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Protein

Heterogeneous nuclear ribonucleoprotein H

Gene

HNRNPH1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

This protein is a component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes which provide the substrate for the processing events that pre-mRNAs undergo before becoming functional, translatable mRNAs in the cytoplasm. Mediates pre-mRNA alternative splicing regulation. Inhibits, together with CUGBP1, insulin receptor (IR) pre-mRNA exon 11 inclusion in myoblast. Binds to the IR RNA. Binds poly(RG).2 Publications

GO - Molecular functioni

  • poly(U) RNA binding Source: ProtInc
  • RNA binding Source: UniProtKB

GO - Biological processi

  • fibroblast growth factor receptor signaling pathway Source: Reactome
  • mRNA splicing, via spliceosome Source: Reactome
  • regulation of RNA splicing Source: UniProtKB
  • RNA metabolic process Source: Reactome
  • RNA processing Source: ProtInc

Keywordsi

Molecular functionRibonucleoprotein, RNA-binding
Biological processmRNA processing, mRNA splicing

Enzyme and pathway databases

ReactomeiR-HSA-6803529 FGFR2 alternative splicing
R-HSA-72163 mRNA Splicing - Major Pathway
R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA

Names & Taxonomyi

Protein namesi
Recommended name:
Heterogeneous nuclear ribonucleoprotein H
Short name:
hnRNP H
Cleaved into the following chain:
Gene namesi
Name:HNRNPH1
Synonyms:HNRPH, HNRPH1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 5

Organism-specific databases

EuPathDBiHostDB:ENSG00000169045.17
HGNCiHGNC:5041 HNRNPH1
MIMi601035 gene
neXtProtiNX_P31943

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus, Spliceosome

Pathology & Biotechi

Organism-specific databases

DisGeNETi3187
MalaCardsiHNRNPH1
OpenTargetsiENSG00000169045
Orphaneti99861 Precursor T-cell acute lymphoblastic leukemia
PharmGKBiPA162391284

Chemistry databases

ChEMBLiCHEMBL3797013

Polymorphism and mutation databases

BioMutaiHNRNPH1
DMDMi1710632

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003671191 – 449Heterogeneous nuclear ribonucleoprotein HAdd BLAST449
Initiator methionineiRemoved; alternateCombined sources2 Publications
ChainiPRO_00000818572 – 449Heterogeneous nuclear ribonucleoprotein H, N-terminally processedAdd BLAST448

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionine; in Heterogeneous nuclear ribonucleoprotein H; alternateCombined sources1 Publication1
Modified residuei2N-acetylmethionine; in Heterogeneous nuclear ribonucleoprotein H, N-terminally processedCombined sources1 Publication1
Modified residuei23PhosphoserineCombined sources1
Cross-linki35Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei54PhosphoserineCombined sources1
Modified residuei63PhosphoserineCombined sources1
Cross-linki87Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki98Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei233Dimethylated arginine; alternate1 Publication1
Modified residuei233Omega-N-methylarginine; alternateCombined sources1 Publication1
Modified residuei246PhosphotyrosineCombined sources1
Modified residuei310PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiP31943
MaxQBiP31943
PaxDbiP31943
PeptideAtlasiP31943
PRIDEiP31943

2D gel databases

REPRODUCTION-2DPAGEiIPI00013881
P31943

PTM databases

iPTMnetiP31943
PhosphoSitePlusiP31943
SwissPalmiP31943

Expressioni

Tissue specificityi

Expressed ubiquitously.

Inductioni

Up-regulated in myotonic dystrophy pathophysiology (DM).1 Publication

Gene expression databases

BgeeiENSG00000169045
CleanExiHS_HNRNPH1
ExpressionAtlasiP31943 baseline and differential
GenevisibleiP31943 HS

Organism-specific databases

HPAiCAB032820
HPA000914
HPA001359
HPA016884

Interactioni

Subunit structurei

Part of a ternary complex containing FUBP2, PTBP1, PTBP2 and HNRNPH1. Identified in the spliceosome C complex. Interacts with IGF2BP1. Interacts with CUGBP1; the interaction is RNA-dependent. Interacts with MBNL1; the interaction in RNA-independent.4 Publications

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi109428, 198 interactors
CORUMiP31943
IntActiP31943, 112 interactors
MINTiP31943
STRINGi9606.ENSP00000349168

Structurei

Secondary structure

1449
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi9 – 17Combined sources9
Helixi24 – 30Combined sources7
Turni31 – 33Combined sources3
Helixi39 – 41Combined sources3
Beta strandi42 – 47Combined sources6
Beta strandi51 – 62Combined sources12
Helixi64 – 71Combined sources8
Turni72 – 75Combined sources4
Beta strandi84 – 88Combined sources5
Helixi90 – 98Combined sources9

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2LXUNMR-A7-111[»]
ProteinModelPortaliP31943
SMRiP31943
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini11 – 90RRM 1PROSITE-ProRule annotationAdd BLAST80
Domaini111 – 188RRM 2PROSITE-ProRule annotationAdd BLAST78
Repeati234 – 2491-1Add BLAST16
Domaini289 – 364RRM 3PROSITE-ProRule annotationAdd BLAST76
Repeati354 – 3722-1Add BLAST19
Repeati374 – 3922-2Add BLAST19
Repeati418 – 4331-2Add BLAST16

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni234 – 4332 X 16 AA Gly-rich approximate repeatsAdd BLAST200
Regioni354 – 3922 X 19 AA perfect repeatsAdd BLAST39

Domaini

Each quasi-RRM repeat bound poly(RG), while only the N-terminal QRRM bound poly(RC) and poly(RU). None of the repeats bound detectable amounts of poly(RA).

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG4211 Eukaryota
ENOG410Z6M0 LUCA
GeneTreeiENSGT00760000119102
HOGENOMiHOG000220896
HOVERGENiHBG055557
InParanoidiP31943
KOiK12898
PhylomeDBiP31943
TreeFamiTF316157

Family and domain databases

Gene3Di3.30.70.330, 3 hits
InterProiView protein in InterPro
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
IPR012996 Znf_CHHC
PfamiView protein in Pfam
PF00076 RRM_1, 3 hits
PF08080 zf-RNPHF, 1 hit
SMARTiView protein in SMART
SM00360 RRM, 3 hits
SUPFAMiSSF54928 SSF54928, 3 hits
PROSITEiView protein in PROSITE
PS50102 RRM, 3 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P31943-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMLGTEGGEG FVVKVRGLPW SCSADEVQRF FSDCKIQNGA QGIRFIYTRE
60 70 80 90 100
GRPSGEAFVE LESEDEVKLA LKKDRETMGH RYVEVFKSNN VEMDWVLKHT
110 120 130 140 150
GPNSPDTAND GFVRLRGLPF GCSKEEIVQF FSGLEIVPNG ITLPVDFQGR
160 170 180 190 200
STGEAFVQFA SQEIAEKALK KHKERIGHRY IEIFKSSRAE VRTHYDPPRK
210 220 230 240 250
LMAMQRPGPY DRPGAGRGYN SIGRGAGFER MRRGAYGGGY GGYDDYNGYN
260 270 280 290 300
DGYGFGSDRF GRDLNYCFSG MSDHRYGDGG STFQSTTGHC VHMRGLPYRA
310 320 330 340 350
TENDIYNFFS PLNPVRVHIE IGPDGRVTGE ADVEFATHED AVAAMSKDKA
360 370 380 390 400
NMQHRYVELF LNSTAGASGG AYEHRYVELF LNSTAGASGG AYGSQMMGGM
410 420 430 440
GLSNQSSYGG PASQQLSGGY GGGYGGQSSM SGYDQVLQEN SSDFQSNIA
Length:449
Mass (Da):49,229
Last modified:January 23, 2007 - v4
Checksum:i4ECF7A075C2526FF
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti188R → G in CAG33059 (Ref. 2) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L22009 mRNA Translation: AAA91346.1
CR456778 mRNA Translation: CAG33059.1
AK124530 mRNA Translation: BAG54048.1
CH471165 Genomic DNA Translation: EAW53807.1
CH471165 Genomic DNA Translation: EAW53808.1
BC001348 mRNA Translation: AAH01348.1
CCDSiCCDS4446.1
PIRiI39358
RefSeqiNP_001244222.1, NM_001257293.1
NP_005511.1, NM_005520.2
XP_016864904.1, XM_017009415.1
XP_016864905.1, XM_017009416.1
XP_016864906.1, XM_017009417.1
UniGeneiHs.604001

Genome annotation databases

EnsembliENST00000356731; ENSP00000349168; ENSG00000169045
ENST00000393432; ENSP00000377082; ENSG00000169045
ENST00000442819; ENSP00000397797; ENSG00000169045
GeneIDi3187
KEGGihsa:3187
UCSCiuc003mke.5 human

Similar proteinsi

Entry informationi

Entry nameiHNRH1_HUMAN
AccessioniPrimary (citable) accession number: P31943
Secondary accession number(s): B3KW86, D3DWQ2, Q6IBM4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: January 23, 2007
Last modified: April 25, 2018
This is version 197 of the entry and version 4 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome
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Main funding by: National Institutes of Health