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Protein

Protein S100-A11

Gene

S100A11

Organism
Sus scrofa (Pig)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Facilitates the differentiation and the cornification of keratinocytes.By similarity

Miscellaneous

Binds two calcium ions per molecule with an affinity similar to that of the S100 proteins.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi23 – 361; low affinityAdd BLAST14
Calcium bindingi66 – 772; high affinityAdd BLAST12

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandCalcium, Metal-binding

Enzyme and pathway databases

ReactomeiR-SSC-6798695. Neutrophil degranulation.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein S100-A11
Alternative name(s):
Calgizzarin
Protein S100-C
S100 calcium-binding protein A11
Gene namesi
Name:S100A11
Synonyms:S100C
OrganismiSus scrofa (Pig)
Taxonomic identifieri9823 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaLaurasiatheriaCetartiodactylaSuinaSuidaeSus
Proteomesi
  • UP000008227 Componenti: Chromosome 4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001440111 – 99Protein S100-A11Add BLAST99

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionine1 Publication1
Modified residuei8PhosphothreonineBy similarity1
Disulfide bondi11InterchainBy similarity

Post-translational modificationi

Phosphorylation at Thr-8 significantly suppresses homodimerization and promotes association with NCL/nucleolin which induces nuclear translocation.By similarity

Keywords - PTMi

Acetylation, Disulfide bond, Phosphoprotein

Proteomic databases

PaxDbiP31950.
PeptideAtlasiP31950.
PRIDEiP31950.

Expressioni

Gene expression databases

BgeeiENSSSCG00000006610.
ExpressionAtlasiP31950. differential.
GenevisibleiP31950. SS.

Interactioni

Subunit structurei

Homodimer; disulfide-linked.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi9823.ENSSSCP00000028839.

Structurei

Secondary structure

199
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi7 – 23Combined sources17
Helixi34 – 41Combined sources8
Helixi46 – 51Combined sources6
Helixi56 – 65Combined sources10
Beta strandi70 – 73Combined sources4
Helixi75 – 97Combined sources23

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1QLSX-ray2.30A1-99[»]
ProteinModelPortaliP31950.
SMRiP31950.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP31950.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini10 – 47EF-hand 1PROSITE-ProRule annotationAdd BLAST38
Domaini53 – 88EF-hand 2PROSITE-ProRule annotationAdd BLAST36

Sequence similaritiesi

Belongs to the S-100 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410J1U7. Eukaryota.
ENOG410YYVE. LUCA.
GeneTreeiENSGT00760000119034.
HOGENOMiHOG000246968.
HOVERGENiHBG001479.
InParanoidiP31950.
OMAiAQACHDS.
OrthoDBiEOG091G10QT.
TreeFamiTF332727.

Family and domain databases

InterProiView protein in InterPro
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR001751. S100/CaBP-9k_CS.
IPR013787. S100_Ca-bd_sub.
IPR028482. S100A11.
PANTHERiPTHR11639:SF85. PTHR11639:SF85. 1 hit.
PfamiView protein in Pfam
PF00036. EF-hand_1. 1 hit.
PF01023. S_100. 1 hit.
SMARTiView protein in SMART
SM00054. EFh. 1 hit.
SM01394. S_100. 1 hit.
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiView protein in PROSITE
PS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 2 hits.
PS00303. S100_CABP. 1 hit.

Sequencei

Sequence statusi: Complete.

P31950-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKRPTETER CIESLIAIFQ KHAGRDGNNT KISKTEFLIF MNTELAAFTQ
60 70 80 90
NQKDPGVLDR MMKKLDLDSD GQLDFQEFLN LIGGLAIACH DSFIKSTQK
Length:99
Mass (Da):11,180
Last modified:July 1, 1993 - v1
Checksum:iC0688AF40F908558
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB004800 mRNA. Translation: BAA20521.1.
AB003363 Genomic DNA. Translation: BAA25189.1.
PIRiS20342.
RefSeqiNP_001004045.1. NM_001004045.1.
XP_003361619.1. XM_003361571.2.
UniGeneiSsc.2115.

Genome annotation databases

EnsembliENSSSCT00000023625; ENSSSCP00000021681; ENSSSCG00000025269.
ENSSSCT00000035044; ENSSSCP00000028839; ENSSSCG00000006610.
ENSSSCT00000035409; ENSSSCP00000028457; ENSSSCG00000006610.
GeneIDi445534.
KEGGissc:100620367.
ssc:445534.

Similar proteinsi

Entry informationi

Entry nameiS10AB_PIG
AccessioniPrimary (citable) accession number: P31950
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: July 1, 1993
Last modified: September 27, 2017
This is version 133 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families