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P31994

- FCG2B_HUMAN

UniProt

P31994 - FCG2B_HUMAN

Protein

Low affinity immunoglobulin gamma Fc region receptor II-b

Gene

FCGR2B

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
    • BLAST
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    • History
      Entry version 167 (01 Oct 2014)
      Sequence version 2 (30 May 2000)
      Previous versions | rss
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    Functioni

    Receptor for the Fc region of complexed or aggregated immunoglobulins gamma. Low affinity receptor. Involved in a variety of effector and regulatory functions such as phagocytosis of immune complexes and modulation of antibody production by B-cells. Binding to this receptor results in down-modulation of previous state of cell activation triggered via antigen receptors on B-cells (BCR), T-cells (TCR) or via another Fc receptor. Isoform IIB1 fails to mediate endocytosis or phagocytosis. Isoform IIB2 does not trigger phagocytosis.

    GO - Molecular functioni

    1. protein binding Source: IntAct

    GO - Biological processi

    1. immune response Source: ProtInc
    2. regulation of immune response Source: Reactome
    3. signal transduction Source: ProtInc
    4. viral process Source: UniProtKB-KW

    Keywords - Molecular functioni

    Receptor

    Keywords - Biological processi

    Host-virus interaction

    Keywords - Ligandi

    IgG-binding protein

    Enzyme and pathway databases

    ReactomeiREACT_11152. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
    SignaLinkiP31994.

    Protein family/group databases

    MEROPSiI43.001.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Low affinity immunoglobulin gamma Fc region receptor II-b
    Short name:
    IgG Fc receptor II-b
    Alternative name(s):
    CDw32
    Fc-gamma RII-b
    Short name:
    Fc-gamma-RIIb
    Short name:
    FcRII-b
    CD_antigen: CD32
    Gene namesi
    Name:FCGR2B
    Synonyms:CD32, FCG2, IGFR2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:3618. FCGR2B.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Involvement in diseasei

    A chromosomal aberration involving FCGR2B is found in a follicular lymphoma. Translocation t(1;22)(q22;q11). The translocation leads to the hyperexpression of the receptor. This may play a role in the tumor progression.
    Systemic lupus erythematosus (SLE) [MIM:152700]: A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow.2 Publications
    Note: Disease susceptibility is associated with variations affecting the gene represented in this entry.
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti232 – 2321I → T Associated with susceptibility to SLE; associated with resistance to malaria; found at an increased frequency in African and Asian populations from areas where malaria is endemic; enhances phagocytosis of Plasmodium falciparum-infected erythrocytes in vitro. 1 Publication
    Corresponds to variant rs1050501 [ dbSNP | Ensembl ].
    VAR_015515

    Keywords - Diseasei

    Proto-oncogene, Systemic lupus erythematosus

    Organism-specific databases

    MIMi152700. phenotype.
    611162. phenotype.
    Orphaneti536. Systemic lupus erythematosus.
    PharmGKBiPA28064.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 4242Sequence AnalysisAdd
    BLAST
    Chaini43 – 310268Low affinity immunoglobulin gamma Fc region receptor II-bPRO_0000015147Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi71 ↔ 1131 PublicationPROSITE-ProRule annotation
    Glycosylationi106 – 1061N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi152 ↔ 1961 PublicationPROSITE-ProRule annotation
    Glycosylationi180 – 1801N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi187 – 1871N-linked (GlcNAc...)Sequence Analysis
    Modified residuei292 – 2921Phosphotyrosine; by SRC-type Tyr-kinases1 Publication

    Post-translational modificationi

    Phosphorylated by the SRC-type Tyr-kinases LYN and BLK.1 Publication

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Phosphoprotein

    Proteomic databases

    MaxQBiP31994.
    PaxDbiP31994.
    PRIDEiP31994.

    PTM databases

    PhosphoSiteiP31994.

    Expressioni

    Tissue specificityi

    Is the most broadly distributed Fc-gamma-receptor. Expressed in monocyte, neutrophils, macrophages, basophils, eosinophils, Langerhans cells, B-cells, platelets cells and placenta (endothelial cells). Not detected in natural killer cells.

    Gene expression databases

    ArrayExpressiP31994.
    BgeeiP31994.
    CleanExiHS_FCGR2B.
    GenevestigatoriP31994.

    Organism-specific databases

    HPAiCAB007796.

    Interactioni

    Subunit structurei

    Isoform IIB1 interacts with measles virus N protein. N protein is released in the blood following lysis of measles infected cells. This interaction presumably block inflammatory immune response. Interacts with INPP5D/SHIP1. Interacts with FGR. Interacts with LYN.3 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    IGHG1P0185731EBI-724784,EBI-356114
    INPP5DQ928352EBI-724784,EBI-1380477
    NCK1P163332EBI-724784,EBI-389883
    PLCG1P191742EBI-724784,EBI-79387
    PTPN6P293503EBI-724784,EBI-78260

    Protein-protein interaction databases

    BioGridi108507. 2 interactions.
    IntActiP31994. 14 interactions.
    MINTiMINT-1376812.
    STRINGi9606.ENSP00000351497.

    Structurei

    Secondary structure

    1
    310
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi51 – 566
    Beta strandi59 – 624
    Beta strandi66 – 727
    Beta strandi83 – 864
    Beta strandi96 – 1027
    Helixi105 – 1073
    Beta strandi109 – 1146
    Beta strandi116 – 1183
    Beta strandi124 – 1296
    Beta strandi131 – 1366
    Beta strandi140 – 1423
    Beta strandi148 – 1547
    Helixi155 – 1573
    Beta strandi161 – 1677
    Beta strandi170 – 1778
    Beta strandi180 – 1834
    Helixi188 – 1903
    Beta strandi192 – 2009
    Beta strandi203 – 2064
    Beta strandi210 – 2145

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2FCBX-ray1.74A46-217[»]
    3WJJX-ray2.60C45-217[»]
    ProteinModelPortaliP31994.
    SMRiP31994. Positions 50-213.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP31994.

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini43 – 217175ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini241 – 31070CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei218 – 24023HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini48 – 12780Ig-like C2-type 1Add
    BLAST
    Domaini131 – 21383Ig-like C2-type 2Add
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi290 – 2956ITIM motif

    Domaini

    Sequence similaritiesi

    Keywords - Domaini

    Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG25177.
    HOGENOMiHOG000251632.
    HOVERGENiHBG051602.
    InParanoidiP31994.
    KOiK12560.
    OMAiHDYQNHI.
    OrthoDBiEOG708W0N.
    PhylomeDBiP31994.
    TreeFamiTF335097.

    Family and domain databases

    Gene3Di2.60.40.10. 2 hits.
    InterProiIPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003599. Ig_sub.
    [Graphical view]
    SMARTiSM00409. IG. 2 hits.
    [Graphical view]
    PROSITEiPS50835. IG_LIKE. 2 hits.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform IIB1 (identifier: P31994-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MGILSFLPVL ATESDWADCK SPQPWGHMLL WTAVLFLAPV AGTPAAPPKA    50
    VLKLEPQWIN VLQEDSVTLT CRGTHSPESD SIQWFHNGNL IPTHTQPSYR 100
    FKANNNDSGE YTCQTGQTSL SDPVHLTVLS EWLVLQTPHL EFQEGETIVL 150
    RCHSWKDKPL VKVTFFQNGK SKKFSRSDPN FSIPQANHSH SGDYHCTGNI 200
    GYTLYSSKPV TITVQAPSSS PMGIIVAVVT GIAVAAIVAA VVALIYCRKK 250
    RISALPGYPE CREMGETLPE KPANPTNPDE ADKVGAENTI TYSLLMHPDA 300
    LEEPDDQNRI 310
    Length:310
    Mass (Da):34,044
    Last modified:May 30, 2000 - v2
    Checksum:i2186F8538FF01F36
    GO
    Isoform IIB2 (identifier: P31994-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         254-272: Missing.

    Show »
    Length:291
    Mass (Da):31,944
    Checksum:i3B76609541B30962
    GO
    Isoform IIB3 (identifier: P31994-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         39-45: Missing.

    Show »
    Length:303
    Mass (Da):33,450
    Checksum:iB84833348A175687
    GO

    Sequence cautioni

    The sequence CAA35645.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti46 – 461Missing in AAD00637. 1 PublicationCurated
    Sequence conflicti46 – 461Missing in AAD00638. 1 PublicationCurated
    Sequence conflicti46 – 461Missing in AAD00639. 1 PublicationCurated
    Sequence conflicti46 – 461Missing in AAD00644. 1 PublicationCurated
    Sequence conflicti178 – 1781D → I in CAA35644. (PubMed:2531080)Curated
    Sequence conflicti178 – 1781D → I in CAA35645. (PubMed:2531080)Curated
    Sequence conflicti230 – 2301T → I in CAA35644. (PubMed:2531080)Curated
    Sequence conflicti230 – 2301T → I in CAA35645. (PubMed:2531080)Curated
    Sequence conflicti242 – 2421V → G in CAA35644. (PubMed:2531080)Curated
    Sequence conflicti242 – 2421V → G in CAA35645. (PubMed:2531080)Curated
    Sequence conflicti275 – 2751P → S(PubMed:2531080)Curated

    Polymorphismi

    Note: FCGR2B polymorphisms can influence susceptibility or resistance to malaria [MIMi:611162].

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti83 – 831Q → P.
    Corresponds to variant rs5017567 [ dbSNP | Ensembl ].
    VAR_059430
    Natural varianti205 – 2051Y → F.1 Publication
    Corresponds to variant rs1050499 [ dbSNP | Ensembl ].
    VAR_027045
    Natural varianti232 – 2321I → T Associated with susceptibility to SLE; associated with resistance to malaria; found at an increased frequency in African and Asian populations from areas where malaria is endemic; enhances phagocytosis of Plasmodium falciparum-infected erythrocytes in vitro. 1 Publication
    Corresponds to variant rs1050501 [ dbSNP | Ensembl ].
    VAR_015515
    Natural varianti258 – 2581Y → D.1 Publication
    Corresponds to variant rs148534844 [ dbSNP | Ensembl ].
    VAR_008798

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei39 – 457Missing in isoform IIB3. 1 PublicationVSP_002642
    Alternative sequencei254 – 27219Missing in isoform IIB2. 6 PublicationsVSP_002643Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U87560 mRNA. Translation: AAD00627.1.
    U87561 mRNA. Translation: AAD00628.1.
    U87562 mRNA. Translation: AAD00629.1.
    U87563 mRNA. Translation: AAD00630.1.
    U87564 mRNA. Translation: AAD00631.1.
    U87565 mRNA. Translation: AAD00632.1.
    U87566 mRNA. Translation: AAD00633.1.
    U87567 mRNA. Translation: AAD00634.1.
    U87568 mRNA. Translation: AAD00635.1.
    U87569 mRNA. Translation: AAD00636.1.
    U87570 mRNA. Translation: AAD00637.1.
    U87571 mRNA. Translation: AAD00638.1.
    U87572 mRNA. Translation: AAD00639.1.
    U87573 mRNA. Translation: AAD00640.1.
    U87574 mRNA. Translation: AAD00641.1.
    U87575 mRNA. Translation: AAD00642.1.
    U87576 mRNA. Translation: AAD00643.1.
    U87577 mRNA. Translation: AAD00644.1.
    X17653 mRNA. Translation: CAA35644.1.
    X17653 mRNA. Translation: CAA35645.1. Different initiation.
    M31933 mRNA. Translation: AAA35841.1.
    M31934 mRNA. Translation: AAA35842.1.
    M31935 mRNA. Translation: AAA35843.1.
    X52473 mRNA. Translation: CAA36713.1.
    CR407635 mRNA. Translation: CAG28563.1.
    AL359541 Genomic DNA. No translation available.
    BC031992 mRNA. Translation: AAH31992.1.
    BC146678 mRNA. Translation: AAI46679.1.
    AB050934 mRNA. Translation: BAB92093.1.
    CCDSiCCDS30924.1. [P31994-1]
    CCDS30925.1. [P31994-2]
    CCDS53414.1. [P31994-3]
    PIRiJL0119.
    RefSeqiNP_001002273.1. NM_001002273.2.
    NP_001002274.1. NM_001002274.2. [P31994-2]
    NP_001002275.1. NM_001002275.2.
    NP_001177757.1. NM_001190828.1. [P31994-3]
    NP_003992.3. NM_004001.4. [P31994-1]
    UniGeneiHs.654395.

    Genome annotation databases

    EnsembliENST00000236937; ENSP00000236937; ENSG00000072694. [P31994-2]
    ENST00000358671; ENSP00000351497; ENSG00000072694. [P31994-1]
    ENST00000367960; ENSP00000356937; ENSG00000072694. [P31994-3]
    ENST00000367961; ENSP00000356938; ENSG00000072694. [P31994-3]
    ENST00000403078; ENSP00000386038; ENSG00000072694. [P31994-2]
    GeneIDi2213.
    KEGGihsa:2213.
    UCSCiuc001gay.2. human. [P31994-1]
    uc001gba.2. human. [P31994-2]
    uc009wun.2. human. [P31994-3]

    Polymorphism databases

    DMDMi8039788.

    Keywords - Coding sequence diversityi

    Alternative splicing, Chromosomal rearrangement, Polymorphism

    Cross-referencesi

    Web resourcesi

    Atlas of Genetics and Cytogenetics in Oncology and Haematology

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U87560 mRNA. Translation: AAD00627.1 .
    U87561 mRNA. Translation: AAD00628.1 .
    U87562 mRNA. Translation: AAD00629.1 .
    U87563 mRNA. Translation: AAD00630.1 .
    U87564 mRNA. Translation: AAD00631.1 .
    U87565 mRNA. Translation: AAD00632.1 .
    U87566 mRNA. Translation: AAD00633.1 .
    U87567 mRNA. Translation: AAD00634.1 .
    U87568 mRNA. Translation: AAD00635.1 .
    U87569 mRNA. Translation: AAD00636.1 .
    U87570 mRNA. Translation: AAD00637.1 .
    U87571 mRNA. Translation: AAD00638.1 .
    U87572 mRNA. Translation: AAD00639.1 .
    U87573 mRNA. Translation: AAD00640.1 .
    U87574 mRNA. Translation: AAD00641.1 .
    U87575 mRNA. Translation: AAD00642.1 .
    U87576 mRNA. Translation: AAD00643.1 .
    U87577 mRNA. Translation: AAD00644.1 .
    X17653 mRNA. Translation: CAA35644.1 .
    X17653 mRNA. Translation: CAA35645.1 . Different initiation.
    M31933 mRNA. Translation: AAA35841.1 .
    M31934 mRNA. Translation: AAA35842.1 .
    M31935 mRNA. Translation: AAA35843.1 .
    X52473 mRNA. Translation: CAA36713.1 .
    CR407635 mRNA. Translation: CAG28563.1 .
    AL359541 Genomic DNA. No translation available.
    BC031992 mRNA. Translation: AAH31992.1 .
    BC146678 mRNA. Translation: AAI46679.1 .
    AB050934 mRNA. Translation: BAB92093.1 .
    CCDSi CCDS30924.1. [P31994-1 ]
    CCDS30925.1. [P31994-2 ]
    CCDS53414.1. [P31994-3 ]
    PIRi JL0119.
    RefSeqi NP_001002273.1. NM_001002273.2.
    NP_001002274.1. NM_001002274.2. [P31994-2 ]
    NP_001002275.1. NM_001002275.2.
    NP_001177757.1. NM_001190828.1. [P31994-3 ]
    NP_003992.3. NM_004001.4. [P31994-1 ]
    UniGenei Hs.654395.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2FCB X-ray 1.74 A 46-217 [» ]
    3WJJ X-ray 2.60 C 45-217 [» ]
    ProteinModelPortali P31994.
    SMRi P31994. Positions 50-213.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 108507. 2 interactions.
    IntActi P31994. 14 interactions.
    MINTi MINT-1376812.
    STRINGi 9606.ENSP00000351497.

    Chemistry

    DrugBanki DB00054. Abciximab.
    DB00051. Adalimumab.
    DB00092. Alefacept.
    DB00087. Alemtuzumab.
    DB00074. Basiliximab.
    DB00112. Bevacizumab.
    DB00002. Cetuximab.
    DB00111. Daclizumab.
    DB00095. Efalizumab.
    DB00005. Etanercept.
    DB00056. Gemtuzumab ozogamicin.
    DB00078. Ibritumomab.
    DB00028. Immune globulin.
    DB00075. Muromonab.
    DB00108. Natalizumab.
    DB00110. Palivizumab.
    DB00073. Rituximab.
    DB00081. Tositumomab.
    DB00072. Trastuzumab.

    Protein family/group databases

    MEROPSi I43.001.

    PTM databases

    PhosphoSitei P31994.

    Polymorphism databases

    DMDMi 8039788.

    Proteomic databases

    MaxQBi P31994.
    PaxDbi P31994.
    PRIDEi P31994.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000236937 ; ENSP00000236937 ; ENSG00000072694 . [P31994-2 ]
    ENST00000358671 ; ENSP00000351497 ; ENSG00000072694 . [P31994-1 ]
    ENST00000367960 ; ENSP00000356937 ; ENSG00000072694 . [P31994-3 ]
    ENST00000367961 ; ENSP00000356938 ; ENSG00000072694 . [P31994-3 ]
    ENST00000403078 ; ENSP00000386038 ; ENSG00000072694 . [P31994-2 ]
    GeneIDi 2213.
    KEGGi hsa:2213.
    UCSCi uc001gay.2. human. [P31994-1 ]
    uc001gba.2. human. [P31994-2 ]
    uc009wun.2. human. [P31994-3 ]

    Organism-specific databases

    CTDi 2213.
    GeneCardsi GC01P161552.
    HGNCi HGNC:3618. FCGR2B.
    HPAi CAB007796.
    MIMi 152700. phenotype.
    604590. gene.
    611162. phenotype.
    neXtProti NX_P31994.
    Orphaneti 536. Systemic lupus erythematosus.
    PharmGKBi PA28064.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG25177.
    HOGENOMi HOG000251632.
    HOVERGENi HBG051602.
    InParanoidi P31994.
    KOi K12560.
    OMAi HDYQNHI.
    OrthoDBi EOG708W0N.
    PhylomeDBi P31994.
    TreeFami TF335097.

    Enzyme and pathway databases

    Reactomei REACT_11152. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
    SignaLinki P31994.

    Miscellaneous databases

    EvolutionaryTracei P31994.
    GeneWikii FCGR2B.
    GenomeRNAii 2213.
    NextBioi 8967.
    PROi P31994.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P31994.
    Bgeei P31994.
    CleanExi HS_FCGR2B.
    Genevestigatori P31994.

    Family and domain databases

    Gene3Di 2.60.40.10. 2 hits.
    InterProi IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003599. Ig_sub.
    [Graphical view ]
    SMARTi SM00409. IG. 2 hits.
    [Graphical view ]
    PROSITEi PS50835. IG_LIKE. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Fc-gamma-RIIb nucleotide sequences in SLE and non-SLE humans in vivo derived lymphocytes."
      Ng S., Sinclair N.R.S., Anderson C., Bell D.A., Cairns E.
      Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS IIB1 AND IIB2).
      Tissue: Lymphocyte.
    2. "Human IgG Fc receptor (hFcRII; CD32) exists as multiple isoforms in macrophages, lymphocytes and IgG-transporting placental epithelium."
      Stuart S.G., Simister N.E., Clarkson S.B., Kacinski B.M., Shapiro M., Mellman I.
      EMBO J. 8:3657-3666(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM IIB2).
      Tissue: Placenta.
    3. "Structure and expression of human IgG FcRII(CD32). Functional heterogeneity is encoded by the alternatively spliced products of multiple genes."
      Brooks D.G., Qiu W.Q., Luster A.D., Ravetch J.V.
      J. Exp. Med. 170:1369-1385(1989) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS IIB1; IIB2 AND IIB3), VARIANT PHE-205.
    4. "Distribution, inducibility and biological function of the cloned and expressed human beta Fc receptor II."
      Engelhardt W., Geerds C., Frey J.
      Eur. J. Immunol. 20:1367-1377(1990) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM IIB2).
      Tissue: Placenta.
    5. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
      Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM IIB2).
    6. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS IIB1 AND IIB2).
      Tissue: Skin.
    8. "Fc gamma receptor gene polymorphisms in Japanese patients with systemic lupus erythematosus: contribution of FCGR2B to genetic susceptibility."
      Kyogoku C., Dijstelbloem H.M., Tsuchiya N., Hatta Y., Kato H., Yamaguchi A., Fukazawa T., Jansen M.D., Hashimoto H., van de Winkel J.G.J., Kallenberg C.G.M., Tokunaga K.
      Arthritis Rheum. 46:1242-1254(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 132-253, INVOLVEMENT IN SLE, VARIANT THR-232.
    9. "Association of immunoglobulin G Fc receptor II with Src-like protein-tyrosine kinase Fgr in neutrophils."
      Hamada F., Aoki M., Akiyama T., Toyoshima K.
      Proc. Natl. Acad. Sci. U.S.A. 90:6305-6309(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH FGR.
    10. "In vivo and in vitro specificity of protein tyrosine kinases for immunoglobulin G receptor (FcgammaRII) phosphorylation."
      Bewarder N., Weinrich V., Budde P., Hartmann D., Flaswinkel H., Reth M., Frey J.
      Mol. Cell. Biol. 16:4735-4743(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION AT TYR-292.
    11. "Fc gamma receptor type IIb induced recruitment of inositol and protein phosphatases to the signal transductory complex of human B-cell."
      Sarmay G., Koncz G., Pecht I., Gergely J.
      Immunol. Lett. 57:159-164(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH LYN.
    12. "Measles virus nucleoprotein induces cell-proliferation arrest and apoptosis through NTAIL-NR and NCORE-FcgammaRIIB1 interactions, respectively."
      Laine D., Bourhis J.-M., Longhi S., Flacher M., Cassard L., Canard B., Sautes-Fridman C., Rabourdin-Combe C., Valentin H.
      J. Gen. Virol. 86:1771-1784(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH MEASLES VIRUS N PROTEIN.
    13. "Crystal structure of the soluble form of the human fcgamma-receptor IIb: a new member of the immunoglobulin superfamily at 1.7 A resolution."
      Sondermann P., Huber R., Jacob U.
      EMBO J. 18:1095-1103(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.74 ANGSTROMS) OF 46-217, DISULFIDE BONDS.
    14. "Interaction of a human Fc gamma RIIb1 (CD32) isoform with murine and human IgG subclasses."
      Warmerdam P.A., van den Herik-Oudijk I.E., Parren P.W., Westerdaal N.A., van de Winkel J.G., Capel P.J.
      Int. Immunol. 5:239-247(1993) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT ASP-258.
    15. "Systemic lupus erythematosus-associated defects in the inhibitory receptor FcgammaRIIb reduce susceptibility to malaria."
      Clatworthy M.R., Willcocks L., Urban B., Langhorne J., Williams T.N., Peshu N., Watkins N.A., Floto R.A., Smith K.G.
      Proc. Natl. Acad. Sci. U.S.A. 104:7169-7174(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: ASSOCIATION OF VARIANT THR-232 WITH RESISTANCE TO MALARIA, CHARACTERIZATION OF VARIANT THR-232.
    16. "A defunctioning polymorphism in FCGR2B is associated with protection against malaria but susceptibility to systemic lupus erythematosus."
      Willcocks L.C., Carr E.J., Niederer H.A., Rayner T.F., Williams T.N., Yang W., Scott J.A., Urban B.C., Peshu N., Vyse T.J., Lau Y.L., Lyons P.A., Smith K.G.
      Proc. Natl. Acad. Sci. U.S.A. 107:7881-7885(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: ASSOCIATION OF VARIANT THR-232 WITH SUSCEPTIBILITY TO SLE, RESISTANCE TO MALARIA.

    Entry informationi

    Entry nameiFCG2B_HUMAN
    AccessioniPrimary (citable) accession number: P31994
    Secondary accession number(s): A6H8N3
    , O95649, Q53X85, Q5VXA9, Q8NIA1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 1993
    Last sequence update: May 30, 2000
    Last modified: October 1, 2014
    This is version 167 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Caution

    Has sometimes been attributed to correspond to FcR-IIC.Curated

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human cell differentiation molecules
      CD nomenclature of surface proteins of human leucocytes and list of entries
    2. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    7. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3