P31950 (S10AB_PIG) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein S100-A11

Alternative name(s):
Calgizzarin
Protein S100-C
S100 calcium-binding protein A11

Gene names

Name:	S100A11
Synonyms:	S100C

Organism

Sus scrofa (Pig) [Reference proteome]

Taxonomic identifier

9823 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Laurasiatheria › Cetartiodactyla › Suina › Suidae › Sus

Protein attributes

Sequence length	99 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Facilitates the differentiation and the cornification of keratinocytes By similarity.
Subunit structure	Homodimer; disulfide-linked By similarity.
Subcellular location	Cytoplasm. Nucleus By similarity.
Post-translational modification	Phosphorylation at Thr-8 significantly suppresses homodimerization and promotes association with NCL/nucleolin which induces nuclear translocation By similarity.
Miscellaneous	Binds two calcium ions per molecule with an affinity similar to that of the S100 proteins By similarity.
Sequence similarities	Belongs to the S-100 family. Contains 2 EF-hand domains.

Ontologies

Keywords
Cellular component	Cytoplasm Nucleus
Domain	Repeat
Ligand	Calcium Metal-binding
PTM	Acetylation Disulfide bond Phosphoprotein
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	calcium ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 99

99

Protein S100-A11

PRO_0000144011

Regions

Domain

10 – 47

38

EF-hand 1

Domain

53 – 88

36

EF-hand 2

Calcium binding

23 – 36

14

1; low affinity

Calcium binding

66 – 77

12

2; high affinity

Amino acid modifications

Modified residue

1

1

N-acetylmethionine

Modified residue

8

1

Phosphothreonine By similarity

Disulfide bond

11

Interchain By similarity

Secondary structure

1

.

.

.

.

.

.

.

.

.

.

.

.

.

99

Helix Strand Turn

Details...

Helix

7 – 23

17

Helix

34 – 41

8

Helix

46 – 51

6

Helix

56 – 65

10

Beta strand

70 – 73

4

Helix

75 – 97

23

Sequences

	Sequence		Length	Mass (Da)
	P31950 [UniParc]. Last modified July 1, 1993. Version 1. Checksum: C0688AF40F908558	FASTA	99	11,180
	10 20 30 40 50 60 MAKRPTETER CIESLIAIFQ KHAGRDGNNT KISKTEFLIF MNTELAAFTQ NQKDPGVLDR 70 80 90 MMKKLDLDSD GQLDFQEFLN LIGGLAIACH DSFIKSTQK

References

[1]	"Molecular cloning and expression of the cDNA coding for a new member of the S100 protein family from porcine cardiac muscle." Ohta H., Sasaki T., Naka M., Hiraoka O., Miyamoto C., Furuichi Y., Tanaka T. FEBS Lett. 295:93-96(1991) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Heart muscle.
[2]	"A unique exon-intron organization of a porcine S100C gene: close evolutionary relationship to calmodulin genes." Nakamura T., Hayashi M., Kato A., Sawazaki T., Yasue H., Nakano T., Tanaka T. Biochem. Biophys. Res. Commun. 243:647-652(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"Structural basis of the Ca(2+)-dependent association between S100C (S100A11) and its target, the N-terminal part of annexin I." Rety S., Osterloh D., Arie J.-P., Tabaries S., Seeman J., Russo-Marie F., Gerke V., Lewit-Bentley A. Structure 8:175-184(2000) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS).

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AB004800 mRNA. Translation: BAA20521.1.
AB003363 Genomic DNA. Translation: BAA25189.1.

PIR

S20342.

RefSeq

NP_001004045.1. NM_001004045.1.
XP_003361619.1. XM_003361571.1.

UniGene

Ssc.2115.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1QLS	X-ray	2.30	A	1-99	[»]

ProteinModelPortal

P31950.

SMR

P31950. Positions 5-99.

ModBase

Search...

Protein-protein interaction databases

STRING

9823.ENSSSCP00000007049.

Proteomic databases

PaxDb

P31950.

PRIDE

P31950.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENSSSCT00000023625; ENSSSCP00000021681; ENSSSCG00000025269.
ENSSSCT00000035044; ENSSSCP00000028839; ENSSSCG00000006610.
ENSSSCT00000035409; ENSSSCP00000028457; ENSSSCG00000006610.

GeneID

100620367.
445534.

KEGG

ssc:100620367.
ssc:445534.

Organism-specific databases

CTD

6282.

Phylogenomic databases

eggNOG

NOG29318.

GeneTree

ENSGT00660000095419.

HOGENOM

HOG000246968.

HOVERGEN

HBG001479.

OMA

MSSPTET.

OrthoDB

EOG4BG8XN.

Family and domain databases

Gene3D

1.10.238.10. 1 hit.

InterPro

IPR011992. EF-hand-like_dom.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR001751. S100/CaBP-9k_CS.
IPR013787. S100_Ca-bd_sub.
[Graphical view]

Pfam

PF00036. efhand. 1 hit.
PF01023. S_100. 1 hit.
[Graphical view]

PROSITE

PS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 2 hits.
PS00303. S100_CABP. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

EvolutionaryTrace

P31950.

Entry information

Entry name

S10AB_PIG

Accession

Primary (citable) accession number: P31950

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 1, 1993
Last sequence update:	July 1, 1993
Last modified:	May 1, 2013
This is version 98 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program