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P31944 (CASPE_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 127. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Caspase-14

Short name=CASP-14
EC=3.4.22.-

Cleaved into the following 2 chains:

  1. Caspase-14 subunit p19
  2. Caspase-14 subunit p10
Gene names
Name:CASP14
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length242 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Believed to be a non-apoptotic caspase which is involved in epidermal differentiation. Seems to play a role in keratinocyte differentiation and cornification. Probably regulates maturation of the epidermis by proteolytically processing filaggrin By similarity.

Subunit structure

Complex of unprocessed caspase-14 and processed 19 kDa (p19) and 10 kDa (p10) subunits. Ref.6

Subcellular location

Cytoplasm. Nucleus Ref.5 Ref.6.

Tissue specificity

Expressed in keratinocytes of adult skin suprabasal layers (from spinous layers to the stratum granulosum and stratum corneum) (at protein level). Expressed in keratinocytes of hair shaft and sebaceous glands (at protein level). In psoriatic skin only expressed at very low levels. Ref.5

Induction

In undifferentiated keratinocytes under postconfluency growth conditions (in vitro). Ref.5

Sequence similarities

Belongs to the peptidase C14A family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Propeptide1 – ? PotentialPRO_0000004652
Chain? – 152Caspase-14 subunit p19PRO_0000004653
Chain153 – 24290Caspase-14 subunit p10
PRO_0000004654

Sites

Active site891 By similarity
Active site1321 By similarity

Sequences

Sequence LengthMass (Da)Tools
P31944 [UniParc].

Last modified January 11, 2001. Version 2.
Checksum: E539FB7E8DD808A2

FASTA24227,680
        10         20         30         40         50         60 
MSNPRSLEEE KYDMSGARLA LILCVTKARE GSEEDLDALE HMFRQLRFES TMKRDPTAEQ 

        70         80         90        100        110        120 
FQEELEKFQQ AIDSREDPVS CAFVVLMAHG REGFLKGEDG EMVKLENLFE ALNNKNCQAL 

       130        140        150        160        170        180 
RAKPKVYIIQ ACRGEQRDPG ETVGGDEIVM VIKDSPQTIP TYTDALHVYS TVEGYIAYRH 

       190        200        210        220        230        240 
DQKGSCFIQT LVDVFTKRKG HILELLTEVT RRMAEAELVQ EGKARKTNPE IQSTLRKRLY 


LQ 

« Hide

References

« Hide 'large scale' references
[1]"Caspase-14: analysis of gene structure and mRNA expression during keratinocyte differentiation."
Eckhart L., Ban J., Fischer H., Tschachler E.
Biochem. Biophys. Res. Commun. 277:655-659(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"Expression and transcriptional regulation of caspase-14 in simple and complex epithelia."
Pistritto G., Jost M., Srinivasula S.M., Baffa R., Poyet J.-L., Kari C., Lazebnik Y., Rodeck U., Alnemri E.S.
Cell Death Differ. 9:995-1006(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Brain.
[3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]"Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes."
Rasmussen H.H., van Damme J., Puype M., Gesser B., Celis J.E., Vandekerckhove J.
Electrophoresis 13:960-969(1992) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 68-74; 137-147 AND 154-162.
Tissue: Keratinocyte.
[5]"Epidermal differentiation does not involve the pro-apoptotic executioner caspases, but is associated with caspase-14 induction and processing."
Lippens S., Kockx M., Knaapen M., Mortier L., Polakowska R., Verheyen A., Garmyn M., Zwijsen A., Formstecher P., Huylebroeck D., Vandenabeele P., Declercq W.
Cell Death Differ. 7:1218-1224(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INDUCTION.
[6]"Processing of native caspase-14 occurs at an atypical cleavage site in normal epidermal differentiation."
Chien A.J., Presland R.B., Kuechle M.K.
Biochem. Biophys. Res. Commun. 296:911-917(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: PROTEIN SEQUENCE OF 153-163, PROTEOLYTIC PROCESSING, SUBUNIT, SUBCELLULAR LOCATION.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF097874 mRNA. Translation: AAD16173.1.
BC069541 mRNA. Translation: AAH69541.1.
BC103868 mRNA. Translation: AAI03869.1.
BC103869 mRNA. Translation: AAI03870.1.
PIRJC7517.
RefSeqNP_036246.1. NM_012114.2.
UniGeneHs.466057.

3D structure databases

ProteinModelPortalP31944.
SMRP31944. Positions 28-241.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid117116. 15 interactions.
IntActP31944. 4 interactions.
STRING9606.ENSP00000221740.

Chemistry

BindingDBP31944.
ChEMBLCHEMBL5991.

Protein family/group databases

MEROPSC14.018.

Polymorphism databases

DMDM12231007.

Proteomic databases

PaxDbP31944.
PeptideAtlasP31944.
PRIDEP31944.

Protocols and materials databases

DNASU23581.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000221740; ENSP00000221740; ENSG00000105141.
ENST00000427043; ENSP00000393417; ENSG00000105141.
GeneID23581.
KEGGhsa:23581.
UCSCuc010dzv.2. human.

Organism-specific databases

CTD23581.
GeneCardsGC19P015160.
HGNCHGNC:1502. CASP14.
HPACAB010059.
HPA027062.
MIM605848. gene.
neXtProtNX_P31944.
PharmGKBPA26085.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG327631.
HOGENOMHOG000231878.
HOVERGENHBG050804.
InParanoidP31944.
KOK04401.
OMACVTKARE.
OrthoDBEOG7VQJDT.
PhylomeDBP31944.
TreeFamTF102023.

Gene expression databases

ArrayExpressP31944.
BgeeP31944.
CleanExHS_CASP14.
GenevestigatorP31944.

Family and domain databases

InterProIPR011600. Pept_C14_caspase.
IPR001309. Pept_C14_ICE_p20.
IPR016129. Pept_C14_ICE_p20_AS.
IPR002138. Pept_C14_p10.
IPR015917. Pept_C14A_p45_core.
[Graphical view]
PfamPF00656. Peptidase_C14. 1 hit.
[Graphical view]
PRINTSPR00376. IL1BCENZYME.
SMARTSM00115. CASc. 1 hit.
[Graphical view]
PROSITEPS01122. CASPASE_CYS. 1 hit.
PS50207. CASPASE_P10. 1 hit.
PS50208. CASPASE_P20. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiCaspase_14.
GenomeRNAi23581.
NextBio46186.
PMAP-CutDBP31944.
PROP31944.
SOURCESearch...

Entry information

Entry nameCASPE_HUMAN
AccessionPrimary (citable) accession number: P31944
Secondary accession number(s): O95823, Q3SYC9
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: January 11, 2001
Last modified: April 16, 2014
This is version 127 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM