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P31994

- FCG2B_HUMAN

UniProt

P31994 - FCG2B_HUMAN

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Protein
Low affinity immunoglobulin gamma Fc region receptor II-b
Gene
FCGR2B, CD32, FCG2, IGFR2
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Receptor for the Fc region of complexed or aggregated immunoglobulins gamma. Low affinity receptor. Involved in a variety of effector and regulatory functions such as phagocytosis of immune complexes and modulation of antibody production by B-cells. Binding to this receptor results in down-modulation of previous state of cell activation triggered via antigen receptors on B-cells (BCR), T-cells (TCR) or via another Fc receptor. Isoform IIB1 fails to mediate endocytosis or phagocytosis. Isoform IIB2 does not trigger phagocytosis.

GO - Molecular functioni

  1. protein binding Source: IntAct
Complete GO annotation...

GO - Biological processi

  1. immune response Source: ProtInc
  2. regulation of immune response Source: Reactome
  3. signal transduction Source: ProtInc
  4. viral process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Host-virus interaction

Keywords - Ligandi

IgG-binding protein

Enzyme and pathway databases

ReactomeiREACT_11152. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
SignaLinkiP31994.

Protein family/group databases

MEROPSiI43.001.

Names & Taxonomyi

Protein namesi
Recommended name:
Low affinity immunoglobulin gamma Fc region receptor II-b
Short name:
IgG Fc receptor II-b
Alternative name(s):
CDw32
Fc-gamma RII-b
Short name:
Fc-gamma-RIIb
Short name:
FcRII-b
CD_antigen: CD32
Gene namesi
Name:FCGR2B
Synonyms:CD32, FCG2, IGFR2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:3618. FCGR2B.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini43 – 217175Extracellular Reviewed prediction
Add
BLAST
Transmembranei218 – 24023Helical; Reviewed prediction
Add
BLAST
Topological domaini241 – 31070Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Involvement in diseasei

A chromosomal aberration involving FCGR2B is found in a follicular lymphoma. Translocation t(1;22)(q22;q11). The translocation leads to the hyperexpression of the receptor. This may play a role in the tumor progression.
Systemic lupus erythematosus (SLE) [MIM:152700]: A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow.
Note: Disease susceptibility is associated with variations affecting the gene represented in this entry.2 Publications
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti232 – 2321I → T Associated with susceptibility to SLE; associated with resistance to malaria; found at an increased frequency in African and Asian populations from areas where malaria is endemic; enhances phagocytosis of Plasmodium falciparum-infected erythrocytes in vitro. 3 Publications
Corresponds to variant rs1050501 [ dbSNP | Ensembl ].
VAR_015515

Keywords - Diseasei

Proto-oncogene, Systemic lupus erythematosus

Organism-specific databases

MIMi152700. phenotype.
611162. phenotype.
Orphaneti536. Systemic lupus erythematosus.
PharmGKBiPA28064.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 4242 Reviewed prediction
Add
BLAST
Chaini43 – 310268Low affinity immunoglobulin gamma Fc region receptor II-b
PRO_0000015147Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi71 ↔ 1131 Publication
Glycosylationi106 – 1061N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi152 ↔ 1961 Publication
Glycosylationi180 – 1801N-linked (GlcNAc...) Reviewed prediction
Glycosylationi187 – 1871N-linked (GlcNAc...) Reviewed prediction
Modified residuei292 – 2921Phosphotyrosine; by SRC-type Tyr-kinases1 Publication

Post-translational modificationi

Phosphorylated by the SRC-type Tyr-kinases LYN and BLK.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiP31994.
PaxDbiP31994.
PRIDEiP31994.

PTM databases

PhosphoSiteiP31994.

Expressioni

Tissue specificityi

Is the most broadly distributed Fc-gamma-receptor. Expressed in monocyte, neutrophils, macrophages, basophils, eosinophils, Langerhans cells, B-cells, platelets cells and placenta (endothelial cells). Not detected in natural killer cells.

Gene expression databases

ArrayExpressiP31994.
BgeeiP31994.
CleanExiHS_FCGR2B.
GenevestigatoriP31994.

Organism-specific databases

HPAiCAB007796.

Interactioni

Subunit structurei

Isoform IIB1 interacts with measles virus N protein. N protein is released in the blood following lysis of measles infected cells. This interaction presumably block inflammatory immune response. Interacts with INPP5D/SHIP1. Interacts with FGR. Interacts with LYN.3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
IGHG1P0185731EBI-724784,EBI-356114
INPP5DQ928352EBI-724784,EBI-1380477
NCK1P163332EBI-724784,EBI-389883
PLCG1P191742EBI-724784,EBI-79387
PTPN6P293503EBI-724784,EBI-78260

Protein-protein interaction databases

BioGridi108507. 2 interactions.
IntActiP31994. 14 interactions.
MINTiMINT-1376812.
STRINGi9606.ENSP00000351497.

Structurei

Secondary structure

Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi51 – 566
Beta strandi59 – 624
Beta strandi66 – 727
Beta strandi83 – 864
Beta strandi96 – 1027
Helixi105 – 1073
Beta strandi109 – 1146
Beta strandi116 – 1183
Beta strandi124 – 1296
Beta strandi131 – 1366
Beta strandi140 – 1423
Beta strandi148 – 1547
Helixi155 – 1573
Beta strandi161 – 1677
Beta strandi170 – 1778
Beta strandi180 – 1834
Helixi188 – 1903
Beta strandi192 – 2009
Beta strandi203 – 2064
Beta strandi210 – 2145

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2FCBX-ray1.74A46-217[»]
3WJJX-ray2.60C45-217[»]
ProteinModelPortaliP31994.
SMRiP31994. Positions 50-213.

Miscellaneous databases

EvolutionaryTraceiP31994.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini48 – 12780Ig-like C2-type 1
Add
BLAST
Domaini131 – 21383Ig-like C2-type 2
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi290 – 2956ITIM motif

Domaini

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG25177.
HOGENOMiHOG000251632.
HOVERGENiHBG051602.
InParanoidiP31994.
KOiK12560.
OMAiHDYQNHI.
OrthoDBiEOG708W0N.
PhylomeDBiP31994.
TreeFamiTF335097.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
[Graphical view]
SMARTiSM00409. IG. 2 hits.
[Graphical view]
PROSITEiPS50835. IG_LIKE. 2 hits.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform IIB1 (identifier: P31994-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MGILSFLPVL ATESDWADCK SPQPWGHMLL WTAVLFLAPV AGTPAAPPKA    50
VLKLEPQWIN VLQEDSVTLT CRGTHSPESD SIQWFHNGNL IPTHTQPSYR 100
FKANNNDSGE YTCQTGQTSL SDPVHLTVLS EWLVLQTPHL EFQEGETIVL 150
RCHSWKDKPL VKVTFFQNGK SKKFSRSDPN FSIPQANHSH SGDYHCTGNI 200
GYTLYSSKPV TITVQAPSSS PMGIIVAVVT GIAVAAIVAA VVALIYCRKK 250
RISALPGYPE CREMGETLPE KPANPTNPDE ADKVGAENTI TYSLLMHPDA 300
LEEPDDQNRI 310
Length:310
Mass (Da):34,044
Last modified:May 30, 2000 - v2
Checksum:i2186F8538FF01F36
GO
Isoform IIB2 (identifier: P31994-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     254-272: Missing.

Show »
Length:291
Mass (Da):31,944
Checksum:i3B76609541B30962
GO
Isoform IIB3 (identifier: P31994-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     39-45: Missing.

Show »
Length:303
Mass (Da):33,450
Checksum:iB84833348A175687
GO

Sequence cautioni

The sequence CAA35645.1 differs from that shown. Reason: Erroneous initiation.

Polymorphismi

Note: FCGR2B polymorphisms can influence susceptibility or resistance to malaria [MIMi:611162].

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti83 – 831Q → P.
Corresponds to variant rs5017567 [ dbSNP | Ensembl ].
VAR_059430
Natural varianti205 – 2051Y → F.1 Publication
Corresponds to variant rs1050499 [ dbSNP | Ensembl ].
VAR_027045
Natural varianti232 – 2321I → T Associated with susceptibility to SLE; associated with resistance to malaria; found at an increased frequency in African and Asian populations from areas where malaria is endemic; enhances phagocytosis of Plasmodium falciparum-infected erythrocytes in vitro. 3 Publications
Corresponds to variant rs1050501 [ dbSNP | Ensembl ].
VAR_015515
Natural varianti258 – 2581Y → D.1 Publication
Corresponds to variant rs148534844 [ dbSNP | Ensembl ].
VAR_008798

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei39 – 457Missing in isoform IIB3.
VSP_002642
Alternative sequencei254 – 27219Missing in isoform IIB2.
VSP_002643Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti46 – 461Missing in AAD00637. 1 Publication
Sequence conflicti46 – 461Missing in AAD00638. 1 Publication
Sequence conflicti46 – 461Missing in AAD00639. 1 Publication
Sequence conflicti46 – 461Missing in AAD00644. 1 Publication
Sequence conflicti178 – 1781D → I in CAA35644. 1 Publication
Sequence conflicti178 – 1781D → I in CAA35645. 1 Publication
Sequence conflicti230 – 2301T → I in CAA35644. 1 Publication
Sequence conflicti230 – 2301T → I in CAA35645. 1 Publication
Sequence conflicti242 – 2421V → G in CAA35644. 1 Publication
Sequence conflicti242 – 2421V → G in CAA35645. 1 Publication
Sequence conflicti275 – 2751P → S1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U87560 mRNA. Translation: AAD00627.1.
U87561 mRNA. Translation: AAD00628.1.
U87562 mRNA. Translation: AAD00629.1.
U87563 mRNA. Translation: AAD00630.1.
U87564 mRNA. Translation: AAD00631.1.
U87565 mRNA. Translation: AAD00632.1.
U87566 mRNA. Translation: AAD00633.1.
U87567 mRNA. Translation: AAD00634.1.
U87568 mRNA. Translation: AAD00635.1.
U87569 mRNA. Translation: AAD00636.1.
U87570 mRNA. Translation: AAD00637.1.
U87571 mRNA. Translation: AAD00638.1.
U87572 mRNA. Translation: AAD00639.1.
U87573 mRNA. Translation: AAD00640.1.
U87574 mRNA. Translation: AAD00641.1.
U87575 mRNA. Translation: AAD00642.1.
U87576 mRNA. Translation: AAD00643.1.
U87577 mRNA. Translation: AAD00644.1.
X17653 mRNA. Translation: CAA35644.1.
X17653 mRNA. Translation: CAA35645.1. Different initiation.
M31933 mRNA. Translation: AAA35841.1.
M31934 mRNA. Translation: AAA35842.1.
M31935 mRNA. Translation: AAA35843.1.
X52473 mRNA. Translation: CAA36713.1.
CR407635 mRNA. Translation: CAG28563.1.
AL359541 Genomic DNA. No translation available.
BC031992 mRNA. Translation: AAH31992.1.
BC146678 mRNA. Translation: AAI46679.1.
AB050934 mRNA. Translation: BAB92093.1.
CCDSiCCDS30924.1. [P31994-1]
CCDS30925.1. [P31994-2]
CCDS53414.1. [P31994-3]
PIRiJL0119.
RefSeqiNP_001002273.1. NM_001002273.2.
NP_001002274.1. NM_001002274.2. [P31994-2]
NP_001002275.1. NM_001002275.2.
NP_001177757.1. NM_001190828.1. [P31994-3]
NP_003992.3. NM_004001.4. [P31994-1]
UniGeneiHs.654395.

Genome annotation databases

EnsembliENST00000236937; ENSP00000236937; ENSG00000072694. [P31994-2]
ENST00000358671; ENSP00000351497; ENSG00000072694. [P31994-1]
ENST00000367960; ENSP00000356937; ENSG00000072694. [P31994-3]
ENST00000367961; ENSP00000356938; ENSG00000072694. [P31994-3]
ENST00000367962; ENSP00000356939; ENSG00000072694. [P31994-1]
ENST00000403078; ENSP00000386038; ENSG00000072694. [P31994-2]
GeneIDi2213.
KEGGihsa:2213.
UCSCiuc001gay.2. human. [P31994-1]
uc001gba.2. human. [P31994-2]
uc009wun.2. human. [P31994-3]

Polymorphism databases

DMDMi8039788.

Keywords - Coding sequence diversityi

Alternative splicing, Chromosomal rearrangement, Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U87560 mRNA. Translation: AAD00627.1 .
U87561 mRNA. Translation: AAD00628.1 .
U87562 mRNA. Translation: AAD00629.1 .
U87563 mRNA. Translation: AAD00630.1 .
U87564 mRNA. Translation: AAD00631.1 .
U87565 mRNA. Translation: AAD00632.1 .
U87566 mRNA. Translation: AAD00633.1 .
U87567 mRNA. Translation: AAD00634.1 .
U87568 mRNA. Translation: AAD00635.1 .
U87569 mRNA. Translation: AAD00636.1 .
U87570 mRNA. Translation: AAD00637.1 .
U87571 mRNA. Translation: AAD00638.1 .
U87572 mRNA. Translation: AAD00639.1 .
U87573 mRNA. Translation: AAD00640.1 .
U87574 mRNA. Translation: AAD00641.1 .
U87575 mRNA. Translation: AAD00642.1 .
U87576 mRNA. Translation: AAD00643.1 .
U87577 mRNA. Translation: AAD00644.1 .
X17653 mRNA. Translation: CAA35644.1 .
X17653 mRNA. Translation: CAA35645.1 . Different initiation.
M31933 mRNA. Translation: AAA35841.1 .
M31934 mRNA. Translation: AAA35842.1 .
M31935 mRNA. Translation: AAA35843.1 .
X52473 mRNA. Translation: CAA36713.1 .
CR407635 mRNA. Translation: CAG28563.1 .
AL359541 Genomic DNA. No translation available.
BC031992 mRNA. Translation: AAH31992.1 .
BC146678 mRNA. Translation: AAI46679.1 .
AB050934 mRNA. Translation: BAB92093.1 .
CCDSi CCDS30924.1. [P31994-1 ]
CCDS30925.1. [P31994-2 ]
CCDS53414.1. [P31994-3 ]
PIRi JL0119.
RefSeqi NP_001002273.1. NM_001002273.2.
NP_001002274.1. NM_001002274.2. [P31994-2 ]
NP_001002275.1. NM_001002275.2.
NP_001177757.1. NM_001190828.1. [P31994-3 ]
NP_003992.3. NM_004001.4. [P31994-1 ]
UniGenei Hs.654395.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2FCB X-ray 1.74 A 46-217 [» ]
3WJJ X-ray 2.60 C 45-217 [» ]
ProteinModelPortali P31994.
SMRi P31994. Positions 50-213.
ModBasei Search...

Protein-protein interaction databases

BioGridi 108507. 2 interactions.
IntActi P31994. 14 interactions.
MINTi MINT-1376812.
STRINGi 9606.ENSP00000351497.

Chemistry

DrugBanki DB00054. Abciximab.
DB00051. Adalimumab.
DB00092. Alefacept.
DB00087. Alemtuzumab.
DB00074. Basiliximab.
DB00112. Bevacizumab.
DB00002. Cetuximab.
DB00111. Daclizumab.
DB00095. Efalizumab.
DB00005. Etanercept.
DB00056. Gemtuzumab ozogamicin.
DB00078. Ibritumomab.
DB00028. Immune globulin.
DB00075. Muromonab.
DB00108. Natalizumab.
DB00110. Palivizumab.
DB00073. Rituximab.
DB00081. Tositumomab.
DB00072. Trastuzumab.

Protein family/group databases

MEROPSi I43.001.

PTM databases

PhosphoSitei P31994.

Polymorphism databases

DMDMi 8039788.

Proteomic databases

MaxQBi P31994.
PaxDbi P31994.
PRIDEi P31994.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000236937 ; ENSP00000236937 ; ENSG00000072694 . [P31994-2 ]
ENST00000358671 ; ENSP00000351497 ; ENSG00000072694 . [P31994-1 ]
ENST00000367960 ; ENSP00000356937 ; ENSG00000072694 . [P31994-3 ]
ENST00000367961 ; ENSP00000356938 ; ENSG00000072694 . [P31994-3 ]
ENST00000367962 ; ENSP00000356939 ; ENSG00000072694 . [P31994-1 ]
ENST00000403078 ; ENSP00000386038 ; ENSG00000072694 . [P31994-2 ]
GeneIDi 2213.
KEGGi hsa:2213.
UCSCi uc001gay.2. human. [P31994-1 ]
uc001gba.2. human. [P31994-2 ]
uc009wun.2. human. [P31994-3 ]

Organism-specific databases

CTDi 2213.
GeneCardsi GC01P161552.
HGNCi HGNC:3618. FCGR2B.
HPAi CAB007796.
MIMi 152700. phenotype.
604590. gene.
611162. phenotype.
neXtProti NX_P31994.
Orphaneti 536. Systemic lupus erythematosus.
PharmGKBi PA28064.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG25177.
HOGENOMi HOG000251632.
HOVERGENi HBG051602.
InParanoidi P31994.
KOi K12560.
OMAi HDYQNHI.
OrthoDBi EOG708W0N.
PhylomeDBi P31994.
TreeFami TF335097.

Enzyme and pathway databases

Reactomei REACT_11152. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
SignaLinki P31994.

Miscellaneous databases

EvolutionaryTracei P31994.
GeneWikii FCGR2B.
GenomeRNAii 2213.
NextBioi 8967.
PROi P31994.
SOURCEi Search...

Gene expression databases

ArrayExpressi P31994.
Bgeei P31994.
CleanExi HS_FCGR2B.
Genevestigatori P31994.

Family and domain databases

Gene3Di 2.60.40.10. 2 hits.
InterProi IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
[Graphical view ]
SMARTi SM00409. IG. 2 hits.
[Graphical view ]
PROSITEi PS50835. IG_LIKE. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Fc-gamma-RIIb nucleotide sequences in SLE and non-SLE humans in vivo derived lymphocytes."
    Ng S., Sinclair N.R.S., Anderson C., Bell D.A., Cairns E.
    Submitted (JAN-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS IIB1 AND IIB2).
    Tissue: Lymphocyte.
  2. "Human IgG Fc receptor (hFcRII; CD32) exists as multiple isoforms in macrophages, lymphocytes and IgG-transporting placental epithelium."
    Stuart S.G., Simister N.E., Clarkson S.B., Kacinski B.M., Shapiro M., Mellman I.
    EMBO J. 8:3657-3666(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM IIB2).
    Tissue: Placenta.
  3. "Structure and expression of human IgG FcRII(CD32). Functional heterogeneity is encoded by the alternatively spliced products of multiple genes."
    Brooks D.G., Qiu W.Q., Luster A.D., Ravetch J.V.
    J. Exp. Med. 170:1369-1385(1989) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS IIB1; IIB2 AND IIB3), VARIANT PHE-205.
  4. "Distribution, inducibility and biological function of the cloned and expressed human beta Fc receptor II."
    Engelhardt W., Geerds C., Frey J.
    Eur. J. Immunol. 20:1367-1377(1990) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM IIB2).
    Tissue: Placenta.
  5. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM IIB2).
  6. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS IIB1 AND IIB2).
    Tissue: Skin.
  8. "Fc gamma receptor gene polymorphisms in Japanese patients with systemic lupus erythematosus: contribution of FCGR2B to genetic susceptibility."
    Kyogoku C., Dijstelbloem H.M., Tsuchiya N., Hatta Y., Kato H., Yamaguchi A., Fukazawa T., Jansen M.D., Hashimoto H., van de Winkel J.G.J., Kallenberg C.G.M., Tokunaga K.
    Arthritis Rheum. 46:1242-1254(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 132-253, INVOLVEMENT IN SLE, VARIANT THR-232.
  9. "Association of immunoglobulin G Fc receptor II with Src-like protein-tyrosine kinase Fgr in neutrophils."
    Hamada F., Aoki M., Akiyama T., Toyoshima K.
    Proc. Natl. Acad. Sci. U.S.A. 90:6305-6309(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH FGR.
  10. "In vivo and in vitro specificity of protein tyrosine kinases for immunoglobulin G receptor (FcgammaRII) phosphorylation."
    Bewarder N., Weinrich V., Budde P., Hartmann D., Flaswinkel H., Reth M., Frey J.
    Mol. Cell. Biol. 16:4735-4743(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION AT TYR-292.
  11. "Fc gamma receptor type IIb induced recruitment of inositol and protein phosphatases to the signal transductory complex of human B-cell."
    Sarmay G., Koncz G., Pecht I., Gergely J.
    Immunol. Lett. 57:159-164(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH LYN.
  12. "Measles virus nucleoprotein induces cell-proliferation arrest and apoptosis through NTAIL-NR and NCORE-FcgammaRIIB1 interactions, respectively."
    Laine D., Bourhis J.-M., Longhi S., Flacher M., Cassard L., Canard B., Sautes-Fridman C., Rabourdin-Combe C., Valentin H.
    J. Gen. Virol. 86:1771-1784(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH MEASLES VIRUS N PROTEIN.
  13. "Crystal structure of the soluble form of the human fcgamma-receptor IIb: a new member of the immunoglobulin superfamily at 1.7 A resolution."
    Sondermann P., Huber R., Jacob U.
    EMBO J. 18:1095-1103(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.74 ANGSTROMS) OF 46-217, DISULFIDE BONDS.
  14. "Interaction of a human Fc gamma RIIb1 (CD32) isoform with murine and human IgG subclasses."
    Warmerdam P.A., van den Herik-Oudijk I.E., Parren P.W., Westerdaal N.A., van de Winkel J.G., Capel P.J.
    Int. Immunol. 5:239-247(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT ASP-258.
  15. "Systemic lupus erythematosus-associated defects in the inhibitory receptor FcgammaRIIb reduce susceptibility to malaria."
    Clatworthy M.R., Willcocks L., Urban B., Langhorne J., Williams T.N., Peshu N., Watkins N.A., Floto R.A., Smith K.G.
    Proc. Natl. Acad. Sci. U.S.A. 104:7169-7174(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: ASSOCIATION OF VARIANT THR-232 WITH RESISTANCE TO MALARIA, CHARACTERIZATION OF VARIANT THR-232.
  16. "A defunctioning polymorphism in FCGR2B is associated with protection against malaria but susceptibility to systemic lupus erythematosus."
    Willcocks L.C., Carr E.J., Niederer H.A., Rayner T.F., Williams T.N., Yang W., Scott J.A., Urban B.C., Peshu N., Vyse T.J., Lau Y.L., Lyons P.A., Smith K.G.
    Proc. Natl. Acad. Sci. U.S.A. 107:7881-7885(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: ASSOCIATION OF VARIANT THR-232 WITH SUSCEPTIBILITY TO SLE, RESISTANCE TO MALARIA.

Entry informationi

Entry nameiFCG2B_HUMAN
AccessioniPrimary (citable) accession number: P31994
Secondary accession number(s): A6H8N3
, O95649, Q53X85, Q5VXA9, Q8NIA1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: May 30, 2000
Last modified: September 3, 2014
This is version 166 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Has sometimes been attributed to correspond to FcR-IIC.

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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