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Protein

Modification methylase AluI

Gene

aluIM

Organism
Cellulosimicrobium cellulans (Arthrobacter luteus)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

This methylase recognizes the double-stranded sequence AGCT, causes specific methylation on C-3 on both strands, and protects the DNA from cleavage by the AluI endonuclease.

Catalytic activityi

S-adenosyl-L-methionine + DNA = S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei84PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionMethyltransferase, Transferase
Biological processRestriction system
LigandS-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
Modification methylase AluI (EC:2.1.1.37)
Short name:
M.AluI
Alternative name(s):
Cytosine-specific methyltransferase AluI
Gene namesi
Name:aluIM
OrganismiCellulosimicrobium cellulans (Arthrobacter luteus)
Taxonomic identifieri1710 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaMicrococcalesPromicromonosporaceaeCellulosimicrobium

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000878581 – 521Modification methylase AluIAdd BLAST521

Structurei

3D structure databases

ProteinModelPortaliP31974
SMRiP31974
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 491SAM-dependent MTase C5-typePROSITE-ProRule annotationAdd BLAST484

Sequence similaritiesi

Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.PROSITE-ProRule annotation

Family and domain databases

InterProiView protein in InterPro
IPR018117 C5_DNA_meth_AS
IPR001525 C5_MeTfrase
IPR029063 SAM-dependent_MTases
PfamiView protein in Pfam
PF00145 DNA_methylase, 1 hit
PRINTSiPR00105 C5METTRFRASE
SUPFAMiSSF53335 SSF53335, 2 hits
TIGRFAMsiTIGR00675 dcm, 1 hit
PROSITEiView protein in PROSITE
PS00094 C5_MTASE_1, 1 hit
PS51679 SAM_MT_C5, 1 hit

Sequencei

Sequence statusi: Complete.

P31974-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKANAKYSF VDLFAGIGGF HAALAATGGV CEYAVEIDRE AAAVYERNWN
60 70 80 90 100
KPALGDITDD ANDEGVTLRG YDGPIDVLTG GFPCQPFSKS GAQHGMAETR
110 120 130 140 150
GTLFWNIARI IEEREPTVLI LENVRNLVGP RHRHEWLTII ETLRFFGYEV
160 170 180 190 200
SGAPAIFSPH LLPAWMGGTP QVRERVFITA TLVPERMRDE RIPRTETGEI
210 220 230 240 250
DAEAIGPKPV ATMNDRFPIK KGGTELFHPG DRKSGWNLLT SGIIREGDPE
260 270 280 290 300
PSNVDLRLTE TETLWIDAWD DLESTIRRAT GRPLEGFPYW ADSWTDFREL
310 320 330 340 350
SRLVVIRGFQ APEREVVGDR KRYVARTDMP EGFVPASVTR PAIDETLPAW
360 370 380 390 400
KQSHLRRNYD FFERHFAEVV AWAYRWGVYT DLFPASRRKL EWQAQDAPRL
410 420 430 440 450
WDTVMHFRPS GIRAKRPTYL PALVAITQTS IVGPLERRLS PRETARLQGL
460 470 480 490 500
PEWFDFGEQR AAATYKQMGN GVNVGVVRHI LREHVRRDRA LLKLTPAGQR
510 520
IINAVLADEP DATVGALGAA E
Length:521
Mass (Da):58,648
Last modified:July 1, 1993 - v1
Checksum:iACBBB2C4E5326BFB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z11841 Genomic DNA Translation: CAA77866.1
PIRiS35614

Similar proteinsi

Entry informationi

Entry nameiMTA1_CELCE
AccessioniPrimary (citable) accession number: P31974
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: March 28, 2018
This is version 76 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health