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P31955

- AREG_MOUSE

UniProt

P31955 - AREG_MOUSE

Protein

Amphiregulin

Gene

Areg

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 119 (01 Oct 2014)
      Sequence version 1 (01 Jul 1993)
      Previous versions | rss
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    Functioni

    Ligand of the EGF receptor/EGFR. Autocrine growth factor as well as a mitogen for a broad range of target cells including astrocytes, Schwann cells and fibroblasts.

    GO - Biological processi

    1. dichotomous subdivision of terminal units involved in mammary gland duct morphogenesis Source: MGI
    2. epidermal growth factor receptor signaling pathway Source: Ensembl
    3. epithelial cell proliferation involved in mammary gland duct elongation Source: MGI
    4. glial cell proliferation Source: Ensembl
    5. mammary gland alveolus development Source: MGI
    6. mammary gland branching involved in thelarche Source: MGI
    7. negative regulation of osteoblast differentiation Source: Ensembl
    8. neuron projection development Source: Ensembl
    9. positive regulation of cell proliferation Source: Ensembl
    10. positive regulation of phosphorylation Source: Ensembl
    11. response to cAMP Source: Ensembl
    12. response to estradiol Source: MGI
    13. response to glucocorticoid Source: Ensembl
    14. response to hydrogen peroxide Source: Ensembl
    15. response to peptide hormone Source: Ensembl

    Keywords - Molecular functioni

    Cytokine, Growth factor

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Amphiregulin
    Short name:
    AR
    Alternative name(s):
    Schwannoma-derived growth factor
    Short name:
    SDGF
    Gene namesi
    Name:Areg
    Synonyms:Sdgf
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 5

    Organism-specific databases

    MGIiMGI:88068. Areg.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: MGI
    2. extracellular space Source: UniProtKB-KW
    3. integral component of membrane Source: UniProtKB-KW
    4. intracellular Source: MGI
    5. nucleus Source: MGI

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2626Sequence AnalysisAdd
    BLAST
    Propeptidei27 – 9973PRO_0000007476Add
    BLAST
    Chaini100 – 248149AmphiregulinPRO_0000007477Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi106 – 1061N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi139 ↔ 152PROSITE-ProRule annotation
    Disulfide bondi147 ↔ 163PROSITE-ProRule annotation
    Disulfide bondi165 ↔ 174PROSITE-ProRule annotation
    Glycosylationi241 – 2411N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PRIDEiP31955.

    PTM databases

    PhosphoSiteiP31955.

    Miscellaneous databases

    PMAP-CutDBP31955.

    Expressioni

    Inductioni

    Androgen-dependent.

    Gene expression databases

    ArrayExpressiP31955.
    BgeeiP31955.
    CleanExiMM_AREG.
    GenevestigatoriP31955.

    Interactioni

    Subunit structurei

    The immature precursor interacts with CNIH.By similarity

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000031325.

    Structurei

    3D structure databases

    ProteinModelPortaliP31955.
    SMRiP31955. Positions 135-177.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei192 – 21524HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini135 – 17541EGF-likePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the amphiregulin family.Curated
    Contains 1 EGF-like domain.PROSITE-ProRule annotation

    Keywords - Domaini

    EGF-like domain, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG41450.
    HOGENOMiHOG000034038.
    HOVERGENiHBG060279.
    InParanoidiP31955.
    KOiK09782.
    OMAiYAEEYDN.
    OrthoDBiEOG7XDBH6.
    PhylomeDBiP31955.
    TreeFamiTF332773.

    Family and domain databases

    InterProiIPR000742. EG-like_dom.
    IPR013032. EGF-like_CS.
    IPR015497. EGF_rcpt_ligand.
    [Graphical view]
    PANTHERiPTHR10740. PTHR10740. 1 hit.
    SMARTiSM00181. EGF. 1 hit.
    [Graphical view]
    PROSITEiPS00022. EGF_1. 1 hit.
    PS50026. EGF_3. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P31955-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRTPLLPLAR SVLLLLVLGS GHYAAALELN DPSSGKGESL SGDHSAGGLE    50
    LSVGREVSTI SEMPSGSELS TGDYDYSEEY DNEPQISGYI IDDSVRVEQV 100
    IKPKKNKTEG EKSTEKPKRK KKGGKNGKGR RNKKKKNPCT AKFQNFCIHG 150
    ECRYIENLEV VTCNCHQDYF GERCGEKSMK THSEDDKDLS KIAVVAVTIF 200
    VSAIILAAIG IGIVITVHLW KRYFREYEGE TEERRRLRQE NGTVHAIA 248
    Length:248
    Mass (Da):27,549
    Last modified:July 1, 1993 - v1
    Checksum:i98C61A1B0E75A64E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D12648 mRNA. Translation: BAA02169.1.
    L41352 Genomic DNA. Translation: AAB00472.1.
    AK018590 mRNA. Translation: BAB31296.1.
    BC009138 mRNA. Translation: AAH09138.1.
    CCDSiCCDS19421.1.
    PIRiJH0612.
    RefSeqiNP_033834.1. NM_009704.3.
    UniGeneiMm.8039.

    Genome annotation databases

    EnsembliENSMUST00000031325; ENSMUSP00000031325; ENSMUSG00000029378.
    GeneIDi11839.
    KEGGimmu:11839.
    UCSCiuc008ybt.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D12648 mRNA. Translation: BAA02169.1 .
    L41352 Genomic DNA. Translation: AAB00472.1 .
    AK018590 mRNA. Translation: BAB31296.1 .
    BC009138 mRNA. Translation: AAH09138.1 .
    CCDSi CCDS19421.1.
    PIRi JH0612.
    RefSeqi NP_033834.1. NM_009704.3.
    UniGenei Mm.8039.

    3D structure databases

    ProteinModelPortali P31955.
    SMRi P31955. Positions 135-177.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000031325.

    PTM databases

    PhosphoSitei P31955.

    Proteomic databases

    PRIDEi P31955.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000031325 ; ENSMUSP00000031325 ; ENSMUSG00000029378 .
    GeneIDi 11839.
    KEGGi mmu:11839.
    UCSCi uc008ybt.1. mouse.

    Organism-specific databases

    CTDi 374.
    MGIi MGI:88068. Areg.

    Phylogenomic databases

    eggNOGi NOG41450.
    HOGENOMi HOG000034038.
    HOVERGENi HBG060279.
    InParanoidi P31955.
    KOi K09782.
    OMAi YAEEYDN.
    OrthoDBi EOG7XDBH6.
    PhylomeDBi P31955.
    TreeFami TF332773.

    Miscellaneous databases

    NextBioi 279779.
    PMAP-CutDB P31955.
    PROi P31955.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi P31955.
    Bgeei P31955.
    CleanExi MM_AREG.
    Genevestigatori P31955.

    Family and domain databases

    InterProi IPR000742. EG-like_dom.
    IPR013032. EGF-like_CS.
    IPR015497. EGF_rcpt_ligand.
    [Graphical view ]
    PANTHERi PTHR10740. PTHR10740. 1 hit.
    SMARTi SM00181. EGF. 1 hit.
    [Graphical view ]
    PROSITEi PS00022. EGF_1. 1 hit.
    PS50026. EGF_3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Androgen-responsive expression and mitogenic activity of schwannoma-derived growth factor on an androgen-dependent Shionogi mouse mammary carcinoma cell line."
      Sonoda H., Yamaguchi T., Watanabe S.
      Biochem. Biophys. Res. Commun. 185:103-109(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Amphiregulin is an implantation-specific and progesterone-regulated gene in the mouse uterus."
      Das S.K., Chakraborty I., Paria B.C., Wang X.N., Plowman G.D., Dey S.K.
      Mol. Endocrinol. 9:691-705(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6J.
      Tissue: Cecum.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/N.
      Tissue: Mammary gland.

    Entry informationi

    Entry nameiAREG_MOUSE
    AccessioniPrimary (citable) accession number: P31955
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 1993
    Last sequence update: July 1, 1993
    Last modified: October 1, 2014
    This is version 119 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3