Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Heterogeneous nuclear ribonucleoprotein H3

Gene

HNRNPH3

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Involved in the splicing process and participates in early heat shock-induced splicing arrest. Due to their great structural variations the different isoforms may possess different functions in the splicing reaction.

GO - Molecular functioni

  • nucleotide binding Source: InterPro
  • poly(A) RNA binding Source: UniProtKB
  • RNA binding Source: UniProtKB

GO - Biological processi

  • epithelial cell differentiation Source: UniProtKB
  • mRNA splicing, via spliceosome Source: UniProtKB
  • RNA processing Source: ProtInc
  • RNA splicing Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Ribonucleoprotein

Keywords - Biological processi

mRNA processing

Keywords - Ligandi

RNA-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000096746-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Heterogeneous nuclear ribonucleoprotein H3
Short name:
hnRNP H3
Alternative name(s):
Heterogeneous nuclear ribonucleoprotein 2H9
Short name:
hnRNP 2H9
Gene namesi
Name:HNRNPH3
Synonyms:HNRPH3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 10

Organism-specific databases

HGNCiHGNC:5043. HNRNPH3.

Subcellular locationi

GO - Cellular componenti

  • nucleoplasm Source: HPA
  • nucleus Source: UniProtKB
  • spliceosomal complex Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000096746.
PharmGKBiPA162391325.

Polymorphism and mutation databases

BioMutaiHNRNPH3.
DMDMi23503095.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000818611 – 346Heterogeneous nuclear ribonucleoprotein H3Add BLAST346

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionine1 Publication1
Modified residuei121Asymmetric dimethylarginine1 Publication1
Modified residuei174Omega-N-methylarginineCombined sources1
Modified residuei216PhosphoserineCombined sources1
Modified residuei287Omega-N-methylarginine1 Publication1
Modified residuei296PhosphotyrosineCombined sources1
Modified residuei298PhosphoserineCombined sources1
Modified residuei314PhosphothreonineCombined sources1
Modified residuei323Omega-N-methylarginineCombined sources1
Modified residuei343Omega-N-methylarginineCombined sources1
Isoform 2 (identifier: P31942-2)
Modified residuei116Omega-N-methylarginineCombined sources1
Modified residuei121Omega-N-methylarginineCombined sources1
Modified residuei129Omega-N-methylarginineCombined sources1

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

EPDiP31942.
MaxQBiP31942.
PaxDbiP31942.
PeptideAtlasiP31942.
PRIDEiP31942.
TopDownProteomicsiP31942-1. [P31942-1]
P31942-2. [P31942-2]

PTM databases

iPTMnetiP31942.
PhosphoSitePlusiP31942.
SwissPalmiP31942.

Expressioni

Gene expression databases

BgeeiENSG00000096746.
CleanExiHS_HNRNPH3.
ExpressionAtlasiP31942. baseline and differential.
GenevisibleiP31942. HS.

Organism-specific databases

HPAiHPA038264.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
HNRNPA1P096513EBI-711437,EBI-352662

Protein-protein interaction databases

BioGridi109430. 98 interactors.
IntActiP31942. 62 interactors.
MINTiMINT-5004191.
STRINGi9606.ENSP00000265866.

Structurei

3D structure databases

ProteinModelPortaliP31942.
SMRiP31942.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini16 – 93RRM 1PROSITE-ProRule annotationAdd BLAST78
Domaini195 – 270RRM 2PROSITE-ProRule annotationAdd BLAST76

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi108 – 344Gly-richAdd BLAST237

Sequence similaritiesi

Contains 2 RRM (RNA recognition motif) domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG4211. Eukaryota.
ENOG410Z6M0. LUCA.
GeneTreeiENSGT00760000119102.
HOVERGENiHBG055557.
InParanoidiP31942.
KOiK12898.
OMAiLPWSCTQ.
OrthoDBiEOG091G0CTJ.
PhylomeDBiP31942.
TreeFamiTF316157.

Family and domain databases

Gene3Di3.30.70.330. 2 hits.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view]
PfamiPF00076. RRM_1. 2 hits.
[Graphical view]
SMARTiSM00360. RRM. 2 hits.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 2 hits.
PROSITEiPS50102. RRM. 2 hits.
[Graphical view]

Sequences (6)i

Sequence statusi: Complete.

This entry describes 6 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: P31942-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDWVMKHNGP NDASDGTVRL RGLPFGCSKE EIVQFFQGLE IVPNGITLTM
60 70 80 90 100
DYQGRSTGEA FVQFASKEIA ENALGKHKER IGHRYIEIFR SSRSEIKGFY
110 120 130 140 150
DPPRRLLGQR PGPYDRPIGG RGGYYGAGRG SMYDRMRRGG DGYDGGYGGF
160 170 180 190 200
DDYGGYNNYG YGNDGFDDRM RDGRGMGGHG YGGAGDASSG FHGGHFVHMR
210 220 230 240 250
GLPFRATEND IANFFSPLNP IRVHIDIGAD GRATGEADVE FVTHEDAVAA
260 270 280 290 300
MSKDKNNMQH RYIELFLNST PGGGSGMGGS GMGGYGRDGM DNQGGYGSVG
310 320 330 340
RMGMGNNYSG GYGTPDGLGG YGRGGGGSGG YYGQGGMSGG GWRGMY
Length:346
Mass (Da):36,926
Last modified:September 19, 2002 - v2
Checksum:iF7D14C2947930E9E
GO
Isoform 2 (identifier: P31942-2) [UniParc]FASTAAdd to basket
Also known as: 2H9A

The sequence of this isoform differs from the canonical sequence as follows:
     132-146: Missing.

Show »
Length:331
Mass (Da):35,239
Checksum:iA3BA8D0F5FC07369
GO
Isoform 3 (identifier: P31942-3) [UniParc]FASTAAdd to basket
Also known as: 2H9B

The sequence of this isoform differs from the canonical sequence as follows:
     1-49: Missing.

Show »
Length:297
Mass (Da):31,525
Checksum:iAAE63A29063E5153
GO
Isoform 4 (identifier: P31942-4) [UniParc]FASTAAdd to basket
Also known as: 2H9C

The sequence of this isoform differs from the canonical sequence as follows:
     1-131: Missing.

Show »
Length:215
Mass (Da):22,322
Checksum:i969F8FE2710D2646
GO
Isoform 5 (identifier: P31942-5) [UniParc]FASTAAdd to basket
Also known as: 2H9D

The sequence of this isoform differs from the canonical sequence as follows:
     1-131: Missing.
     259-276: QHRYIELFLNSTPGGGSG → RKWCLWHTILFPKREFIK
     277-346: Missing.

Show »
Length:145
Mass (Da):16,084
Checksum:i286234CBE7C9C996
GO
Isoform 6 (identifier: P31942-6) [UniParc]FASTAAdd to basket
Also known as: 2H9E

The sequence of this isoform differs from the canonical sequence as follows:
     1-137: Missing.
     138-145: RGGDGYDG → MCFSLNYT
     259-276: QHRYIELFLNSTPGGGSG → RKWCLWHTILFPKREFIK
     277-346: Missing.

Show »
Length:139
Mass (Da):15,413
Checksum:iF1E137E637675D93
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_020333163N → S.Corresponds to variant rs2273903dbSNPEnsembl.1
Natural variantiVAR_052226284G → A.Corresponds to variant rs16925347dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0058411 – 137Missing in isoform 6. 1 PublicationAdd BLAST137
Alternative sequenceiVSP_0058391 – 131Missing in isoform 4 and isoform 5. 3 PublicationsAdd BLAST131
Alternative sequenceiVSP_0058381 – 49Missing in isoform 3. 1 PublicationAdd BLAST49
Alternative sequenceiVSP_005840132 – 146Missing in isoform 2. 3 PublicationsAdd BLAST15
Alternative sequenceiVSP_005842138 – 145RGGDGYDG → MCFSLNYT in isoform 6. 1 Publication8
Alternative sequenceiVSP_005843259 – 276QHRYI…GGGSG → RKWCLWHTILFPKREFIK in isoform 5 and isoform 6. 1 PublicationAdd BLAST18
Alternative sequenceiVSP_005844277 – 346Missing in isoform 5 and isoform 6. 1 PublicationAdd BLAST70

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L32610 mRNA. Translation: AAD45179.1.
AF132360 Genomic DNA. Translation: AAF68843.1.
AF132360 Genomic DNA. Translation: AAF68844.1.
AF132360 Genomic DNA. Translation: AAF68845.1.
AF132360 Genomic DNA. Translation: AAF68846.1.
AF132360 Genomic DNA. Translation: AAF68847.1.
AF132360 Genomic DNA. Translation: AAF68848.1.
AF132361 mRNA. Translation: AAF68849.1.
AF132362 mRNA. Translation: AAF68850.1.
AF132363 mRNA. Translation: AAF68851.1.
AF132364 mRNA. Translation: AAF68852.1.
AK091411 mRNA. Translation: BAG52353.1.
AK291547 mRNA. Translation: BAF84236.1.
AL117395 mRNA. Translation: CAB55897.1.
CH471083 Genomic DNA. Translation: EAW54281.1.
CH471083 Genomic DNA. Translation: EAW54282.1.
BC004511 mRNA. Translation: AAH04511.2.
BC039824 mRNA. Translation: AAH39824.1.
CCDSiCCDS7278.1. [P31942-1]
CCDS7279.1. [P31942-2]
PIRiT17207.
RefSeqiNP_001309363.1. NM_001322434.1. [P31942-1]
NP_001309365.1. NM_001322436.1. [P31942-1]
NP_001309366.1. NM_001322437.1. [P31942-1]
NP_001309367.1. NM_001322438.1. [P31942-2]
NP_001309368.1. NM_001322439.1. [P31942-2]
NP_001309369.1. NM_001322440.1. [P31942-2]
NP_001309370.1. NM_001322441.1. [P31942-2]
NP_001309374.1. NM_001322445.1. [P31942-4]
NP_001309375.1. NM_001322446.1. [P31942-4]
NP_001309376.1. NM_001322447.1. [P31942-4]
NP_001309377.1. NM_001322448.1. [P31942-4]
NP_001309378.1. NM_001322449.1. [P31942-4]
NP_036339.1. NM_012207.2. [P31942-1]
NP_067676.2. NM_021644.3. [P31942-2]
XP_016871657.1. XM_017016168.1. [P31942-1]
XP_016871658.1. XM_017016169.1. [P31942-4]
UniGeneiHs.643472.

Genome annotation databases

EnsembliENST00000265866; ENSP00000265866; ENSG00000096746. [P31942-1]
ENST00000354695; ENSP00000346726; ENSG00000096746. [P31942-2]
GeneIDi3189.
KEGGihsa:3189.
UCSCiuc001jnw.5. human. [P31942-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L32610 mRNA. Translation: AAD45179.1.
AF132360 Genomic DNA. Translation: AAF68843.1.
AF132360 Genomic DNA. Translation: AAF68844.1.
AF132360 Genomic DNA. Translation: AAF68845.1.
AF132360 Genomic DNA. Translation: AAF68846.1.
AF132360 Genomic DNA. Translation: AAF68847.1.
AF132360 Genomic DNA. Translation: AAF68848.1.
AF132361 mRNA. Translation: AAF68849.1.
AF132362 mRNA. Translation: AAF68850.1.
AF132363 mRNA. Translation: AAF68851.1.
AF132364 mRNA. Translation: AAF68852.1.
AK091411 mRNA. Translation: BAG52353.1.
AK291547 mRNA. Translation: BAF84236.1.
AL117395 mRNA. Translation: CAB55897.1.
CH471083 Genomic DNA. Translation: EAW54281.1.
CH471083 Genomic DNA. Translation: EAW54282.1.
BC004511 mRNA. Translation: AAH04511.2.
BC039824 mRNA. Translation: AAH39824.1.
CCDSiCCDS7278.1. [P31942-1]
CCDS7279.1. [P31942-2]
PIRiT17207.
RefSeqiNP_001309363.1. NM_001322434.1. [P31942-1]
NP_001309365.1. NM_001322436.1. [P31942-1]
NP_001309366.1. NM_001322437.1. [P31942-1]
NP_001309367.1. NM_001322438.1. [P31942-2]
NP_001309368.1. NM_001322439.1. [P31942-2]
NP_001309369.1. NM_001322440.1. [P31942-2]
NP_001309370.1. NM_001322441.1. [P31942-2]
NP_001309374.1. NM_001322445.1. [P31942-4]
NP_001309375.1. NM_001322446.1. [P31942-4]
NP_001309376.1. NM_001322447.1. [P31942-4]
NP_001309377.1. NM_001322448.1. [P31942-4]
NP_001309378.1. NM_001322449.1. [P31942-4]
NP_036339.1. NM_012207.2. [P31942-1]
NP_067676.2. NM_021644.3. [P31942-2]
XP_016871657.1. XM_017016168.1. [P31942-1]
XP_016871658.1. XM_017016169.1. [P31942-4]
UniGeneiHs.643472.

3D structure databases

ProteinModelPortaliP31942.
SMRiP31942.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109430. 98 interactors.
IntActiP31942. 62 interactors.
MINTiMINT-5004191.
STRINGi9606.ENSP00000265866.

PTM databases

iPTMnetiP31942.
PhosphoSitePlusiP31942.
SwissPalmiP31942.

Polymorphism and mutation databases

BioMutaiHNRNPH3.
DMDMi23503095.

Proteomic databases

EPDiP31942.
MaxQBiP31942.
PaxDbiP31942.
PeptideAtlasiP31942.
PRIDEiP31942.
TopDownProteomicsiP31942-1. [P31942-1]
P31942-2. [P31942-2]

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000265866; ENSP00000265866; ENSG00000096746. [P31942-1]
ENST00000354695; ENSP00000346726; ENSG00000096746. [P31942-2]
GeneIDi3189.
KEGGihsa:3189.
UCSCiuc001jnw.5. human. [P31942-1]

Organism-specific databases

CTDi3189.
GeneCardsiHNRNPH3.
HGNCiHGNC:5043. HNRNPH3.
HPAiHPA038264.
MIMi602324. gene.
neXtProtiNX_P31942.
OpenTargetsiENSG00000096746.
PharmGKBiPA162391325.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4211. Eukaryota.
ENOG410Z6M0. LUCA.
GeneTreeiENSGT00760000119102.
HOVERGENiHBG055557.
InParanoidiP31942.
KOiK12898.
OMAiLPWSCTQ.
OrthoDBiEOG091G0CTJ.
PhylomeDBiP31942.
TreeFamiTF316157.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000096746-MONOMER.

Miscellaneous databases

ChiTaRSiHNRNPH3. human.
GeneWikiiHNRPH3.
GenomeRNAii3189.
PROiP31942.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000096746.
CleanExiHS_HNRNPH3.
ExpressionAtlasiP31942. baseline and differential.
GenevisibleiP31942. HS.

Family and domain databases

Gene3Di3.30.70.330. 2 hits.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
[Graphical view]
PfamiPF00076. RRM_1. 2 hits.
[Graphical view]
SMARTiSM00360. RRM. 2 hits.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 2 hits.
PROSITEiPS50102. RRM. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHNRH3_HUMAN
AccessioniPrimary (citable) accession number: P31942
Secondary accession number(s): A8K682
, B3KRE1, Q9BSX1, Q9NP53, Q9NP96, Q9NPA7, Q9NPI4, Q9UFU4, Q9Y4J5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: September 19, 2002
Last modified: November 2, 2016
This is version 171 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.