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P31949

- S10AB_HUMAN

UniProt

P31949 - S10AB_HUMAN

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Protein

Protein S100-A11

Gene

S100A11

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Facilitates the differentiation and the cornification of keratinocytes.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi25 – 38141; low affinityPROSITE-ProRule annotationAdd
BLAST
Calcium bindingi68 – 79122; high affinityPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. calcium-dependent protein binding Source: UniProtKB
  2. calcium ion binding Source: InterPro
  3. protein homodimerization activity Source: UniProtKB
  4. S100 protein binding Source: UniProtKB

GO - Biological processi

  1. negative regulation of cell proliferation Source: ProtInc
  2. negative regulation of DNA replication Source: ProtInc
  3. signal transduction Source: UniProtKB
Complete GO annotation...

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Protein S100-A11
Alternative name(s):
Calgizzarin
Metastatic lymph node gene 70 protein
Short name:
MLN 70
Protein S100-C
S100 calcium-binding protein A11
Cleaved into the following chain:
Gene namesi
Name:S100A11
Synonyms:MLN70, S100C
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:10488. S100A11.

Subcellular locationi

Cytoplasm 1 Publication. Nucleus 1 Publication

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. extracellular space Source: UniProt
  3. extracellular vesicular exosome Source: UniProtKB
  4. nucleus Source: UniProtKB
  5. ruffle Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA34900.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 105105Protein S100-A11PRO_0000144009Add
BLAST
Initiator methioninei1 – 11Removed; alternate1 Publication
Chaini2 – 105104Protein S100-A11, N-terminally processedPRO_0000424465Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionine1 Publication
Modified residuei2 – 21N-acetylalanine; in Protein S100-A11, N-terminally processed2 Publications
Modified residuei3 – 31N6-acetyllysine1 Publication
Modified residuei6 – 61Phosphoserine2 Publications
Modified residuei10 – 101Phosphothreonine1 Publication
Disulfide bondi13 – 13Interchain1 Publication
Modified residuei27 – 271N6-acetyllysineBy similarity

Post-translational modificationi

Phosphorylation at Thr-10 by PRKCA significantly suppresses homodimerization and promotes association with NCL/nucleolin which induces nuclear translocation.3 Publications

Keywords - PTMi

Acetylation, Disulfide bond, Phosphoprotein

Proteomic databases

MaxQBiP31949.
PaxDbiP31949.
PeptideAtlasiP31949.
PRIDEiP31949.

2D gel databases

DOSAC-COBS-2DPAGEP31949.
SWISS-2DPAGEP31949.

PTM databases

PhosphoSiteiP31949.

Expressioni

Gene expression databases

BgeeiP31949.
CleanExiHS_S100A11.
ExpressionAtlasiP31949. baseline and differential.
GenevestigatoriP31949.

Organism-specific databases

HPAiCAB034320.
HPA042745.

Interactioni

Subunit structurei

Homodimer; disulfide-linked.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
S100BP042715EBI-701862,EBI-458391

Protein-protein interaction databases

BioGridi112190. 16 interactions.
IntActiP31949. 7 interactions.
MINTiMINT-5002556.
STRINGi9606.ENSP00000271638.

Structurei

Secondary structure

1
105
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi7 – 1812
Beta strandi30 – 323
Helixi36 – 4510
Helixi48 – 547
Helixi58 – 6710
Beta strandi70 – 756
Helixi77 – 9620

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1V4ZNMR-A1-19[»]
1V50NMR-A1-19[»]
2LUCNMR-A/B1-105[»]
ProteinModelPortaliP31949.
SMRiP31949. Positions 1-105.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP31949.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini13 – 4937EF-hand 1PROSITE-ProRule annotationAdd
BLAST
Domaini55 – 9036EF-hand 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the S-100 family.Curated
Contains 2 EF-hand domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG29318.
HOGENOMiHOG000246968.
HOVERGENiHBG001479.
InParanoidiP31949.
OMAiIFMNTEL.
OrthoDBiEOG7XH6SB.
PhylomeDBiP31949.
TreeFamiTF332727.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR001751. S100/CaBP-9k_CS.
IPR013787. S100_Ca-bd_sub.
IPR028482. S100A11.
[Graphical view]
PANTHERiPTHR11639:SF68. PTHR11639:SF68. 1 hit.
PfamiPF00036. EF-hand_1. 1 hit.
PF01023. S_100. 1 hit.
[Graphical view]
PROSITEiPS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 1 hit.
PS00303. S100_CABP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P31949-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAKISSPTET ERCIESLIAV FQKYAGKDGY NYTLSKTEFL SFMNTELAAF
60 70 80 90 100
TKNQKDPGVL DRMMKKLDTN SDGQLDFSEF LNLIGGLAMA CHDSFLKAVP

SQKRT
Length:105
Mass (Da):11,740
Last modified:October 1, 1996 - v2
Checksum:i1729ED680290CFE4
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D38583 mRNA. Translation: BAA07597.1.
X80201 mRNA. Translation: CAA56492.1.
D49355 mRNA. Translation: BAA08354.1.
D50374 mRNA. Translation: BAA23325.1.
BT009912 mRNA. Translation: AAP88914.1.
AL591893 Genomic DNA. Translation: CAH72895.1.
BC001410 mRNA. Translation: AAH01410.1.
BC014354 mRNA. Translation: AAH14354.1.
CCDSiCCDS1009.1.
PIRiI37080.
RefSeqiNP_005611.1. NM_005620.1.
UniGeneiHs.417004.

Genome annotation databases

EnsembliENST00000271638; ENSP00000271638; ENSG00000163191.
GeneIDi6282.
KEGGihsa:6282.
UCSCiuc001ezn.3. human.

Polymorphism databases

DMDMi1710818.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D38583 mRNA. Translation: BAA07597.1 .
X80201 mRNA. Translation: CAA56492.1 .
D49355 mRNA. Translation: BAA08354.1 .
D50374 mRNA. Translation: BAA23325.1 .
BT009912 mRNA. Translation: AAP88914.1 .
AL591893 Genomic DNA. Translation: CAH72895.1 .
BC001410 mRNA. Translation: AAH01410.1 .
BC014354 mRNA. Translation: AAH14354.1 .
CCDSi CCDS1009.1.
PIRi I37080.
RefSeqi NP_005611.1. NM_005620.1.
UniGenei Hs.417004.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1V4Z NMR - A 1-19 [» ]
1V50 NMR - A 1-19 [» ]
2LUC NMR - A/B 1-105 [» ]
ProteinModelPortali P31949.
SMRi P31949. Positions 1-105.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 112190. 16 interactions.
IntActi P31949. 7 interactions.
MINTi MINT-5002556.
STRINGi 9606.ENSP00000271638.

PTM databases

PhosphoSitei P31949.

Polymorphism databases

DMDMi 1710818.

2D gel databases

DOSAC-COBS-2DPAGE P31949.
SWISS-2DPAGE P31949.

Proteomic databases

MaxQBi P31949.
PaxDbi P31949.
PeptideAtlasi P31949.
PRIDEi P31949.

Protocols and materials databases

DNASUi 6282.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000271638 ; ENSP00000271638 ; ENSG00000163191 .
GeneIDi 6282.
KEGGi hsa:6282.
UCSCi uc001ezn.3. human.

Organism-specific databases

CTDi 6282.
GeneCardsi GC01M152004.
HGNCi HGNC:10488. S100A11.
HPAi CAB034320.
HPA042745.
MIMi 603114. gene.
neXtProti NX_P31949.
PharmGKBi PA34900.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG29318.
HOGENOMi HOG000246968.
HOVERGENi HBG001479.
InParanoidi P31949.
OMAi IFMNTEL.
OrthoDBi EOG7XH6SB.
PhylomeDBi P31949.
TreeFami TF332727.

Miscellaneous databases

EvolutionaryTracei P31949.
GeneWikii S100A11.
GenomeRNAii 6282.
NextBioi 24385.
PROi P31949.
SOURCEi Search...

Gene expression databases

Bgeei P31949.
CleanExi HS_S100A11.
ExpressionAtlasi P31949. baseline and differential.
Genevestigatori P31949.

Family and domain databases

Gene3Di 1.10.238.10. 1 hit.
InterProi IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR001751. S100/CaBP-9k_CS.
IPR013787. S100_Ca-bd_sub.
IPR028482. S100A11.
[Graphical view ]
PANTHERi PTHR11639:SF68. PTHR11639:SF68. 1 hit.
Pfami PF00036. EF-hand_1. 1 hit.
PF01023. S_100. 1 hit.
[Graphical view ]
PROSITEi PS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 1 hit.
PS00303. S100_CABP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Human calgizzarin; one colorectal cancer-related gene selected by a large scale random cDNA sequencing and northern blot analysis."
    Tanaka M., Adzuma K., Iwami M., Yoshimoto K., Monden Y., Itakura M.
    Cancer Lett. 89:195-200(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Identification of four novel human genes amplified and overexpressed in breast carcinoma and localized to the q11-q21.3 region of chromosome 17."
    Tomasetto C.L., Regnier C.H., Moog-Lutz C., Mattei M.-G., Chenard M.-P., Lidereau R., Basset P., Rio M.-C.
    Genomics 28:367-376(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Mammary carcinoma.
  3. "Isolation and characterization of cDNA for human S100C protein and a related gene."
    Nakatani K., Kato A., Sugimoto M., Kumano K., Komada T., Tsunoda H., Ito M., Nakano T., Shima T., Tanaka T.
    Submitted (OCT-1995) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Lung.
  4. "Molecular cloning of a human homologue of the two calcium binding protein, porcine S100 and rabbit calgizzarin."
    Fujiwara T., Kawai A., Shimizu F., Shinomiya K., Hirano H., Okuno S., Ozaki K., Katagiri T., Takeda S., Kuga Y., Shimada Y., Nagata M., Takaichi A., Watanabe T., Horie M., Nakamura Y., Takahashi E., Hirai Y.
    Submitted (NOV-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.
  5. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  6. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Placenta and Urinary bladder.
  8. "Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes."
    Rasmussen H.H., van Damme J., Puype M., Gesser B., Celis J.E., Vandekerckhove J.
    Electrophoresis 13:960-969(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 4-12; 43-51 AND 56-62.
    Tissue: Keratinocyte.
  9. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-6, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  10. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
    Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
    Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2 AND LYS-3, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
  11. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-6, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  12. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  13. Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1 AND ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  14. "The structure of S100A11 fragment explains a local structural change induced by phosphorylation."
    Kouno T., Mizuguchi M., Sakaguchi M., Makino E., Mori Y., Shinoda H., Aizawa T., Demura M., Huh N.H., Kawano K.
    J. Pept. Sci. 14:1129-1138(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR OF 1-19, DISULFIDE BOND, PHOSPHORYLATION AT THR-10, FUNCTION, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiS10AB_HUMAN
AccessioniPrimary (citable) accession number: P31949
Secondary accession number(s): Q5VTK0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: October 1, 1996
Last modified: October 29, 2014
This is version 157 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Binds two calcium ions per molecule with an affinity similar to that of the S-100 proteins.By similarity

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3