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Protein

Amphiregulin

Gene

Areg

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Ligand of the EGF receptor/EGFR. Autocrine growth factor as well as a mitogen for a broad range of target cells including astrocytes, Schwann cells and fibroblasts.

GO - Molecular functioni

  1. epidermal growth factor receptor binding Source: GO_Central
  2. growth factor activity Source: GO_Central

GO - Biological processi

  1. dichotomous subdivision of terminal units involved in mammary gland duct morphogenesis Source: MGI
  2. epidermal growth factor receptor signaling pathway Source: MGI
  3. epithelial cell proliferation involved in mammary gland duct elongation Source: MGI
  4. glial cell proliferation Source: Ensembl
  5. G-protein coupled receptor signaling pathway Source: MGI
  6. mammary gland alveolus development Source: MGI
  7. mammary gland branching involved in thelarche Source: MGI
  8. negative regulation of osteoblast differentiation Source: Ensembl
  9. neuron projection development Source: Ensembl
  10. positive regulation of cell proliferation Source: GO_Central
  11. positive regulation of DNA replication Source: MGI
  12. positive regulation of phosphorylation Source: Ensembl
  13. response to cAMP Source: Ensembl
  14. response to estradiol Source: MGI
  15. response to glucocorticoid Source: Ensembl
  16. response to hydrogen peroxide Source: Ensembl
  17. response to peptide hormone Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Cytokine, Growth factor

Names & Taxonomyi

Protein namesi
Recommended name:
Amphiregulin
Short name:
AR
Alternative name(s):
Schwannoma-derived growth factor
Short name:
SDGF
Gene namesi
Name:Areg
Synonyms:Sdgf
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:88068. Areg.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei192 – 21524HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. cell surface Source: MGI
  2. cytoplasm Source: MGI
  3. extracellular space Source: MGI
  4. integral component of membrane Source: UniProtKB-KW
  5. intracellular Source: MGI
  6. nucleus Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2626Sequence AnalysisAdd
BLAST
Propeptidei27 – 9973PRO_0000007476Add
BLAST
Chaini100 – 248149AmphiregulinPRO_0000007477Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi106 – 1061N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi139 ↔ 152PROSITE-ProRule annotation
Disulfide bondi147 ↔ 163PROSITE-ProRule annotation
Disulfide bondi165 ↔ 174PROSITE-ProRule annotation
Glycosylationi241 – 2411N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiP31955.

PTM databases

PhosphoSiteiP31955.

Miscellaneous databases

PMAP-CutDBP31955.

Expressioni

Inductioni

Androgen-dependent.

Gene expression databases

BgeeiP31955.
CleanExiMM_AREG.
ExpressionAtlasiP31955. baseline and differential.
GenevestigatoriP31955.

Interactioni

Subunit structurei

The immature precursor interacts with CNIH.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000031325.

Structurei

3D structure databases

ProteinModelPortaliP31955.
SMRiP31955. Positions 135-177.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini135 – 17541EGF-likePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the amphiregulin family.Curated
Contains 1 EGF-like domain.PROSITE-ProRule annotation

Keywords - Domaini

EGF-like domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG41450.
HOGENOMiHOG000034038.
HOVERGENiHBG060279.
InParanoidiP31955.
KOiK09782.
OMAiCKCHQDY.
OrthoDBiEOG7XDBH6.
PhylomeDBiP31955.
TreeFamiTF332773.

Family and domain databases

InterProiIPR000742. EG-like_dom.
IPR013032. EGF-like_CS.
IPR015497. EGF_rcpt_ligand.
[Graphical view]
PANTHERiPTHR10740. PTHR10740. 1 hit.
SMARTiSM00181. EGF. 1 hit.
[Graphical view]
PROSITEiPS00022. EGF_1. 1 hit.
PS50026. EGF_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P31955-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRTPLLPLAR SVLLLLVLGS GHYAAALELN DPSSGKGESL SGDHSAGGLE
60 70 80 90 100
LSVGREVSTI SEMPSGSELS TGDYDYSEEY DNEPQISGYI IDDSVRVEQV
110 120 130 140 150
IKPKKNKTEG EKSTEKPKRK KKGGKNGKGR RNKKKKNPCT AKFQNFCIHG
160 170 180 190 200
ECRYIENLEV VTCNCHQDYF GERCGEKSMK THSEDDKDLS KIAVVAVTIF
210 220 230 240
VSAIILAAIG IGIVITVHLW KRYFREYEGE TEERRRLRQE NGTVHAIA
Length:248
Mass (Da):27,549
Last modified:July 1, 1993 - v1
Checksum:i98C61A1B0E75A64E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D12648 mRNA. Translation: BAA02169.1.
L41352 Genomic DNA. Translation: AAB00472.1.
AK018590 mRNA. Translation: BAB31296.1.
BC009138 mRNA. Translation: AAH09138.1.
CCDSiCCDS19421.1.
PIRiJH0612.
RefSeqiNP_033834.1. NM_009704.3.
UniGeneiMm.8039.

Genome annotation databases

EnsembliENSMUST00000031325; ENSMUSP00000031325; ENSMUSG00000029378.
GeneIDi11839.
KEGGimmu:11839.
UCSCiuc008ybt.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D12648 mRNA. Translation: BAA02169.1.
L41352 Genomic DNA. Translation: AAB00472.1.
AK018590 mRNA. Translation: BAB31296.1.
BC009138 mRNA. Translation: AAH09138.1.
CCDSiCCDS19421.1.
PIRiJH0612.
RefSeqiNP_033834.1. NM_009704.3.
UniGeneiMm.8039.

3D structure databases

ProteinModelPortaliP31955.
SMRiP31955. Positions 135-177.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000031325.

PTM databases

PhosphoSiteiP31955.

Proteomic databases

PRIDEiP31955.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000031325; ENSMUSP00000031325; ENSMUSG00000029378.
GeneIDi11839.
KEGGimmu:11839.
UCSCiuc008ybt.1. mouse.

Organism-specific databases

CTDi374.
MGIiMGI:88068. Areg.

Phylogenomic databases

eggNOGiNOG41450.
HOGENOMiHOG000034038.
HOVERGENiHBG060279.
InParanoidiP31955.
KOiK09782.
OMAiCKCHQDY.
OrthoDBiEOG7XDBH6.
PhylomeDBiP31955.
TreeFamiTF332773.

Miscellaneous databases

NextBioi279779.
PMAP-CutDBP31955.
PROiP31955.
SOURCEiSearch...

Gene expression databases

BgeeiP31955.
CleanExiMM_AREG.
ExpressionAtlasiP31955. baseline and differential.
GenevestigatoriP31955.

Family and domain databases

InterProiIPR000742. EG-like_dom.
IPR013032. EGF-like_CS.
IPR015497. EGF_rcpt_ligand.
[Graphical view]
PANTHERiPTHR10740. PTHR10740. 1 hit.
SMARTiSM00181. EGF. 1 hit.
[Graphical view]
PROSITEiPS00022. EGF_1. 1 hit.
PS50026. EGF_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Androgen-responsive expression and mitogenic activity of schwannoma-derived growth factor on an androgen-dependent Shionogi mouse mammary carcinoma cell line."
    Sonoda H., Yamaguchi T., Watanabe S.
    Biochem. Biophys. Res. Commun. 185:103-109(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Amphiregulin is an implantation-specific and progesterone-regulated gene in the mouse uterus."
    Das S.K., Chakraborty I., Paria B.C., Wang X.N., Plowman G.D., Dey S.K.
    Mol. Endocrinol. 9:691-705(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Cecum.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Mammary gland.

Entry informationi

Entry nameiAREG_MOUSE
AccessioniPrimary (citable) accession number: P31955
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: February 4, 2015
This is version 122 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.