P31994 (FCG2B_HUMAN) Reviewed, UniProtKB/Swiss-Prot
Last modified
January 25, 2012.
Version 139.
History...
Names·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Interactions·Alt products·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Low affinity immunoglobulin gamma Fc region receptor II-b Short name=IgG Fc receptor II-b Alternative name(s): CDw32 Fc-gamma RII-b Short name=Fc-gamma-RIIb Short name=FcRII-b CD_antigen=CD32 | ||||
| Gene names |
| ||||
| Organism | Homo sapiens (Human) | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 310 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at protein level |
General annotation (Comments)
| Function | Receptor for the Fc region of complexed or aggregated immunoglobulins gamma. Low affinity receptor. Involved in a variety of effector and regulatory functions such as phagocytosis of immune complexes and modulation of antibody production by B-cells. Binding to this receptor results in down-modulation of previous state of cell activation triggered via antigen receptors on B-cells (BCR), T-cells (TCR) or via another Fc receptor. Isoform IIB1 fails to mediate endocytosis or phagocytosis. Isoform IIB2 does not trigger phagocytosis. |
| Subunit structure | Isoform IIB1 interacts with measles virus N protein. N protein is released in the blood following lysis of measles infected cells. This interaction presumably block inflammatory immune response. Interacts with INPP5D/SHIP1. Interacts with FGR. Interacts with LYN. Ref.9 Ref.11 Ref.12 |
| Subcellular location | |
| Tissue specificity | Is the most broadly distributed Fc-gamma-receptor. Expressed in monocyte, neutrophils, macrophages, basophils, eosinophils, Langerhans cells, B-cells, platelets cells and placenta (endothelial cells). Not detected in natural killer cells. |
| Domain | Contains 1 copy of a cytoplasmic motif that is referred to as the immunoreceptor tyrosine-based inhibitor motif (ITIM). This motif is involved in modulation of cellular responses. The phosphorylated ITIM motif can bind the SH2 domain of several SH2-containing phosphatases. |
| Post-translational modification | Phosphorylated by SRC-type Tyr-kinases such as LYN, BLK, FYN and SYK. Ref.10 |
| Polymorphism | Note=FCGR2B polymorphisms can influence susceptibility or resistance to malaria [MIM:611162]. |
| Involvement in disease | Note=A chromosomal aberration involving FCGR2B is found in a follicular lymphoma. Translocation t(1;22)(q22;q11). The translocation leads to the hyperexpression of the receptor. This may play a role in the tumor progression. Defects in FCGR2B are a cause of susceptibility to systemic lupus erythematosus (SLE) [MIM:152700]. A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow. Ref.8 Ref.16 |
| Sequence similarities | Contains 2 Ig-like C2-type (immunoglobulin-like) domains. |
| Caution | Has sometimes been attributed to correspond to FcR-IIC. |
| Sequence caution | The sequence CAA35645.1 differs from that shown. Reason: Erroneous initiation. |
Ontologies
Binary interactions
With | Entry | #Exp. | IntAct | Notes |
|---|---|---|---|---|
| IGHG1 | P01857 | 31 | EBI-724784,EBI-356114 | |
| NCK1 | P16333 | 2 | EBI-724784,EBI-389883 | |
| PLCG1 | P19174 | 2 | EBI-724784,EBI-79387 |
Alternative products
| This entry describes 3 isoforms produced by alternative splicing. [Align] [Select] | ||||||
| Isoform IIB1 (identifier: P31994-1) This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. | ||||||
| Isoform IIB2 (identifier: P31994-2) The sequence of this isoform differs from the canonical sequence as follows: 254-272: Missing. | ||||||
| Isoform IIB3 (identifier: P31994-3) The sequence of this isoform differs from the canonical sequence as follows: 39-45: Missing. |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | |||||||||||||||||||||||||||||||||||||||||
Molecule processing | ||||||||||||||||||||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Signal peptide | 1 – 42 | 42 | Potential | |||||||||||||||||||||||||||||||||||||||||||
| Chain | 43 – 310 | 268 | Low affinity immunoglobulin gamma Fc region receptor II-b | PRO_0000015147 | ||||||||||||||||||||||||||||||||||||||||||
Regions | ||||||||||||||||||||||||||||||||||||||||||||||
| Topological domain | 43 – 217 | 175 | Extracellular Potential | |||||||||||||||||||||||||||||||||||||||||||
| Transmembrane | 218 – 240 | 23 | Helical; Potential | |||||||||||||||||||||||||||||||||||||||||||
| Topological domain | 241 – 310 | 70 | Cytoplasmic Potential | |||||||||||||||||||||||||||||||||||||||||||
| Domain | 48 – 127 | 80 | Ig-like C2-type 1 | |||||||||||||||||||||||||||||||||||||||||||
| Domain | 131 – 213 | 83 | Ig-like C2-type 2 | |||||||||||||||||||||||||||||||||||||||||||
| Motif | 290 – 295 | 6 | ITIM motif | |||||||||||||||||||||||||||||||||||||||||||
Amino acid modifications | ||||||||||||||||||||||||||||||||||||||||||||||
| Modified residue | 292 | 1 | Phosphotyrosine; by SRC-type Tyr-kinases Ref.10 | |||||||||||||||||||||||||||||||||||||||||||
| Glycosylation | 106 | 1 | N-linked (GlcNAc...) Potential | |||||||||||||||||||||||||||||||||||||||||||
| Glycosylation | 180 | 1 | N-linked (GlcNAc...) Potential | |||||||||||||||||||||||||||||||||||||||||||
| Glycosylation | 187 | 1 | N-linked (GlcNAc...) Potential | |||||||||||||||||||||||||||||||||||||||||||
| Disulfide bond | 71 ↔ 113 | Ref.13 | ||||||||||||||||||||||||||||||||||||||||||||
| Disulfide bond | 152 ↔ 196 | Ref.13 | ||||||||||||||||||||||||||||||||||||||||||||
Natural variations | ||||||||||||||||||||||||||||||||||||||||||||||
| Alternative sequence | 39 – 45 | 7 | Missing in isoform IIB3. | VSP_002642 | ||||||||||||||||||||||||||||||||||||||||||
| Alternative sequence | 254 – 272 | 19 | Missing in isoform IIB2. | VSP_002643 | ||||||||||||||||||||||||||||||||||||||||||
| Natural variant | 83 | 1 | Q → P. Corresponds to variant rs5017567 [ dbSNP | Ensembl ]. | VAR_059430 | ||||||||||||||||||||||||||||||||||||||||||
| Natural variant | 205 | 1 | Y → F. Ref.3 Corresponds to variant rs1050499 [ dbSNP | Ensembl ]. | VAR_027045 | ||||||||||||||||||||||||||||||||||||||||||
| Natural variant | 232 | 1 | I → T Associated with susceptibility to SLE; associated with resistance to malaria; found at an increased frequency in African and Asian populations from areas where malaria is endemic; enhances phagocytosis of Plasmodium falciparum-infected erythrocytes in vitro. Ref.8 Ref.15 Ref.16 | VAR_015515 | ||||||||||||||||||||||||||||||||||||||||||
| Natural variant | 258 | 1 | Y → D. Ref.14 | VAR_008798 | ||||||||||||||||||||||||||||||||||||||||||
Experimental info | ||||||||||||||||||||||||||||||||||||||||||||||
| Sequence conflict | 46 | 1 | Missing in AAD00637. Ref.1 | |||||||||||||||||||||||||||||||||||||||||||
| Sequence conflict | 46 | 1 | Missing in AAD00638. Ref.1 | |||||||||||||||||||||||||||||||||||||||||||
| Sequence conflict | 46 | 1 | Missing in AAD00639. Ref.1 | |||||||||||||||||||||||||||||||||||||||||||
| Sequence conflict | 46 | 1 | Missing in AAD00644. Ref.1 | |||||||||||||||||||||||||||||||||||||||||||
| Sequence conflict | 178 | 1 | D → I in CAA35644. Ref.2 | |||||||||||||||||||||||||||||||||||||||||||
| Sequence conflict | 178 | 1 | D → I in CAA35645. Ref.2 | |||||||||||||||||||||||||||||||||||||||||||
| Sequence conflict | 230 | 1 | T → I in CAA35644. Ref.2 | |||||||||||||||||||||||||||||||||||||||||||
| Sequence conflict | 230 | 1 | T → I in CAA35645. Ref.2 | |||||||||||||||||||||||||||||||||||||||||||
| Sequence conflict | 242 | 1 | V → G in CAA35644. Ref.2 | |||||||||||||||||||||||||||||||||||||||||||
| Sequence conflict | 242 | 1 | V → G in CAA35645. Ref.2 | |||||||||||||||||||||||||||||||||||||||||||
| Sequence conflict | 275 | 1 | P → S Ref.2 | |||||||||||||||||||||||||||||||||||||||||||
Secondary structure | ||||||||||||||||||||||||||||||||||||||||||||||
Helix Strand Turn | ||||||||||||||||||||||||||||||||||||||||||||||
| Beta strand | 51 – 56 | 6 | ||||||||||||||||||||||||||||||||||||||||||||
| Beta strand | 59 – 62 | 4 | ||||||||||||||||||||||||||||||||||||||||||||
| Beta strand | 66 – 72 | 7 | ||||||||||||||||||||||||||||||||||||||||||||
| Beta strand | 83 – 86 | 4 | ||||||||||||||||||||||||||||||||||||||||||||
| Beta strand | 96 – 102 | 7 | ||||||||||||||||||||||||||||||||||||||||||||
| Helix | 105 – 107 | 3 | ||||||||||||||||||||||||||||||||||||||||||||
| Beta strand | 109 – 114 | 6 | ||||||||||||||||||||||||||||||||||||||||||||
| Beta strand | 124 – 129 | 6 | ||||||||||||||||||||||||||||||||||||||||||||
| Beta strand | 131 – 136 | 6 | ||||||||||||||||||||||||||||||||||||||||||||
| Beta strand | 140 – 142 | 3 | ||||||||||||||||||||||||||||||||||||||||||||
| Beta strand | 148 – 154 | 7 | ||||||||||||||||||||||||||||||||||||||||||||
| Helix | 155 – 157 | 3 | ||||||||||||||||||||||||||||||||||||||||||||
| Beta strand | 161 – 167 | 7 | ||||||||||||||||||||||||||||||||||||||||||||
| Beta strand | 170 – 177 | 8 | ||||||||||||||||||||||||||||||||||||||||||||
| Beta strand | 180 – 183 | 4 | ||||||||||||||||||||||||||||||||||||||||||||
| Helix | 188 – 190 | 3 | ||||||||||||||||||||||||||||||||||||||||||||
| Beta strand | 192 – 200 | 9 | ||||||||||||||||||||||||||||||||||||||||||||
| Beta strand | 203 – 206 | 4 | ||||||||||||||||||||||||||||||||||||||||||||
| Beta strand | 210 – 214 | 5 | ||||||||||||||||||||||||||||||||||||||||||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Fc-gamma-RIIb nucleotide sequences in SLE and non-SLE humans in vivo derived lymphocytes." Ng S., Sinclair N.R.S., Anderson C., Bell D.A., Cairns E. Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS IIB1 AND IIB2). Tissue: Lymphocyte. |
| [2] | "Human IgG Fc receptor (hFcRII; CD32) exists as multiple isoforms in macrophages, lymphocytes and IgG-transporting placental epithelium." Stuart S.G., Simister N.E., Clarkson S.B., Kacinski B.M., Shapiro M., Mellman I. EMBO J. 8:3657-3666(1989) [PubMed: 2531080] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM IIB2). Tissue: Placenta. |
| [3] | "Structure and expression of human IgG FcRII(CD32). Functional heterogeneity is encoded by the alternatively spliced products of multiple genes." Brooks D.G., Qiu W.Q., Luster A.D., Ravetch J.V. J. Exp. Med. 170:1369-1385(1989) [PubMed: 2529342] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS IIB1; IIB2 AND IIB3), VARIANT PHE-205. |
| [4] | "Distribution, inducibility and biological function of the cloned and expressed human beta Fc receptor II." Engelhardt W., Geerds C., Frey J. Eur. J. Immunol. 20:1367-1377(1990) [PubMed: 2142460] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM IIB2). Tissue: Placenta. |
| [5] | "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)." Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B. Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM IIB2). |
| [6] | "The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. Bentley D.R.Nature 441:315-321(2006) [PubMed: 16710414] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [7] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS IIB1 AND IIB2). Tissue: Skin. |
| [8] | "Fc gamma receptor gene polymorphisms in Japanese patients with systemic lupus erythematosus: contribution of FCGR2B to genetic susceptibility." Kyogoku C., Dijstelbloem H.M., Tsuchiya N., Hatta Y., Kato H., Yamaguchi A., Fukazawa T., Jansen M.D., Hashimoto H., van de Winkel J.G.J., Kallenberg C.G.M., Tokunaga K. Arthritis Rheum. 46:1242-1254(2002) [PubMed: 12115230] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 132-253, INVOLVEMENT IN SLE, VARIANT THR-232. |
| [9] | "Association of immunoglobulin G Fc receptor II with Src-like protein-tyrosine kinase Fgr in neutrophils." Hamada F., Aoki M., Akiyama T., Toyoshima K. Proc. Natl. Acad. Sci. U.S.A. 90:6305-6309(1993) [PubMed: 8327512] [Abstract] Cited for: INTERACTION WITH FGR. |
| [10] | "In vivo and in vitro specificity of protein tyrosine kinases for immunoglobulin G receptor (FcgammaRII) phosphorylation." Bewarder N., Weinrich V., Budde P., Hartmann D., Flaswinkel H., Reth M., Frey J. Mol. Cell. Biol. 16:4735-4743(1996) [PubMed: 8756631] [Abstract] Cited for: PHOSPHORYLATION AT TYR-292. |
| [11] | "Fc gamma receptor type IIb induced recruitment of inositol and protein phosphatases to the signal transductory complex of human B-cell." Sarmay G., Koncz G., Pecht I., Gergely J. Immunol. Lett. 57:159-164(1997) [PubMed: 9232445] [Abstract] Cited for: INTERACTION WITH LYN. |
| [12] | "Measles virus nucleoprotein induces cell-proliferation arrest and apoptosis through NTAIL-NR and NCORE-FcgammaRIIB1 interactions, respectively." Laine D., Bourhis J.-M., Longhi S., Flacher M., Cassard L., Canard B., Sautes-Fridman C., Rabourdin-Combe C., Valentin H. J. Gen. Virol. 86:1771-1784(2005) [PubMed: 15914856] [Abstract] Cited for: INTERACTION WITH MEASLES VIRUS N PROTEIN. |
| [13] | "Crystal structure of the soluble form of the human fcgamma-receptor IIb: a new member of the immunoglobulin superfamily at 1.7 A resolution." Sondermann P., Huber R., Jacob U. EMBO J. 18:1095-1103(1999) [PubMed: 10064577] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (1.74 ANGSTROMS) OF 46-217, DISULFIDE BONDS. |
| [14] | "Interaction of a human Fc gamma RIIb1 (CD32) isoform with murine and human IgG subclasses." Warmerdam P.A., van den Herik-Oudijk I.E., Parren P.W., Westerdaal N.A., van de Winkel J.G., Capel P.J. Int. Immunol. 5:239-247(1993) [PubMed: 8466861] [Abstract] Cited for: VARIANT ASP-258. |
| [15] | "Systemic lupus erythematosus-associated defects in the inhibitory receptor FcgammaRIIb reduce susceptibility to malaria." Clatworthy M.R., Willcocks L., Urban B., Langhorne J., Williams T.N., Peshu N., Watkins N.A., Floto R.A., Smith K.G. Proc. Natl. Acad. Sci. U.S.A. 104:7169-7174(2007) [PubMed: 17435165] [Abstract] Cited for: ASSOCIATION OF VARIANT THR-232 WITH RESISTANCE TO MALARIA, CHARACTERIZATION OF VARIANT THR-232. |
| [16] | "A defunctioning polymorphism in FCGR2B is associated with protection against malaria but susceptibility to systemic lupus erythematosus." Willcocks L.C., Carr E.J., Niederer H.A., Rayner T.F., Williams T.N., Yang W., Scott J.A., Urban B.C., Peshu N., Vyse T.J., Lau Y.L., Lyons P.A., Smith K.G. Proc. Natl. Acad. Sci. U.S.A. 107:7881-7885(2010) [PubMed: 20385827] [Abstract] Cited for: ASSOCIATION OF VARIANT THR-232 WITH SUSCEPTIBILITY TO SLE, RESISTANCE TO MALARIA. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| EMBL GenBank DDBJ | U87560 mRNA. Translation: AAD00627.1. U87561 mRNA. Translation: AAD00628.1. U87562 mRNA. Translation: AAD00629.1. U87563 mRNA. Translation: AAD00630.1. U87564 mRNA. Translation: AAD00631.1. U87565 mRNA. Translation: AAD00632.1. U87566 mRNA. Translation: AAD00633.1. U87567 mRNA. Translation: AAD00634.1. U87568 mRNA. Translation: AAD00635.1. U87569 mRNA. Translation: AAD00636.1. U87570 mRNA. Translation: AAD00637.1. U87571 mRNA. Translation: AAD00638.1. U87572 mRNA. Translation: AAD00639.1. U87573 mRNA. Translation: AAD00640.1. U87574 mRNA. Translation: AAD00641.1. U87575 mRNA. Translation: AAD00642.1. U87576 mRNA. Translation: AAD00643.1. U87577 mRNA. Translation: AAD00644.1. X17653 mRNA. Translation: CAA35644.1. X17653 mRNA. Translation: CAA35645.1. Different initiation. M31933 mRNA. Translation: AAA35841.1. M31934 mRNA. Translation: AAA35842.1. M31935 mRNA. Translation: AAA35843.1. X52473 mRNA. Translation: CAA36713.1. CR407635 mRNA. Translation: CAG28563.1. AL359541 Genomic DNA. No translation available. BC031992 mRNA. Translation: AAH31992.1. BC146678 mRNA. Translation: AAI46679.1. AB050934 mRNA. Translation: BAB92093.1. | ||||||||||||
| IPI | IPI00013969. IPI00479827. IPI00903316. | ||||||||||||
| PIR | JL0119. | ||||||||||||
| RefSeq | NP_001002273.1. NM_001002273.2. NP_001002274.1. NM_001002274.2. NP_001002275.1. NM_001002275.2. NP_001177757.1. NM_001190828.1. NP_003992.3. NM_004001.4. | ||||||||||||
| UniGene | Hs.654395. | ||||||||||||
3D structure databases | |||||||||||||
| PDBe RCSB PDB PDBj |
| ||||||||||||
| ProteinModelPortal | P31994. | ||||||||||||
| SMR | P31994. Positions 46-218. | ||||||||||||
| ModBase | Search... | ||||||||||||
Protein-protein interaction databases | |||||||||||||
| IntAct | P31994. 9 interactions. | ||||||||||||
| MINT | MINT-1376812. | ||||||||||||
| STRING | P31994. | ||||||||||||
PTM databases | |||||||||||||
| PhosphoSite | P31994. | ||||||||||||
Polymorphism databases | |||||||||||||
| DMDM | 8039788. | ||||||||||||
Proteomic databases | |||||||||||||
| PRIDE | P31994. | ||||||||||||
Protocols and materials databases | |||||||||||||
| StructuralBiologyKnowledgebase | Search... | ||||||||||||
Genome annotation databases | |||||||||||||
| Ensembl | ENST00000358671; ENSP00000351497; ENSG00000072694. ENST00000367962; ENSP00000356939; ENSG00000072694. ENST00000452001; ENSP00000401407; ENSG00000072694. | ||||||||||||
| GeneID | 2213. | ||||||||||||
| KEGG | hsa:2213. | ||||||||||||
| UCSC | uc001gay.1. human. uc001gba.1. human. uc009wun.1. human. | ||||||||||||
Organism-specific databases | |||||||||||||
| CTD | 2213. | ||||||||||||
| GeneCards | GC01P161552. | ||||||||||||
| HGNC | HGNC:3618. FCGR2B. | ||||||||||||
| HPA | CAB007796. | ||||||||||||
| MIM | 152700. phenotype. 604590. gene. 611162. phenotype. | ||||||||||||
| neXtProt | NX_P31994. | ||||||||||||
| PharmGKB | PA28064. | ||||||||||||
| GenAtlas | Search... | ||||||||||||
Phylogenomic databases | |||||||||||||
| eggNOG | prNOG16290. | ||||||||||||
| HOGENOM | HBG282714. | ||||||||||||
| HOVERGEN | HBG051602. | ||||||||||||
| InParanoid | P31994. | ||||||||||||
| OMA | LYKITFF. | ||||||||||||
Enzyme and pathway databases | |||||||||||||
| Pathway_Interaction_DB | bcr_5pathway. BCR signaling pathway. fcer1pathway. Fc-epsilon receptor I signaling in mast cells. | ||||||||||||
| Reactome | REACT_6900. Immune System. | ||||||||||||
Gene expression databases | |||||||||||||
| ArrayExpress | P31994. | ||||||||||||
| Bgee | P31994. | ||||||||||||
| CleanEx | HS_FCGR2B. | ||||||||||||
| Genevestigator | P31994. | ||||||||||||
| GermOnline | ENSG00000072694. Homo sapiens. | ||||||||||||
Family and domain databases | |||||||||||||
| InterPro | IPR007110. Ig-like. IPR013783. Ig-like_fold. IPR003599. Ig_sub. [Graphical view] | ||||||||||||
| Gene3D | G3DSA:2.60.40.10. Ig-like_fold. 2 hits. | ||||||||||||
| KO | K12560. | ||||||||||||
| SMART | SM00409. IG. 2 hits. [Graphical view] | ||||||||||||
| PROSITE | PS50835. IG_LIKE. 2 hits. [Graphical view] | ||||||||||||
| ProtoNet | Search... | ||||||||||||
Other | |||||||||||||
| DrugBank | DB00054. Abciximab. DB00051. Adalimumab. DB00092. Alefacept. DB00087. Alemtuzumab. DB00074. Basiliximab. DB00112. Bevacizumab. DB00002. Cetuximab. DB00111. Daclizumab. DB00095. Efalizumab. DB00005. Etanercept. DB00056. Gemtuzumab ozogamicin. DB00078. Ibritumomab. DB00028. Immune globulin. DB00075. Muromonab. DB00108. Natalizumab. DB00110. Palivizumab. DB00073. Rituximab. DB00081. Tositumomab. DB00072. Trastuzumab. | ||||||||||||
| NextBio | 8967. | ||||||||||||
| SOURCE | Search... | ||||||||||||
Entry information
| Entry name | FCG2B_HUMAN | ||||||||
| Accession | Primary (citable) accession number: P31994 Secondary accession number(s): A6H8N3 Q8NIA1 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Chordata Protein Annotation Program | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documents
| Human cell differentiation molecules CD nomenclature of surface proteins of human leucocytes and list of entries |
| Human chromosome 1 Human chromosome 1: entries, gene names and cross-references to MIM |
| Human entries with polymorphisms or disease mutations List of human entries with polymorphisms or disease mutations |
| Human polymorphisms and disease mutations Index of human polymorphisms and disease mutations |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| PDB cross-references Index of Protein Data Bank (PDB) cross-references |
| SIMILARITY comments Index of protein domains and families |

Clusters with