domaini131 – 213Ig-like C2-type 2Add BLAST83

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi290 – 295ITIM motif6

Domaini

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J9AP. Eukaryota.
ENOG410YXNK. LUCA.
GeneTreeiENSGT00760000119130.
HOGENOMiHOG000251632.
HOVERGENiHBG051602.
InParanoidiP31994.
KOiK12560.
OMAiXAENTIT.
OrthoDBiEOG091G0JSA.
PhylomeDBiP31994.
TreeFamiTF335097.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiView protein in InterPro
IPR007110. Ig-like_dom.
IPR036179. Ig-like_dom_sf.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
PfamiView protein in Pfam
PF13895. Ig_2. 2 hits.
SMARTiView protein in SMART
SM00409. IG. 2 hits.
SM00408. IGc2. 2 hits.
SUPFAMiSSF48726. SSF48726. 2 hits.
PROSITEiView protein in PROSITE
PS50835. IG_LIKE. 2 hits.

Sequences (5)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform IIB11 Publication (identifier: P31994-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGILSFLPVL ATESDWADCK SPQPWGHMLL WTAVLFLAPV AGTPAAPPKA
60 70 80 90 100
VLKLEPQWIN VLQEDSVTLT CRGTHSPESD SIQWFHNGNL IPTHTQPSYR
110 120 130 140 150
FKANNNDSGE YTCQTGQTSL SDPVHLTVLS EWLVLQTPHL EFQEGETIVL
160 170 180 190 200
RCHSWKDKPL VKVTFFQNGK SKKFSRSDPN FSIPQANHSH SGDYHCTGNI
210 220 230 240 250
GYTLYSSKPV TITVQAPSSS PMGIIVAVVT GIAVAAIVAA VVALIYCRKK
260 270 280 290 300
RISALPGYPE CREMGETLPE KPANPTNPDE ADKVGAENTI TYSLLMHPDA
310
LEEPDDQNRI
Length:310
Mass (Da):34,044
Last modified:May 30, 2000 - v2
Checksum:i2186F8538FF01F36
GO
Isoform IIB21 Publication (identifier: P31994-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     254-272: Missing.

Show »
Length:291
Mass (Da):31,944
Checksum:i3B76609541B30962
GO
Isoform IIB31 Publication (identifier: P31994-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     39-45: Missing.

Show »
Length:303
Mass (Da):33,450
Checksum:iB84833348A175687
GO
Isoform 4 (identifier: P31994-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     46-46: Missing.

Show »
Length:309
Mass (Da):33,973
Checksum:i0D56C5FB9C0998C0
GO
Isoform 5 (identifier: P31994-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     46-46: Missing.
     254-272: Missing.

Show »
Length:290
Mass (Da):31,873
Checksum:i0D393C1EFDD6C0E4
GO

Sequence cautioni

The sequence CAA35645 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti178D → I in CAA35644 (PubMed:2531080).Curated1
Sequence conflicti178D → I in CAA35645 (PubMed:2531080).Curated1
Sequence conflicti230T → I in CAA35644 (PubMed:2531080).Curated1
Sequence conflicti230T → I in CAA35645 (PubMed:2531080).Curated1
Sequence conflicti242V → G in CAA35644 (PubMed:2531080).Curated1
Sequence conflicti242V → G in CAA35645 (PubMed:2531080).Curated1
Sequence conflicti275P → S in CAA35644 (PubMed:2531080).Curated1
Sequence conflicti275P → S in CAA35645 (PubMed:2531080).Curated1

Polymorphismi

Note: FCGR2B polymorphisms can influence susceptibility or resistance to malaria [MIMi:611162].2 Publications

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05943083Q → P. Corresponds to variant dbSNP:rs5017567Ensembl.1
Natural variantiVAR_027045205Y → F1 PublicationCorresponds to variant dbSNP:rs1050499Ensembl.1
Natural variantiVAR_015515232I → T Associated with susceptibility to SLE; associated with resistance to malaria; found at an increased frequency in African and Asian populations from areas where malaria is endemic; enhances phagocytosis of Plasmodium falciparum-infected erythrocytes in vitro. 4 PublicationsCorresponds to variant dbSNP:rs1050501Ensembl.1
Natural variantiVAR_008798258Y → D1 PublicationCorresponds to variant dbSNP:rs148534844Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_00264239 – 45Missing in isoform IIB3. 1 Publication7
Alternative sequenceiVSP_05863546Missing in isoform 4 and isoform 5. 1 Publication1
Alternative sequenceiVSP_002643254 – 272Missing in isoform IIB2 and isoform 5. 6 PublicationsAdd BLAST19

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U87560 mRNA. Translation: AAD00627.1.
U87561 mRNA. Translation: AAD00628.1.
U87562 mRNA. Translation: AAD00629.1.
U87563 mRNA. Translation: AAD00630.1.
U87564 mRNA. Translation: AAD00631.1.
U87565 mRNA. Translation: AAD00632.1.
U87566 mRNA. Translation: AAD00633.1.
U87567 mRNA. Translation: AAD00634.1.
U87568 mRNA. Translation: AAD00635.1.
U87569 mRNA. Translation: AAD00636.1.
U87570 mRNA. Translation: AAD00637.1.
U87571 mRNA. Translation: AAD00638.1.
U87572 mRNA. Translation: AAD00639.1.
U87573 mRNA. Translation: AAD00640.1.
U87574 mRNA. Translation: AAD00641.1.
U87575 mRNA. Translation: AAD00642.1.
U87576 mRNA. Translation: AAD00643.1.
U87577 mRNA. Translation: AAD00644.1.
X17653 mRNA. Translation: CAA35644.1.
X17653 mRNA. Translation: CAA35645.1. Different initiation.
M31933 mRNA. Translation: AAA35841.1.
M31934 mRNA. Translation: AAA35842.1.
M31935 mRNA. Translation: AAA35843.1.
X52473 mRNA. Translation: CAA36713.1.
CR407635 mRNA. Translation: CAG28563.1.
AL359541 Genomic DNA. No translation available.
BC031992 mRNA. Translation: AAH31992.1.
BC146678 mRNA. Translation: AAI46679.1.
AB050934 mRNA. Translation: BAB92093.1.
CCDSiCCDS30924.1. [P31994-1]
CCDS30925.1. [P31994-2]
CCDS53414.1. [P31994-3]
PIRiJL0119.
RefSeqiNP_001002273.1. NM_001002273.2. [P31994-5]
NP_001002274.1. NM_001002274.2. [P31994-2]
NP_001002275.1. NM_001002275.2. [P31994-4]
NP_001177757.1. NM_001190828.1. [P31994-3]
NP_003992.3. NM_004001.4. [P31994-1]
XP_016856160.1. XM_017000671.1. [P31994-1]
XP_016856161.1. XM_017000672.1. [P31994-2]
UniGeneiHs.654395.

Genome annotation databases

EnsembliENST00000236937; ENSP00000236937; ENSG00000072694. [P31994-2]
ENST00000358671; ENSP00000351497; ENSG00000072694. [P31994-1]
ENST00000367961; ENSP00000356938; ENSG00000072694. [P31994-3]
GeneIDi2213.
KEGGihsa:2213.
UCSCiuc001gaz.3. human. [P31994-1]

Keywords - Coding sequence diversityi

Alternative splicing, Chromosomal rearrangement, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiFCG2B_HUMAN
AccessioniPrimary (citable) accession number: P31994
Secondary accession number(s): A6H8N3
, O95649, Q53X85, Q5VXA9, Q8NIA1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: May 30, 2000
Last modified: October 25, 2017
This is version 200 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Has sometimes been attributed to correspond to FcR-IIC.Curated

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references