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Protein

Amphiregulin

Gene

Areg

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Ligand of the EGF receptor/EGFR. Autocrine growth factor as well as a mitogen for a broad range of target cells including astrocytes, Schwann cells and fibroblasts.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCytokine, Growth factor

Enzyme and pathway databases

ReactomeiR-MMU-204005. COPII (Coat Protein 2) Mediated Vesicle Transport.
R-MMU-5694530. Cargo concentration in the ER.

Names & Taxonomyi

Protein namesi
Recommended name:
Amphiregulin
Short name:
AR
Alternative name(s):
Schwannoma-derived growth factor
Short name:
SDGF
Gene namesi
Name:Areg
Synonyms:Sdgf
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:88068. Areg.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei192 – 215HelicalSequence analysisAdd BLAST24

GO - Cellular componenti

  • cell surface Source: MGI
  • cytoplasm Source: MGI
  • extracellular space Source: MGI
  • integral component of membrane Source: UniProtKB-KW
  • intracellular Source: MGI
  • nucleus Source: MGI

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Sequence analysisAdd BLAST26
PropeptideiPRO_000000747627 – 99Add BLAST73
ChainiPRO_0000007477100 – 248AmphiregulinAdd BLAST149

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi106N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi139 ↔ 152PROSITE-ProRule annotation
Disulfide bondi147 ↔ 163PROSITE-ProRule annotation
Disulfide bondi165 ↔ 174PROSITE-ProRule annotation
Glycosylationi241N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP31955.
PRIDEiP31955.

PTM databases

iPTMnetiP31955.
PhosphoSitePlusiP31955.

Miscellaneous databases

PMAP-CutDBiP31955.

Expressioni

Inductioni

Androgen-dependent.

Gene expression databases

BgeeiENSMUSG00000029378.
CleanExiMM_AREG.
ExpressionAtlasiP31955. baseline and differential.
GenevisibleiP31955. MM.

Interactioni

Subunit structurei

The immature precursor interacts with CNIH.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000031325.

Structurei

3D structure databases

ProteinModelPortaliP31955.
SMRiP31955.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini135 – 175EGF-likePROSITE-ProRule annotationAdd BLAST41

Sequence similaritiesi

Belongs to the amphiregulin family.Curated

Keywords - Domaini

EGF-like domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IXZG. Eukaryota.
ENOG4112CXY. LUCA.
GeneTreeiENSGT00530000063708.
HOGENOMiHOG000034038.
HOVERGENiHBG060279.
InParanoidiP31955.
KOiK09782.
OMAiCKCHQDY.
OrthoDBiEOG091G0XMN.
PhylomeDBiP31955.
TreeFamiTF332773.

Family and domain databases

InterProiView protein in InterPro
IPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR015497. EGF_rcpt_ligand.
PANTHERiPTHR10740. PTHR10740. 1 hit.
PROSITEiView protein in PROSITE
PS00022. EGF_1. 1 hit.
PS50026. EGF_3. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P31955-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRTPLLPLAR SVLLLLVLGS GHYAAALELN DPSSGKGESL SGDHSAGGLE
60 70 80 90 100
LSVGREVSTI SEMPSGSELS TGDYDYSEEY DNEPQISGYI IDDSVRVEQV
110 120 130 140 150
IKPKKNKTEG EKSTEKPKRK KKGGKNGKGR RNKKKKNPCT AKFQNFCIHG
160 170 180 190 200
ECRYIENLEV VTCNCHQDYF GERCGEKSMK THSEDDKDLS KIAVVAVTIF
210 220 230 240
VSAIILAAIG IGIVITVHLW KRYFREYEGE TEERRRLRQE NGTVHAIA
Length:248
Mass (Da):27,549
Last modified:July 1, 1993 - v1
Checksum:i98C61A1B0E75A64E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D12648 mRNA. Translation: BAA02169.1.
L41352 Genomic DNA. Translation: AAB00472.1.
AK018590 mRNA. Translation: BAB31296.1.
BC009138 mRNA. Translation: AAH09138.1.
CCDSiCCDS19421.1.
PIRiJH0612.
RefSeqiNP_033834.1. NM_009704.4.
UniGeneiMm.8039.

Genome annotation databases

EnsembliENSMUST00000031325; ENSMUSP00000031325; ENSMUSG00000029378.
GeneIDi11839.
KEGGimmu:11839.
UCSCiuc008ybt.1. mouse.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiAREG_MOUSE
AccessioniPrimary (citable) accession number: P31955
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: May 10, 2017
This is version 139 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families