Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Protein S100-A11

Gene

S100A11

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Facilitates the differentiation and the cornification of keratinocytes.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi23 – 361; low affinityAdd BLAST14
Calcium bindingi66 – 772; high affinityAdd BLAST12

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Calcium, Metal-binding

Enzyme and pathway databases

ReactomeiR-SSC-6798695. Neutrophil degranulation.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein S100-A11
Alternative name(s):
Calgizzarin
Protein S100-C
S100 calcium-binding protein A11
Gene namesi
Name:S100A11
Synonyms:S100C
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Chromosome 4

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001440111 – 99Protein S100-A11Add BLAST99

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionine1 Publication1
Modified residuei8PhosphothreonineBy similarity1
Disulfide bondi11InterchainBy similarity

Post-translational modificationi

Phosphorylation at Thr-8 significantly suppresses homodimerization and promotes association with NCL/nucleolin which induces nuclear translocation.By similarity

Keywords - PTMi

Acetylation, Disulfide bond, Phosphoprotein

Proteomic databases

PaxDbiP31950.
PeptideAtlasiP31950.
PRIDEiP31950.

Expressioni

Gene expression databases

BgeeiENSSSCG00000006610.
ExpressionAtlasiP31950. baseline.
GenevisibleiP31950. SS.

Interactioni

Subunit structurei

Homodimer; disulfide-linked.By similarity

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000028839.

Structurei

Secondary structure

199
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi7 – 23Combined sources17
Helixi34 – 41Combined sources8
Helixi46 – 51Combined sources6
Helixi56 – 65Combined sources10
Beta strandi70 – 73Combined sources4
Helixi75 – 97Combined sources23

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1QLSX-ray2.30A1-99[»]
ProteinModelPortaliP31950.
SMRiP31950.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP31950.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini10 – 47EF-hand 1PROSITE-ProRule annotationAdd BLAST38
Domaini53 – 88EF-hand 2PROSITE-ProRule annotationAdd BLAST36

Sequence similaritiesi

Belongs to the S-100 family.Curated
Contains 2 EF-hand domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410J1U7. Eukaryota.
ENOG410YYVE. LUCA.
GeneTreeiENSGT00760000119034.
HOGENOMiHOG000246968.
HOVERGENiHBG001479.
InParanoidiP31950.
OMAiLIFMNTE.
OrthoDBiEOG091G10QT.
TreeFamiTF332727.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR001751. S100/CaBP-9k_CS.
IPR013787. S100_Ca-bd_sub.
IPR028482. S100A11.
[Graphical view]
PANTHERiPTHR11639:SF60. PTHR11639:SF60. 1 hit.
PfamiPF00036. EF-hand_1. 1 hit.
PF01023. S_100. 1 hit.
[Graphical view]
SMARTiSM00054. EFh. 1 hit.
SM01394. S_100. 1 hit.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 2 hits.
PS00303. S100_CABP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P31950-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKRPTETER CIESLIAIFQ KHAGRDGNNT KISKTEFLIF MNTELAAFTQ
60 70 80 90
NQKDPGVLDR MMKKLDLDSD GQLDFQEFLN LIGGLAIACH DSFIKSTQK
Length:99
Mass (Da):11,180
Last modified:July 1, 1993 - v1
Checksum:iC0688AF40F908558
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB004800 mRNA. Translation: BAA20521.1.
AB003363 Genomic DNA. Translation: BAA25189.1.
PIRiS20342.
RefSeqiNP_001004045.1. NM_001004045.1.
XP_003361619.1. XM_003361571.2.
UniGeneiSsc.2115.

Genome annotation databases

EnsembliENSSSCT00000023625; ENSSSCP00000021681; ENSSSCG00000025269.
ENSSSCT00000035044; ENSSSCP00000028839; ENSSSCG00000006610.
ENSSSCT00000035409; ENSSSCP00000028457; ENSSSCG00000006610.
GeneIDi100620367.
445534.
KEGGissc:100620367.
ssc:445534.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB004800 mRNA. Translation: BAA20521.1.
AB003363 Genomic DNA. Translation: BAA25189.1.
PIRiS20342.
RefSeqiNP_001004045.1. NM_001004045.1.
XP_003361619.1. XM_003361571.2.
UniGeneiSsc.2115.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1QLSX-ray2.30A1-99[»]
ProteinModelPortaliP31950.
SMRiP31950.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000028839.

Proteomic databases

PaxDbiP31950.
PeptideAtlasiP31950.
PRIDEiP31950.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSSSCT00000023625; ENSSSCP00000021681; ENSSSCG00000025269.
ENSSSCT00000035044; ENSSSCP00000028839; ENSSSCG00000006610.
ENSSSCT00000035409; ENSSSCP00000028457; ENSSSCG00000006610.
GeneIDi100620367.
445534.
KEGGissc:100620367.
ssc:445534.

Organism-specific databases

CTDi6282.

Phylogenomic databases

eggNOGiENOG410J1U7. Eukaryota.
ENOG410YYVE. LUCA.
GeneTreeiENSGT00760000119034.
HOGENOMiHOG000246968.
HOVERGENiHBG001479.
InParanoidiP31950.
OMAiLIFMNTE.
OrthoDBiEOG091G10QT.
TreeFamiTF332727.

Enzyme and pathway databases

ReactomeiR-SSC-6798695. Neutrophil degranulation.

Miscellaneous databases

EvolutionaryTraceiP31950.

Gene expression databases

BgeeiENSSSCG00000006610.
ExpressionAtlasiP31950. baseline.
GenevisibleiP31950. SS.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR001751. S100/CaBP-9k_CS.
IPR013787. S100_Ca-bd_sub.
IPR028482. S100A11.
[Graphical view]
PANTHERiPTHR11639:SF60. PTHR11639:SF60. 1 hit.
PfamiPF00036. EF-hand_1. 1 hit.
PF01023. S_100. 1 hit.
[Graphical view]
SMARTiSM00054. EFh. 1 hit.
SM01394. S_100. 1 hit.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 2 hits.
PS00303. S100_CABP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiS10AB_PIG
AccessioniPrimary (citable) accession number: P31950
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: November 30, 2016
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Binds two calcium ions per molecule with an affinity similar to that of the S100 proteins.By similarity

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.