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P31950 (S10AB_PIG) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 106. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein S100-A11
Alternative name(s):
Calgizzarin
Protein S100-C
S100 calcium-binding protein A11
Gene names
Name:S100A11
Synonyms:S100C
OrganismSus scrofa (Pig) [Reference proteome]
Taxonomic identifier9823 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus

Protein attributes

Sequence length99 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Facilitates the differentiation and the cornification of keratinocytes By similarity.

Subunit structure

Homodimer; disulfide-linked By similarity.

Subcellular location

Cytoplasm. Nucleus By similarity.

Post-translational modification

Phosphorylation at Thr-8 significantly suppresses homodimerization and promotes association with NCL/nucleolin which induces nuclear translocation By similarity.

Miscellaneous

Binds two calcium ions per molecule with an affinity similar to that of the S100 proteins By similarity.

Sequence similarities

Belongs to the S-100 family.

Contains 2 EF-hand domains.

Ontologies

Keywords
   Cellular componentCytoplasm
Nucleus
   DomainRepeat
   LigandCalcium
Metal-binding
   PTMAcetylation
Disulfide bond
Phosphoprotein
   Technical term3D-structure
Complete proteome
Reference proteome
Gene Ontology (GO)
   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

nucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functioncalcium ion binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 9999Protein S100-A11
PRO_0000144011

Regions

Domain10 – 4738EF-hand 1
Domain53 – 8836EF-hand 2
Calcium binding23 – 36141; low affinity
Calcium binding66 – 77122; high affinity

Amino acid modifications

Modified residue11N-acetylmethionine
Modified residue81Phosphothreonine By similarity
Disulfide bond11Interchain By similarity

Secondary structure

............. 99
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
P31950 [UniParc].

Last modified July 1, 1993. Version 1.
Checksum: C0688AF40F908558

FASTA9911,180
        10         20         30         40         50         60 
MAKRPTETER CIESLIAIFQ KHAGRDGNNT KISKTEFLIF MNTELAAFTQ NQKDPGVLDR 

        70         80         90 
MMKKLDLDSD GQLDFQEFLN LIGGLAIACH DSFIKSTQK 

« Hide

References

[1]"Molecular cloning and expression of the cDNA coding for a new member of the S100 protein family from porcine cardiac muscle."
Ohta H., Sasaki T., Naka M., Hiraoka O., Miyamoto C., Furuichi Y., Tanaka T.
FEBS Lett. 295:93-96(1991) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Heart muscle.
[2]"A unique exon-intron organization of a porcine S100C gene: close evolutionary relationship to calmodulin genes."
Nakamura T., Hayashi M., Kato A., Sawazaki T., Yasue H., Nakano T., Tanaka T.
Biochem. Biophys. Res. Commun. 243:647-652(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"Structural basis of the Ca(2+)-dependent association between S100C (S100A11) and its target, the N-terminal part of annexin I."
Rety S., Osterloh D., Arie J.-P., Tabaries S., Seeman J., Russo-Marie F., Gerke V., Lewit-Bentley A.
Structure 8:175-184(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS).

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB004800 mRNA. Translation: BAA20521.1.
AB003363 Genomic DNA. Translation: BAA25189.1.
PIRS20342.
RefSeqNP_001004045.1. NM_001004045.1.
XP_003361619.1. XM_003361571.2.
UniGeneSsc.2115.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1QLSX-ray2.30A1-99[»]
ProteinModelPortalP31950.
SMRP31950. Positions 5-99.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9823.ENSSSCP00000007049.

Proteomic databases

PaxDbP31950.
PRIDEP31950.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSSSCT00000023625; ENSSSCP00000021681; ENSSSCG00000025269.
ENSSSCT00000035044; ENSSSCP00000028839; ENSSSCG00000006610.
ENSSSCT00000035409; ENSSSCP00000028457; ENSSSCG00000006610.
GeneID100620367.
445534.
KEGGssc:100620367.
ssc:445534.

Organism-specific databases

CTD6282.

Phylogenomic databases

eggNOGNOG29318.
GeneTreeENSGT00740000114954.
HOGENOMHOG000246968.
HOVERGENHBG001479.
OMAIFMNTEL.
OrthoDBEOG7XH6SB.
TreeFamTF332727.

Gene expression databases

ArrayExpressP31950.

Family and domain databases

Gene3D1.10.238.10. 1 hit.
InterProIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR001751. S100/CaBP-9k_CS.
IPR013787. S100_Ca-bd_sub.
IPR028482. S100A11.
[Graphical view]
PANTHERPTHR11639:SF68. PTHR11639:SF68. 1 hit.
PfamPF00036. EF-hand_1. 1 hit.
PF01023. S_100. 1 hit.
[Graphical view]
PROSITEPS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 2 hits.
PS00303. S100_CABP. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

EvolutionaryTraceP31950.

Entry information

Entry nameS10AB_PIG
AccessionPrimary (citable) accession number: P31950
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: June 11, 2014
This is version 106 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references