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Protein

Protein S100-A11

Gene

S100A11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Facilitates the differentiation and the cornification of keratinocytes.1 Publication

Miscellaneous

Binds two calcium ions per molecule with an affinity similar to that of the S-100 proteins.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi25 – 381; low affinityPROSITE-ProRule annotationAdd BLAST14
Calcium bindingi68 – 792; high affinityPROSITE-ProRule annotationAdd BLAST12

GO - Molecular functioni

  • cadherin binding involved in cell-cell adhesion Source: BHF-UCL
  • calcium-dependent protein binding Source: UniProtKB
  • calcium ion binding Source: InterPro
  • protein homodimerization activity Source: UniProtKB
  • S100 protein binding Source: UniProtKB

GO - Biological processi

  • negative regulation of cell proliferation Source: ProtInc
  • negative regulation of DNA replication Source: ProtInc
  • neutrophil degranulation Source: Reactome
  • signal transduction Source: UniProtKB

Keywordsi

LigandCalcium, Metal-binding

Enzyme and pathway databases

ReactomeiR-HSA-6798695. Neutrophil degranulation.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein S100-A11
Alternative name(s):
Calgizzarin
Metastatic lymph node gene 70 protein
Short name:
MLN 70
Protein S100-C
S100 calcium-binding protein A11
Cleaved into the following chain:
Gene namesi
Name:S100A11
Synonyms:MLN70, S100C
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000163191.5.
HGNCiHGNC:10488. S100A11.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi6282.
OpenTargetsiENSG00000163191.
PharmGKBiPA34900.

Chemistry databases

DrugBankiDB02482. Phosphonothreonine.

Polymorphism and mutation databases

BioMutaiS100A11.
DMDMi1710818.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004244651 – 105Protein S100-A11Add BLAST105
Initiator methionineiRemoved; alternateCombined sources
ChainiPRO_00001440092 – 105Protein S100-A11, N-terminally processedAdd BLAST104

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineCombined sources1
Modified residuei2N-acetylalanine; in Protein S100-A11, N-terminally processedCombined sources1
Modified residuei3N6-acetyllysineCombined sources1
Modified residuei5PhosphoserineCombined sources1
Modified residuei6PhosphoserineCombined sources1
Modified residuei10Phosphothreonine1 Publication1
Disulfide bondi13Interchain1 Publication
Modified residuei27N6-acetyllysineBy similarity1

Post-translational modificationi

Phosphorylation at Thr-10 by PRKCA significantly suppresses homodimerization and promotes association with NCL/nucleolin which induces nuclear translocation.1 Publication

Keywords - PTMi

Acetylation, Disulfide bond, Phosphoprotein

Proteomic databases

EPDiP31949.
PaxDbiP31949.
PeptideAtlasiP31949.
PRIDEiP31949.
TopDownProteomicsiP31949.

2D gel databases

DOSAC-COBS-2DPAGEiP31949.
SWISS-2DPAGEiP31949.

PTM databases

iPTMnetiP31949.
PhosphoSitePlusiP31949.
SwissPalmiP31949.

Expressioni

Gene expression databases

BgeeiENSG00000163191.
CleanExiHS_S100A11.
ExpressionAtlasiP31949. baseline and differential.
GenevisibleiP31949. HS.

Organism-specific databases

HPAiCAB034320.
HPA042745.

Interactioni

Subunit structurei

Homodimer; disulfide-linked.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
S100BP042715EBI-701862,EBI-458391

GO - Molecular functioni

  • cadherin binding involved in cell-cell adhesion Source: BHF-UCL
  • calcium-dependent protein binding Source: UniProtKB
  • protein homodimerization activity Source: UniProtKB
  • S100 protein binding Source: UniProtKB

Protein-protein interaction databases

BioGridi112190. 21 interactors.
IntActiP31949. 8 interactors.
MINTiMINT-5002556.
STRINGi9606.ENSP00000271638.

Structurei

Secondary structure

1105
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi7 – 18Combined sources12
Beta strandi30 – 32Combined sources3
Helixi36 – 45Combined sources10
Helixi48 – 54Combined sources7
Helixi58 – 67Combined sources10
Beta strandi70 – 75Combined sources6
Helixi77 – 96Combined sources20

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1V4ZNMR-A1-19[»]
1V50NMR-A1-19[»]
2LUCNMR-A/B1-105[»]
ProteinModelPortaliP31949.
SMRiP31949.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP31949.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini13 – 49EF-hand 1PROSITE-ProRule annotationAdd BLAST37
Domaini55 – 90EF-hand 2PROSITE-ProRule annotationAdd BLAST36

Sequence similaritiesi

Belongs to the S-100 family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiENOG410J1U7. Eukaryota.
ENOG410YYVE. LUCA.
GeneTreeiENSGT00760000119034.
HOGENOMiHOG000246968.
HOVERGENiHBG001479.
InParanoidiP31949.
OMAiAQACHDS.
OrthoDBiEOG091G10QT.
PhylomeDBiP31949.
TreeFamiTF332727.

Family and domain databases

InterProiView protein in InterPro
IPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
IPR001751. S100/CaBP-9k_CS.
IPR013787. S100_Ca-bd_sub.
IPR028482. S100A11.
PANTHERiPTHR11639:SF60. PTHR11639:SF60. 1 hit.
PfamiView protein in Pfam
PF00036. EF-hand_1. 1 hit.
PF01023. S_100. 1 hit.
SMARTiView protein in SMART
SM00054. EFh. 1 hit.
SM01394. S_100. 1 hit.
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiView protein in PROSITE
PS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 1 hit.
PS00303. S100_CABP. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P31949-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKISSPTET ERCIESLIAV FQKYAGKDGY NYTLSKTEFL SFMNTELAAF
60 70 80 90 100
TKNQKDPGVL DRMMKKLDTN SDGQLDFSEF LNLIGGLAMA CHDSFLKAVP

SQKRT
Length:105
Mass (Da):11,740
Last modified:October 1, 1996 - v2
Checksum:i1729ED680290CFE4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D38583 mRNA. Translation: BAA07597.1.
X80201 mRNA. Translation: CAA56492.1.
D49355 mRNA. Translation: BAA08354.1.
D50374 mRNA. Translation: BAA23325.1.
BT009912 mRNA. Translation: AAP88914.1.
AL591893 Genomic DNA. No translation available.
BC001410 mRNA. Translation: AAH01410.1.
BC014354 mRNA. Translation: AAH14354.1.
CCDSiCCDS1009.1.
PIRiI37080.
RefSeqiNP_005611.1. NM_005620.1.
UniGeneiHs.417004.

Genome annotation databases

EnsembliENST00000271638; ENSP00000271638; ENSG00000163191.
GeneIDi6282.
KEGGihsa:6282.

Similar proteinsi

Entry informationi

Entry nameiS10AB_HUMAN
AccessioniPrimary (citable) accession number: P31949
Secondary accession number(s): Q5VTK0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: October 1, 1996
Last modified: October 25, 2017
This is version 189 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families