P31949 (S10AB_HUMAN) Reviewed, UniProtKB/Swiss-Prot
Last modified
January 25, 2012.
Version 129.
History...
Names·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Interactions·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Protein S100-A11 Alternative name(s): Calgizzarin Metastatic lymph node gene 70 protein Short name=MLN 70 Protein S100-C S100 calcium-binding protein A11 | ||||
| Gene names |
| ||||
| Organism | Homo sapiens (Human) | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 105 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at protein level |
General annotation (Comments)
| Function | Facilitates the differentiation and the cornification of keratinocytes. Ref.16 |
| Subunit structure | Homodimer; disulfide-linked. Ref.16 |
| Subcellular location | |
| Post-translational modification | Phosphorylation at Thr-10 by PRKCA significantly suppresses homodimerization and promotes association with NCL/nucleolin which induces nuclear translocation. |
| Miscellaneous | Binds two calcium ions per molecule with an affinity similar to that of the S-100 proteins By similarity. |
| Sequence similarities | Belongs to the S-100 family. Contains 2 EF-hand domains. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Cytoplasm Nucleus |
| Domain | Repeat |
| Ligand | Calcium |
| PTM | Acetylation Disulfide bond Phosphoprotein |
| Technical term | 3D-structure Complete proteome Direct protein sequencing Reference proteome |
| Gene Ontology (GO) | |
| Biological process | negative regulation of DNA replication Traceable author statement. Source: ProtInc negative regulation of cell proliferationTraceable author statement. Source: ProtInc signal transductionTraceable author statement. Source: UniProtKB |
| Cellular component | cytoplasm Inferred from direct assay. Source: UniProtKB nucleusInferred from direct assay. Source: UniProtKB ruffleInferred from direct assay. Source: UniProtKB |
| Molecular function | S100 beta binding Inferred from physical interaction. Source: UniProtKB calcium ion bindingInferred from electronic annotation. Source: InterPro calcium-dependent protein bindingInferred from direct assay. Source: UniProtKB protein homodimerization activityInferred from direct assay. Source: UniProtKB |
| Complete GO annotation... | |
Binary interactions
With | Entry | #Exp. | IntAct | Notes |
|---|---|---|---|---|
| S100B | P04271 | 5 | EBI-701862,EBI-458391 |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||||
Molecule processing | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 105 | 105 | Protein S100-A11 | PRO_0000144009 | |||||||
Regions | |||||||||||
| Domain | 13 – 49 | 37 | EF-hand 1 | ||||||||
| Domain | 55 – 90 | 36 | EF-hand 2 | ||||||||
| Calcium binding | 25 – 38 | 14 | 1; low affinity Potential | ||||||||
| Calcium binding | 68 – 79 | 12 | 2; high affinity Potential | ||||||||
Amino acid modifications | |||||||||||
| Modified residue | 3 | 1 | N6-acetyllysine Ref.14 | ||||||||
| Modified residue | 6 | 1 | Phosphoserine Ref.9 Ref.10 Ref.12 | ||||||||
| Modified residue | 10 | 1 | Phosphothreonine Ref.16 | ||||||||
| Modified residue | 30 | 1 | Phosphotyrosine Ref.11 Ref.13 | ||||||||
| Modified residue | 32 | 1 | Phosphotyrosine Ref.11 | ||||||||
| Disulfide bond | 13 | Interchain Ref.16 | |||||||||
Secondary structure | |||||||||||
Helix Strand Turn | |||||||||||
| Helix | 7 – 18 | 12 | |||||||||
Sequences
References
| « Hide 'large scale' references | |
| [1] | "Human calgizzarin; one colorectal cancer-related gene selected by a large scale random cDNA sequencing and northern blot analysis." Tanaka M., Adzuma K., Iwami M., Yoshimoto K., Monden Y., Itakura M. Cancer Lett. 89:195-200(1995) [PubMed: 7889529] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| [2] | "Identification of four novel human genes amplified and overexpressed in breast carcinoma and localized to the q11-q21.3 region of chromosome 17." Tomasetto C.L., Regnier C.H., Moog-Lutz C., Mattei M.-G., Chenard M.-P., Lidereau R., Basset P., Rio M.-C. Genomics 28:367-376(1995) [PubMed: 7490069] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Mammary carcinoma. |
| [3] | "Isolation and characterization of cDNA for human S100C protein and a related gene." Nakatani K., Kato A., Sugimoto M., Kumano K., Komada T., Tsunoda H., Ito M., Nakano T., Shima T., Tanaka T. Submitted (OCT-1995) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Lung. |
| [4] | "Molecular cloning of a human homologue of the two calcium binding protein, porcine S100 and rabbit calgizzarin." Fujiwara T., Kawai A., Shimizu F., Shinomiya K., Hirano H., Okuno S., Ozaki K., Katagiri T., Takeda S., Kuga Y., Shimada Y., Nagata M., Takaichi A., Watanabe T., Horie M., Nakamura Y., Takahashi E., Hirai Y. Submitted (NOV-1997) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Brain. |
| [5] | "Cloning of human full-length CDSs in BD Creator(TM) system donor vector." Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A. Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. |
| [6] | "The DNA sequence and biological annotation of human chromosome 1." Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K. Bentley D.R.Nature 441:315-321(2006) [PubMed: 16710414] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
| [7] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Placenta and Urinary bladder. |
| [8] | "Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes." Rasmussen H.H., van Damme J., Puype M., Gesser B., Celis J.E., Vandekerckhove J. Electrophoresis 13:960-969(1992) [PubMed: 1286667] [Abstract] Cited for: PROTEIN SEQUENCE OF 4-12; 43-51 AND 56-62. Tissue: Keratinocyte. |
| [9] | "Large-scale characterization of HeLa cell nuclear phosphoproteins." Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J., Li J., Cohn M.A., Cantley L.C., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004) [PubMed: 15302935] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-6, MASS SPECTROMETRY. Tissue: Cervix carcinoma. |
| [10] | "A probability-based approach for high-throughput protein phosphorylation analysis and site localization." Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P. Nat. Biotechnol. 24:1285-1292(2006) [PubMed: 16964243] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-6, MASS SPECTROMETRY. Tissue: Cervix carcinoma. |
| [11] | "Global survey of phosphotyrosine signaling identifies oncogenic kinases in lung cancer." Rikova K., Guo A., Zeng Q., Possemato A., Yu J., Haack H., Nardone J., Lee K., Reeves C., Li Y., Hu Y., Tan Z., Stokes M., Sullivan L., Mitchell J., Wetzel R., Macneill J., Ren J.M. Comb M.J.Cell 131:1190-1203(2007) [PubMed: 18083107] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-30 AND TYR-32, MASS SPECTROMETRY. Tissue: Lung carcinoma. |
| [12] | "A quantitative atlas of mitotic phosphorylation." Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., Elledge S.J., Gygi S.P. Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008) [PubMed: 18669648] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-6, MASS SPECTROMETRY. Tissue: Cervix carcinoma. |
| [13] | "An extensive survey of tyrosine phosphorylation revealing new sites in human mammary epithelial cells." Heibeck T.H., Ding S.-J., Opresko L.K., Zhao R., Schepmoes A.A., Yang F., Tolmachev A.V., Monroe M.E., Camp D.G. II, Smith R.D., Wiley H.S., Qian W.-J. J. Proteome Res. 8:3852-3861(2009) [PubMed: 19534553] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-30, MASS SPECTROMETRY. Tissue: Mammary epithelium. |
| [14] | "Lysine acetylation targets protein complexes and co-regulates major cellular functions." Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T., Olsen J.V., Mann M. Science 325:834-840(2009) [PubMed: 19608861] [Abstract] Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-3, MASS SPECTROMETRY. |
| [15] | "Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed: 21269460] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. |
| [16] | "The structure of S100A11 fragment explains a local structural change induced by phosphorylation." Kouno T., Mizuguchi M., Sakaguchi M., Makino E., Mori Y., Shinoda H., Aizawa T., Demura M., Huh N.H., Kawano K. J. Pept. Sci. 14:1129-1138(2008) [PubMed: 18618420] [Abstract] Cited for: STRUCTURE BY NMR OF 1-19, DISULFIDE BOND, PHOSPHORYLATION AT THR-10, FUNCTION, SUBCELLULAR LOCATION. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| EMBL GenBank DDBJ | D38583 mRNA. Translation: BAA07597.1. X80201 mRNA. Translation: CAA56492.1. D49355 mRNA. Translation: BAA08354.1. D50374 mRNA. Translation: BAA23325.1. BT009912 mRNA. Translation: AAP88914.1. AL591893 Genomic DNA. Translation: CAH72895.1. BC001410 mRNA. Translation: AAH01410.1. BC014354 mRNA. Translation: AAH14354.1. | ||||||||||||||||||
| IPI | IPI00013895. | ||||||||||||||||||
| PIR | I37080. | ||||||||||||||||||
| RefSeq | NP_005611.1. NM_005620.1. | ||||||||||||||||||
| UniGene | Hs.417004. | ||||||||||||||||||
3D structure databases | |||||||||||||||||||
| PDBe RCSB PDB PDBj |
| ||||||||||||||||||
| ProteinModelPortal | P31949. | ||||||||||||||||||
| SMR | P31949. Positions 5-104. | ||||||||||||||||||
| ModBase | Search... | ||||||||||||||||||
Protein-protein interaction databases | |||||||||||||||||||
| IntAct | P31949. 7 interactions. | ||||||||||||||||||
| STRING | P31949. | ||||||||||||||||||
PTM databases | |||||||||||||||||||
| PhosphoSite | P31949. | ||||||||||||||||||
Polymorphism databases | |||||||||||||||||||
| DMDM | 1710818. | ||||||||||||||||||
2D gel databases | |||||||||||||||||||
| SWISS-2DPAGE | P31949. | ||||||||||||||||||
| Aarhus/Ghent-2DPAGE | 4006. IEF. | ||||||||||||||||||
| DOSAC-COBS-2DPAGE | P31949. | ||||||||||||||||||
| PMMA-2DPAGE | P31949. | ||||||||||||||||||
Proteomic databases | |||||||||||||||||||
| PeptideAtlas | P31949. | ||||||||||||||||||
| PRIDE | P31949. | ||||||||||||||||||
Protocols and materials databases | |||||||||||||||||||
| StructuralBiologyKnowledgebase | Search... | ||||||||||||||||||
Genome annotation databases | |||||||||||||||||||
| Ensembl | ENST00000271638; ENSP00000271638; ENSG00000163191. | ||||||||||||||||||
| GeneID | 6282. | ||||||||||||||||||
| KEGG | hsa:6282. | ||||||||||||||||||
| UCSC | uc001ezn.1. human. | ||||||||||||||||||
Organism-specific databases | |||||||||||||||||||
| CTD | 6282. | ||||||||||||||||||
| GeneCards | GC01M152004. | ||||||||||||||||||
| H-InvDB | HIX0001073. | ||||||||||||||||||
| HGNC | HGNC:10488. S100A11. | ||||||||||||||||||
| MIM | 603114. gene. | ||||||||||||||||||
| neXtProt | NX_P31949. | ||||||||||||||||||
| PharmGKB | PA34900. | ||||||||||||||||||
| GenAtlas | Search... | ||||||||||||||||||
Phylogenomic databases | |||||||||||||||||||
| eggNOG | prNOG20799. | ||||||||||||||||||
| GeneTree | ENSGT00600000084283. | ||||||||||||||||||
| HOGENOM | HBG716817. | ||||||||||||||||||
| HOVERGEN | HBG001479. | ||||||||||||||||||
| InParanoid | P31949. | ||||||||||||||||||
| OMA | MSSPTET. | ||||||||||||||||||
| OrthoDB | EOG4BG8XN. | ||||||||||||||||||
| PhylomeDB | P31949. | ||||||||||||||||||
Gene expression databases | |||||||||||||||||||
| ArrayExpress | P31949. | ||||||||||||||||||
| Bgee | P31949. | ||||||||||||||||||
| CleanEx | HS_S100A11. | ||||||||||||||||||
| Genevestigator | P31949. | ||||||||||||||||||
| GermOnline | ENSG00000163191. Homo sapiens. | ||||||||||||||||||
Family and domain databases | |||||||||||||||||||
| InterPro | IPR018248. EF-hand. IPR011992. EF-hand-like_dom. IPR018247. EF_Hand_1_Ca_BS. IPR018249. EF_HAND_2. IPR001751. S100/CaBP-9k_CS. IPR013787. S100_Ca-bd_sub. [Graphical view] | ||||||||||||||||||
| Gene3D | G3DSA:1.10.238.10. EF-Hand_type. 1 hit. | ||||||||||||||||||
| Pfam | PF00036. efhand. 1 hit. PF01023. S_100. 1 hit. [Graphical view] | ||||||||||||||||||
| PROSITE | PS00018. EF_HAND_1. 1 hit. PS50222. EF_HAND_2. 1 hit. PS00303. S100_CABP. 1 hit. [Graphical view] | ||||||||||||||||||
| ProtoNet | Search... | ||||||||||||||||||
Other | |||||||||||||||||||
| NextBio | 24385. | ||||||||||||||||||
| SOURCE | Search... | ||||||||||||||||||
Entry information
| Entry name | S10AB_HUMAN | ||||||||
| Accession | Primary (citable) accession number: P31949 Secondary accession number(s): Q5VTK0 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Chordata Protein Annotation Program | ||||||||
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | ||||||||
Relevant documents
| Human chromosome 1 Human chromosome 1: entries, gene names and cross-references to MIM |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| PDB cross-references Index of Protein Data Bank (PDB) cross-references |
| SIMILARITY comments Index of protein domains and families |

Clusters with