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Protein

Protein S100-A11

Gene

S100A11

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Facilitates the differentiation and the cornification of keratinocytes.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi23 – 36141; low affinityAdd
BLAST
Calcium bindingi66 – 77122; high affinityAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Protein S100-A11
Alternative name(s):
Calgizzarin
Protein S100-C
S100 calcium-binding protein A11
Gene namesi
Name:S100A11
Synonyms:S100C
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
ProteomesiUP000008227 Componentsi: Chromosome 4, Unplaced

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 9999Protein S100-A11PRO_0000144011Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionine
Modified residuei8 – 81PhosphothreonineBy similarity
Disulfide bondi11 – 11InterchainBy similarity

Post-translational modificationi

Phosphorylation at Thr-8 significantly suppresses homodimerization and promotes association with NCL/nucleolin which induces nuclear translocation.By similarity

Keywords - PTMi

Acetylation, Disulfide bond, Phosphoprotein

Proteomic databases

PaxDbiP31950.
PRIDEiP31950.

Expressioni

Gene expression databases

GenevisibleiP31950. SS.

Interactioni

Subunit structurei

Homodimer; disulfide-linked.By similarity

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000028839.

Structurei

Secondary structure

1
99
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi7 – 2317Combined sources
Helixi34 – 418Combined sources
Helixi46 – 516Combined sources
Helixi56 – 6510Combined sources
Beta strandi70 – 734Combined sources
Helixi75 – 9723Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1QLSX-ray2.30A1-99[»]
ProteinModelPortaliP31950.
SMRiP31950. Positions 5-99.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP31950.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini10 – 4738EF-hand 1PROSITE-ProRule annotationAdd
BLAST
Domaini53 – 8836EF-hand 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the S-100 family.Curated
Contains 2 EF-hand domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG29318.
GeneTreeiENSGT00760000119034.
HOGENOMiHOG000246968.
HOVERGENiHBG001479.
InParanoidiP31950.
OMAiLIFMNTE.
OrthoDBiEOG7XH6SB.
TreeFamiTF332727.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR001751. S100/CaBP-9k_CS.
IPR013787. S100_Ca-bd_sub.
IPR028482. S100A11.
[Graphical view]
PANTHERiPTHR11639:SF68. PTHR11639:SF68. 1 hit.
PfamiPF00036. EF-hand_1. 1 hit.
PF01023. S_100. 1 hit.
[Graphical view]
PROSITEiPS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 2 hits.
PS00303. S100_CABP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

P31950-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKRPTETER CIESLIAIFQ KHAGRDGNNT KISKTEFLIF MNTELAAFTQ
60 70 80 90
NQKDPGVLDR MMKKLDLDSD GQLDFQEFLN LIGGLAIACH DSFIKSTQK
Length:99
Mass (Da):11,180
Last modified:July 1, 1993 - v1
Checksum:iC0688AF40F908558
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB004800 mRNA. Translation: BAA20521.1.
AB003363 Genomic DNA. Translation: BAA25189.1.
PIRiS20342.
RefSeqiNP_001004045.1. NM_001004045.1.
XP_003361619.1. XM_003361571.2.
UniGeneiSsc.2115.

Genome annotation databases

EnsembliENSSSCT00000023625; ENSSSCP00000021681; ENSSSCG00000025269.
ENSSSCT00000035044; ENSSSCP00000028839; ENSSSCG00000006610.
ENSSSCT00000035409; ENSSSCP00000028457; ENSSSCG00000006610.
GeneIDi100620367.
445534.
KEGGissc:100620367.
ssc:445534.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB004800 mRNA. Translation: BAA20521.1.
AB003363 Genomic DNA. Translation: BAA25189.1.
PIRiS20342.
RefSeqiNP_001004045.1. NM_001004045.1.
XP_003361619.1. XM_003361571.2.
UniGeneiSsc.2115.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1QLSX-ray2.30A1-99[»]
ProteinModelPortaliP31950.
SMRiP31950. Positions 5-99.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000028839.

Proteomic databases

PaxDbiP31950.
PRIDEiP31950.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSSSCT00000023625; ENSSSCP00000021681; ENSSSCG00000025269.
ENSSSCT00000035044; ENSSSCP00000028839; ENSSSCG00000006610.
ENSSSCT00000035409; ENSSSCP00000028457; ENSSSCG00000006610.
GeneIDi100620367.
445534.
KEGGissc:100620367.
ssc:445534.

Organism-specific databases

CTDi6282.

Phylogenomic databases

eggNOGiNOG29318.
GeneTreeiENSGT00760000119034.
HOGENOMiHOG000246968.
HOVERGENiHBG001479.
InParanoidiP31950.
OMAiLIFMNTE.
OrthoDBiEOG7XH6SB.
TreeFamiTF332727.

Miscellaneous databases

EvolutionaryTraceiP31950.

Gene expression databases

GenevisibleiP31950. SS.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR001751. S100/CaBP-9k_CS.
IPR013787. S100_Ca-bd_sub.
IPR028482. S100A11.
[Graphical view]
PANTHERiPTHR11639:SF68. PTHR11639:SF68. 1 hit.
PfamiPF00036. EF-hand_1. 1 hit.
PF01023. S_100. 1 hit.
[Graphical view]
PROSITEiPS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 2 hits.
PS00303. S100_CABP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Molecular cloning and expression of the cDNA coding for a new member of the S100 protein family from porcine cardiac muscle."
    Ohta H., Sasaki T., Naka M., Hiraoka O., Miyamoto C., Furuichi Y., Tanaka T.
    FEBS Lett. 295:93-96(1991) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Heart muscle.
  2. "A unique exon-intron organization of a porcine S100C gene: close evolutionary relationship to calmodulin genes."
    Nakamura T., Hayashi M., Kato A., Sawazaki T., Yasue H., Nakano T., Tanaka T.
    Biochem. Biophys. Res. Commun. 243:647-652(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "Structural basis of the Ca(2+)-dependent association between S100C (S100A11) and its target, the N-terminal part of annexin I."
    Rety S., Osterloh D., Arie J.-P., Tabaries S., Seeman J., Russo-Marie F., Gerke V., Lewit-Bentley A.
    Structure 8:175-184(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS).

Entry informationi

Entry nameiS10AB_PIG
AccessioniPrimary (citable) accession number: P31950
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: July 22, 2015
This is version 114 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Binds two calcium ions per molecule with an affinity similar to that of the S100 proteins.By similarity

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.