YWHAB

Functionⁱ

Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negative regulator of osteogenesis. Blocks the nuclear translocation of the phosphorylated form (by AKT1) of SRPK2 and antagonizes its stimulatory effect on cyclin D1 expression resulting in blockage of neuronal apoptosis elicited by SRPK2. Negative regulator of signaling cascades that mediate activation of MAP kinases via AKAP13.3 Publications

GO - Molecular functionⁱ

cadherin binding
Source: BHF-UCL
Inferred from direct assayⁱ
- 25468996
enzyme binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 17255105
histone deacetylase binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 10869435
phosphoprotein binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 10869435
phosphoserine binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 10869435
protein complex binding Source: Ensembl
protein C-terminus binding Source: Ensembl
protein domain specific binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 11984006
transcription corepressor activity Source: Ensembl

Complete GO annotation...

GO - Biological processⁱ

cytoplasmic sequestering of protein
Source: BHF-UCL
Inferred from direct assayⁱ
- 10869435
hippo signaling Source: Reactome
MAPK cascade Source: Reactome
membrane organization Source: Reactome
negative regulation of G-protein coupled receptor protein signaling pathway
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 21224381
negative regulation of protein dephosphorylation
Source: BHF-UCL
Inferred from direct assayⁱ
- 17255105
negative regulation of transcription, DNA-templated Source: Ensembl
positive regulation of catalytic activity
Source: BHF-UCL
Inferred from direct assayⁱ
- 17255105
positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway Source: Reactome
protein heterooligomerization Source: Ensembl
protein targeting Source: Ensembl
regulation of mRNA stability Source: Reactome
viral process Source: UniProtKB-KW

Complete GO annotation...

Keywordsⁱ

Biological process	Host-virus interaction

Biological process

Host-virus interaction

Enzyme and pathway databases

Reactomeⁱ	R-HSA-111447. Activation of BAD and translocation to mitochondria. R-HSA-1445148. Translocation of GLUT4 to the plasma membrane. R-HSA-165159. mTOR signalling. R-HSA-166208. mTORC1-mediated signalling. R-HSA-170968. Frs2-mediated activation. R-HSA-170984. ARMS-mediated activation. R-HSA-2028269. Signaling by Hippo. R-HSA-392517. Rap1 signalling. R-HSA-450385. Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA. R-HSA-450513. Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA. R-HSA-5625740. RHO GTPases activate PKNs. R-HSA-5628897. TP53 Regulates Metabolic Genes. R-HSA-5673000. RAF activation. R-HSA-5674135. MAP2K and MAPK activation. R-HSA-5675221. Negative regulation of MAPK pathway. R-HSA-6802946. Signaling by moderate kinase activity BRAF mutants. R-HSA-6802948. Signaling by high-kinase activity BRAF mutants. R-HSA-6802949. Signaling by RAS mutants. R-HSA-6802952. Signaling by BRAF and RAF fusions. R-HSA-6802955. Paradoxical activation of RAF signaling by kinase inactive BRAF. R-HSA-75035. Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex.
SignaLinkⁱ	P31946.
SIGNORⁱ	P31946.

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: 14-3-3 protein beta/alpha Alternative name(s): Protein 1054 Protein kinase C inhibitor protein 1 Short name: KCIP-1 Cleaved into the following chain: 14-3-3 protein beta/alpha, N-terminally processed
Gene namesⁱ	Name:YWHAB
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 20

Organism-specific databases

Human Gene Nomenclature Database More...HGNCⁱ	HGNC:12849. YWHAB.

HGNCⁱ

HGNC:12849. YWHAB.

Subcellular locationⁱ

Note:

Identified by mass spectrometry in melanosome fractions from stage I to stage IV.

GO - Cellular componentⁱ

cytoplasm
Source: UniProtKB
Inferred from direct assayⁱ
- 12963375
cytoplasmic vesicle membrane Source: Reactome
cytosol Source: HPA
extracellular exosome
Source: UniProtKB
Inferred from direct assayⁱ
- 19199708
- 20458337
focal adhesion
Source: UniProtKB
Inferred from direct assayⁱ
- 21423176
melanosome Source: UniProtKB-SubCell
membrane
Source: UniProtKB
Inferred from direct assayⁱ
- 19946888
mitochondrion Source: GOC
nucleus Source: Ensembl
perinuclear region of cytoplasm
Source: UniProtKB
Inferred from direct assayⁱ
- 12963375
protein complex Source: Ensembl
transcriptional repressor complex Source: Ensembl

Complete GO annotation...

Keywords - Cellular componentⁱ

Cytoplasm

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	7529.
Open Targets More...OpenTargetsⁱ	ENSG00000166913.
PharmGKBⁱ	PA37438.

Polymorphism and mutation databases

DMDMⁱ	1345590.

DMDMⁱ

1345590.

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Length
ChainⁱPRO_0000367900	1 – 246	14-3-3 protein beta/alphaAdd BLAST	246
Initiator methionineⁱ		Removed; alternateCombined sources1 Publication
ChainⁱPRO_0000000003	2 – 246	14-3-3 protein beta/alpha, N-terminally processedAdd BLAST	245

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	1	N-acetylmethionine; in 14-3-3 protein beta/alpha; alternateCombined sources1 Publication	1
Modified residueⁱ	2	N-acetylthreonine; in 14-3-3 protein beta/alpha, N-terminally processedCombined sources1 Publication	1
Modified residueⁱ	2	PhosphothreonineCombined sources	1
Modified residueⁱ	60	PhosphoserineBy similarity	1
Modified residueⁱ	70	N6-acetyllysineCombined sources	1
Modified residueⁱ	84	Nitrated tyrosineBy similarity	1
Modified residueⁱ	106	Nitrated tyrosineBy similarity	1
Modified residueⁱ	117	N6-acetyllysineCombined sources	1
Modified residueⁱ	186	PhosphoserineBy similarity	1
Modified residueⁱ	232	PhosphoserineCombined sources	1
Isoform Short (identifier: P31946-2)
Modified residueⁱ	1	N-acetylmethionineCombined sources	1

Post-translational modificationⁱ

The alpha, brain-specific form differs from the beta form in being phosphorylated. Phosphorylated on Ser-60 by protein kinase C delta type catalytic subunit in a sphingosine-dependent fashion.By similarity

Keywords - PTMⁱ

Acetylation, Nitration, Phosphoprotein

Proteomic databases

EPDⁱ	P31946.
PaxDbⁱ	P31946.
PeptideAtlas More...PeptideAtlasⁱ	P31946.
PRIDEⁱ	P31946.
TopDownProteomicsⁱ	P31946-1. [P31946-1] P31946-2. [P31946-2]

2D gel databases

USC-OGP 2-DE database More...OGPⁱ	P31946.
REPRODUCTION-2DPAGE More...REPRODUCTION-2DPAGEⁱ	IPI00216318.

PTM databases

iPTMnetⁱ	P31946.
PhosphoSitePlusⁱ	P31946.
SwissPalmⁱ	P31946.

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000166913.
CleanExⁱ	HS_YWHAB.
ExpressionAtlasⁱ	P31946. baseline and differential.
Genevisibleⁱ	P31946. HS.

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB003759. HPA007925. HPA011212.

HPAⁱ

CAB003759.
HPA007925.
HPA011212.

Interactionⁱ

Subunit structureⁱ

Homodimer (PubMed:17717073). Interacts with SAMSN1 and PRKCE (By similarity). Interacts with AKAP13 (PubMed:21224381). Interacts with SSH1 and TORC2/CRTC2 (PubMed:15454081, PubMed:15159416). Interacts with ABL1; the interaction results in cytoplasmic location of ABL1 and inhibition of cABL-mediated apoptosis (PubMed:15696159). Interacts with ROR2 (dimer); the interaction results in phosphorylation of YWHAB on tyrosine residues (PubMed:17717073). Interacts with GAB2 (PubMed:19172738). Interacts with YAP1 (phosphorylated form) (PubMed:17974916). Interacts with the phosphorylated (by AKT1) form of SRPK2 (PubMed:19592491). Interacts with PKA-phosphorylated AANAT (PubMed:11427721). Interacts with MYO1C (PubMed:24636949). Interacts with SIRT2 (PubMed:18249187). Interacts with the 'Thr-369' phosphorylated form of DAPK2 (PubMed:26047703). Interacts with PI4KB, TBC1D22A and TBC1D22B (PubMed:23572552). Interacts with the 'Ser-1134' and 'Ser-1161' phosphorylated form of SOS1 (PubMed:22827337). Interacts (via phosphorylated form) with YWHAB; this interaction occurs in a protein kinase AKT1-dependent manner (PubMed:15538381). Interacts with SLITRK1 (PubMed:19640509). Interacts with SYNPO2 (phosphorylated form); YWHAB competes with ACTN2 for interaction with SYNPO2 (By similarity). Interacts with RIPOR2 (via phosphorylated form) isoform 2; this interaction occurs in a chemokine-dependent manner and does not compete for binding of RIPOR2 with RHOA nor blocks inhibition of RIPOR2-mediated RHOA activity (PubMed:25588844).By similarity18 Publications

(Microbial infection) Interacts with herpes simplex virus 1 protein UL46.1 Publication

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Siteⁱ	58	Interaction with phosphoserine on interacting proteinBy similarity		1
Siteⁱ	129	Interaction with phosphoserine on interacting proteinBy similarity		1

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
	Q76353	3	EBI-359815,EBI-6248077	From Human immunodeficiency virus 1.
ADAM22	Q9P0K1-3	2	EBI-359815,EBI-1567267
BRAF	P15056	3	EBI-359815,EBI-365980
CBL	P22681	3	EBI-359815,EBI-518228
CBX4	O00257	2	EBI-359815,EBI-722425
CDC25A	P30304	10	EBI-359815,EBI-747671
CDC25B	P30305	5	EBI-359815,EBI-1051746
CDK14	O94921	5	EBI-359815,EBI-1043945
CSNK1A1	P67828	3	EBI-359815,EBI-7540603	From Oryctolagus cuniculus.
DACT1	Q9NYF0	4	EBI-359815,EBI-3951744
DYRK1A	Q13627-2	3	EBI-359815,EBI-1053621
GAB2	Q9UQC2	4	EBI-359815,EBI-975200
GEM	P55040	3	EBI-359815,EBI-744104
Gem	P55041	3	EBI-359815,EBI-7082069	From Mus musculus.
HDAC4	P56524	3	EBI-359815,EBI-308629
let-756	Q11184	2	EBI-359815,EBI-3843983	From Caenorhabditis elegans.
LRRK2	Q5S007	5	EBI-359815,EBI-5323863
MAP3K3	Q99759	2	EBI-359815,EBI-307281
MAP3K5	Q99683	3	EBI-359815,EBI-476263
MARK2	Q7KZI7	3	EBI-359815,EBI-516560
MARK3	P27448	4	EBI-359815,EBI-707595
PTPN3	P26045	4	EBI-359815,EBI-1047946
RAF1	P04049	18	EBI-359815,EBI-365996
RMDN3	Q96TC7	5	EBI-359815,EBI-1056589
RND3	P61587	2	EBI-359815,EBI-1111534
Rnd3	P61588	5	EBI-359815,EBI-6930266	From Mus musculus.
SRPK2	P78362	2	EBI-359815,EBI-593303
SSH1	Q8WYL5	3	EBI-359815,EBI-1222387
Synpo2	Q91YE8	3	EBI-359815,EBI-7623057	From Mus musculus.
TSC2	P49815	4	EBI-359815,EBI-396587
YAP1	P46937	5	EBI-359815,EBI-1044059
YWHAE	P62258	3	EBI-359815,EBI-356498
Zfp36	P22893	5	EBI-359815,EBI-647803	From Mus musculus.

Show more details

GO - Molecular functionⁱ

cadherin binding
Source: BHF-UCL
Inferred from direct assayⁱ
- 25468996
enzyme binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 17255105
histone deacetylase binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 10869435
phosphoprotein binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 10869435
phosphoserine binding
Source: BHF-UCL
Inferred from physical interactionⁱ
- 10869435
protein complex binding Source: Ensembl
protein C-terminus binding Source: Ensembl
protein domain specific binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 11984006

Complete GO annotation...

Protein-protein interaction databases

BioGridⁱ	113361. 341 interactors.
Database of interacting proteins More...DIPⁱ	DIP-743N.
IntActⁱ	P31946. 267 interactors.
Molecular INTeraction database More...MINTⁱ	MINT-99570.
STRINGⁱ	9606.ENSP00000300161.

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Show more details

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	5 – 17	Combined sources	13
Helixⁱ	21 – 33	Combined sources	13
Helixⁱ	40 – 69	Combined sources	30
Helixⁱ	75 – 105	Combined sources	31
Helixⁱ	107 – 110	Combined sources	4
Helixⁱ	114 – 133	Combined sources	20
Helixⁱ	139 – 161	Combined sources	23
Helixⁱ	167 – 182	Combined sources	16
Helixⁱ	187 – 202	Combined sources	16
Helixⁱ	203 – 207	Combined sources	5
Turnⁱ	210 – 212	Combined sources	3
Helixⁱ	213 – 232	Combined sources	20

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2BQ0	X-ray	2.50	A/B	2-239	[»]
	2C23	X-ray	2.65	A	2-239	[»]
	4DNK	X-ray	2.20	A/B	1-246	[»]
ProteinModelPortalⁱ	P31946.
SMRⁱ	P31946.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	P31946.

EvolutionaryTraceⁱ

P31946.

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the 14-3-3 family.Curated

Phylogenomic databases

eggNOGⁱ	KOG0841. Eukaryota. COG5040. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000119116.
HOGENOMⁱ	HOG000240379.
HOVERGENⁱ	HBG050423.
InParanoidⁱ	P31946.
KEGG Orthology (KO) More...KOⁱ	K16197.
OMAⁱ	KKQQMGR.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0VKY.
PhylomeDBⁱ	P31946.
TreeFamⁱ	TF102003.

Family and domain databases

Gene3Dⁱ	1.20.190.20. 1 hit.
InterProⁱ	View protein in InterPro IPR000308. 14-3-3. IPR023409. 14-3-3_CS. IPR023410. 14-3-3_domain.
PANTHERⁱ	PTHR18860. PTHR18860. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00244. 14-3-3. 1 hit.
PIRSFⁱ	PIRSF000868. 14-3-3. 1 hit.
PRINTSⁱ	PR00305. 1433ZETA.
SMARTⁱ	View protein in SMART SM00101. 14_3_3. 1 hit.
SUPFAMⁱ	SSF48445. SSF48445. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00796. 1433_1. 1 hit. PS00797. 1433_2. 1 hit.

Sequences (2)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsⁱ produced by alternative initiation. Align Add to basket Added to basket

Isoform Long (identifier: P31946-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MTMDKSELVQ KAKLAEQAER YDDMAAAMKA VTEQGHELSN EERNLLSVAY 
        60         70         80         90        100
KNVVGARRSS WRVISSIEQK TERNEKKQQM GKEYREKIEA ELQDICNDVL 
       110        120        130        140        150
ELLDKYLIPN ATQPESKVFY LKMKGDYFRY LSEVASGDNK QTTVSNSQQA 
       160        170        180        190        200
YQEAFEISKK EMQPTHPIRL GLALNFSVFY YEILNSPEKA CSLAKTAFDE 
       210        220        230        240 
AIAELDTLNE ESYKDSTLIM QLLRDNLTLW TSENQGDEGD AGEGEN

Length:246

Mass (Da):28,082

Last modified:January 23, 2007 - v3

Checksum:ⁱ6BE1A9BF97468017

GO

Isoform Short (identifier: P31946-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-2: Missing.

« Hide

        10         20         30         40         50
MDKSELVQKA KLAEQAERYD DMAAAMKAVT EQGHELSNEE RNLLSVAYKN 
        60         70         80         90        100
VVGARRSSWR VISSIEQKTE RNEKKQQMGK EYREKIEAEL QDICNDVLEL 
       110        120        130        140        150
LDKYLIPNAT QPESKVFYLK MKGDYFRYLS EVASGDNKQT TVSNSQQAYQ 
       160        170        180        190        200
EAFEISKKEM QPTHPIRLGL ALNFSVFYYE ILNSPEKACS LAKTAFDEAI 
       210        220        230        240 
AELDTLNEES YKDSTLIMQL LRDNLTLWTS ENQGDEGDAG EGEN

Show »

Length:244

Mass (Da):27,850

Checksum:ⁱCE0A59BF8C33FE2F

GO

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_064762	99	V → I Found in a renal cell carcinoma sample; somatic mutation. 1 Publication		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_018632	1 – 2	Missing in isoform Short. Curated		2

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X57346 mRNA. Translation: CAA40621.1. AK292717 mRNA. Translation: BAF85406.1. AL008725 Genomic DNA. Translation: CAA15497.1. CH471077 Genomic DNA. Translation: EAW75893.1. CH471077 Genomic DNA. Translation: EAW75894.1. CH471077 Genomic DNA. Translation: EAW75896.1. BC001359 mRNA. Translation: AAH01359.1.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS13339.1. [P31946-1]
PIRⁱ	S34755.
NCBI Reference Sequences More...RefSeqⁱ	NP_003395.1. NM_003404.4. [P31946-1] NP_647539.1. NM_139323.3. [P31946-1] XP_016883528.1. XM_017028039.1. [P31946-1]
UniGeneⁱ	Hs.643544.

Genome annotation databases

Ensemblⁱ	ENST00000353703; ENSP00000300161; ENSG00000166913. [P31946-1] ENST00000372839; ENSP00000361930; ENSG00000166913. [P31946-1]
GeneIDⁱ	7529.
KEGGⁱ	hsa:7529.

Keywords - Coding sequence diversityⁱ

Alternative initiation, Polymorphism

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X57346 mRNA. Translation: CAA40621.1. AK292717 mRNA. Translation: BAF85406.1. AL008725 Genomic DNA. Translation: CAA15497.1. CH471077 Genomic DNA. Translation: EAW75893.1. CH471077 Genomic DNA. Translation: EAW75894.1. CH471077 Genomic DNA. Translation: EAW75896.1. BC001359 mRNA. Translation: AAH01359.1.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS13339.1. [P31946-1]
PIRⁱ	S34755.
NCBI Reference Sequences More...RefSeqⁱ	NP_003395.1. NM_003404.4. [P31946-1] NP_647539.1. NM_139323.3. [P31946-1] XP_016883528.1. XM_017028039.1. [P31946-1]
UniGeneⁱ	Hs.643544.

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	2BQ0	X-ray	2.50	A/B	2-239	[»]
	2C23	X-ray	2.65	A	2-239	[»]
	4DNK	X-ray	2.20	A/B	1-246	[»]
ProteinModelPortalⁱ	P31946.
SMRⁱ	P31946.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	113361. 341 interactors.
Database of interacting proteins More...DIPⁱ	DIP-743N.
IntActⁱ	P31946. 267 interactors.
Molecular INTeraction database More...MINTⁱ	MINT-99570.
STRINGⁱ	9606.ENSP00000300161.

PTM databases

iPTMnetⁱ	P31946.
PhosphoSitePlusⁱ	P31946.
SwissPalmⁱ	P31946.

Polymorphism and mutation databases

DMDMⁱ	1345590.

DMDMⁱ

1345590.

2D gel databases

USC-OGP 2-DE database More...OGPⁱ	P31946.
REPRODUCTION-2DPAGE More...REPRODUCTION-2DPAGEⁱ	IPI00216318.

Proteomic databases

EPDⁱ	P31946.
PaxDbⁱ	P31946.
PeptideAtlas More...PeptideAtlasⁱ	P31946.
PRIDEⁱ	P31946.
TopDownProteomicsⁱ	P31946-1. [P31946-1] P31946-2. [P31946-2]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	7529.
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000353703; ENSP00000300161; ENSG00000166913. [P31946-1] ENST00000372839; ENSP00000361930; ENSG00000166913. [P31946-1]
GeneIDⁱ	7529.
KEGGⁱ	hsa:7529.

Organism-specific databases

CTDⁱ	7529.
DisGeNET More...DisGeNETⁱ	7529.
GeneCardsⁱ	YWHAB.
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:12849. YWHAB.
Human Protein Atlas More...HPAⁱ	CAB003759. HPA007925. HPA011212.
MIMⁱ	601289. gene.
neXtProtⁱ	NX_P31946.
Open Targets More...OpenTargetsⁱ	ENSG00000166913.
PharmGKBⁱ	PA37438.
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG0841. Eukaryota. COG5040. LUCA.
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000119116.
HOGENOMⁱ	HOG000240379.
HOVERGENⁱ	HBG050423.
InParanoidⁱ	P31946.
KEGG Orthology (KO) More...KOⁱ	K16197.
OMAⁱ	KKQQMGR.
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0VKY.
PhylomeDBⁱ	P31946.
TreeFamⁱ	TF102003.

Enzyme and pathway databases

Reactomeⁱ	R-HSA-111447. Activation of BAD and translocation to mitochondria. R-HSA-1445148. Translocation of GLUT4 to the plasma membrane. R-HSA-165159. mTOR signalling. R-HSA-166208. mTORC1-mediated signalling. R-HSA-170968. Frs2-mediated activation. R-HSA-170984. ARMS-mediated activation. R-HSA-2028269. Signaling by Hippo. R-HSA-392517. Rap1 signalling. R-HSA-450385. Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA. R-HSA-450513. Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA. R-HSA-5625740. RHO GTPases activate PKNs. R-HSA-5628897. TP53 Regulates Metabolic Genes. R-HSA-5673000. RAF activation. R-HSA-5674135. MAP2K and MAPK activation. R-HSA-5675221. Negative regulation of MAPK pathway. R-HSA-6802946. Signaling by moderate kinase activity BRAF mutants. R-HSA-6802948. Signaling by high-kinase activity BRAF mutants. R-HSA-6802949. Signaling by RAS mutants. R-HSA-6802952. Signaling by BRAF and RAF fusions. R-HSA-6802955. Paradoxical activation of RAF signaling by kinase inactive BRAF. R-HSA-75035. Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex.
SignaLinkⁱ	P31946.
SIGNORⁱ	P31946.

Miscellaneous databases

ChiTaRSⁱ	YWHAB. human.
EvolutionaryTraceⁱ	P31946.
GeneWikiⁱ	YWHAB.
GenomeRNAiⁱ	7529.
Protein Ontology More...PROⁱ	PR:P31946.
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000166913.
CleanExⁱ	HS_YWHAB.
ExpressionAtlasⁱ	P31946. baseline and differential.
Genevisibleⁱ	P31946. HS.

Family and domain databases

Gene3Dⁱ	1.20.190.20. 1 hit.
InterProⁱ	View protein in InterPro IPR000308. 14-3-3. IPR023409. 14-3-3_CS. IPR023410. 14-3-3_domain.
PANTHERⁱ	PTHR18860. PTHR18860. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00244. 14-3-3. 1 hit.
PIRSFⁱ	PIRSF000868. 14-3-3. 1 hit.
PRINTSⁱ	PR00305. 1433ZETA.
SMARTⁱ	View protein in SMART SM00101. 14_3_3. 1 hit.
SUPFAMⁱ	SSF48445. SSF48445. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00796. 1433_1. 1 hit. PS00797. 1433_2. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	1433B_HUMAN
Accessionⁱ	P31946Primary (citable) accession number: P31946 Secondary accession number(s): A8K9K2, E1P616
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	July 1, 1993
	Last sequence update:	January 23, 2007
	Last modified:	July 5, 2017
	This is version 199 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

Human chromosome 20
Human chromosome 20: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
SIMILARITY comments
Index of protein domains and families
UniProtKB entry view manual
User manual for the UniProtKB entry view

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UniProtKB - P31946 (1433B_HUMAN)

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14-3-3 protein beta/alpha

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

2D gel databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

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PTM databases

Polymorphism and mutation databases

2D gel databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequences (2)ⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ