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P31944

- CASPE_HUMAN

UniProt

P31944 - CASPE_HUMAN

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Protein

Caspase-14

Gene
CASP14
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Believed to be a non-apoptotic caspase which is involved in epidermal differentiation. Seems to play a role in keratinocyte differentiation and cornification. Probably regulates maturation of the epidermis by proteolytically processing filaggrin By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei89 – 891 By similarity
Active sitei132 – 1321 By similarity

GO - Molecular functioni

  1. cysteine-type endopeptidase activity Source: RefGenome

GO - Biological processi

  1. cornification Source: UniProtKB
  2. epidermis development Source: ProtInc
  3. extrinsic apoptotic signaling pathway in absence of ligand Source: RefGenome
  4. intrinsic apoptotic signaling pathway in response to DNA damage Source: RefGenome
  5. keratinization Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Thiol protease

Keywords - Biological processi

Differentiation

Protein family/group databases

MEROPSiC14.018.

Names & Taxonomyi

Protein namesi
Recommended name:
Caspase-14 (EC:3.4.22.-)
Short name:
CASP-14
Cleaved into the following 2 chains:
Gene namesi
Name:CASP14
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:1502. CASP14.

Subcellular locationi

Cytoplasm. Nucleus 2 Publications

GO - Cellular componenti

  1. cytoplasm Source: RefGenome
  2. extracellular vesicular exosome Source: UniProt
  3. keratin filament Source: Ensembl
  4. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26085.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini? – 152Caspase-14 subunit p19PRO_0000004653
Propeptidei1 – ? Reviewed predictionPRO_0000004652
Chaini153 – 24290Caspase-14 subunit p10PRO_0000004654Add
BLAST

Keywords - PTMi

Zymogen

Proteomic databases

MaxQBiP31944.
PaxDbiP31944.
PeptideAtlasiP31944.
PRIDEiP31944.

Miscellaneous databases

PMAP-CutDBP31944.

Expressioni

Tissue specificityi

Expressed in keratinocytes of adult skin suprabasal layers (from spinous layers to the stratum granulosum and stratum corneum) (at protein level). Expressed in keratinocytes of hair shaft and sebaceous glands (at protein level). In psoriatic skin only expressed at very low levels.1 Publication

Inductioni

In undifferentiated keratinocytes under postconfluency growth conditions (in vitro).1 Publication

Gene expression databases

ArrayExpressiP31944.
BgeeiP31944.
CleanExiHS_CASP14.
GenevestigatoriP31944.

Organism-specific databases

HPAiCAB010059.
HPA027062.

Interactioni

Subunit structurei

Complex of unprocessed caspase-14 and processed 19 kDa (p19) and 10 kDa (p10) subunits.1 Publication

Protein-protein interaction databases

BioGridi117116. 15 interactions.
IntActiP31944. 4 interactions.
STRINGi9606.ENSP00000221740.

Structurei

3D structure databases

ProteinModelPortaliP31944.
SMRiP31944. Positions 28-241.

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase C14A family.

Phylogenomic databases

eggNOGiNOG327631.
HOGENOMiHOG000231878.
HOVERGENiHBG050804.
InParanoidiP31944.
KOiK04401.
OMAiCVTKARE.
OrthoDBiEOG7VQJDT.
PhylomeDBiP31944.
TreeFamiTF102023.

Family and domain databases

Gene3Di3.40.50.1460. 1 hit.
InterProiIPR029030. Caspase-like_dom.
IPR011600. Pept_C14_caspase.
IPR001309. Pept_C14_ICE_p20.
IPR016129. Pept_C14_ICE_p20_AS.
IPR002138. Pept_C14_p10.
IPR015917. Pept_C14A_p45_core.
[Graphical view]
PfamiPF00656. Peptidase_C14. 1 hit.
[Graphical view]
PRINTSiPR00376. IL1BCENZYME.
SMARTiSM00115. CASc. 1 hit.
[Graphical view]
PROSITEiPS01122. CASPASE_CYS. 1 hit.
PS50207. CASPASE_P10. 1 hit.
PS50208. CASPASE_P20. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P31944-1 [UniParc]FASTAAdd to Basket

« Hide

MSNPRSLEEE KYDMSGARLA LILCVTKARE GSEEDLDALE HMFRQLRFES    50
TMKRDPTAEQ FQEELEKFQQ AIDSREDPVS CAFVVLMAHG REGFLKGEDG 100
EMVKLENLFE ALNNKNCQAL RAKPKVYIIQ ACRGEQRDPG ETVGGDEIVM 150
VIKDSPQTIP TYTDALHVYS TVEGYIAYRH DQKGSCFIQT LVDVFTKRKG 200
HILELLTEVT RRMAEAELVQ EGKARKTNPE IQSTLRKRLY LQ 242
Length:242
Mass (Da):27,680
Last modified:January 11, 2001 - v2
Checksum:iE539FB7E8DD808A2
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF097874 mRNA. Translation: AAD16173.1.
BC069541 mRNA. Translation: AAH69541.1.
BC103868 mRNA. Translation: AAI03869.1.
BC103869 mRNA. Translation: AAI03870.1.
CCDSiCCDS12323.1.
PIRiJC7517.
RefSeqiNP_036246.1. NM_012114.2.
UniGeneiHs.466057.

Genome annotation databases

EnsembliENST00000221740; ENSP00000221740; ENSG00000105141.
ENST00000427043; ENSP00000393417; ENSG00000105141.
GeneIDi23581.
KEGGihsa:23581.
UCSCiuc010dzv.2. human.

Polymorphism databases

DMDMi12231007.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF097874 mRNA. Translation: AAD16173.1 .
BC069541 mRNA. Translation: AAH69541.1 .
BC103868 mRNA. Translation: AAI03869.1 .
BC103869 mRNA. Translation: AAI03870.1 .
CCDSi CCDS12323.1.
PIRi JC7517.
RefSeqi NP_036246.1. NM_012114.2.
UniGenei Hs.466057.

3D structure databases

ProteinModelPortali P31944.
SMRi P31944. Positions 28-241.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 117116. 15 interactions.
IntActi P31944. 4 interactions.
STRINGi 9606.ENSP00000221740.

Chemistry

BindingDBi P31944.
ChEMBLi CHEMBL5991.

Protein family/group databases

MEROPSi C14.018.

Polymorphism databases

DMDMi 12231007.

Proteomic databases

MaxQBi P31944.
PaxDbi P31944.
PeptideAtlasi P31944.
PRIDEi P31944.

Protocols and materials databases

DNASUi 23581.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000221740 ; ENSP00000221740 ; ENSG00000105141 .
ENST00000427043 ; ENSP00000393417 ; ENSG00000105141 .
GeneIDi 23581.
KEGGi hsa:23581.
UCSCi uc010dzv.2. human.

Organism-specific databases

CTDi 23581.
GeneCardsi GC19P015160.
HGNCi HGNC:1502. CASP14.
HPAi CAB010059.
HPA027062.
MIMi 605848. gene.
neXtProti NX_P31944.
PharmGKBi PA26085.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG327631.
HOGENOMi HOG000231878.
HOVERGENi HBG050804.
InParanoidi P31944.
KOi K04401.
OMAi CVTKARE.
OrthoDBi EOG7VQJDT.
PhylomeDBi P31944.
TreeFami TF102023.

Miscellaneous databases

GeneWikii Caspase_14.
GenomeRNAii 23581.
NextBioi 46186.
PMAP-CutDB P31944.
PROi P31944.
SOURCEi Search...

Gene expression databases

ArrayExpressi P31944.
Bgeei P31944.
CleanExi HS_CASP14.
Genevestigatori P31944.

Family and domain databases

Gene3Di 3.40.50.1460. 1 hit.
InterProi IPR029030. Caspase-like_dom.
IPR011600. Pept_C14_caspase.
IPR001309. Pept_C14_ICE_p20.
IPR016129. Pept_C14_ICE_p20_AS.
IPR002138. Pept_C14_p10.
IPR015917. Pept_C14A_p45_core.
[Graphical view ]
Pfami PF00656. Peptidase_C14. 1 hit.
[Graphical view ]
PRINTSi PR00376. IL1BCENZYME.
SMARTi SM00115. CASc. 1 hit.
[Graphical view ]
PROSITEi PS01122. CASPASE_CYS. 1 hit.
PS50207. CASPASE_P10. 1 hit.
PS50208. CASPASE_P20. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Caspase-14: analysis of gene structure and mRNA expression during keratinocyte differentiation."
    Eckhart L., Ban J., Fischer H., Tschachler E.
    Biochem. Biophys. Res. Commun. 277:655-659(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Expression and transcriptional regulation of caspase-14 in simple and complex epithelia."
    Pistritto G., Jost M., Srinivasula S.M., Baffa R., Poyet J.-L., Kari C., Lazebnik Y., Rodeck U., Alnemri E.S.
    Cell Death Differ. 9:995-1006(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes."
    Rasmussen H.H., van Damme J., Puype M., Gesser B., Celis J.E., Vandekerckhove J.
    Electrophoresis 13:960-969(1992) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 68-74; 137-147 AND 154-162.
    Tissue: Keratinocyte.
  5. "Epidermal differentiation does not involve the pro-apoptotic executioner caspases, but is associated with caspase-14 induction and processing."
    Lippens S., Kockx M., Knaapen M., Mortier L., Polakowska R., Verheyen A., Garmyn M., Zwijsen A., Formstecher P., Huylebroeck D., Vandenabeele P., Declercq W.
    Cell Death Differ. 7:1218-1224(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INDUCTION.
  6. "Processing of native caspase-14 occurs at an atypical cleavage site in normal epidermal differentiation."
    Chien A.J., Presland R.B., Kuechle M.K.
    Biochem. Biophys. Res. Commun. 296:911-917(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 153-163, PROTEOLYTIC PROCESSING, SUBUNIT, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiCASPE_HUMAN
AccessioniPrimary (citable) accession number: P31944
Secondary accession number(s): O95823, Q3SYC9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: January 11, 2001
Last modified: September 3, 2014
This is version 131 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Peptidase families
    Classification of peptidase families and list of entries
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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