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P31950

- S10AB_PIG

UniProt

P31950 - S10AB_PIG

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Protein

Protein S100-A11

Gene

S100A11

Organism
Sus scrofa (Pig)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Facilitates the differentiation and the cornification of keratinocytes.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi23 – 36141; low affinityAdd
BLAST
Calcium bindingi66 – 77122; high affinityAdd
BLAST

GO - Molecular functioni

  1. calcium ion binding Source: InterPro

GO - Biological processi

  1. regulation of cell proliferation Source: InterPro
Complete GO annotation...

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Protein S100-A11
Alternative name(s):
Calgizzarin
Protein S100-C
S100 calcium-binding protein A11
Gene namesi
Name:S100A11
Synonyms:S100C
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
ProteomesiUP000008227: Chromosome 4

Subcellular locationi

Cytoplasm. Nucleus By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 9999Protein S100-A11PRO_0000144011Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionine
Modified residuei8 – 81PhosphothreonineBy similarity
Disulfide bondi11 – 11InterchainBy similarity

Post-translational modificationi

Phosphorylation at Thr-8 significantly suppresses homodimerization and promotes association with NCL/nucleolin which induces nuclear translocation.By similarity

Keywords - PTMi

Acetylation, Disulfide bond, Phosphoprotein

Proteomic databases

PaxDbiP31950.
PRIDEiP31950.

Interactioni

Subunit structurei

Homodimer; disulfide-linked.By similarity

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000007049.

Structurei

Secondary structure

1
99
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi7 – 2317
Helixi34 – 418
Helixi46 – 516
Helixi56 – 6510
Beta strandi70 – 734
Helixi75 – 9723

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1QLSX-ray2.30A1-99[»]
ProteinModelPortaliP31950.
SMRiP31950. Positions 5-99.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP31950.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini10 – 4738EF-hand 1PROSITE-ProRule annotationAdd
BLAST
Domaini53 – 8836EF-hand 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the S-100 family.Curated
Contains 2 EF-hand domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG29318.
GeneTreeiENSGT00760000119034.
HOGENOMiHOG000246968.
HOVERGENiHBG001479.
InParanoidiP31950.
OMAiIFMNTEL.
OrthoDBiEOG7XH6SB.
TreeFamiTF332727.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR001751. S100/CaBP-9k_CS.
IPR013787. S100_Ca-bd_sub.
IPR028482. S100A11.
[Graphical view]
PANTHERiPTHR11639:SF68. PTHR11639:SF68. 1 hit.
PfamiPF00036. EF-hand_1. 1 hit.
PF01023. S_100. 1 hit.
[Graphical view]
PROSITEiPS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 2 hits.
PS00303. S100_CABP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P31950-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAKRPTETER CIESLIAIFQ KHAGRDGNNT KISKTEFLIF MNTELAAFTQ
60 70 80 90
NQKDPGVLDR MMKKLDLDSD GQLDFQEFLN LIGGLAIACH DSFIKSTQK
Length:99
Mass (Da):11,180
Last modified:July 1, 1993 - v1
Checksum:iC0688AF40F908558
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB004800 mRNA. Translation: BAA20521.1.
AB003363 Genomic DNA. Translation: BAA25189.1.
PIRiS20342.
RefSeqiNP_001004045.1. NM_001004045.1.
XP_003361619.1. XM_003361571.2.
UniGeneiSsc.2115.

Genome annotation databases

EnsembliENSSSCT00000023625; ENSSSCP00000021681; ENSSSCG00000025269.
ENSSSCT00000035044; ENSSSCP00000028839; ENSSSCG00000006610.
ENSSSCT00000035409; ENSSSCP00000028457; ENSSSCG00000006610.
GeneIDi100620367.
445534.
KEGGissc:100620367.
ssc:445534.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AB004800 mRNA. Translation: BAA20521.1 .
AB003363 Genomic DNA. Translation: BAA25189.1 .
PIRi S20342.
RefSeqi NP_001004045.1. NM_001004045.1.
XP_003361619.1. XM_003361571.2.
UniGenei Ssc.2115.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1QLS X-ray 2.30 A 1-99 [» ]
ProteinModelPortali P31950.
SMRi P31950. Positions 5-99.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9823.ENSSSCP00000007049.

Proteomic databases

PaxDbi P31950.
PRIDEi P31950.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSSSCT00000023625 ; ENSSSCP00000021681 ; ENSSSCG00000025269 .
ENSSSCT00000035044 ; ENSSSCP00000028839 ; ENSSSCG00000006610 .
ENSSSCT00000035409 ; ENSSSCP00000028457 ; ENSSSCG00000006610 .
GeneIDi 100620367.
445534.
KEGGi ssc:100620367.
ssc:445534.

Organism-specific databases

CTDi 6282.

Phylogenomic databases

eggNOGi NOG29318.
GeneTreei ENSGT00760000119034.
HOGENOMi HOG000246968.
HOVERGENi HBG001479.
InParanoidi P31950.
OMAi IFMNTEL.
OrthoDBi EOG7XH6SB.
TreeFami TF332727.

Miscellaneous databases

EvolutionaryTracei P31950.

Family and domain databases

Gene3Di 1.10.238.10. 1 hit.
InterProi IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR001751. S100/CaBP-9k_CS.
IPR013787. S100_Ca-bd_sub.
IPR028482. S100A11.
[Graphical view ]
PANTHERi PTHR11639:SF68. PTHR11639:SF68. 1 hit.
Pfami PF00036. EF-hand_1. 1 hit.
PF01023. S_100. 1 hit.
[Graphical view ]
PROSITEi PS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 2 hits.
PS00303. S100_CABP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular cloning and expression of the cDNA coding for a new member of the S100 protein family from porcine cardiac muscle."
    Ohta H., Sasaki T., Naka M., Hiraoka O., Miyamoto C., Furuichi Y., Tanaka T.
    FEBS Lett. 295:93-96(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Heart muscle.
  2. "A unique exon-intron organization of a porcine S100C gene: close evolutionary relationship to calmodulin genes."
    Nakamura T., Hayashi M., Kato A., Sawazaki T., Yasue H., Nakano T., Tanaka T.
    Biochem. Biophys. Res. Commun. 243:647-652(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Structural basis of the Ca(2+)-dependent association between S100C (S100A11) and its target, the N-terminal part of annexin I."
    Rety S., Osterloh D., Arie J.-P., Tabaries S., Seeman J., Russo-Marie F., Gerke V., Lewit-Bentley A.
    Structure 8:175-184(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS).

Entry informationi

Entry nameiS10AB_PIG
AccessioniPrimary (citable) accession number: P31950
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: October 29, 2014
This is version 109 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Binds two calcium ions per molecule with an affinity similar to that of the S100 proteins.By similarity

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3