ID 1433S_HUMAN Reviewed; 248 AA. AC P31947; Q6FH30; Q6FH51; Q96DH0; DT 01-JUL-1993, integrated into UniProtKB/Swiss-Prot. DT 01-JUL-1993, sequence version 1. DT 27-MAR-2024, entry version 234. DE RecName: Full=14-3-3 protein sigma {ECO:0000303|PubMed:9659898}; DE AltName: Full=Epithelial cell marker protein 1 {ECO:0000303|PubMed:1390337}; DE AltName: Full=Stratifin {ECO:0000303|PubMed:8515476}; GN Name=SFN; Synonyms=HME1 {ECO:0000303|PubMed:1390337}; OS Homo sapiens (Human). OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; OC Homo. OX NCBI_TaxID=9606; RN [1] RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), AND TISSUE SPECIFICITY. RC TISSUE=Epithelium; RX PubMed=1390337; RA Prasad G.L., Valverius E.M., McDuffie E., Cooper H.L.; RT "Complementary DNA cloning of a novel epithelial cell marker protein, HME1, RT that may be down-regulated in neoplastic mammary cells."; RL Cell Growth Differ. 3:507-513(1992). RN [2] RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), PROTEIN SEQUENCE OF 19-25; 42-49; RP 118-122; 130-139; 149-159; 161-181; 196-199; 225-229 AND 231-239, AND RP SUBCELLULAR LOCATION. RC TISSUE=Keratinocyte; RX PubMed=8515476; DOI=10.1006/jmbi.1993.1346; RA Leffers H., Madsen P., Rasmussen H.H., Honore B., Andersen A.H., Walbum E., RA Vandekerckhove J., Celis J.E.; RT "Molecular cloning and expression of the transformation sensitive RT epithelial marker stratifin. A member of a protein family that has been RT involved in the protein kinase C signalling pathway."; RL J. Mol. Biol. 231:982-998(1993). RN [3] RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1), AND FUNCTION. RX PubMed=9659898; DOI=10.1016/s1097-2765(00)80002-7; RA Hermeking H., Lengauer C., Polyak K., He T.-C., Zhang L., Thiagalingam S., RA Kinzler K.W., Vogelstein B.; RT "14-3-3 sigma is a p53-regulated inhibitor of G2/M progression."; RL Mol. Cell 1:3-11(1997). RN [4] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). RA Halleck A., Ebert L., Mkoundinya M., Schick M., Eisenstein S., Neubert P., RA Kstrang K., Schatten R., Shen B., Henze S., Mar W., Korn B., Zuo D., Hu Y., RA LaBaer J.; RT "Cloning of human full open reading frames in Gateway(TM) system entry RT vector (pDONR201)."; RL Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases. RN [5] RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RX PubMed=16710414; DOI=10.1038/nature04727; RA Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., RA Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., RA Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K., RA Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., RA Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., RA Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., RA Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., RA Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., RA Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., RA Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., RA Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., RA Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., RA Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., RA Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., RA Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., RA Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., RA Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., RA Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., RA Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., RA McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., RA Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., RA Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., RA Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., RA Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., RA Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., RA White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., RA Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., RA Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., RA Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.; RT "The DNA sequence and biological annotation of human chromosome 1."; RL Nature 441:315-321(2006). RN [6] RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). RC TISSUE=Cervix, Lung, and Placenta; RX PubMed=15489334; DOI=10.1101/gr.2596504; RG The MGC Project Team; RT "The status, quality, and expansion of the NIH full-length cDNA project: RT the Mammalian Gene Collection (MGC)."; RL Genome Res. 14:2121-2127(2004). RN [7] RP PROTEIN SEQUENCE OF 42-49 AND 118-122. RC TISSUE=Keratinocyte; RX PubMed=1286667; DOI=10.1002/elps.11501301199; RA Rasmussen H.H., van Damme J., Puype M., Gesser B., Celis J.E., RA Vandekerckhove J.; RT "Microsequences of 145 proteins recorded in the two-dimensional gel protein RT database of normal human epidermal keratinocytes."; RL Electrophoresis 13:960-969(1992). RN [8] RP IDENTIFICATION IN A COMPLEX WITH XPO7; ARHGAP1; EIF4A1; VPS26A; VPS29 AND RP VPS35. RX PubMed=15282546; DOI=10.1038/sj.emboj.7600338; RA Mingot J.-M., Bohnsack M.T., Jaekle U., Goerlich D.; RT "Exportin 7 defines a novel general nuclear export pathway."; RL EMBO J. 23:3227-3236(2004). RN [9] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-248, AND IDENTIFICATION BY RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Cervix carcinoma; RX PubMed=16964243; DOI=10.1038/nbt1240; RA Beausoleil S.A., Villen J., Gerber S.A., Rush J., Gygi S.P.; RT "A probability-based approach for high-throughput protein phosphorylation RT analysis and site localization."; RL Nat. Biotechnol. 24:1285-1292(2006). RN [10] RP FUNCTION IN MDM2 UBIQUITINATION, AND UBIQUITINATION BY RFFL. RX PubMed=18382127; DOI=10.4161/cc.7.5.5701; RA Yang W., Dicker D.T., Chen J., El-Deiry W.S.; RT "CARPs enhance p53 turnover by degrading 14-3-3sigma and stabilizing RT MDM2."; RL Cell Cycle 7:670-682(2008). RN [11] RP INTERACTION WITH GAB2. RX PubMed=19172738; DOI=10.1038/emboj.2008.159; RA Brummer T., Larance M., Herrera Abreu M.T., Lyons R.J., Timpson P., RA Emmerich C.H., Fleuren E.D.G., Lehrbach G.M., Schramek D., Guilhaus M., RA James D.E., Daly R.J.; RT "Phosphorylation-dependent binding of 14-3-3 terminates signalling by the RT Gab2 docking protein."; RL EMBO J. 27:2305-2316(2008). RN [12] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-248, AND IDENTIFICATION BY RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Cervix carcinoma; RX PubMed=18691976; DOI=10.1016/j.molcel.2008.07.007; RA Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., RA Greff Z., Keri G., Stemmann O., Mann M.; RT "Kinase-selective enrichment enables quantitative phosphoproteomics of the RT kinome across the cell cycle."; RL Mol. Cell 31:438-448(2008). RN [13] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-248, AND IDENTIFICATION BY RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Cervix carcinoma; RX PubMed=18669648; DOI=10.1073/pnas.0805139105; RA Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E., RA Elledge S.J., Gygi S.P.; RT "A quantitative atlas of mitotic phosphorylation."; RL Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). RN [14] RP INTERACTION WITH SLITRK1. RX PubMed=19640509; DOI=10.1016/j.biopsych.2009.05.033; RA Kajiwara Y., Buxbaum J.D., Grice D.E.; RT "SLITRK1 binds 14-3-3 and regulates neurite outgrowth in a phosphorylation- RT dependent manner."; RL Biol. Psychiatry 66:918-925(2009). RN [15] RP INTERACTION WITH SRPK2. RX PubMed=19592491; DOI=10.1074/jbc.m109.026237; RA Jang S.W., Liu X., Fu H., Rees H., Yepes M., Levey A., Ye K.; RT "Interaction of Akt-phosphorylated SRPK2 with 14-3-3 mediates cell cycle RT and cell death in neurons."; RL J. Biol. Chem. 284:24512-24525(2009). RN [16] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-5 AND SER-248, AND RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Cervix carcinoma; RX PubMed=20068231; DOI=10.1126/scisignal.2000475; RA Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., RA Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.; RT "Quantitative phosphoproteomics reveals widespread full phosphorylation RT site occupancy during mitosis."; RL Sci. Signal. 3:RA3-RA3(2010). RN [17] RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RX PubMed=21269460; DOI=10.1186/1752-0509-5-17; RA Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., RA Bennett K.L., Superti-Furga G., Colinge J.; RT "Initial characterization of the human central proteome."; RL BMC Syst. Biol. 5:17-17(2011). RN [18] RP INTERACTION WITH COPS6 AND COP1. RX PubMed=21625211; DOI=10.1038/onc.2011.192; RA Choi H.H., Gully C., Su C.H., Velazquez-Torres G., Chou P.C., Tseng C., RA Zhao R., Phan L., Shaiken T., Chen J., Yeung S.C., Lee M.H.; RT "COP9 signalosome subunit 6 stabilizes COP1, which functions as an E3 RT ubiquitin ligase for 14-3-3sigma."; RL Oncogene 30:4791-4801(2011). RN [19] RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-74, AND IDENTIFICATION BY RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS]. RC TISSUE=Cervix carcinoma; RX PubMed=23186163; DOI=10.1021/pr300630k; RA Zhou H., Di Palma S., Preisinger C., Peng M., Polat A.N., Heck A.J., RA Mohammed S.; RT "Toward a comprehensive characterization of a human cancer cell RT phosphoproteome."; RL J. Proteome Res. 12:260-271(2013). RN [20] RP INTERACTION WITH PI4KB, AND IDENTIFICATION BY MASS SPECTROMETRY. RX PubMed=23572552; DOI=10.1128/mbio.00098-13; RA Greninger A.L., Knudsen G.M., Betegon M., Burlingame A.L., DeRisi J.L.; RT "ACBD3 interaction with TBC1 domain 22 protein is differentially affected RT by enteroviral and kobuviral 3A protein binding."; RL MBio 4:E00098-E00098(2013). RN [21] RP INTERACTION WITH DAPK2. RX PubMed=26047703; DOI=10.1016/j.bbrc.2015.05.105; RA Yuasa K., Ota R., Matsuda S., Isshiki K., Inoue M., Tsuji A.; RT "Suppression of death-associated protein kinase 2 by interaction with 14-3- RT 3 proteins."; RL Biochem. Biophys. Res. Commun. 464:70-75(2015). RN [22] RP X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) IN COMPLEX WITH PHOSPHOSERINE RP PEPTIDE, AND FUNCTION. RX PubMed=15731107; DOI=10.1074/jbc.m500982200; RA Wilker E.W., Grant R.A., Artim S.C., Yaffe M.B.; RT "A structural basis for 14-3-3sigma functional specificity."; RL J. Biol. Chem. 280:18891-18898(2005). RN [23] RP X-RAY CRYSTALLOGRAPHY (1.4 ANGSTROMS) OF 1-231 IN COMPLEX WITH PADI6 RP PHOSPHOPEPTIDES, AND FUNCTION. RX PubMed=22634725; DOI=10.1016/j.jsb.2012.05.010; RA Rose R., Rose M., Ottmann C.; RT "Identification and structural characterization of two 14-3-3 binding sites RT in the human peptidylarginine deiminase type VI."; RL J. Struct. Biol. 180:65-72(2012). RN [24] {ECO:0007744|PDB:5MY9, ECO:0007744|PDB:5MYC} RP X-RAY CRYSTALLOGRAPHY (1.33 ANGSTROMS) OF 1-231 IN COMPLEX WITH LRRK2 RP PHOSPHOPEPTIDE, FUNCTION, AND SUBUNIT. RX PubMed=28202711; DOI=10.1042/bcj20161078; RA Stevers L.M., de Vries R.M., Doveston R.G., Milroy L.G., Brunsveld L., RA Ottmann C.; RT "Structural interface between LRRK2 and 14-3-3 protein."; RL Biochem. J. 474:1273-1287(2017). RN [25] {ECO:0007744|PDB:8Q4L} RP STRUCTURE BY ELECTRON MICROSCOPY (5.12 ANGSTROMS) OF 1-231 IN COMPLEX WITH RP GBP1, FUNCTION, AND SUBCELLULAR LOCATION. RX PubMed=37797010; DOI=10.1126/science.adg2253; RA Fisch D., Pfleiderer M.M., Anastasakou E., Mackie G.M., Wendt F., Liu X., RA Clough B., Lara-Reyna S., Encheva V., Snijders A.P., Bando H., Yamamoto M., RA Beggs A.D., Mercer J., Shenoy A.R., Wollscheid B., Maslowski K.M., RA Galej W.P., Frickel E.M.; RT "PIM1 controls GBP1 activity to limit self-damage and to guard against RT pathogen infection."; RL Science 382:eadg2253-eadg2253(2023). CC -!- FUNCTION: Adapter protein implicated in the regulation of a large CC spectrum of both general and specialized signaling pathways CC (PubMed:15731107, PubMed:22634725, PubMed:28202711, PubMed:37797010). CC Binds to a large number of partners, usually by recognition of a CC phosphoserine or phosphothreonine motif (PubMed:15731107, CC PubMed:22634725, PubMed:28202711, PubMed:37797010). Binding generally CC results in the modulation of the activity of the binding partner CC (PubMed:15731107, PubMed:22634725, PubMed:28202711, PubMed:37797010). CC Promotes cytosolic retention of GBP1 GTPase by binding to CC phosphorylated GBP1, thereby inhibiting the innate immune response CC (PubMed:37797010). Also acts as a TP53/p53-regulated inhibitor of G2/M CC progression (PubMed:9659898). When bound to KRT17, regulates protein CC synthesis and epithelial cell growth by stimulating Akt/mTOR pathway CC (By similarity). May also regulate MDM2 autoubiquitination and CC degradation and thereby activate p53/TP53 (PubMed:18382127). CC {ECO:0000250|UniProtKB:O70456, ECO:0000269|PubMed:15731107, CC ECO:0000269|PubMed:18382127, ECO:0000269|PubMed:22634725, CC ECO:0000269|PubMed:28202711, ECO:0000269|PubMed:37797010, CC ECO:0000269|PubMed:9659898}. CC -!- SUBUNIT: Homodimer (PubMed:28202711). Interacts with KRT17 and SAMSN1 CC (By similarity). Found in a complex with XPO7, EIF4A1, ARHGAP1, VPS26A, CC VPS29 and VPS35 (PubMed:15282546). Interacts with GAB2 CC (PubMed:19172738). Interacts with SRPK2 (PubMed:19592491). Interacts CC with COPS6 (PubMed:21625211). Interacts with COP1; this interaction CC leads to proteasomal degradation (PubMed:21625211). Interacts with the CC 'Thr-369' phosphorylated form of DAPK2 (PubMed:26047703). Interacts CC with PI4KB (PubMed:23572552). Interacts with SLITRK1 (PubMed:19640509). CC Interacts with LRRK2; this interaction is dependent on LRRK2 CC phosphorylation (PubMed:28202711). {ECO:0000250|UniProtKB:O70456, CC ECO:0000269|PubMed:15282546, ECO:0000269|PubMed:15731107, CC ECO:0000269|PubMed:19172738, ECO:0000269|PubMed:19592491, CC ECO:0000269|PubMed:19640509, ECO:0000269|PubMed:21625211, CC ECO:0000269|PubMed:22634725, ECO:0000269|PubMed:23572552, CC ECO:0000269|PubMed:26047703, ECO:0000269|PubMed:28202711}. CC -!- INTERACTION: CC P31947; P00519: ABL1; NbExp=5; IntAct=EBI-476295, EBI-375543; CC P31947; O14639: ABLIM1; NbExp=5; IntAct=EBI-476295, EBI-487024; CC P31947; Q96IF1: AJUBA; NbExp=2; IntAct=EBI-476295, EBI-949782; CC P31947; Q92625: ANKS1A; NbExp=4; IntAct=EBI-476295, EBI-1048612; CC P31947; P10398: ARAF; NbExp=4; IntAct=EBI-476295, EBI-365961; CC P31947; Q5T5U3: ARHGAP21; NbExp=4; IntAct=EBI-476295, EBI-1642518; CC P31947; A7KAX9: ARHGAP32; NbExp=3; IntAct=EBI-476295, EBI-308663; CC P31947; Q5VV41: ARHGEF16; NbExp=5; IntAct=EBI-476295, EBI-1057448; CC P31947; Q92974: ARHGEF2; NbExp=4; IntAct=EBI-476295, EBI-302405; CC P31947; Q12774: ARHGEF5; NbExp=4; IntAct=EBI-476295, EBI-602199; CC P31947; Q92934: BAD; NbExp=8; IntAct=EBI-476295, EBI-700771; CC P31947; Q9UQB8: BAIAP2; NbExp=4; IntAct=EBI-476295, EBI-525456; CC P31947; P15056: BRAF; NbExp=5; IntAct=EBI-476295, EBI-365980; CC P31947; P22681: CBL; NbExp=2; IntAct=EBI-476295, EBI-518228; CC P31947; Q68D86: CCDC102B; NbExp=3; IntAct=EBI-476295, EBI-10171570; CC P31947; Q86Z20: CCDC125; NbExp=3; IntAct=EBI-476295, EBI-11977221; CC P31947; P51946: CCNH; NbExp=4; IntAct=EBI-476295, EBI-741406; CC P31947; P30305: CDC25B; NbExp=2; IntAct=EBI-476295, EBI-1051746; CC P31947; Q9P2M7: CGN; NbExp=4; IntAct=EBI-476295, EBI-79537; CC P31947; Q7Z460: CLASP1; NbExp=3; IntAct=EBI-476295, EBI-913476; CC P31947; O75122: CLASP2; NbExp=4; IntAct=EBI-476295, EBI-913524; CC P31947; Q8NHY2: COP1; NbExp=6; IntAct=EBI-476295, EBI-1176214; CC P31947; Q7L5N1: COPS6; NbExp=7; IntAct=EBI-476295, EBI-486838; CC P31947; P25685: DNAJB1; NbExp=2; IntAct=EBI-476295, EBI-357034; CC P31947; Q96F86: EDC3; NbExp=4; IntAct=EBI-476295, EBI-997311; CC P31947; P00533: EGFR; NbExp=9; IntAct=EBI-476295, EBI-297353; CC P31947; O43491: EPB41L2; NbExp=3; IntAct=EBI-476295, EBI-1052044; CC P31947; Q9UJM3: ERRFI1; NbExp=3; IntAct=EBI-476295, EBI-2941912; CC P31947; Q6P1L5: FAM117B; NbExp=4; IntAct=EBI-476295, EBI-3893327; CC P31947; Q9NYF3: FAM53C; NbExp=3; IntAct=EBI-476295, EBI-1644252; CC P31947; Q8IZU0: FAM9B; NbExp=3; IntAct=EBI-476295, EBI-10175124; CC P31947; O43524: FOXO3; NbExp=3; IntAct=EBI-476295, EBI-1644164; CC P31947; P98177: FOXO4; NbExp=4; IntAct=EBI-476295, EBI-4481939; CC P31947; Q9H2C0: GAN; NbExp=3; IntAct=EBI-476295, EBI-764342; CC P31947; O60269: GPRIN2; NbExp=2; IntAct=EBI-476295, EBI-740397; CC P31947; Q13322: GRB10; NbExp=2; IntAct=EBI-476295, EBI-80275; CC P31947; P56524: HDAC4; NbExp=8; IntAct=EBI-476295, EBI-308629; CC P31947; Q9UQL6: HDAC5; NbExp=3; IntAct=EBI-476295, EBI-715576; CC P31947; Q8WUI4: HDAC7; NbExp=3; IntAct=EBI-476295, EBI-1048378; CC P31947; Q5T1R4: HIVEP3; NbExp=5; IntAct=EBI-476295, EBI-28989979; CC P31947; Q14103-4: HNRNPD; NbExp=7; IntAct=EBI-476295, EBI-432545; CC P31947; Q16352: INA; NbExp=2; IntAct=EBI-476295, EBI-366258; CC P31947; P35568: IRS1; NbExp=2; IntAct=EBI-476295, EBI-517592; CC P31947; Q9Y4H2: IRS2; NbExp=4; IntAct=EBI-476295, EBI-1049582; CC P31947; O14654: IRS4; NbExp=4; IntAct=EBI-476295, EBI-356594; CC P31947; Q9H1K1: ISCU; NbExp=2; IntAct=EBI-476295, EBI-1047335; CC P31947; Q08881: ITK; NbExp=2; IntAct=EBI-476295, EBI-968552; CC P31947; Q6ICG6: KIAA0930; NbExp=2; IntAct=EBI-476295, EBI-1053969; CC P31947; O60333: KIF1B; NbExp=4; IntAct=EBI-476295, EBI-465633; CC P31947; Q02241: KIF23; NbExp=4; IntAct=EBI-476295, EBI-306852; CC P31947; Q9H0B6: KLC2; NbExp=5; IntAct=EBI-476295, EBI-726994; CC P31947; Q9NSK0: KLC4; NbExp=4; IntAct=EBI-476295, EBI-949319; CC P31947; Q6PKG0: LARP1; NbExp=4; IntAct=EBI-476295, EBI-1052114; CC P31947; Q17RB8: LONRF1; NbExp=3; IntAct=EBI-476295, EBI-2341787; CC P31947; Q5S007: LRRK2; NbExp=5; IntAct=EBI-476295, EBI-5323863; CC P31947; Q86V48: LUZP1; NbExp=4; IntAct=EBI-476295, EBI-350467; CC P31947; P43355: MAGEA1; NbExp=3; IntAct=EBI-476295, EBI-740978; CC P31947; Q9Y2U5: MAP3K2; NbExp=3; IntAct=EBI-476295, EBI-357393; CC P31947; Q9NYL2: MAP3K20; NbExp=4; IntAct=EBI-476295, EBI-602273; CC P31947; O95382: MAP3K6; NbExp=2; IntAct=EBI-476295, EBI-1254761; CC P31947; P10636-2: MAPT; NbExp=2; IntAct=EBI-476295, EBI-7796412; CC P31947; P27448: MARK3; NbExp=5; IntAct=EBI-476295, EBI-707595; CC P31947; O15151: MDM4; NbExp=2; IntAct=EBI-476295, EBI-398437; CC P31947; Q8N4C8: MINK1; NbExp=3; IntAct=EBI-476295, EBI-2133481; CC P31947; Q13064: MKRN3; NbExp=3; IntAct=EBI-476295, EBI-2340269; CC P31947; Q6WCQ1: MPRIP; NbExp=3; IntAct=EBI-476295, EBI-1022605; CC P31947; O75592: MYCBP2; NbExp=4; IntAct=EBI-476295, EBI-1043774; CC P31947; Q8NEY1: NAV1; NbExp=4; IntAct=EBI-476295, EBI-308358; CC P31947; Q96HA8: NTAQ1; NbExp=4; IntAct=EBI-476295, EBI-741158; CC P31947; Q16288: NTRK3; NbExp=2; IntAct=EBI-476295, EBI-3936704; CC P31947; Q9H093: NUAK2; NbExp=2; IntAct=EBI-476295, EBI-1181722; CC P31947; O96013: PAK4; NbExp=5; IntAct=EBI-476295, EBI-713738; CC P31947; Q8TEW0: PARD3; NbExp=4; IntAct=EBI-476295, EBI-81968; CC P31947; P55771: PAX9; NbExp=3; IntAct=EBI-476295, EBI-12111000; CC P31947; P16234: PDGFRA; NbExp=2; IntAct=EBI-476295, EBI-2861522; CC P31947; O00750: PIK3C2B; NbExp=4; IntAct=EBI-476295, EBI-641107; CC P31947; Q99959: PKP2; NbExp=5; IntAct=EBI-476295, EBI-702235; CC P31947; Q6IQ23: PLEKHA7; NbExp=4; IntAct=EBI-476295, EBI-2125301; CC P31947; O00444: PLK4; NbExp=3; IntAct=EBI-476295, EBI-746202; CC P31947; Q86W92: PPFIBP1; NbExp=4; IntAct=EBI-476295, EBI-1045582; CC P31947; Q86YV5: PRAG1; NbExp=2; IntAct=EBI-476295, EBI-719420; CC P31947; Q02156: PRKCE; NbExp=2; IntAct=EBI-476295, EBI-706254; CC P31947; Q14671: PUM1; NbExp=4; IntAct=EBI-476295, EBI-948453; CC P31947; Q96QF0: RAB3IP; NbExp=3; IntAct=EBI-476295, EBI-747844; CC P31947; P04049: RAF1; NbExp=9; IntAct=EBI-476295, EBI-365996; CC P31947; Q86X27: RALGPS2; NbExp=2; IntAct=EBI-476295, EBI-1050841; CC P31947; Q6NUK4: REEP3; NbExp=2; IntAct=EBI-476295, EBI-7545786; CC P31947; Q9H6H4: REEP4; NbExp=4; IntAct=EBI-476295, EBI-7545592; CC P31947; Q8NFH8: REPS2; NbExp=2; IntAct=EBI-476295, EBI-7067016; CC P31947; Q6R327: RICTOR; NbExp=4; IntAct=EBI-476295, EBI-1387196; CC P31947; Q9UPU9: SAMD4A; NbExp=4; IntAct=EBI-476295, EBI-1047497; CC P31947; O94885: SASH1; NbExp=4; IntAct=EBI-476295, EBI-1761310; CC P31947; P31947: SFN; NbExp=5; IntAct=EBI-476295, EBI-476295; CC P31947; Q7Z6J0: SH3RF1; NbExp=2; IntAct=EBI-476295, EBI-311339; CC P31947; O43166: SIPA1L1; NbExp=3; IntAct=EBI-476295, EBI-310678; CC P31947; O60292: SIPA1L3; NbExp=4; IntAct=EBI-476295, EBI-2559690; CC P31947; O94875: SORBS2; NbExp=4; IntAct=EBI-476295, EBI-311323; CC P31947; O75494: SRSF10; NbExp=3; IntAct=EBI-476295, EBI-353655; CC P31947; O60343: TBC1D4; NbExp=4; IntAct=EBI-476295, EBI-522028; CC P31947; Q13470: TNK1; NbExp=3; IntAct=EBI-476295, EBI-1383444; CC P31947; P04637: TP53; NbExp=5; IntAct=EBI-476295, EBI-366083; CC P31947; P40818: USP8; NbExp=5; IntAct=EBI-476295, EBI-1050865; CC P31947; O43379: WDR62; NbExp=4; IntAct=EBI-476295, EBI-714790; CC P31947; P30291: WEE1; NbExp=5; IntAct=EBI-476295, EBI-914695; CC P31947; Q9H4A3: WNK1; NbExp=4; IntAct=EBI-476295, EBI-457907; CC P31947; P62258: YWHAE; NbExp=5; IntAct=EBI-476295, EBI-356498; CC P31947; P61981: YWHAG; NbExp=2; IntAct=EBI-476295, EBI-359832; CC P31947; P63104: YWHAZ; NbExp=6; IntAct=EBI-476295, EBI-347088; CC P31947; Q53FD0: ZC2HC1C; NbExp=3; IntAct=EBI-476295, EBI-740767; CC P31947; P47974: ZFP36L2; NbExp=4; IntAct=EBI-476295, EBI-1644149; CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol {ECO:0000269|PubMed:37797010}. CC Nucleus {ECO:0000250|UniProtKB:O70456}. Secreted CC {ECO:0000305|PubMed:8515476}. Note=May be secreted by a non-classical CC secretory pathway. {ECO:0000305|PubMed:8515476}. CC -!- ALTERNATIVE PRODUCTS: CC Event=Alternative splicing; Named isoforms=2; CC Name=1; CC IsoId=P31947-1; Sequence=Displayed; CC Name=2; CC IsoId=P31947-2; Sequence=VSP_021768; CC -!- TISSUE SPECIFICITY: Present mainly in tissues enriched in stratified CC squamous keratinizing epithelium. {ECO:0000269|PubMed:1390337}. CC -!- PTM: Ubiquitinated. Ubiquitination by RFFL induces proteasomal CC degradation and indirectly regulates p53/TP53 activation. CC {ECO:0000269|PubMed:18382127}. CC -!- SIMILARITY: Belongs to the 14-3-3 family. {ECO:0000305}. CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; M93010; AAA59546.1; -; mRNA. DR EMBL; X57348; CAA40623.1; -; mRNA. DR EMBL; AF029081; AAC52029.1; -; Genomic_DNA. DR EMBL; AF029082; AAC52030.1; -; mRNA. DR EMBL; CR541905; CAG46703.1; -; mRNA. DR EMBL; CR541926; CAG46724.1; -; mRNA. DR EMBL; AL034380; -; NOT_ANNOTATED_CDS; Genomic_DNA. DR EMBL; BC000329; AAH00329.1; -; mRNA. DR EMBL; BC000995; AAH00995.1; -; mRNA. DR EMBL; BC001550; AAH01550.1; -; mRNA. DR EMBL; BC002995; AAH02995.1; -; mRNA. DR EMBL; BC023552; AAH23552.1; -; mRNA. DR CCDS; CCDS288.1; -. [P31947-1] DR PIR; S34753; S34753. DR PIR; S38956; S38956. DR RefSeq; NP_006133.1; NM_006142.3. [P31947-1] DR PDB; 1YWT; X-ray; 2.40 A; A/B=1-248. DR PDB; 1YZ5; X-ray; 2.80 A; A/B=1-248. DR PDB; 3IQJ; X-ray; 1.15 A; A=1-231. DR PDB; 3IQU; X-ray; 1.05 A; A=1-231. DR PDB; 3IQV; X-ray; 1.20 A; A=1-231. DR PDB; 3LW1; X-ray; 1.28 A; A=1-248. DR PDB; 3MHR; X-ray; 1.15 A; A=1-231. DR PDB; 3O8I; X-ray; 2.00 A; A=1-231. DR PDB; 3P1N; X-ray; 1.40 A; A=1-231. DR PDB; 3P1O; X-ray; 1.90 A; A=1-231. DR PDB; 3P1P; X-ray; 1.95 A; A=1-231. DR PDB; 3P1Q; X-ray; 1.70 A; A=1-231. DR PDB; 3P1R; X-ray; 1.70 A; A=1-231. DR PDB; 3P1S; X-ray; 1.65 A; A=1-231. DR PDB; 3SMK; X-ray; 2.10 A; A=1-231. DR PDB; 3SML; X-ray; 1.90 A; A=1-231. DR PDB; 3SMM; X-ray; 2.00 A; A=1-231. DR PDB; 3SMN; X-ray; 2.00 A; A=1-231. DR PDB; 3SMO; X-ray; 1.80 A; A=1-231. DR PDB; 3SP5; X-ray; 1.80 A; A=1-231. DR PDB; 3SPR; X-ray; 1.99 A; A=1-231. DR PDB; 3T0L; X-ray; 1.60 A; A=1-231. DR PDB; 3T0M; X-ray; 1.62 A; A=1-231. DR PDB; 3U9X; X-ray; 1.80 A; A=1-231. DR PDB; 3UX0; X-ray; 1.75 A; A=1-231. DR PDB; 4DAT; X-ray; 1.40 A; A=1-231. DR PDB; 4DAU; X-ray; 2.00 A; A=1-231. DR PDB; 4DHM; X-ray; 1.70 A; A=1-231. DR PDB; 4DHN; X-ray; 1.80 A; A=1-231. DR PDB; 4DHO; X-ray; 1.70 A; A=1-231. DR PDB; 4DHP; X-ray; 1.75 A; A=1-231. DR PDB; 4DHQ; X-ray; 1.75 A; A=1-231. DR PDB; 4DHR; X-ray; 1.40 A; A=1-231. DR PDB; 4DHS; X-ray; 1.74 A; A=1-231. DR PDB; 4DHT; X-ray; 1.80 A; A=1-231. DR PDB; 4DHU; X-ray; 1.67 A; A=1-231. DR PDB; 4FL5; X-ray; 1.90 A; A/B=1-231. DR PDB; 4FR3; X-ray; 1.90 A; A=1-231. DR PDB; 4IEA; X-ray; 1.70 A; A=1-231. DR PDB; 4JC3; X-ray; 2.05 A; A=1-231. DR PDB; 4JDD; X-ray; 2.10 A; A=1-231. DR PDB; 4QLI; X-ray; 1.45 A; A=1-231. DR PDB; 4Y32; X-ray; 1.70 A; A/B=1-231. DR PDB; 4Y3B; X-ray; 1.80 A; A/B=1-231. DR PDB; 4Y5I; X-ray; 1.40 A; A/B=1-231. DR PDB; 5BTV; X-ray; 1.70 A; A=1-231. DR PDB; 5HF3; X-ray; 1.80 A; A=1-231. DR PDB; 5LTW; X-ray; 4.50 A; A/B/E/F/I/J=1-231. DR PDB; 5LU1; X-ray; 2.40 A; A/B/E/F=1-231. DR PDB; 5LU2; X-ray; 2.50 A; A/B=1-231. DR PDB; 5MHC; X-ray; 1.20 A; A=1-231. DR PDB; 5MOC; X-ray; 1.80 A; A=1-231. DR PDB; 5MXO; X-ray; 1.20 A; A=1-231. DR PDB; 5MY9; X-ray; 1.33 A; A=1-231. DR PDB; 5MYC; X-ray; 1.46 A; A=1-231. DR PDB; 5N5R; X-ray; 1.80 A; A=1-231. DR PDB; 5N5T; X-ray; 1.80 A; A=1-231. DR PDB; 5N5W; X-ray; 1.37 A; A=1-231. DR PDB; 5N75; X-ray; 1.80 A; A=1-231. DR PDB; 5OEG; X-ray; 3.15 A; A=1-231. DR PDB; 5OEH; X-ray; 2.35 A; A=1-231. DR PDB; 5OK9; X-ray; 2.35 A; A/B/E/F=1-231. DR PDB; 5OKF; X-ray; 3.20 A; A/B/C/D=1-231. DR PDB; 5OM0; X-ray; 3.20 A; A/B=1-231. DR PDB; 5OMA; X-ray; 3.90 A; A/B/C/D=1-231. DR PDB; 6FAU; X-ray; 1.25 A; A/C=1-231. DR PDB; 6FAV; X-ray; 1.40 A; A/C=1-231. DR PDB; 6FAW; X-ray; 1.40 A; A/C=1-231. DR PDB; 6FBB; X-ray; 1.30 A; A=1-231. DR PDB; 6FBW; X-ray; 1.45 A; A/C=1-231. DR PDB; 6FBY; X-ray; 1.50 A; A/C=1-231. DR PDB; 6FCP; X-ray; 1.45 A; A=1-231. DR PDB; 6FI4; X-ray; 2.00 A; A=1-231. DR PDB; 6FI5; X-ray; 1.70 A; A=1-231. DR PDB; 6G6X; X-ray; 1.13 A; A=1-231. DR PDB; 6G8I; X-ray; 1.60 A; A=1-231. DR PDB; 6G8J; X-ray; 1.47 A; A=1-231. DR PDB; 6G8K; X-ray; 1.25 A; A=1-231. DR PDB; 6G8L; X-ray; 1.37 A; A=1-231. DR PDB; 6G8P; X-ray; 1.90 A; A=1-231. DR PDB; 6G8Q; X-ray; 1.85 A; A=1-231. DR PDB; 6GHP; X-ray; 1.95 A; A=1-231. DR PDB; 6HHP; X-ray; 1.80 A; A=1-231. DR PDB; 6HKB; X-ray; 1.70 A; A=1-231. DR PDB; 6HKF; X-ray; 1.80 A; A=1-231. DR PDB; 6HMT; X-ray; 1.10 A; A=1-231. DR PDB; 6HMU; X-ray; 1.20 A; A=1-231. DR PDB; 6HN2; X-ray; 1.70 A; A=1-231. DR PDB; 6NV2; X-ray; 1.13 A; A=1-231. DR PDB; 6QDR; X-ray; 1.61 A; A=1-231. DR PDB; 6QDS; X-ray; 1.72 A; A=1-231. DR PDB; 6QDT; X-ray; 1.70 A; A=1-231. DR PDB; 6QDU; X-ray; 1.63 A; A=1-231. DR PDB; 6QHL; X-ray; 1.20 A; A=1-248. DR PDB; 6QHM; X-ray; 1.25 A; A=1-248. DR PDB; 6QIU; X-ray; 1.80 A; A=1-231. DR PDB; 6QZR; X-ray; 2.30 A; A/B/C/D/E/F/G/H=1-248. DR PDB; 6QZS; X-ray; 1.90 A; A/B=1-248. DR PDB; 6R5L; X-ray; 1.88 A; A=1-231. DR PDB; 6RHC; X-ray; 1.20 A; A=1-231. DR PDB; 6RJL; X-ray; 1.28 A; A=1-248. DR PDB; 6RJQ; X-ray; 1.89 A; A=1-248. DR PDB; 6RJZ; X-ray; 1.58 A; A=1-248. DR PDB; 6RK8; X-ray; 1.60 A; A=1-248. DR PDB; 6RKI; X-ray; 1.88 A; A=1-248. DR PDB; 6RKK; X-ray; 1.88 A; A=1-248. DR PDB; 6RKM; X-ray; 1.88 A; A=1-248. DR PDB; 6RL3; X-ray; 1.30 A; A=1-248. DR PDB; 6RL4; X-ray; 1.60 A; A=1-248. DR PDB; 6RL6; X-ray; 1.60 A; A=1-248. DR PDB; 6RM5; X-ray; 1.88 A; A=1-248. DR PDB; 6RM7; X-ray; 1.60 A; A=1-248. DR PDB; 6RP6; X-ray; 1.89 A; A=1-231. DR PDB; 6RWH; X-ray; 1.68 A; A=1-248. DR PDB; 6RWI; X-ray; 1.65 A; A=1-248. DR PDB; 6RWS; X-ray; 1.53 A; A=1-248. DR PDB; 6RWU; X-ray; 1.46 A; A=1-248. DR PDB; 6RX2; X-ray; 1.82 A; A=1-248. DR PDB; 6S39; X-ray; 1.88 A; A=1-248. DR PDB; 6S3C; X-ray; 2.00 A; A=1-248. DR PDB; 6S40; X-ray; 1.90 A; A=1-248. DR PDB; 6S9Q; X-ray; 1.69 A; A=1-248. DR PDB; 6SIN; X-ray; 1.64 A; A=1-231. DR PDB; 6SIO; X-ray; 1.60 A; A=1-231. DR PDB; 6SIP; X-ray; 1.60 A; A=1-231. DR PDB; 6SIQ; X-ray; 1.60 A; A=1-231. DR PDB; 6SLV; X-ray; 1.90 A; A=1-231. DR PDB; 6SLW; X-ray; 2.00 A; A=1-248. DR PDB; 6SLX; X-ray; 1.80 A; A=1-248. DR PDB; 6T5F; X-ray; 2.63 A; A/B/C/D=1-231. DR PDB; 6T5H; X-ray; 2.04 A; A/B=1-231. DR PDB; 6T80; X-ray; 2.99 A; A/B/C/D=1-231. DR PDB; 6TCH; X-ray; 1.80 A; B=1-231. DR PDB; 6TJM; X-ray; 1.85 A; A=1-231. DR PDB; 6TL3; X-ray; 2.46 A; A=1-231. DR PDB; 6TLF; X-ray; 2.90 A; A=1-248. DR PDB; 6TLG; X-ray; 2.40 A; A=1-248. DR PDB; 6TM7; X-ray; 3.00 A; A/B=1-248. DR PDB; 6TWZ; X-ray; 2.80 A; A/B/C/D=1-231. DR PDB; 6W0L; X-ray; 2.30 A; A=1-231. DR PDB; 6XWD; X-ray; 1.60 A; A=1-231. DR PDB; 6XXC; X-ray; 1.30 A; A=1-231. DR PDB; 6XY5; X-ray; 1.30 A; A=1-231. DR PDB; 6Y18; X-ray; 1.30 A; A=1-231. DR PDB; 6Y1D; X-ray; 1.38 A; A=1-231. DR PDB; 6Y1J; X-ray; 1.13 A; A=1-248. DR PDB; 6Y3M; X-ray; 1.50 A; A=1-248. DR PDB; 6Y3O; X-ray; 1.50 A; A=1-248. DR PDB; 6Y3R; X-ray; 1.50 A; A=1-248. DR PDB; 6Y3S; X-ray; 1.95 A; A=1-248. DR PDB; 6Y3V; X-ray; 1.50 A; A=1-248. DR PDB; 6Y3W; X-ray; 1.34 A; A=1-231. DR PDB; 6Y40; X-ray; 1.75 A; A=1-248. DR PDB; 6Y44; X-ray; 1.71 A; A=1-248. DR PDB; 6Y58; X-ray; 1.90 A; A=1-231. DR PDB; 6Y7T; X-ray; 2.50 A; A/F/K/P=1-248. DR PDB; 6Y8A; X-ray; 1.50 A; A=1-248. DR PDB; 6Y8B; X-ray; 1.54 A; A=1-248. DR PDB; 6Y8D; X-ray; 1.51 A; A=1-248. DR PDB; 6Y8E; X-ray; 1.42 A; A=1-248. DR PDB; 6YE9; X-ray; 1.80 A; A=1-231. DR PDB; 6YIA; X-ray; 1.30 A; A=1-231. DR PDB; 6YIB; X-ray; 1.70 A; A=1-231. DR PDB; 6YIC; X-ray; 1.60 A; A=1-231. DR PDB; 6YLU; X-ray; 1.88 A; A=1-231. DR PDB; 6YOW; X-ray; 1.23 A; A=1-231. DR PDB; 6YOX; X-ray; 2.05 A; A=1-248. DR PDB; 6YOY; X-ray; 1.80 A; A=1-231. DR PDB; 6YP2; X-ray; 1.80 A; A=1-231. DR PDB; 6YP3; X-ray; 1.80 A; A=1-231. DR PDB; 6YP8; X-ray; 1.80 A; A=1-231. DR PDB; 6YPL; X-ray; 1.80 A; A=1-231. DR PDB; 6YPY; X-ray; 1.40 A; A=1-231. DR PDB; 6YQ2; X-ray; 1.40 A; A=1-231. DR PDB; 6YR5; X-ray; 2.25 A; A/B/C/D=1-231. DR PDB; 6YR6; X-ray; 1.75 A; A/C/E/G=1-231. DR PDB; 6YR7; X-ray; 2.10 A; A/B=1-231. DR PDB; 6ZCJ; X-ray; 1.53 A; A=1-231. DR PDB; 6ZVB; X-ray; 2.51 A; A=1-248. DR PDB; 6ZVC; X-ray; 2.51 A; A=1-248. DR PDB; 6ZVD; X-ray; 2.50 A; A=1-248. DR PDB; 6ZVE; X-ray; 2.51 A; A=1-248. DR PDB; 7AEW; X-ray; 1.20 A; AAA=1-231. DR PDB; 7AOG; X-ray; 1.50 A; A=1-248. DR PDB; 7AXN; X-ray; 1.40 A; A=1-248. DR PDB; 7AYF; X-ray; 1.75 A; A=1-248. DR PDB; 7AZ1; X-ray; 1.15 A; A=1-248. DR PDB; 7AZ2; X-ray; 1.08 A; A=1-248. DR PDB; 7B13; X-ray; 1.37 A; A=1-231. DR PDB; 7B15; X-ray; 1.59 A; A=1-231. DR PDB; 7B9M; X-ray; 1.70 A; A=1-231. DR PDB; 7B9R; X-ray; 1.15 A; A=1-231. DR PDB; 7B9T; X-ray; 1.15 A; A=1-231. DR PDB; 7BA3; X-ray; 1.40 A; A=1-231. DR PDB; 7BA5; X-ray; 1.45 A; A=1-231. DR PDB; 7BA6; X-ray; 1.40 A; A=1-231. DR PDB; 7BA7; X-ray; 1.45 A; A=1-231. DR PDB; 7BA8; X-ray; 1.20 A; A=1-231. DR PDB; 7BA9; X-ray; 1.48 A; A=1-231. DR PDB; 7BAA; X-ray; 1.10 A; A=1-231. DR PDB; 7BAB; X-ray; 1.30 A; A=1-231. DR PDB; 7BDP; X-ray; 1.75 A; A=1-248. DR PDB; 7BDT; X-ray; 1.75 A; A=1-248. DR PDB; 7BDY; X-ray; 1.80 A; A=1-248. DR PDB; 7BFW; X-ray; 1.80 A; A=1-248. DR PDB; 7BG3; X-ray; 1.40 A; A=1-248. DR PDB; 7BGQ; X-ray; 1.75 A; A=1-248. DR PDB; 7BGR; X-ray; 1.80 A; A=1-248. DR PDB; 7BGV; X-ray; 1.68 A; A=1-248. DR PDB; 7BGW; X-ray; 1.90 A; A=1-248. DR PDB; 7BI3; X-ray; 1.20 A; A=1-248. DR PDB; 7BIQ; X-ray; 1.20 A; A=1-248. DR PDB; 7BIW; X-ray; 1.20 A; A=1-248. DR PDB; 7BIY; X-ray; 1.80 A; A=1-248. DR PDB; 7BJB; X-ray; 1.80 A; A=1-248. DR PDB; 7BJF; X-ray; 1.40 A; A=1-248. DR PDB; 7BJL; X-ray; 1.40 A; A=1-248. DR PDB; 7BJW; X-ray; 1.40 A; A=1-248. DR PDB; 7BKH; X-ray; 1.40 A; A=1-248. DR PDB; 7BM9; X-ray; 1.80 A; A=1-248. DR PDB; 7BMC; X-ray; 2.00 A; A=1-248. DR PDB; 7NFW; X-ray; 1.19 A; A=1-248. DR PDB; 7NIF; X-ray; 1.71 A; A=1-248. DR PDB; 7NIG; X-ray; 1.90 A; A=1-248. DR PDB; 7NIX; X-ray; 1.90 A; A=1-248. DR PDB; 7NIZ; X-ray; 1.48 A; A=1-248. DR PDB; 7NJ6; X-ray; 1.59 A; A=1-248. DR PDB; 7NJ8; X-ray; 1.80 A; A=1-248. DR PDB; 7NJ9; X-ray; 1.40 A; A=1-248. DR PDB; 7NJA; X-ray; 1.75 A; A=1-248. DR PDB; 7NJB; X-ray; 1.40 A; A=1-248. DR PDB; 7NK3; X-ray; 1.40 A; A=1-248. DR PDB; 7NK5; X-ray; 1.40 A; A=1-248. DR PDB; 7NLA; X-ray; 1.40 A; A=1-248. DR PDB; 7NLE; X-ray; 1.40 A; A=1-248. DR PDB; 7NM1; X-ray; 1.40 A; A=1-248. DR PDB; 7NM3; X-ray; 1.40 A; A=1-248. DR PDB; 7NM9; X-ray; 1.70 A; A=1-248. DR PDB; 7NMA; X-ray; 1.75 A; A=1-248. DR PDB; 7NMH; X-ray; 1.40 A; A=1-248. DR PDB; 7NMW; X-ray; 1.50 A; A=1-248. DR PDB; 7NMX; X-ray; 2.30 A; A=1-248. DR PDB; 7NN2; X-ray; 1.80 A; A=1-248. DR PDB; 7NND; X-ray; 1.40 A; A=1-248. DR PDB; 7NNE; X-ray; 1.96 A; A=1-248. DR PDB; 7NP2; X-ray; 1.27 A; A=1-248. DR PDB; 7NPB; X-ray; 1.37 A; A=1-248. DR PDB; 7NPG; X-ray; 1.37 A; A=1-248. DR PDB; 7NQP; X-ray; 1.24 A; A=1-248. DR PDB; 7NR7; X-ray; 1.40 A; A=1-248. DR PDB; 7NRK; X-ray; 1.75 A; A=1-248. DR PDB; 7NRL; X-ray; 1.80 A; A=1-248. DR PDB; 7NSV; X-ray; 1.33 A; A=1-248. DR PDB; 7NV4; X-ray; 1.20 A; A=1-231. DR PDB; 7NVI; X-ray; 1.20 A; A=1-231. DR PDB; 7NWS; X-ray; 1.20 A; A=1-231. DR PDB; 7NXS; X-ray; 1.20 A; A=1-231. DR PDB; 7NXT; X-ray; 1.20 A; A=1-231. DR PDB; 7NXW; X-ray; 1.20 A; A=1-231. DR PDB; 7NXY; X-ray; 1.20 A; A=1-231. DR PDB; 7NY4; X-ray; 1.40 A; A=1-231. DR PDB; 7NYE; X-ray; 1.40 A; A=1-231. DR PDB; 7NYF; X-ray; 1.40 A; A=1-231. DR PDB; 7NYG; X-ray; 1.40 A; A=1-231. DR PDB; 7NZ6; X-ray; 1.40 A; A=1-231. DR PDB; 7NZG; X-ray; 1.40 A; A=1-231. DR PDB; 7NZK; X-ray; 1.40 A; A=1-231. DR PDB; 7NZV; X-ray; 1.40 A; A=1-231. DR PDB; 7O07; X-ray; 1.20 A; A=1-231. DR PDB; 7O34; X-ray; 1.20 A; A=1-231. DR PDB; 7O3A; X-ray; 1.20 A; A=1-231. DR PDB; 7O3F; X-ray; 1.40 A; A=1-231. DR PDB; 7O3P; X-ray; 1.40 A; A=1-231. DR PDB; 7O3Q; X-ray; 1.80 A; A=1-231. DR PDB; 7O3R; X-ray; 1.80 A; A=1-231. DR PDB; 7O3S; X-ray; 2.00 A; A=1-231. DR PDB; 7O57; X-ray; 1.40 A; A=1-231. DR PDB; 7O59; X-ray; 1.20 A; A=1-231. DR PDB; 7O5A; X-ray; 1.80 A; A=1-231. DR PDB; 7O5C; X-ray; 1.80 A; A=1-231. DR PDB; 7O5D; X-ray; 1.80 A; A=1-231. DR PDB; 7O5F; X-ray; 1.80 A; A=1-231. DR PDB; 7O5G; X-ray; 1.80 A; A=1-231. DR PDB; 7O5O; X-ray; 1.80 A; A=1-231. DR PDB; 7O5P; X-ray; 1.80 A; A=1-231. DR PDB; 7O5S; X-ray; 1.80 A; A=1-231. DR PDB; 7O5U; X-ray; 1.80 A; A=1-231. DR PDB; 7O5X; X-ray; 1.80 A; A=1-231. DR PDB; 7O6F; X-ray; 2.00 A; A=1-231. DR PDB; 7O6G; X-ray; 1.80 A; A=1-231. DR PDB; 7O6I; X-ray; 1.80 A; A=1-231. DR PDB; 7O6J; X-ray; 1.40 A; A=1-231. DR PDB; 7O6K; X-ray; 1.40 A; A=1-231. DR PDB; 7O6M; X-ray; 1.40 A; A=1-231. DR PDB; 7O6O; X-ray; 1.40 A; A=1-231. DR PDB; 7OB5; X-ray; 1.80 A; A=1-248. DR PDB; 7OB8; X-ray; 1.80 A; A=1-248. DR PDB; 7OBC; X-ray; 1.90 A; A=1-248. DR PDB; 7OBD; X-ray; 2.00 A; A=1-248. DR PDB; 7OBG; X-ray; 1.80 A; A=1-248. DR PDB; 7OBH; X-ray; 2.00 A; A=1-248. DR PDB; 7OBK; X-ray; 1.80 A; A=1-248. DR PDB; 7OBL; X-ray; 1.80 A; A=1-248. DR PDB; 7OBS; X-ray; 1.80 A; A=1-248. DR PDB; 7OBT; X-ray; 2.30 A; A=1-248. DR PDB; 7OBX; X-ray; 1.80 A; A=1-248. DR PDB; 7OBY; X-ray; 2.10 A; A=1-248. DR PDB; 7OPW; X-ray; 1.81 A; A=1-248. DR PDB; 7OQ7; X-ray; 1.60 A; A=1-248. DR PDB; 7OQ8; X-ray; 1.43 A; A=1-248. DR PDB; 7OQ9; X-ray; 1.80 A; A=1-248. DR PDB; 7OQA; X-ray; 1.80 A; A=1-248. DR PDB; 7OQG; X-ray; 1.50 A; A=1-248. DR PDB; 7OQJ; X-ray; 1.40 A; A=1-248. DR PDB; 7OQS; X-ray; 1.34 A; A=1-248. DR PDB; 7OQU; X-ray; 1.40 A; A=1-248. DR PDB; 7OQW; X-ray; 1.90 A; A=1-248. DR PDB; 7OR3; X-ray; 1.80 A; A=1-248. DR PDB; 7OR5; X-ray; 1.80 A; A=1-248. DR PDB; 7OR7; X-ray; 1.80 A; A=1-248. DR PDB; 7OR8; X-ray; 1.80 A; A=1-248. DR PDB; 7ORG; X-ray; 1.80 A; A=1-248. DR PDB; 7ORH; X-ray; 1.80 A; A=1-248. DR PDB; 7ORS; X-ray; 1.80 A; A=1-248. DR PDB; 7ORT; X-ray; 2.33 A; A=1-248. DR PDB; 7PWT; X-ray; 2.31 A; A=1-231. DR PDB; 7PWZ; X-ray; 2.50 A; A=1-231. DR PDB; 7QIK; X-ray; 2.01 A; A/B=1-231. DR PDB; 7QIP; X-ray; 2.65 A; A/B=1-231. DR PDB; 7ZMU; X-ray; 1.60 A; A=1-231. DR PDB; 7ZMW; X-ray; 1.80 A; A=1-231. DR PDB; 8A62; X-ray; 1.60 A; A=1-231. DR PDB; 8A65; X-ray; 1.60 A; A=1-231. DR PDB; 8A68; X-ray; 1.60 A; A=1-231. DR PDB; 8A6F; X-ray; 1.60 A; A=1-231. DR PDB; 8A6H; X-ray; 1.60 A; A=1-231. DR PDB; 8ADM; X-ray; 1.70 A; A=1-231. DR PDB; 8AFN; X-ray; 1.36 A; A=1-231. DR PDB; 8AI0; X-ray; 1.60 A; A=1-231. DR PDB; 8ALR; X-ray; 1.40 A; A=1-231. DR PDB; 8ALT; X-ray; 1.40 A; A=1-231. DR PDB; 8ALV; X-ray; 1.60 A; A=1-231. DR PDB; 8ALW; X-ray; 1.50 A; A=1-231. DR PDB; 8AM7; X-ray; 1.50 A; A=1-231. DR PDB; 8ANB; X-ray; 1.64 A; A=1-231. DR PDB; 8ANC; X-ray; 1.11 A; A=1-231. DR PDB; 8ANF; X-ray; 1.40 A; A=1-231. DR PDB; 8AOY; X-ray; 1.40 A; A=1-231. DR PDB; 8APS; X-ray; 1.20 A; A=1-231. DR PDB; 8AQ1; X-ray; 1.40 A; A=1-231. DR PDB; 8AQC; X-ray; 1.50 A; A=1-231. DR PDB; 8AQE; X-ray; 1.60 A; A=1-231. DR PDB; 8AQZ; X-ray; 1.40 A; A=1-231. DR PDB; 8AR4; X-ray; 1.50 A; A=1-231. DR PDB; 8AR5; X-ray; 1.40 A; A=1-231. DR PDB; 8ARG; X-ray; 1.50 A; A=1-231. DR PDB; 8ARO; X-ray; 1.60 A; A=1-231. DR PDB; 8ARQ; X-ray; 1.40 A; A=1-231. DR PDB; 8ARR; X-ray; 1.35 A; A=1-231. DR PDB; 8ARW; X-ray; 1.50 A; A=1-231. DR PDB; 8ARX; X-ray; 1.40 A; A=1-231. DR PDB; 8ARY; X-ray; 1.45 A; A=1-231. DR PDB; 8ARZ; X-ray; 1.50 A; A=1-231. DR PDB; 8AS1; X-ray; 1.50 A; A=1-231. DR PDB; 8AT9; X-ray; 1.40 A; A=1-231. DR PDB; 8ATP; X-ray; 1.40 A; A=1-231. DR PDB; 8ATR; X-ray; 1.70 A; A=1-231. DR PDB; 8ATS; X-ray; 1.40 A; A=1-231. DR PDB; 8AU2; X-ray; 1.60 A; A=1-231. DR PDB; 8AUS; X-ray; 1.40 A; A=1-231. DR PDB; 8AUY; X-ray; 1.50 A; A=1-231. DR PDB; 8AV0; X-ray; 1.50 A; A=1-231. DR PDB; 8AV3; X-ray; 1.80 A; A=1-231. DR PDB; 8AV4; X-ray; 1.60 A; A=1-231. DR PDB; 8AV7; X-ray; 1.40 A; A=1-232. DR PDB; 8AV8; X-ray; 1.80 A; A=1-231. DR PDB; 8AWG; X-ray; 1.80 A; A=1-231. DR PDB; 8AXE; X-ray; 1.80 A; A=1-231. DR PDB; 8AXU; X-ray; 1.60 A; A=1-231. DR PDB; 8AZE; X-ray; 1.60 A; A=1-231. DR PDB; 8B2I; X-ray; 1.40 A; A=1-231. DR PDB; 8B2K; X-ray; 1.40 A; A=1-231. DR PDB; 8B39; X-ray; 1.40 A; A=1-231. DR PDB; 8B4Q; X-ray; 1.40 A; A=1-231. DR PDB; 8B5P; X-ray; 1.40 A; A=1-231. DR PDB; 8BFC; X-ray; 1.40 A; A=1-231. DR PDB; 8BI7; X-ray; 1.40 A; A=1-231. DR PDB; 8BJG; X-ray; 1.40 A; A=1-231. DR PDB; 8BJN; X-ray; 1.40 A; A=1-231. DR PDB; 8BM5; X-ray; 1.40 A; A=1-231. DR PDB; 8BWJ; X-ray; 1.60 A; A=1-231. DR PDB; 8BWX; X-ray; 1.60 A; A=1-231. DR PDB; 8BWZ; X-ray; 1.60 A; A=1-231. DR PDB; 8BX0; X-ray; 1.60 A; A=1-231. DR PDB; 8BX3; X-ray; 1.20 A; A=1-231. DR PDB; 8BX4; X-ray; 1.60 A; A=1-231. DR PDB; 8BXI; X-ray; 1.20 A; A=1-231. DR PDB; 8BXM; X-ray; 1.60 A; A=1-231. DR PDB; 8BXN; X-ray; 1.60 A; A=1-231. DR PDB; 8BXO; X-ray; 1.60 A; A=1-231. DR PDB; 8BXQ; X-ray; 1.60 A; A=1-231. DR PDB; 8BXS; X-ray; 1.60 A; A=1-231. DR PDB; 8BY9; X-ray; 1.60 A; A=1-231. DR PDB; 8BYB; X-ray; 1.60 A; A=1-231. DR PDB; 8BYC; X-ray; 1.60 A; A=1-231. DR PDB; 8BYD; X-ray; 1.60 A; A=1-231. DR PDB; 8BYE; X-ray; 1.60 A; A=1-231. DR PDB; 8BYF; X-ray; 1.65 A; A=1-231. DR PDB; 8BYG; X-ray; 1.70 A; A=1-231. DR PDB; 8BYO; X-ray; 1.20 A; A=1-231. DR PDB; 8BYY; X-ray; 1.60 A; A=1-231. DR PDB; 8BYZ; X-ray; 1.40 A; A=1-231. DR PDB; 8BZ0; X-ray; 1.20 A; A=1-231. DR PDB; 8BZ9; X-ray; 1.30 A; A=1-231. DR PDB; 8BZA; X-ray; 1.25 A; A=1-231. DR PDB; 8BZB; X-ray; 1.70 A; A=1-231. DR PDB; 8BZW; X-ray; 1.10 A; A=1-231. DR PDB; 8C04; X-ray; 1.10 A; A=1-231. DR PDB; 8C0K; X-ray; 1.40 A; A=1-231. DR PDB; 8C2D; X-ray; 2.15 A; AAA=1-231. DR PDB; 8C2E; X-ray; 2.20 A; A=1-231. DR PDB; 8C2F; X-ray; 2.30 A; A=1-231. DR PDB; 8C2G; X-ray; 1.60 A; A=1-231. DR PDB; 8C3C; X-ray; 1.60 A; A=1-231. DR PDB; 8C4F; X-ray; 1.40 A; A=1-231. DR PDB; 8C4G; X-ray; 1.46 A; A=1-231. DR PDB; 8Q4L; EM; 5.12 A; B/C=1-231. DR PDBsum; 1YWT; -. DR PDBsum; 1YZ5; -. DR PDBsum; 3IQJ; -. DR PDBsum; 3IQU; -. DR PDBsum; 3IQV; -. DR PDBsum; 3LW1; -. DR PDBsum; 3MHR; -. DR PDBsum; 3O8I; -. DR PDBsum; 3P1N; -. DR PDBsum; 3P1O; -. DR PDBsum; 3P1P; -. DR PDBsum; 3P1Q; -. DR PDBsum; 3P1R; -. DR PDBsum; 3P1S; -. DR PDBsum; 3SMK; -. DR PDBsum; 3SML; -. DR PDBsum; 3SMM; -. DR PDBsum; 3SMN; -. DR PDBsum; 3SMO; -. DR PDBsum; 3SP5; -. DR PDBsum; 3SPR; -. DR PDBsum; 3T0L; -. DR PDBsum; 3T0M; -. DR PDBsum; 3U9X; -. DR PDBsum; 3UX0; -. DR PDBsum; 4DAT; -. DR PDBsum; 4DAU; -. DR PDBsum; 4DHM; -. DR PDBsum; 4DHN; -. DR PDBsum; 4DHO; -. DR PDBsum; 4DHP; -. DR PDBsum; 4DHQ; -. DR PDBsum; 4DHR; -. DR PDBsum; 4DHS; -. DR PDBsum; 4DHT; -. DR PDBsum; 4DHU; -. DR PDBsum; 4FL5; -. DR PDBsum; 4FR3; -. DR PDBsum; 4IEA; -. DR PDBsum; 4JC3; -. DR PDBsum; 4JDD; -. DR PDBsum; 4QLI; -. DR PDBsum; 4Y32; -. DR PDBsum; 4Y3B; -. DR PDBsum; 4Y5I; -. DR PDBsum; 5BTV; -. DR PDBsum; 5HF3; -. DR PDBsum; 5LTW; -. DR PDBsum; 5LU1; -. DR PDBsum; 5LU2; -. DR PDBsum; 5MHC; -. DR PDBsum; 5MOC; -. DR PDBsum; 5MXO; -. DR PDBsum; 5MY9; -. DR PDBsum; 5MYC; -. DR PDBsum; 5N5R; -. DR PDBsum; 5N5T; -. DR PDBsum; 5N5W; -. DR PDBsum; 5N75; -. DR PDBsum; 5OEG; -. DR PDBsum; 5OEH; -. DR PDBsum; 5OK9; -. DR PDBsum; 5OKF; -. DR PDBsum; 5OM0; -. DR PDBsum; 5OMA; -. DR PDBsum; 6FAU; -. DR PDBsum; 6FAV; -. DR PDBsum; 6FAW; -. DR PDBsum; 6FBB; -. DR PDBsum; 6FBW; -. DR PDBsum; 6FBY; -. DR PDBsum; 6FCP; -. DR PDBsum; 6FI4; -. DR PDBsum; 6FI5; -. DR PDBsum; 6G6X; -. DR PDBsum; 6G8I; -. DR PDBsum; 6G8J; -. DR PDBsum; 6G8K; -. DR PDBsum; 6G8L; -. DR PDBsum; 6G8P; -. DR PDBsum; 6G8Q; -. DR PDBsum; 6GHP; -. DR PDBsum; 6HHP; -. DR PDBsum; 6HKB; -. DR PDBsum; 6HKF; -. DR PDBsum; 6HMT; -. DR PDBsum; 6HMU; -. DR PDBsum; 6HN2; -. DR PDBsum; 6NV2; -. DR PDBsum; 6QDR; -. DR PDBsum; 6QDS; -. DR PDBsum; 6QDT; -. DR PDBsum; 6QDU; -. DR PDBsum; 6QHL; -. DR PDBsum; 6QHM; -. DR PDBsum; 6QIU; -. DR PDBsum; 6QZR; -. DR PDBsum; 6QZS; -. DR PDBsum; 6R5L; -. DR PDBsum; 6RHC; -. DR PDBsum; 6RJL; -. DR PDBsum; 6RJQ; -. DR PDBsum; 6RJZ; -. DR PDBsum; 6RK8; -. DR PDBsum; 6RKI; -. DR PDBsum; 6RKK; -. DR PDBsum; 6RKM; -. DR PDBsum; 6RL3; -. DR PDBsum; 6RL4; -. DR PDBsum; 6RL6; -. DR PDBsum; 6RM5; -. DR PDBsum; 6RM7; -. DR PDBsum; 6RP6; -. DR PDBsum; 6RWH; -. DR PDBsum; 6RWI; -. DR PDBsum; 6RWS; -. DR PDBsum; 6RWU; -. DR PDBsum; 6RX2; -. DR PDBsum; 6S39; -. DR PDBsum; 6S3C; -. DR PDBsum; 6S40; -. DR PDBsum; 6S9Q; -. DR PDBsum; 6SIN; -. DR PDBsum; 6SIO; -. DR PDBsum; 6SIP; -. DR PDBsum; 6SIQ; -. DR PDBsum; 6SLV; -. DR PDBsum; 6SLW; -. DR PDBsum; 6SLX; -. DR PDBsum; 6T5F; -. DR PDBsum; 6T5H; -. DR PDBsum; 6T80; -. DR PDBsum; 6TCH; -. DR PDBsum; 6TJM; -. DR PDBsum; 6TL3; -. DR PDBsum; 6TLF; -. DR PDBsum; 6TLG; -. DR PDBsum; 6TM7; -. DR PDBsum; 6TWZ; -. DR PDBsum; 6W0L; -. DR PDBsum; 6XWD; -. DR PDBsum; 6XXC; -. DR PDBsum; 6XY5; -. DR PDBsum; 6Y18; -. DR PDBsum; 6Y1D; -. DR PDBsum; 6Y1J; -. DR PDBsum; 6Y3M; -. DR PDBsum; 6Y3O; -. DR PDBsum; 6Y3R; -. DR PDBsum; 6Y3S; -. DR PDBsum; 6Y3V; -. DR PDBsum; 6Y3W; -. DR PDBsum; 6Y40; -. DR PDBsum; 6Y44; -. DR PDBsum; 6Y58; -. DR PDBsum; 6Y7T; -. DR PDBsum; 6Y8A; -. DR PDBsum; 6Y8B; -. DR PDBsum; 6Y8D; -. DR PDBsum; 6Y8E; -. DR PDBsum; 6YE9; -. DR PDBsum; 6YIA; -. DR PDBsum; 6YIB; -. DR PDBsum; 6YIC; -. DR PDBsum; 6YLU; -. DR PDBsum; 6YOW; -. DR PDBsum; 6YOX; -. DR PDBsum; 6YOY; -. DR PDBsum; 6YP2; -. DR PDBsum; 6YP3; -. DR PDBsum; 6YP8; -. DR PDBsum; 6YPL; -. DR PDBsum; 6YPY; -. DR PDBsum; 6YQ2; -. DR PDBsum; 6YR5; -. DR PDBsum; 6YR6; -. DR PDBsum; 6YR7; -. DR PDBsum; 6ZCJ; -. DR PDBsum; 6ZVB; -. DR PDBsum; 6ZVC; -. DR PDBsum; 6ZVD; -. DR PDBsum; 6ZVE; -. DR PDBsum; 7AEW; -. DR PDBsum; 7AOG; -. DR PDBsum; 7AXN; -. DR PDBsum; 7AYF; -. DR PDBsum; 7AZ1; -. DR PDBsum; 7AZ2; -. DR PDBsum; 7B13; -. DR PDBsum; 7B15; -. DR PDBsum; 7B9M; -. DR PDBsum; 7B9R; -. DR PDBsum; 7B9T; -. DR PDBsum; 7BA3; -. DR PDBsum; 7BA5; -. DR PDBsum; 7BA6; -. DR PDBsum; 7BA7; -. DR PDBsum; 7BA8; -. DR PDBsum; 7BA9; -. DR PDBsum; 7BAA; -. DR PDBsum; 7BAB; -. DR PDBsum; 7BDP; -. DR PDBsum; 7BDT; -. DR PDBsum; 7BDY; -. DR PDBsum; 7BFW; -. DR PDBsum; 7BG3; -. DR PDBsum; 7BGQ; -. DR PDBsum; 7BGR; -. DR PDBsum; 7BGV; -. DR PDBsum; 7BGW; -. DR PDBsum; 7BI3; -. DR PDBsum; 7BIQ; -. DR PDBsum; 7BIW; -. DR PDBsum; 7BIY; -. DR PDBsum; 7BJB; -. DR PDBsum; 7BJF; -. DR PDBsum; 7BJL; -. DR PDBsum; 7BJW; -. DR PDBsum; 7BKH; -. DR PDBsum; 7BM9; -. DR PDBsum; 7BMC; -. DR PDBsum; 7NFW; -. DR PDBsum; 7NIF; -. DR PDBsum; 7NIG; -. DR PDBsum; 7NIX; -. DR PDBsum; 7NIZ; -. DR PDBsum; 7NJ6; -. DR PDBsum; 7NJ8; -. DR PDBsum; 7NJ9; -. DR PDBsum; 7NJA; -. DR PDBsum; 7NJB; -. DR PDBsum; 7NK3; -. DR PDBsum; 7NK5; -. DR PDBsum; 7NLA; -. DR PDBsum; 7NLE; -. DR PDBsum; 7NM1; -. DR PDBsum; 7NM3; -. DR PDBsum; 7NM9; -. DR PDBsum; 7NMA; -. DR PDBsum; 7NMH; -. DR PDBsum; 7NMW; -. DR PDBsum; 7NMX; -. DR PDBsum; 7NN2; -. DR PDBsum; 7NND; -. DR PDBsum; 7NNE; -. DR PDBsum; 7NP2; -. DR PDBsum; 7NPB; -. DR PDBsum; 7NPG; -. DR PDBsum; 7NQP; -. DR PDBsum; 7NR7; -. DR PDBsum; 7NRK; -. DR PDBsum; 7NRL; -. DR PDBsum; 7NSV; -. DR PDBsum; 7NV4; -. DR PDBsum; 7NVI; -. DR PDBsum; 7NWS; -. DR PDBsum; 7NXS; -. DR PDBsum; 7NXT; -. DR PDBsum; 7NXW; -. DR PDBsum; 7NXY; -. DR PDBsum; 7NY4; -. DR PDBsum; 7NYE; -. DR PDBsum; 7NYF; -. DR PDBsum; 7NYG; -. DR PDBsum; 7NZ6; -. DR PDBsum; 7NZG; -. DR PDBsum; 7NZK; -. DR PDBsum; 7NZV; -. DR PDBsum; 7O07; -. DR PDBsum; 7O34; -. DR PDBsum; 7O3A; -. DR PDBsum; 7O3F; -. DR PDBsum; 7O3P; -. DR PDBsum; 7O3Q; -. DR PDBsum; 7O3R; -. DR PDBsum; 7O3S; -. DR PDBsum; 7O57; -. DR PDBsum; 7O59; -. DR PDBsum; 7O5A; -. DR PDBsum; 7O5C; -. DR PDBsum; 7O5D; -. DR PDBsum; 7O5F; -. DR PDBsum; 7O5G; -. DR PDBsum; 7O5O; -. DR PDBsum; 7O5P; -. DR PDBsum; 7O5S; -. DR PDBsum; 7O5U; -. DR PDBsum; 7O5X; -. DR PDBsum; 7O6F; -. DR PDBsum; 7O6G; -. DR PDBsum; 7O6I; -. DR PDBsum; 7O6J; -. DR PDBsum; 7O6K; -. DR PDBsum; 7O6M; -. DR PDBsum; 7O6O; -. DR PDBsum; 7OB5; -. DR PDBsum; 7OB8; -. DR PDBsum; 7OBC; -. DR PDBsum; 7OBD; -. DR PDBsum; 7OBG; -. DR PDBsum; 7OBH; -. DR PDBsum; 7OBK; -. DR PDBsum; 7OBL; -. DR PDBsum; 7OBS; -. DR PDBsum; 7OBT; -. DR PDBsum; 7OBX; -. DR PDBsum; 7OBY; -. DR PDBsum; 7OPW; -. DR PDBsum; 7OQ7; -. DR PDBsum; 7OQ8; -. DR PDBsum; 7OQ9; -. DR PDBsum; 7OQA; -. DR PDBsum; 7OQG; -. DR PDBsum; 7OQJ; -. DR PDBsum; 7OQS; -. DR PDBsum; 7OQU; -. DR PDBsum; 7OQW; -. DR PDBsum; 7OR3; -. DR PDBsum; 7OR5; -. DR PDBsum; 7OR7; -. DR PDBsum; 7OR8; -. DR PDBsum; 7ORG; -. DR PDBsum; 7ORH; -. DR PDBsum; 7ORS; -. DR PDBsum; 7ORT; -. DR PDBsum; 7PWT; -. DR PDBsum; 7PWZ; -. DR PDBsum; 7QIK; -. DR PDBsum; 7QIP; -. DR PDBsum; 7ZMU; -. DR PDBsum; 7ZMW; -. DR PDBsum; 8A62; -. DR PDBsum; 8A65; -. DR PDBsum; 8A68; -. DR PDBsum; 8A6F; -. DR PDBsum; 8A6H; -. DR PDBsum; 8ADM; -. DR PDBsum; 8AFN; -. DR PDBsum; 8AI0; -. DR PDBsum; 8ALR; -. DR PDBsum; 8ALT; -. DR PDBsum; 8ALV; -. DR PDBsum; 8ALW; -. DR PDBsum; 8AM7; -. DR PDBsum; 8ANB; -. DR PDBsum; 8ANC; -. DR PDBsum; 8ANF; -. DR PDBsum; 8AOY; -. DR PDBsum; 8APS; -. DR PDBsum; 8AQ1; -. DR PDBsum; 8AQC; -. DR PDBsum; 8AQE; -. DR PDBsum; 8AQZ; -. DR PDBsum; 8AR4; -. DR PDBsum; 8AR5; -. DR PDBsum; 8ARG; -. DR PDBsum; 8ARO; -. DR PDBsum; 8ARQ; -. DR PDBsum; 8ARR; -. DR PDBsum; 8ARW; -. DR PDBsum; 8ARX; -. DR PDBsum; 8ARY; -. DR PDBsum; 8ARZ; -. DR PDBsum; 8AS1; -. DR PDBsum; 8AT9; -. DR PDBsum; 8ATP; -. DR PDBsum; 8ATR; -. DR PDBsum; 8ATS; -. DR PDBsum; 8AU2; -. DR PDBsum; 8AUS; -. DR PDBsum; 8AUY; -. DR PDBsum; 8AV0; -. DR PDBsum; 8AV3; -. DR PDBsum; 8AV4; -. DR PDBsum; 8AV7; -. DR PDBsum; 8AV8; -. DR PDBsum; 8AWG; -. DR PDBsum; 8AXE; -. DR PDBsum; 8AXU; -. DR PDBsum; 8AZE; -. DR PDBsum; 8B2I; -. DR PDBsum; 8B2K; -. DR PDBsum; 8B39; -. DR PDBsum; 8B4Q; -. DR PDBsum; 8B5P; -. DR PDBsum; 8BFC; -. DR PDBsum; 8BI7; -. DR PDBsum; 8BJG; -. DR PDBsum; 8BJN; -. DR PDBsum; 8BM5; -. DR PDBsum; 8BWJ; -. DR PDBsum; 8BWX; -. DR PDBsum; 8BWZ; -. DR PDBsum; 8BX0; -. DR PDBsum; 8BX3; -. DR PDBsum; 8BX4; -. DR PDBsum; 8BXI; -. DR PDBsum; 8BXM; -. DR PDBsum; 8BXN; -. DR PDBsum; 8BXO; -. DR PDBsum; 8BXQ; -. DR PDBsum; 8BXS; -. DR PDBsum; 8BY9; -. DR PDBsum; 8BYB; -. DR PDBsum; 8BYC; -. DR PDBsum; 8BYD; -. DR PDBsum; 8BYE; -. DR PDBsum; 8BYF; -. DR PDBsum; 8BYG; -. DR PDBsum; 8BYO; -. DR PDBsum; 8BYY; -. DR PDBsum; 8BYZ; -. DR PDBsum; 8BZ0; -. DR PDBsum; 8BZ9; -. DR PDBsum; 8BZA; -. DR PDBsum; 8BZB; -. DR PDBsum; 8BZW; -. DR PDBsum; 8C04; -. DR PDBsum; 8C0K; -. DR PDBsum; 8C2D; -. DR PDBsum; 8C2E; -. DR PDBsum; 8C2F; -. DR PDBsum; 8C2G; -. DR PDBsum; 8C3C; -. DR PDBsum; 8C4F; -. DR PDBsum; 8C4G; -. DR PDBsum; 8Q4L; -. DR AlphaFoldDB; P31947; -. DR EMDB; EMD-18149; -. DR SMR; P31947; -. DR BioGRID; 109072; 685. DR DIP; DIP-29861N; -. DR ELM; P31947; -. DR IntAct; P31947; 590. DR MINT; P31947; -. DR STRING; 9606.ENSP00000340989; -. DR BindingDB; P31947; -. DR ChEMBL; CHEMBL1909482; -. DR GlyGen; P31947; 2 sites, 1 O-linked glycan (2 sites). DR iPTMnet; P31947; -. DR MetOSite; P31947; -. DR PhosphoSitePlus; P31947; -. DR SwissPalm; P31947; -. DR BioMuta; SFN; -. DR DMDM; 398953; -. DR OGP; P31947; -. DR EPD; P31947; -. DR jPOST; P31947; -. DR MassIVE; P31947; -. DR MaxQB; P31947; -. DR PaxDb; 9606-ENSP00000340989; -. DR PeptideAtlas; P31947; -. DR PRIDE; P31947; -. DR ProteomicsDB; 54818; -. DR ProteomicsDB; 54819; -. [P31947-2] DR Pumba; P31947; -. DR TopDownProteomics; P31947-1; -. [P31947-1] DR TopDownProteomics; P31947-2; -. [P31947-2] DR Antibodypedia; 1907; 852 antibodies from 45 providers. DR CPTC; P31947; 3 antibodies. DR DNASU; 2810; -. DR Ensembl; ENST00000339276.6; ENSP00000340989.4; ENSG00000175793.12. [P31947-1] DR GeneID; 2810; -. DR KEGG; hsa:2810; -. DR MANE-Select; ENST00000339276.6; ENSP00000340989.4; NM_006142.5; NP_006133.1. DR UCSC; uc001bnc.2; human. [P31947-1] DR AGR; HGNC:10773; -. DR CTD; 2810; -. DR DisGeNET; 2810; -. DR GeneCards; SFN; -. DR HGNC; HGNC:10773; SFN. DR HPA; ENSG00000175793; Group enriched (esophagus, skin, vagina). DR MIM; 601290; gene. DR neXtProt; NX_P31947; -. DR OpenTargets; ENSG00000175793; -. DR PharmGKB; PA177; -. DR VEuPathDB; HostDB:ENSG00000175793; -. DR eggNOG; KOG0841; Eukaryota. DR GeneTree; ENSGT01090000260040; -. DR HOGENOM; CLU_058290_1_0_1; -. DR InParanoid; P31947; -. DR OMA; TLWTAEC; -. DR OrthoDB; 920089at2759; -. DR PhylomeDB; P31947; -. DR TreeFam; TF102003; -. DR PathwayCommons; P31947; -. DR Reactome; R-HSA-111447; Activation of BAD and translocation to mitochondria. DR Reactome; R-HSA-1445148; Translocation of SLC2A4 (GLUT4) to the plasma membrane. DR Reactome; R-HSA-5625740; RHO GTPases activate PKNs. DR Reactome; R-HSA-5628897; TP53 Regulates Metabolic Genes. DR Reactome; R-HSA-6804114; TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest. DR Reactome; R-HSA-75035; Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex. DR Reactome; R-HSA-9614399; Regulation of localization of FOXO transcription factors. DR Reactome; R-HSA-9735871; SARS-CoV-1 targets host intracellular signalling and regulatory pathways. DR Reactome; R-HSA-9755779; SARS-CoV-2 targets host intracellular signalling and regulatory pathways. DR SignaLink; P31947; -. DR SIGNOR; P31947; -. DR BioGRID-ORCS; 2810; 18 hits in 1161 CRISPR screens. DR ChiTaRS; SFN; human. DR EvolutionaryTrace; P31947; -. DR GeneWiki; Stratifin; -. DR GenomeRNAi; 2810; -. DR Pharos; P31947; Tbio. DR PRO; PR:P31947; -. DR Proteomes; UP000005640; Chromosome 1. DR RNAct; P31947; Protein. DR Bgee; ENSG00000175793; Expressed in cervix squamous epithelium and 197 other cell types or tissues. DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central. DR GO; GO:0005829; C:cytosol; IDA:HPA. DR GO; GO:0070062; C:extracellular exosome; HDA:UniProtKB. DR GO; GO:0005615; C:extracellular space; TAS:ProtInc. DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. DR GO; GO:0045296; F:cadherin binding; HDA:BHF-UCL. DR GO; GO:0042802; F:identical protein binding; IPI:IntAct. DR GO; GO:0050815; F:phosphoserine residue binding; IDA:UniProtKB. DR GO; GO:0019901; F:protein kinase binding; IBA:GO_Central. DR GO; GO:0008426; F:protein kinase C inhibitor activity; TAS:ProtInc. DR GO; GO:0140311; F:protein sequestering activity; IDA:UniProtKB. DR GO; GO:0061436; P:establishment of skin barrier; ISS:UniProtKB. DR GO; GO:0008630; P:intrinsic apoptotic signaling pathway in response to DNA damage; IDA:HGNC-UCL. DR GO; GO:0031424; P:keratinization; IEA:Ensembl. DR GO; GO:0003334; P:keratinocyte development; IEA:Ensembl. DR GO; GO:0043616; P:keratinocyte proliferation; IEA:Ensembl. DR GO; GO:0043154; P:negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; IDA:HGNC-UCL. DR GO; GO:0045824; P:negative regulation of innate immune response; IDA:UniProtKB. DR GO; GO:0010839; P:negative regulation of keratinocyte proliferation; IEA:Ensembl. DR GO; GO:0006469; P:negative regulation of protein kinase activity; TAS:ProtInc. DR GO; GO:2000647; P:negative regulation of stem cell proliferation; IEA:Ensembl. DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IEA:Ensembl. DR GO; GO:0030307; P:positive regulation of cell growth; IEA:Ensembl. DR GO; GO:0045606; P:positive regulation of epidermal cell differentiation; ISS:UniProtKB. DR GO; GO:0046827; P:positive regulation of protein export from nucleus; IEA:Ensembl. DR GO; GO:0006611; P:protein export from nucleus; IEA:Ensembl. DR GO; GO:0010737; P:protein kinase A signaling; IEA:Ensembl. DR GO; GO:0051726; P:regulation of cell cycle; IEA:Ensembl. DR GO; GO:0010482; P:regulation of epidermal cell division; ISS:UniProtKB. DR GO; GO:0001836; P:release of cytochrome c from mitochondria; IDA:HGNC-UCL. DR GO; GO:0007165; P:signal transduction; IBA:GO_Central. DR GO; GO:0072089; P:stem cell proliferation; IEA:Ensembl. DR CDD; cd10019; 14-3-3_sigma; 1. DR Gene3D; 1.20.190.20; 14-3-3 domain; 1. DR IDEAL; IID00301; -. DR InterPro; IPR000308; 14-3-3. DR InterPro; IPR023409; 14-3-3_CS. DR InterPro; IPR036815; 14-3-3_dom_sf. DR InterPro; IPR023410; 14-3-3_domain. DR InterPro; IPR037435; 14-3-3_sigma. DR PANTHER; PTHR18860; 14-3-3 PROTEIN; 1. DR PANTHER; PTHR18860:SF14; 14-3-3 PROTEIN SIGMA; 1. DR Pfam; PF00244; 14-3-3; 1. DR PIRSF; PIRSF000868; 14-3-3; 1. DR PRINTS; PR00305; 1433ZETA. DR SMART; SM00101; 14_3_3; 1. DR SUPFAM; SSF48445; 14-3-3 protein; 1. DR PROSITE; PS00796; 1433_1; 1. DR PROSITE; PS00797; 1433_2; 1. DR SWISS-2DPAGE; P31947; -. DR Genevisible; P31947; HS. PE 1: Evidence at protein level; KW 3D-structure; Alternative splicing; Cytoplasm; Direct protein sequencing; KW Nucleus; Phosphoprotein; Reference proteome; Secreted; Ubl conjugation. FT CHAIN 1..248 FT /note="14-3-3 protein sigma" FT /id="PRO_0000058643" FT SITE 56 FT /note="Interaction with phosphoserine on interacting FT protein" FT SITE 129 FT /note="Interaction with phosphoserine on interacting FT protein" FT MOD_RES 5 FT /note="Phosphoserine" FT /evidence="ECO:0007744|PubMed:20068231" FT MOD_RES 74 FT /note="Phosphoserine" FT /evidence="ECO:0007744|PubMed:23186163" FT MOD_RES 248 FT /note="Phosphoserine" FT /evidence="ECO:0007744|PubMed:16964243, FT ECO:0007744|PubMed:18669648, ECO:0007744|PubMed:18691976, FT ECO:0007744|PubMed:20068231" FT VAR_SEQ 85..116 FT /note="Missing (in isoform 2)" FT /evidence="ECO:0000303|PubMed:15489334" FT /id="VSP_021768" FT VARIANT 155 FT /note="M -> I (in dbSNP:rs11542705)" FT /id="VAR_048095" FT CONFLICT 77 FT /note="K -> M (in Ref. 4; CAG46703)" FT /evidence="ECO:0000305" FT CONFLICT 120 FT /note="Y -> H (in Ref. 2; AAA59546)" FT /evidence="ECO:0000305" FT CONFLICT 242 FT /note="A -> V (in Ref. 2; AAA59546)" FT /evidence="ECO:0000305" FT HELIX 3..15 FT /evidence="ECO:0007829|PDB:3IQU" FT HELIX 19..31 FT /evidence="ECO:0007829|PDB:3IQU" FT HELIX 38..69 FT /evidence="ECO:0007829|PDB:3IQU" FT STRAND 71..73 FT /evidence="ECO:0007829|PDB:8BX3" FT HELIX 80..104 FT /evidence="ECO:0007829|PDB:3IQU" FT HELIX 107..110 FT /evidence="ECO:0007829|PDB:3IQU" FT HELIX 114..134 FT /evidence="ECO:0007829|PDB:3IQU" FT HELIX 137..139 FT /evidence="ECO:0007829|PDB:6RJL" FT HELIX 140..161 FT /evidence="ECO:0007829|PDB:3IQU" FT HELIX 167..182 FT /evidence="ECO:0007829|PDB:3IQU" FT HELIX 187..204 FT /evidence="ECO:0007829|PDB:3IQU" FT HELIX 205..207 FT /evidence="ECO:0007829|PDB:3IQU" FT HELIX 210..230 FT /evidence="ECO:0007829|PDB:3IQU" SQ SEQUENCE 248 AA; 27774 MW; 7F4B44E3AA59ECE6 CRC64; MERASLIQKA KLAEQAERYE DMAAFMKGAV EKGEELSCEE RNLLSVAYKN VVGGQRAAWR VLSSIEQKSN EEGSEEKGPE VREYREKVET ELQGVCDTVL GLLDSHLIKE AGDAESRVFY LKMKGDYYRY LAEVATGDDK KRIIDSARSA YQEAMDISKK EMPPTNPIRL GLALNFSVFH YEIANSPEEA ISLAKTTFDE AMADLHTLSE DSYKDSTLIM QLLRDNLTLW TADNAGEEGG EAPQEPQS //