Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

P31949

- S10AB_HUMAN

UniProt

P31949 - S10AB_HUMAN

Protein

Protein S100-A11

Gene

S100A11

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Facilitates the differentiation and the cornification of keratinocytes.1 Publication

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Calcium bindingi25 – 38141; low affinityPROSITE-ProRule annotationAdd
    BLAST
    Calcium bindingi68 – 79122; high affinityPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. calcium-dependent protein binding Source: UniProtKB
    2. calcium ion binding Source: InterPro
    3. protein binding Source: IntAct
    4. protein homodimerization activity Source: UniProtKB
    5. S100 protein binding Source: UniProtKB

    GO - Biological processi

    1. negative regulation of cell proliferation Source: ProtInc
    2. negative regulation of DNA replication Source: ProtInc
    3. signal transduction Source: UniProtKB

    Keywords - Ligandi

    Calcium, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein S100-A11
    Alternative name(s):
    Calgizzarin
    Metastatic lymph node gene 70 protein
    Short name:
    MLN 70
    Protein S100-C
    S100 calcium-binding protein A11
    Cleaved into the following chain:
    Gene namesi
    Name:S100A11
    Synonyms:MLN70, S100C
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:10488. S100A11.

    Subcellular locationi

    Cytoplasm 1 Publication. Nucleus 1 Publication

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB
    2. extracellular space Source: UniProt
    3. extracellular vesicular exosome Source: UniProt
    4. nucleus Source: UniProtKB
    5. ruffle Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA34900.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 105105Protein S100-A11PRO_0000144009Add
    BLAST
    Initiator methioninei1 – 11Removed; alternate1 Publication
    Chaini2 – 105104Protein S100-A11, N-terminally processedPRO_0000424465Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1 – 11N-acetylmethionine1 Publication
    Modified residuei2 – 21N-acetylalanine; in Protein S100-A11, N-terminally processed2 Publications
    Modified residuei3 – 31N6-acetyllysine1 Publication
    Modified residuei6 – 61Phosphoserine2 Publications
    Modified residuei10 – 101Phosphothreonine1 Publication
    Disulfide bondi13 – 13Interchain1 Publication
    Modified residuei27 – 271N6-acetyllysineBy similarity

    Post-translational modificationi

    Phosphorylation at Thr-10 by PRKCA significantly suppresses homodimerization and promotes association with NCL/nucleolin which induces nuclear translocation.3 Publications

    Keywords - PTMi

    Acetylation, Disulfide bond, Phosphoprotein

    Proteomic databases

    MaxQBiP31949.
    PaxDbiP31949.
    PeptideAtlasiP31949.
    PRIDEiP31949.

    2D gel databases

    DOSAC-COBS-2DPAGEP31949.
    SWISS-2DPAGEP31949.

    PTM databases

    PhosphoSiteiP31949.

    Expressioni

    Gene expression databases

    BgeeiP31949.
    CleanExiHS_S100A11.
    GenevestigatoriP31949.

    Organism-specific databases

    HPAiCAB034320.
    HPA042745.

    Interactioni

    Subunit structurei

    Homodimer; disulfide-linked.1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    S100BP042715EBI-701862,EBI-458391

    Protein-protein interaction databases

    BioGridi112190. 16 interactions.
    IntActiP31949. 7 interactions.
    MINTiMINT-5002556.
    STRINGi9606.ENSP00000271638.

    Structurei

    Secondary structure

    1
    105
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi7 – 1812
    Beta strandi30 – 323
    Helixi36 – 4510
    Helixi48 – 547
    Helixi58 – 6710
    Beta strandi70 – 756
    Helixi77 – 9620

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1V4ZNMR-A1-19[»]
    1V50NMR-A1-19[»]
    2LUCNMR-A/B1-105[»]
    ProteinModelPortaliP31949.
    SMRiP31949. Positions 1-105.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiP31949.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini13 – 4937EF-hand 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini55 – 9036EF-hand 2PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the S-100 family.Curated
    Contains 2 EF-hand domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiNOG29318.
    HOGENOMiHOG000246968.
    HOVERGENiHBG001479.
    InParanoidiP31949.
    OMAiIFMNTEL.
    OrthoDBiEOG7XH6SB.
    PhylomeDBiP31949.
    TreeFamiTF332727.

    Family and domain databases

    Gene3Di1.10.238.10. 1 hit.
    InterProiIPR011992. EF-hand-dom_pair.
    IPR018247. EF_Hand_1_Ca_BS.
    IPR002048. EF_hand_dom.
    IPR001751. S100/CaBP-9k_CS.
    IPR013787. S100_Ca-bd_sub.
    IPR028482. S100A11.
    [Graphical view]
    PANTHERiPTHR11639:SF68. PTHR11639:SF68. 1 hit.
    PfamiPF00036. EF-hand_1. 1 hit.
    PF01023. S_100. 1 hit.
    [Graphical view]
    PROSITEiPS00018. EF_HAND_1. 1 hit.
    PS50222. EF_HAND_2. 1 hit.
    PS00303. S100_CABP. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    P31949-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAKISSPTET ERCIESLIAV FQKYAGKDGY NYTLSKTEFL SFMNTELAAF    50
    TKNQKDPGVL DRMMKKLDTN SDGQLDFSEF LNLIGGLAMA CHDSFLKAVP 100
    SQKRT 105
    Length:105
    Mass (Da):11,740
    Last modified:October 1, 1996 - v2
    Checksum:i1729ED680290CFE4
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D38583 mRNA. Translation: BAA07597.1.
    X80201 mRNA. Translation: CAA56492.1.
    D49355 mRNA. Translation: BAA08354.1.
    D50374 mRNA. Translation: BAA23325.1.
    BT009912 mRNA. Translation: AAP88914.1.
    AL591893 Genomic DNA. Translation: CAH72895.1.
    BC001410 mRNA. Translation: AAH01410.1.
    BC014354 mRNA. Translation: AAH14354.1.
    CCDSiCCDS1009.1.
    PIRiI37080.
    RefSeqiNP_005611.1. NM_005620.1.
    UniGeneiHs.417004.

    Genome annotation databases

    EnsembliENST00000271638; ENSP00000271638; ENSG00000163191.
    GeneIDi6282.
    KEGGihsa:6282.
    UCSCiuc001ezn.3. human.

    Polymorphism databases

    DMDMi1710818.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D38583 mRNA. Translation: BAA07597.1 .
    X80201 mRNA. Translation: CAA56492.1 .
    D49355 mRNA. Translation: BAA08354.1 .
    D50374 mRNA. Translation: BAA23325.1 .
    BT009912 mRNA. Translation: AAP88914.1 .
    AL591893 Genomic DNA. Translation: CAH72895.1 .
    BC001410 mRNA. Translation: AAH01410.1 .
    BC014354 mRNA. Translation: AAH14354.1 .
    CCDSi CCDS1009.1.
    PIRi I37080.
    RefSeqi NP_005611.1. NM_005620.1.
    UniGenei Hs.417004.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1V4Z NMR - A 1-19 [» ]
    1V50 NMR - A 1-19 [» ]
    2LUC NMR - A/B 1-105 [» ]
    ProteinModelPortali P31949.
    SMRi P31949. Positions 1-105.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 112190. 16 interactions.
    IntActi P31949. 7 interactions.
    MINTi MINT-5002556.
    STRINGi 9606.ENSP00000271638.

    PTM databases

    PhosphoSitei P31949.

    Polymorphism databases

    DMDMi 1710818.

    2D gel databases

    DOSAC-COBS-2DPAGE P31949.
    SWISS-2DPAGE P31949.

    Proteomic databases

    MaxQBi P31949.
    PaxDbi P31949.
    PeptideAtlasi P31949.
    PRIDEi P31949.

    Protocols and materials databases

    DNASUi 6282.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000271638 ; ENSP00000271638 ; ENSG00000163191 .
    GeneIDi 6282.
    KEGGi hsa:6282.
    UCSCi uc001ezn.3. human.

    Organism-specific databases

    CTDi 6282.
    GeneCardsi GC01M152004.
    HGNCi HGNC:10488. S100A11.
    HPAi CAB034320.
    HPA042745.
    MIMi 603114. gene.
    neXtProti NX_P31949.
    PharmGKBi PA34900.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG29318.
    HOGENOMi HOG000246968.
    HOVERGENi HBG001479.
    InParanoidi P31949.
    OMAi IFMNTEL.
    OrthoDBi EOG7XH6SB.
    PhylomeDBi P31949.
    TreeFami TF332727.

    Miscellaneous databases

    EvolutionaryTracei P31949.
    GeneWikii S100A11.
    GenomeRNAii 6282.
    NextBioi 24385.
    PROi P31949.
    SOURCEi Search...

    Gene expression databases

    Bgeei P31949.
    CleanExi HS_S100A11.
    Genevestigatori P31949.

    Family and domain databases

    Gene3Di 1.10.238.10. 1 hit.
    InterProi IPR011992. EF-hand-dom_pair.
    IPR018247. EF_Hand_1_Ca_BS.
    IPR002048. EF_hand_dom.
    IPR001751. S100/CaBP-9k_CS.
    IPR013787. S100_Ca-bd_sub.
    IPR028482. S100A11.
    [Graphical view ]
    PANTHERi PTHR11639:SF68. PTHR11639:SF68. 1 hit.
    Pfami PF00036. EF-hand_1. 1 hit.
    PF01023. S_100. 1 hit.
    [Graphical view ]
    PROSITEi PS00018. EF_HAND_1. 1 hit.
    PS50222. EF_HAND_2. 1 hit.
    PS00303. S100_CABP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Human calgizzarin; one colorectal cancer-related gene selected by a large scale random cDNA sequencing and northern blot analysis."
      Tanaka M., Adzuma K., Iwami M., Yoshimoto K., Monden Y., Itakura M.
      Cancer Lett. 89:195-200(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Identification of four novel human genes amplified and overexpressed in breast carcinoma and localized to the q11-q21.3 region of chromosome 17."
      Tomasetto C.L., Regnier C.H., Moog-Lutz C., Mattei M.-G., Chenard M.-P., Lidereau R., Basset P., Rio M.-C.
      Genomics 28:367-376(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Mammary carcinoma.
    3. "Isolation and characterization of cDNA for human S100C protein and a related gene."
      Nakatani K., Kato A., Sugimoto M., Kumano K., Komada T., Tsunoda H., Ito M., Nakano T., Shima T., Tanaka T.
      Submitted (OCT-1995) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Lung.
    4. "Molecular cloning of a human homologue of the two calcium binding protein, porcine S100 and rabbit calgizzarin."
      Fujiwara T., Kawai A., Shimizu F., Shinomiya K., Hirano H., Okuno S., Ozaki K., Katagiri T., Takeda S., Kuga Y., Shimada Y., Nagata M., Takaichi A., Watanabe T., Horie M., Nakamura Y., Takahashi E., Hirai Y.
      Submitted (NOV-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Brain.
    5. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
      Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    6. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Placenta and Urinary bladder.
    8. "Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes."
      Rasmussen H.H., van Damme J., Puype M., Gesser B., Celis J.E., Vandekerckhove J.
      Electrophoresis 13:960-969(1992) [PubMed] [Europe PMC] [Abstract]
      Cited for: PROTEIN SEQUENCE OF 4-12; 43-51 AND 56-62.
      Tissue: Keratinocyte.
    9. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-6, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    10. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
      Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
      Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2 AND LYS-3, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
    11. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-6, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    12. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    13. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1 AND ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    14. "The structure of S100A11 fragment explains a local structural change induced by phosphorylation."
      Kouno T., Mizuguchi M., Sakaguchi M., Makino E., Mori Y., Shinoda H., Aizawa T., Demura M., Huh N.H., Kawano K.
      J. Pept. Sci. 14:1129-1138(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: STRUCTURE BY NMR OF 1-19, DISULFIDE BOND, PHOSPHORYLATION AT THR-10, FUNCTION, SUBCELLULAR LOCATION.

    Entry informationi

    Entry nameiS10AB_HUMAN
    AccessioniPrimary (citable) accession number: P31949
    Secondary accession number(s): Q5VTK0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 1, 1993
    Last sequence update: October 1, 1996
    Last modified: October 1, 2014
    This is version 156 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    Binds two calcium ions per molecule with an affinity similar to that of the S-100 proteins.By similarity

    Keywords - Technical termi

    3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3