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Protein

Heterogeneous nuclear ribonucleoprotein H

Gene

HNRNPH1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

This protein is a component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Mediates pre-mRNA alternative splicing regulation. Inhibits, together with CUGBP1, insulin receptor (IR) pre-mRNA exon 11 inclusion in myoblast. Binds to the IR RNA. Binds poly(RG).2 Publications

GO - Molecular functioni

  • nucleotide binding Source: InterPro
  • poly(A) RNA binding Source: UniProtKB
  • poly(U) RNA binding Source: ProtInc
  • RNA binding Source: UniProtKB

GO - Biological processi

  • fibroblast growth factor receptor signaling pathway Source: Reactome
  • gene expression Source: Reactome
  • mRNA splicing, via spliceosome Source: UniProtKB
  • regulation of RNA splicing Source: UniProtKB
  • RNA processing Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein

Keywords - Biological processi

mRNA processing, mRNA splicing

Keywords - Ligandi

RNA-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000169045-MONOMER.
ReactomeiR-HSA-6803529. FGFR2 alternative splicing.
R-HSA-72163. mRNA Splicing - Major Pathway.
R-HSA-72203. Processing of Capped Intron-Containing Pre-mRNA.

Names & Taxonomyi

Protein namesi
Recommended name:
Heterogeneous nuclear ribonucleoprotein H
Short name:
hnRNP H
Cleaved into the following chain:
Gene namesi
Name:HNRNPH1
Synonyms:HNRPH, HNRPH1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

HGNCiHGNC:5041. HNRNPH1.

Subcellular locationi

GO - Cellular componenti

  • catalytic step 2 spliceosome Source: UniProtKB
  • cytoplasm Source: HPA
  • membrane Source: UniProtKB
  • nucleoplasm Source: HPA
  • nucleus Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Nucleus, Spliceosome

Pathology & Biotechi

Organism-specific databases

DisGeNETi3187.
MalaCardsiHNRNPH1.
OpenTargetsiENSG00000169045.
Orphaneti99861. Precursor T-cell acute lymphoblastic leukemia.
PharmGKBiPA162391284.

Polymorphism and mutation databases

BioMutaiHNRNPH1.
DMDMi1710632.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003671191 – 449Heterogeneous nuclear ribonucleoprotein HAdd BLAST449
Initiator methionineiRemoved; alternateCombined sources2 Publications
ChainiPRO_00000818572 – 449Heterogeneous nuclear ribonucleoprotein H, N-terminally processedAdd BLAST448

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionine; in Heterogeneous nuclear ribonucleoprotein H; alternateCombined sources1 Publication1
Modified residuei2N-acetylmethionine; in Heterogeneous nuclear ribonucleoprotein H, N-terminally processedCombined sources1 Publication1
Modified residuei23PhosphoserineCombined sources1
Modified residuei54PhosphoserineCombined sources1
Modified residuei63PhosphoserineCombined sources1
Modified residuei233Dimethylated arginine; alternate1 Publication1
Modified residuei233Omega-N-methylarginine; alternateCombined sources1 Publication1
Modified residuei246PhosphotyrosineCombined sources1
Modified residuei310PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

EPDiP31943.
MaxQBiP31943.
PaxDbiP31943.
PeptideAtlasiP31943.
PRIDEiP31943.

2D gel databases

REPRODUCTION-2DPAGEIPI00013881.
P31943.

PTM databases

iPTMnetiP31943.
PhosphoSitePlusiP31943.
SwissPalmiP31943.

Expressioni

Tissue specificityi

Expressed ubiquitously.

Inductioni

Up-regulated in myotonic dystrophy pathophysiology (DM).1 Publication

Gene expression databases

BgeeiENSG00000169045.
CleanExiHS_HNRNPH1.
ExpressionAtlasiP31943. baseline and differential.
GenevisibleiP31943. HS.

Organism-specific databases

HPAiCAB032820.
HPA000914.
HPA001359.
HPA016884.

Interactioni

Subunit structurei

Part of a ternary complex containing FUBP2, PTBP1, PTBP2 and HNRNPH1. Identified in the spliceosome C complex. Interacts with IGF2BP1. Interacts with CUGBP1; the interaction is RNA-dependent. Interacts with MBNL1; the interaction in RNA-independent.4 Publications

Protein-protein interaction databases

BioGridi109428. 187 interactors.
IntActiP31943. 80 interactors.
MINTiMINT-1160934.
STRINGi9606.ENSP00000349168.

Structurei

Secondary structure

1449
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi9 – 17Combined sources9
Helixi24 – 30Combined sources7
Turni31 – 33Combined sources3
Helixi39 – 41Combined sources3
Beta strandi42 – 47Combined sources6
Beta strandi51 – 62Combined sources12
Helixi64 – 71Combined sources8
Turni72 – 75Combined sources4
Beta strandi84 – 88Combined sources5
Helixi90 – 98Combined sources9

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2LXUNMR-A7-111[»]
ProteinModelPortaliP31943.
SMRiP31943.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini11 – 90RRM 1PROSITE-ProRule annotationAdd BLAST80
Domaini111 – 188RRM 2PROSITE-ProRule annotationAdd BLAST78
Repeati234 – 2491-1Add BLAST16
Domaini289 – 364RRM 3PROSITE-ProRule annotationAdd BLAST76
Repeati354 – 3722-1Add BLAST19
Repeati374 – 3922-2Add BLAST19
Repeati418 – 4331-2Add BLAST16

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni234 – 4332 X 16 AA Gly-rich approximate repeatsAdd BLAST200
Regioni354 – 3922 X 19 AA perfect repeatsAdd BLAST39

Domaini

Each quasi-RRM repeat bound poly(RG), while only the N-terminal QRRM bound poly(RC) and poly(RU). None of the repeats bound detectable amounts of poly(RA).

Sequence similaritiesi

Contains 3 RRM (RNA recognition motif) domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG4211. Eukaryota.
ENOG410Z6M0. LUCA.
GeneTreeiENSGT00760000119102.
HOGENOMiHOG000220896.
HOVERGENiHBG055557.
InParanoidiP31943.
KOiK12898.
PhylomeDBiP31943.
TreeFamiTF316157.

Family and domain databases

Gene3Di3.30.70.330. 3 hits.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
IPR012996. Znf_CHHC.
[Graphical view]
PfamiPF00076. RRM_1. 3 hits.
PF08080. zf-RNPHF. 1 hit.
[Graphical view]
SMARTiSM00360. RRM. 3 hits.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 3 hits.
PROSITEiPS50102. RRM. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P31943-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMLGTEGGEG FVVKVRGLPW SCSADEVQRF FSDCKIQNGA QGIRFIYTRE
60 70 80 90 100
GRPSGEAFVE LESEDEVKLA LKKDRETMGH RYVEVFKSNN VEMDWVLKHT
110 120 130 140 150
GPNSPDTAND GFVRLRGLPF GCSKEEIVQF FSGLEIVPNG ITLPVDFQGR
160 170 180 190 200
STGEAFVQFA SQEIAEKALK KHKERIGHRY IEIFKSSRAE VRTHYDPPRK
210 220 230 240 250
LMAMQRPGPY DRPGAGRGYN SIGRGAGFER MRRGAYGGGY GGYDDYNGYN
260 270 280 290 300
DGYGFGSDRF GRDLNYCFSG MSDHRYGDGG STFQSTTGHC VHMRGLPYRA
310 320 330 340 350
TENDIYNFFS PLNPVRVHIE IGPDGRVTGE ADVEFATHED AVAAMSKDKA
360 370 380 390 400
NMQHRYVELF LNSTAGASGG AYEHRYVELF LNSTAGASGG AYGSQMMGGM
410 420 430 440
GLSNQSSYGG PASQQLSGGY GGGYGGQSSM SGYDQVLQEN SSDFQSNIA
Length:449
Mass (Da):49,229
Last modified:January 23, 2007 - v4
Checksum:i4ECF7A075C2526FF
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti188R → G in CAG33059 (Ref. 2) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L22009 mRNA. Translation: AAA91346.1.
CR456778 mRNA. Translation: CAG33059.1.
AK124530 mRNA. Translation: BAG54048.1.
CH471165 Genomic DNA. Translation: EAW53807.1.
CH471165 Genomic DNA. Translation: EAW53808.1.
BC001348 mRNA. Translation: AAH01348.1.
CCDSiCCDS4446.1.
PIRiI39358.
RefSeqiNP_001244222.1. NM_001257293.1.
NP_005511.1. NM_005520.2.
XP_016864904.1. XM_017009415.1.
XP_016864905.1. XM_017009416.1.
XP_016864906.1. XM_017009417.1.
UniGeneiHs.604001.

Genome annotation databases

EnsembliENST00000356731; ENSP00000349168; ENSG00000169045.
ENST00000393432; ENSP00000377082; ENSG00000169045.
ENST00000442819; ENSP00000397797; ENSG00000169045.
GeneIDi3187.
KEGGihsa:3187.
UCSCiuc003mke.5. human.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L22009 mRNA. Translation: AAA91346.1.
CR456778 mRNA. Translation: CAG33059.1.
AK124530 mRNA. Translation: BAG54048.1.
CH471165 Genomic DNA. Translation: EAW53807.1.
CH471165 Genomic DNA. Translation: EAW53808.1.
BC001348 mRNA. Translation: AAH01348.1.
CCDSiCCDS4446.1.
PIRiI39358.
RefSeqiNP_001244222.1. NM_001257293.1.
NP_005511.1. NM_005520.2.
XP_016864904.1. XM_017009415.1.
XP_016864905.1. XM_017009416.1.
XP_016864906.1. XM_017009417.1.
UniGeneiHs.604001.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2LXUNMR-A7-111[»]
ProteinModelPortaliP31943.
SMRiP31943.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109428. 187 interactors.
IntActiP31943. 80 interactors.
MINTiMINT-1160934.
STRINGi9606.ENSP00000349168.

PTM databases

iPTMnetiP31943.
PhosphoSitePlusiP31943.
SwissPalmiP31943.

Polymorphism and mutation databases

BioMutaiHNRNPH1.
DMDMi1710632.

2D gel databases

REPRODUCTION-2DPAGEIPI00013881.
P31943.

Proteomic databases

EPDiP31943.
MaxQBiP31943.
PaxDbiP31943.
PeptideAtlasiP31943.
PRIDEiP31943.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000356731; ENSP00000349168; ENSG00000169045.
ENST00000393432; ENSP00000377082; ENSG00000169045.
ENST00000442819; ENSP00000397797; ENSG00000169045.
GeneIDi3187.
KEGGihsa:3187.
UCSCiuc003mke.5. human.

Organism-specific databases

CTDi3187.
DisGeNETi3187.
GeneCardsiHNRNPH1.
HGNCiHGNC:5041. HNRNPH1.
HPAiCAB032820.
HPA000914.
HPA001359.
HPA016884.
MalaCardsiHNRNPH1.
MIMi601035. gene.
neXtProtiNX_P31943.
OpenTargetsiENSG00000169045.
Orphaneti99861. Precursor T-cell acute lymphoblastic leukemia.
PharmGKBiPA162391284.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4211. Eukaryota.
ENOG410Z6M0. LUCA.
GeneTreeiENSGT00760000119102.
HOGENOMiHOG000220896.
HOVERGENiHBG055557.
InParanoidiP31943.
KOiK12898.
PhylomeDBiP31943.
TreeFamiTF316157.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000169045-MONOMER.
ReactomeiR-HSA-6803529. FGFR2 alternative splicing.
R-HSA-72163. mRNA Splicing - Major Pathway.
R-HSA-72203. Processing of Capped Intron-Containing Pre-mRNA.

Miscellaneous databases

ChiTaRSiHNRNPH1. human.
GeneWikiiHNRPH1.
GenomeRNAii3187.
PROiP31943.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000169045.
CleanExiHS_HNRNPH1.
ExpressionAtlasiP31943. baseline and differential.
GenevisibleiP31943. HS.

Family and domain databases

Gene3Di3.30.70.330. 3 hits.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
IPR012996. Znf_CHHC.
[Graphical view]
PfamiPF00076. RRM_1. 3 hits.
PF08080. zf-RNPHF. 1 hit.
[Graphical view]
SMARTiSM00360. RRM. 3 hits.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 3 hits.
PROSITEiPS50102. RRM. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHNRH1_HUMAN
AccessioniPrimary (citable) accession number: P31943
Secondary accession number(s): B3KW86, D3DWQ2, Q6IBM4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: January 23, 2007
Last modified: November 30, 2016
This is version 187 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 5
    Human chromosome 5: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.