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P31950

- S10AB_PIG

UniProt

P31950 - S10AB_PIG

Protein

Protein S100-A11

Gene

S100A11

Organism
Sus scrofa (Pig)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Facilitates the differentiation and the cornification of keratinocytes.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Calcium bindingi23 – 36141; low affinityAdd
    BLAST
    Calcium bindingi66 – 77122; high affinityAdd
    BLAST

    GO - Molecular functioni

    1. calcium ion binding Source: InterPro

    GO - Biological processi

    1. regulation of cell proliferation Source: InterPro

    Keywords - Ligandi

    Calcium, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein S100-A11
    Alternative name(s):
    Calgizzarin
    Protein S100-C
    S100 calcium-binding protein A11
    Gene namesi
    Name:S100A11
    Synonyms:S100C
    OrganismiSus scrofa (Pig)
    Taxonomic identifieri9823 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
    ProteomesiUP000008227: Chromosome 4

    Subcellular locationi

    Cytoplasm. Nucleus By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 9999Protein S100-A11PRO_0000144011Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1 – 11N-acetylmethionine
    Modified residuei8 – 81PhosphothreonineBy similarity
    Disulfide bondi11 – 11InterchainBy similarity

    Post-translational modificationi

    Phosphorylation at Thr-8 significantly suppresses homodimerization and promotes association with NCL/nucleolin which induces nuclear translocation.By similarity

    Keywords - PTMi

    Acetylation, Disulfide bond, Phosphoprotein

    Proteomic databases

    PaxDbiP31950.
    PRIDEiP31950.

    Expressioni

    Gene expression databases

    ArrayExpressiP31950.

    Interactioni

    Subunit structurei

    Homodimer; disulfide-linked.By similarity

    Protein-protein interaction databases

    STRINGi9823.ENSSSCP00000007049.

    Structurei

    Secondary structure

    1
    99
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi7 – 2317
    Helixi34 – 418
    Helixi46 – 516
    Helixi56 – 6510
    Beta strandi70 – 734
    Helixi75 – 9723

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1QLSX-ray2.30A1-99[»]
    ProteinModelPortaliP31950.
    SMRiP31950. Positions 5-99.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP31950.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini10 – 4738EF-hand 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini53 – 8836EF-hand 2PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the S-100 family.Curated
    Contains 2 EF-hand domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiNOG29318.
    GeneTreeiENSGT00740000114954.
    HOGENOMiHOG000246968.
    HOVERGENiHBG001479.
    OMAiIFMNTEL.
    OrthoDBiEOG7XH6SB.
    TreeFamiTF332727.

    Family and domain databases

    Gene3Di1.10.238.10. 1 hit.
    InterProiIPR011992. EF-hand-dom_pair.
    IPR018247. EF_Hand_1_Ca_BS.
    IPR002048. EF_hand_dom.
    IPR001751. S100/CaBP-9k_CS.
    IPR013787. S100_Ca-bd_sub.
    IPR028482. S100A11.
    [Graphical view]
    PANTHERiPTHR11639:SF68. PTHR11639:SF68. 1 hit.
    PfamiPF00036. EF-hand_1. 1 hit.
    PF01023. S_100. 1 hit.
    [Graphical view]
    PROSITEiPS00018. EF_HAND_1. 1 hit.
    PS50222. EF_HAND_2. 2 hits.
    PS00303. S100_CABP. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    P31950-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAKRPTETER CIESLIAIFQ KHAGRDGNNT KISKTEFLIF MNTELAAFTQ   50
    NQKDPGVLDR MMKKLDLDSD GQLDFQEFLN LIGGLAIACH DSFIKSTQK 99
    Length:99
    Mass (Da):11,180
    Last modified:July 1, 1993 - v1
    Checksum:iC0688AF40F908558
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB004800 mRNA. Translation: BAA20521.1.
    AB003363 Genomic DNA. Translation: BAA25189.1.
    PIRiS20342.
    RefSeqiNP_001004045.1. NM_001004045.1.
    XP_003361619.1. XM_003361571.2.
    UniGeneiSsc.2115.

    Genome annotation databases

    EnsembliENSSSCT00000023625; ENSSSCP00000021681; ENSSSCG00000025269.
    ENSSSCT00000035044; ENSSSCP00000028839; ENSSSCG00000006610.
    ENSSSCT00000035409; ENSSSCP00000028457; ENSSSCG00000006610.
    GeneIDi100620367.
    445534.
    KEGGissc:100620367.
    ssc:445534.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB004800 mRNA. Translation: BAA20521.1 .
    AB003363 Genomic DNA. Translation: BAA25189.1 .
    PIRi S20342.
    RefSeqi NP_001004045.1. NM_001004045.1.
    XP_003361619.1. XM_003361571.2.
    UniGenei Ssc.2115.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1QLS X-ray 2.30 A 1-99 [» ]
    ProteinModelPortali P31950.
    SMRi P31950. Positions 5-99.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9823.ENSSSCP00000007049.

    Proteomic databases

    PaxDbi P31950.
    PRIDEi P31950.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSSSCT00000023625 ; ENSSSCP00000021681 ; ENSSSCG00000025269 .
    ENSSSCT00000035044 ; ENSSSCP00000028839 ; ENSSSCG00000006610 .
    ENSSSCT00000035409 ; ENSSSCP00000028457 ; ENSSSCG00000006610 .
    GeneIDi 100620367.
    445534.
    KEGGi ssc:100620367.
    ssc:445534.

    Organism-specific databases

    CTDi 6282.

    Phylogenomic databases

    eggNOGi NOG29318.
    GeneTreei ENSGT00740000114954.
    HOGENOMi HOG000246968.
    HOVERGENi HBG001479.
    OMAi IFMNTEL.
    OrthoDBi EOG7XH6SB.
    TreeFami TF332727.

    Miscellaneous databases

    EvolutionaryTracei P31950.

    Gene expression databases

    ArrayExpressi P31950.

    Family and domain databases

    Gene3Di 1.10.238.10. 1 hit.
    InterProi IPR011992. EF-hand-dom_pair.
    IPR018247. EF_Hand_1_Ca_BS.
    IPR002048. EF_hand_dom.
    IPR001751. S100/CaBP-9k_CS.
    IPR013787. S100_Ca-bd_sub.
    IPR028482. S100A11.
    [Graphical view ]
    PANTHERi PTHR11639:SF68. PTHR11639:SF68. 1 hit.
    Pfami PF00036. EF-hand_1. 1 hit.
    PF01023. S_100. 1 hit.
    [Graphical view ]
    PROSITEi PS00018. EF_HAND_1. 1 hit.
    PS50222. EF_HAND_2. 2 hits.
    PS00303. S100_CABP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning and expression of the cDNA coding for a new member of the S100 protein family from porcine cardiac muscle."
      Ohta H., Sasaki T., Naka M., Hiraoka O., Miyamoto C., Furuichi Y., Tanaka T.
      FEBS Lett. 295:93-96(1991) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Heart muscle.
    2. "A unique exon-intron organization of a porcine S100C gene: close evolutionary relationship to calmodulin genes."
      Nakamura T., Hayashi M., Kato A., Sawazaki T., Yasue H., Nakano T., Tanaka T.
      Biochem. Biophys. Res. Commun. 243:647-652(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "Structural basis of the Ca(2+)-dependent association between S100C (S100A11) and its target, the N-terminal part of annexin I."
      Rety S., Osterloh D., Arie J.-P., Tabaries S., Seeman J., Russo-Marie F., Gerke V., Lewit-Bentley A.
      Structure 8:175-184(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS).

    Entry informationi

    Entry nameiS10AB_PIG
    AccessioniPrimary (citable) accession number: P31950
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 1993
    Last sequence update: July 1, 1993
    Last modified: October 1, 2014
    This is version 108 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    Binds two calcium ions per molecule with an affinity similar to that of the S100 proteins.By similarity

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3