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Protein

Low affinity immunoglobulin gamma Fc region receptor II-b

Gene

FCGR2B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Receptor for the Fc region of complexed or aggregated immunoglobulins gamma. Low affinity receptor. Involved in a variety of effector and regulatory functions such as phagocytosis of immune complexes and modulation of antibody production by B-cells. Binding to this receptor results in down-modulation of previous state of cell activation triggered via antigen receptors on B-cells (BCR), T-cells (TCR) or via another Fc receptor. Isoform IIB1 fails to mediate endocytosis or phagocytosis. Isoform IIB2 does not trigger phagocytosis.

GO - Biological processi

  • immune response Source: ProtInc
  • regulation of immune response Source: Reactome
  • signal transduction Source: ProtInc
  • viral process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Host-virus interaction

Keywords - Ligandi

IgG-binding protein

Enzyme and pathway databases

ReactomeiR-HSA-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
SignaLinkiP31994.

Protein family/group databases

MEROPSiI43.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Low affinity immunoglobulin gamma Fc region receptor II-b
Short name:
IgG Fc receptor II-b
Alternative name(s):
CDw32
Fc-gamma RII-b
Short name:
Fc-gamma-RIIb
Short name:
FcRII-b
CD_antigen: CD32
Gene namesi
Name:FCGR2B
Synonyms:CD32, FCG2, IGFR2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:3618. FCGR2B.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini43 – 217175ExtracellularSequence analysisAdd
BLAST
Transmembranei218 – 24023HelicalSequence analysisAdd
BLAST
Topological domaini241 – 31070CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Involvement in diseasei

Systemic lupus erythematosus (SLE)2 Publications
Disease susceptibility is associated with variations affecting the gene represented in this entry.
Disease descriptionA chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow.
See also OMIM:152700
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti232 – 2321I → T Associated with susceptibility to SLE; associated with resistance to malaria; found at an increased frequency in African and Asian populations from areas where malaria is endemic; enhances phagocytosis of Plasmodium falciparum-infected erythrocytes in vitro. 3 Publications
Corresponds to variant rs1050501 [ dbSNP | Ensembl ].
VAR_015515

Keywords - Diseasei

Proto-oncogene, Systemic lupus erythematosus

Organism-specific databases

MalaCardsiFCGR2B.
MIMi152700. phenotype.
611162. phenotype.
Orphaneti536. Systemic lupus erythematosus.
PharmGKBiPA28064.

Chemistry

DrugBankiDB00054. Abciximab.
DB00051. Adalimumab.
DB00092. Alefacept.
DB00087. Alemtuzumab.
DB00098. Anti-thymocyte Globulin (Rabbit).
DB00074. Basiliximab.
DB00112. Bevacizumab.
DB00002. Cetuximab.
DB00111. Daclizumab.
DB00095. Efalizumab.
DB00005. Etanercept.
DB00056. Gemtuzumab ozogamicin.
DB00078. Ibritumomab.
DB00028. Intravenous Immunoglobulin.
DB00075. Muromonab.
DB00108. Natalizumab.
DB00110. Palivizumab.
DB00073. Rituximab.
DB00081. Tositumomab.
DB00072. Trastuzumab.

Polymorphism and mutation databases

BioMutaiFCGR2B.
DMDMi8039788.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 4242Sequence analysisAdd
BLAST
Chaini43 – 310268Low affinity immunoglobulin gamma Fc region receptor II-bPRO_0000015147Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi71 ↔ 113PROSITE-ProRule annotation1 Publication
Glycosylationi106 – 1061N-linked (GlcNAc...)Sequence analysis
Disulfide bondi152 ↔ 196PROSITE-ProRule annotation1 Publication
Glycosylationi180 – 1801N-linked (GlcNAc...)Sequence analysis
Glycosylationi187 – 1871N-linked (GlcNAc...)Sequence analysis
Modified residuei292 – 2921Phosphotyrosine; by SRC-type Tyr-kinases1 Publication

Post-translational modificationi

Phosphorylated by the SRC-type Tyr-kinases LYN and BLK.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiP31994.
PaxDbiP31994.
PeptideAtlasiP31994.
PRIDEiP31994.

PTM databases

iPTMnetiP31994.
PhosphoSiteiP31994.

Expressioni

Tissue specificityi

Is the most broadly distributed Fc-gamma-receptor. Expressed in monocyte, neutrophils, macrophages, basophils, eosinophils, Langerhans cells, B-cells, platelets cells and placenta (endothelial cells). Not detected in natural killer cells.

Gene expression databases

BgeeiENSG00000072694.
CleanExiHS_FCGR2B.
GenevisibleiP31994. HS.

Organism-specific databases

HPAiCAB007796.
HPA014730.

Interactioni

Subunit structurei

Isoform IIB1 interacts with measles virus N protein. N protein is released in the blood following lysis of measles infected cells. This interaction presumably block inflammatory immune response. Interacts with INPP5D/SHIP1. Interacts with FGR. Interacts with LYN.3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
IGHG1P0185731EBI-724784,EBI-356114
INPP5DQ928353EBI-724784,EBI-1380477
NCK1P163332EBI-724784,EBI-389883
PLCG1P191742EBI-724784,EBI-79387
PTPN6P293503EBI-724784,EBI-78260

Protein-protein interaction databases

BioGridi108507. 5 interactions.
DIPiDIP-36638N.
IntActiP31994. 14 interactions.
MINTiMINT-1376812.
STRINGi9606.ENSP00000351497.

Structurei

Secondary structure

1
310
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi51 – 566Combined sources
Beta strandi59 – 624Combined sources
Beta strandi66 – 727Combined sources
Beta strandi83 – 864Combined sources
Beta strandi96 – 1027Combined sources
Helixi105 – 1073Combined sources
Beta strandi109 – 1146Combined sources
Beta strandi116 – 1183Combined sources
Beta strandi124 – 1296Combined sources
Beta strandi131 – 1366Combined sources
Beta strandi140 – 1423Combined sources
Beta strandi148 – 1547Combined sources
Helixi155 – 1573Combined sources
Beta strandi161 – 1677Combined sources
Beta strandi170 – 1778Combined sources
Beta strandi180 – 1834Combined sources
Helixi188 – 1903Combined sources
Beta strandi192 – 2009Combined sources
Beta strandi203 – 2064Combined sources
Beta strandi210 – 2145Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2FCBX-ray1.74A46-217[»]
3WJJX-ray2.60C45-217[»]
ProteinModelPortaliP31994.
SMRiP31994. Positions 49-258.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP31994.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini48 – 12780Ig-like C2-type 1Add
BLAST
Domaini131 – 21383Ig-like C2-type 2Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi290 – 2956ITIM motif

Domaini

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410J9AP. Eukaryota.
ENOG410YXNK. LUCA.
GeneTreeiENSGT00760000119130.
HOGENOMiHOG000251632.
HOVERGENiHBG051602.
InParanoidiP31994.
KOiK12560.
OMAiDMLLWTA.
OrthoDBiEOG091G0JSA.
PhylomeDBiP31994.
TreeFamiTF335097.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
[Graphical view]
PfamiPF13895. Ig_2. 2 hits.
[Graphical view]
SMARTiSM00409. IG. 2 hits.
SM00408. IGc2. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 2 hits.
PROSITEiPS50835. IG_LIKE. 2 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform IIB1 (identifier: P31994-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGILSFLPVL ATESDWADCK SPQPWGHMLL WTAVLFLAPV AGTPAAPPKA
60 70 80 90 100
VLKLEPQWIN VLQEDSVTLT CRGTHSPESD SIQWFHNGNL IPTHTQPSYR
110 120 130 140 150
FKANNNDSGE YTCQTGQTSL SDPVHLTVLS EWLVLQTPHL EFQEGETIVL
160 170 180 190 200
RCHSWKDKPL VKVTFFQNGK SKKFSRSDPN FSIPQANHSH SGDYHCTGNI
210 220 230 240 250
GYTLYSSKPV TITVQAPSSS PMGIIVAVVT GIAVAAIVAA VVALIYCRKK
260 270 280 290 300
RISALPGYPE CREMGETLPE KPANPTNPDE ADKVGAENTI TYSLLMHPDA
310
LEEPDDQNRI
Length:310
Mass (Da):34,044
Last modified:May 30, 2000 - v2
Checksum:i2186F8538FF01F36
GO
Isoform IIB2 (identifier: P31994-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     254-272: Missing.

Show »
Length:291
Mass (Da):31,944
Checksum:i3B76609541B30962
GO
Isoform IIB3 (identifier: P31994-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     39-45: Missing.

Show »
Length:303
Mass (Da):33,450
Checksum:iB84833348A175687
GO

Sequence cautioni

The sequence CAA35645 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti46 – 461Missing in AAD00637 (Ref. 1) Curated
Sequence conflicti46 – 461Missing in AAD00638 (Ref. 1) Curated
Sequence conflicti46 – 461Missing in AAD00639 (Ref. 1) Curated
Sequence conflicti46 – 461Missing in AAD00644 (Ref. 1) Curated
Sequence conflicti178 – 1781D → I in CAA35644 (PubMed:2531080).Curated
Sequence conflicti178 – 1781D → I in CAA35645 (PubMed:2531080).Curated
Sequence conflicti230 – 2301T → I in CAA35644 (PubMed:2531080).Curated
Sequence conflicti230 – 2301T → I in CAA35645 (PubMed:2531080).Curated
Sequence conflicti242 – 2421V → G in CAA35644 (PubMed:2531080).Curated
Sequence conflicti242 – 2421V → G in CAA35645 (PubMed:2531080).Curated
Sequence conflicti275 – 2751P → S (PubMed:2531080).Curated

Polymorphismi

Note: FCGR2B polymorphisms can influence susceptibility or resistance to malaria [MIMi:611162].2 Publications

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti83 – 831Q → P.
Corresponds to variant rs5017567 [ dbSNP | Ensembl ].
VAR_059430
Natural varianti205 – 2051Y → F.1 Publication
Corresponds to variant rs1050499 [ dbSNP | Ensembl ].
VAR_027045
Natural varianti232 – 2321I → T Associated with susceptibility to SLE; associated with resistance to malaria; found at an increased frequency in African and Asian populations from areas where malaria is endemic; enhances phagocytosis of Plasmodium falciparum-infected erythrocytes in vitro. 3 Publications
Corresponds to variant rs1050501 [ dbSNP | Ensembl ].
VAR_015515
Natural varianti258 – 2581Y → D.1 Publication
Corresponds to variant rs148534844 [ dbSNP | Ensembl ].
VAR_008798

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei39 – 457Missing in isoform IIB3. 1 PublicationVSP_002642
Alternative sequencei254 – 27219Missing in isoform IIB2. 6 PublicationsVSP_002643Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U87560 mRNA. Translation: AAD00627.1.
U87561 mRNA. Translation: AAD00628.1.
U87562 mRNA. Translation: AAD00629.1.
U87563 mRNA. Translation: AAD00630.1.
U87564 mRNA. Translation: AAD00631.1.
U87565 mRNA. Translation: AAD00632.1.
U87566 mRNA. Translation: AAD00633.1.
U87567 mRNA. Translation: AAD00634.1.
U87568 mRNA. Translation: AAD00635.1.
U87569 mRNA. Translation: AAD00636.1.
U87570 mRNA. Translation: AAD00637.1.
U87571 mRNA. Translation: AAD00638.1.
U87572 mRNA. Translation: AAD00639.1.
U87573 mRNA. Translation: AAD00640.1.
U87574 mRNA. Translation: AAD00641.1.
U87575 mRNA. Translation: AAD00642.1.
U87576 mRNA. Translation: AAD00643.1.
U87577 mRNA. Translation: AAD00644.1.
X17653 mRNA. Translation: CAA35644.1.
X17653 mRNA. Translation: CAA35645.1. Different initiation.
M31933 mRNA. Translation: AAA35841.1.
M31934 mRNA. Translation: AAA35842.1.
M31935 mRNA. Translation: AAA35843.1.
X52473 mRNA. Translation: CAA36713.1.
CR407635 mRNA. Translation: CAG28563.1.
AL359541 Genomic DNA. No translation available.
BC031992 mRNA. Translation: AAH31992.1.
BC146678 mRNA. Translation: AAI46679.1.
AB050934 mRNA. Translation: BAB92093.1.
CCDSiCCDS30924.1. [P31994-1]
CCDS30925.1. [P31994-2]
CCDS53414.1. [P31994-3]
PIRiJL0119.
RefSeqiNP_001002273.1. NM_001002273.2.
NP_001002274.1. NM_001002274.2. [P31994-2]
NP_001002275.1. NM_001002275.2.
NP_001177757.1. NM_001190828.1. [P31994-3]
NP_003992.3. NM_004001.4. [P31994-1]
UniGeneiHs.654395.

Genome annotation databases

EnsembliENST00000236937; ENSP00000236937; ENSG00000072694. [P31994-2]
ENST00000358671; ENSP00000351497; ENSG00000072694. [P31994-1]
ENST00000367961; ENSP00000356938; ENSG00000072694. [P31994-3]
ENST00000428605; ENSP00000404329; ENSG00000072694. [P31994-1]
GeneIDi2213.
KEGGihsa:2213.
UCSCiuc001gaz.3. human. [P31994-1]

Keywords - Coding sequence diversityi

Alternative splicing, Chromosomal rearrangement, Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U87560 mRNA. Translation: AAD00627.1.
U87561 mRNA. Translation: AAD00628.1.
U87562 mRNA. Translation: AAD00629.1.
U87563 mRNA. Translation: AAD00630.1.
U87564 mRNA. Translation: AAD00631.1.
U87565 mRNA. Translation: AAD00632.1.
U87566 mRNA. Translation: AAD00633.1.
U87567 mRNA. Translation: AAD00634.1.
U87568 mRNA. Translation: AAD00635.1.
U87569 mRNA. Translation: AAD00636.1.
U87570 mRNA. Translation: AAD00637.1.
U87571 mRNA. Translation: AAD00638.1.
U87572 mRNA. Translation: AAD00639.1.
U87573 mRNA. Translation: AAD00640.1.
U87574 mRNA. Translation: AAD00641.1.
U87575 mRNA. Translation: AAD00642.1.
U87576 mRNA. Translation: AAD00643.1.
U87577 mRNA. Translation: AAD00644.1.
X17653 mRNA. Translation: CAA35644.1.
X17653 mRNA. Translation: CAA35645.1. Different initiation.
M31933 mRNA. Translation: AAA35841.1.
M31934 mRNA. Translation: AAA35842.1.
M31935 mRNA. Translation: AAA35843.1.
X52473 mRNA. Translation: CAA36713.1.
CR407635 mRNA. Translation: CAG28563.1.
AL359541 Genomic DNA. No translation available.
BC031992 mRNA. Translation: AAH31992.1.
BC146678 mRNA. Translation: AAI46679.1.
AB050934 mRNA. Translation: BAB92093.1.
CCDSiCCDS30924.1. [P31994-1]
CCDS30925.1. [P31994-2]
CCDS53414.1. [P31994-3]
PIRiJL0119.
RefSeqiNP_001002273.1. NM_001002273.2.
NP_001002274.1. NM_001002274.2. [P31994-2]
NP_001002275.1. NM_001002275.2.
NP_001177757.1. NM_001190828.1. [P31994-3]
NP_003992.3. NM_004001.4. [P31994-1]
UniGeneiHs.654395.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2FCBX-ray1.74A46-217[»]
3WJJX-ray2.60C45-217[»]
ProteinModelPortaliP31994.
SMRiP31994. Positions 49-258.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi108507. 5 interactions.
DIPiDIP-36638N.
IntActiP31994. 14 interactions.
MINTiMINT-1376812.
STRINGi9606.ENSP00000351497.

Chemistry

DrugBankiDB00054. Abciximab.
DB00051. Adalimumab.
DB00092. Alefacept.
DB00087. Alemtuzumab.
DB00098. Anti-thymocyte Globulin (Rabbit).
DB00074. Basiliximab.
DB00112. Bevacizumab.
DB00002. Cetuximab.
DB00111. Daclizumab.
DB00095. Efalizumab.
DB00005. Etanercept.
DB00056. Gemtuzumab ozogamicin.
DB00078. Ibritumomab.
DB00028. Intravenous Immunoglobulin.
DB00075. Muromonab.
DB00108. Natalizumab.
DB00110. Palivizumab.
DB00073. Rituximab.
DB00081. Tositumomab.
DB00072. Trastuzumab.

Protein family/group databases

MEROPSiI43.001.

PTM databases

iPTMnetiP31994.
PhosphoSiteiP31994.

Polymorphism and mutation databases

BioMutaiFCGR2B.
DMDMi8039788.

Proteomic databases

MaxQBiP31994.
PaxDbiP31994.
PeptideAtlasiP31994.
PRIDEiP31994.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000236937; ENSP00000236937; ENSG00000072694. [P31994-2]
ENST00000358671; ENSP00000351497; ENSG00000072694. [P31994-1]
ENST00000367961; ENSP00000356938; ENSG00000072694. [P31994-3]
ENST00000428605; ENSP00000404329; ENSG00000072694. [P31994-1]
GeneIDi2213.
KEGGihsa:2213.
UCSCiuc001gaz.3. human. [P31994-1]

Organism-specific databases

CTDi2213.
GeneCardsiFCGR2B.
HGNCiHGNC:3618. FCGR2B.
HPAiCAB007796.
HPA014730.
MalaCardsiFCGR2B.
MIMi152700. phenotype.
604590. gene.
611162. phenotype.
neXtProtiNX_P31994.
Orphaneti536. Systemic lupus erythematosus.
PharmGKBiPA28064.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J9AP. Eukaryota.
ENOG410YXNK. LUCA.
GeneTreeiENSGT00760000119130.
HOGENOMiHOG000251632.
HOVERGENiHBG051602.
InParanoidiP31994.
KOiK12560.
OMAiDMLLWTA.
OrthoDBiEOG091G0JSA.
PhylomeDBiP31994.
TreeFamiTF335097.

Enzyme and pathway databases

ReactomeiR-HSA-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
SignaLinkiP31994.

Miscellaneous databases

EvolutionaryTraceiP31994.
GeneWikiiFCGR2B.
GenomeRNAii2213.
PROiP31994.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000072694.
CleanExiHS_FCGR2B.
GenevisibleiP31994. HS.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
[Graphical view]
PfamiPF13895. Ig_2. 2 hits.
[Graphical view]
SMARTiSM00409. IG. 2 hits.
SM00408. IGc2. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 2 hits.
PROSITEiPS50835. IG_LIKE. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiFCG2B_HUMAN
AccessioniPrimary (citable) accession number: P31994
Secondary accession number(s): A6H8N3
, O95649, Q53X85, Q5VXA9, Q8NIA1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: May 30, 2000
Last modified: September 7, 2016
This is version 189 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Has sometimes been attributed to correspond to FcR-IIC.Curated

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.