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Protein

NAD(P)H-quinone oxidoreductase chain 5

Gene

ndhF

Organism
Synechococcus sp. (strain ATCC 27264 / PCC 7002 / PR-6) (Agmenellum quadruplicatum)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

NDH-1 shuttles electrons from NAD(P)H, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient (By similarity).By similarity

Catalytic activityi

NAD(P)H + plastoquinone = NAD(P)+ + plastoquinol.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandNAD, NADP, Plastoquinone

Names & Taxonomyi

Protein namesi
Recommended name:
NAD(P)H-quinone oxidoreductase chain 5 (EC:1.6.5.-)
Alternative name(s):
NAD(P)H dehydrogenase I, chain 5
NDH-1, chain 5
Gene namesi
Name:ndhF
Ordered Locus Names:SYNPCC7002_A0854
OrganismiSynechococcus sp. (strain ATCC 27264 / PCC 7002 / PR-6) (Agmenellum quadruplicatum)
Taxonomic identifieri32049 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaSynechococcalesSynechococcaceaeSynechococcus
Proteomesi
  • UP000001688 Componenti: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei7 – 27HelicalSequence analysisAdd BLAST21
Transmembranei39 – 59HelicalSequence analysisAdd BLAST21
Transmembranei91 – 111HelicalSequence analysisAdd BLAST21
Transmembranei120 – 140HelicalSequence analysisAdd BLAST21
Transmembranei144 – 164HelicalSequence analysisAdd BLAST21
Transmembranei187 – 207HelicalSequence analysisAdd BLAST21
Transmembranei219 – 239HelicalSequence analysisAdd BLAST21
Transmembranei258 – 278HelicalSequence analysisAdd BLAST21
Transmembranei290 – 310HelicalSequence analysisAdd BLAST21
Transmembranei327 – 347HelicalSequence analysisAdd BLAST21
Transmembranei352 – 372HelicalSequence analysisAdd BLAST21
Transmembranei395 – 415HelicalSequence analysisAdd BLAST21
Transmembranei420 – 440HelicalSequence analysisAdd BLAST21
Transmembranei495 – 515HelicalSequence analysisAdd BLAST21
Transmembranei541 – 561HelicalSequence analysisAdd BLAST21
Transmembranei643 – 663HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001182091 – 664NAD(P)H-quinone oxidoreductase chain 5Add BLAST664

Keywords - PTMi

Quinone

Interactioni

Protein-protein interaction databases

STRINGi32049.SYNPCC7002_A0854.

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I subunit 5 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105D65. Bacteria.
COG1009. LUCA.
HOGENOMiHOG000100569.
KOiK05577.
OMAiQFYALIV.
OrthoDBiPOG091H0A12.

Family and domain databases

InterProiView protein in InterPro
IPR002128. NADH_UbQ_OxRdtase_chlpt_su5_C.
IPR003945. NADHpl_OxRdtase_5.
IPR018393. NADHpl_OxRdtase_5_subgr.
IPR001750. ND/Mrp_mem.
IPR001516. Proton_antipo_N.
PfamiView protein in Pfam
PF01010. Proton_antipo_C. 1 hit.
PF00361. Proton_antipo_M. 1 hit.
PF00662. Proton_antipo_N. 1 hit.
PRINTSiPR01435. NPOXDRDTASE5.
TIGRFAMsiTIGR01974. NDH_I_L. 1 hit.

Sequencei

Sequence statusi: Complete.

P31971-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEPLYQYAWL IPVLPLLGAM VIGIGLISLN KFTNKLRQLN AVFVLSLIGT
60 70 80 90 100
SMALSFGLLW SQIQGHEAFT YTLEWAAAGD FHLQMGYTVD HLSALMSVIV
110 120 130 140 150
TTVALLVMIY TDGYMAHDPG YVRFYAYLSI FSSSMLGLVF SPNLVQVYIF
160 170 180 190 200
WELVGMCSYL LIGFWYDRKA AADACQKAFV TNRVGDFGLL LGMLGLYWAT
210 220 230 240 250
GSFEFDLMGD RLMDLVSTGQ ISSLLAIVFA VLVFLGPVAK SAQFPLHVWL
260 270 280 290 300
PDAMEGPTPI SALIHAATMV AAGVFLVARM YPVFEPIPEA MNVIAWTGAT
310 320 330 340 350
TAFLGATIAL TQNDIKKGLA YSTMSQLGYM VMAMGIGGYT AGLFHLMTHA
360 370 380 390 400
YFKAMLFLGS GSVIHGMEEV VGHNAVLAQD MRLMGGLRKY MPITATTFLI
410 420 430 440 450
GTLAICGIPP FAGFWSKDEI LGLAFEANPV LWFIGWATAG MTAFYMFRMY
460 470 480 490 500
FLTFEGEFRG TDQQLQEKLL TAAGQAPEEG HHGSKPHESP LTMTFPLMAL
510 520 530 540 550
AVPSVLIGLL GVPWGNRFEA FVFSPNEAAE AAEHGFELTE FLIMGGNSVG
560 570 580 590 600
IALIGITIAS LMYLQQRIDP ARLAEKFPVL YQLSLNKWYF DDIYNNVFVM
610 620 630 640 650
GTRRLARQIL EVDYRVVDGA VNLTGIATLL SGEGLKYIEN GRVQFYALIV
660
FGAVLGFVIF FSVA
Length:664
Mass (Da):72,878
Last modified:June 10, 2008 - v2
Checksum:iF8AE5DA8A1F8F26B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti40N → Y in AAA27311 (PubMed:8501038).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M99378 Genomic DNA. Translation: AAA27311.1.
CP000951 Genomic DNA. Translation: ACA98858.1.
M86234 Genomic DNA. No translation available.
RefSeqiWP_012306482.1. NC_010475.1.

Genome annotation databases

EnsemblBacteriaiACA98858; ACA98858; SYNPCC7002_A0854.
KEGGisyp:SYNPCC7002_A0854.

Similar proteinsi

Entry informationi

Entry nameiNU5C_SYNP2
AccessioniPrimary (citable) accession number: P31971
Secondary accession number(s): B1XII7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: June 10, 2008
Last modified: June 7, 2017
This is version 95 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families