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Protein

Cytochrome b-c1 complex subunit 1, mitochondrial

Gene

UQCRC1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. This protein may mediate formation of the complex between cytochromes c and c1.

GO - Molecular functioni

  • metalloendopeptidase activity Source: GO_Central
  • protein complex binding Source: Ensembl
  • ubiquinol-cytochrome-c reductase activity Source: ProtInc
  • ubiquitin protein ligase binding Source: ParkinsonsUK-UCL
  • zinc ion binding Source: GO_Central

GO - Biological processi

  • aerobic respiration Source: ProtInc
  • mitochondrial electron transport, ubiquinol to cytochrome c Source: GO_Central
  • oxidation-reduction process Source: ProtInc
  • oxidative phosphorylation Source: ProtInc
  • protein processing Source: GO_Central
  • response to activity Source: Ensembl
  • response to alkaloid Source: Ensembl

Keywordsi

Biological processElectron transport, Respiratory chain, Transport

Enzyme and pathway databases

ReactomeiR-HSA-611105. Respiratory electron transport.
SignaLinkiP31930.

Protein family/group databases

MEROPSiM16.973.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome b-c1 complex subunit 1, mitochondrial
Alternative name(s):
Complex III subunit 1
Core protein I
Ubiquinol-cytochrome-c reductase complex core protein 1
Gene namesi
Name:UQCRC1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:12585. UQCRC1.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: HPA
  • mitochondrial inner membrane Source: Reactome
  • mitochondrial respiratory chain Source: ProtInc
  • mitochondrial respiratory chain complex III Source: GO_Central
  • mitochondrion Source: UniProtKB
  • myelin sheath Source: Ensembl

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi7384.
OpenTargetsiENSG00000010256.
PharmGKBiPA37216.

Chemistry databases

DrugBankiDB08453. 2-NONYL-4-HYDROXYQUINOLINE N-OXIDE.
DB07778. FAMOXADONE.
DB07401. METHYL (2Z)-2-(2-{[6-(2-CYANOPHENOXY)PYRIMIDIN-4-YL]OXY}PHENYL)-3-METHOXYACRYLATE.
DB08330. METHYL (2Z)-3-METHOXY-2-{2-[(E)-2-PHENYLVINYL]PHENYL}ACRYLATE.
DB04741. Myxothiazol.
DB08690. UBIQUINONE-2.

Polymorphism and mutation databases

BioMutaiUQCRC1.
DMDMi92090651.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 34MitochondrionCombined sources1 PublicationAdd BLAST34
ChainiPRO_000002678635 – 480Cytochrome b-c1 complex subunit 1, mitochondrialAdd BLAST446

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei111N6-acetyllysineCombined sources1
Modified residuei138N6-acetyllysineBy similarity1
Modified residuei163N6-acetyllysine; alternateBy similarity1
Modified residuei163N6-succinyllysine; alternateBy similarity1
Modified residuei212PhosphoserineBy similarity1
Modified residuei248N6-acetyllysineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiP31930.
MaxQBiP31930.
PaxDbiP31930.
PeptideAtlasiP31930.
PRIDEiP31930.

2D gel databases

OGPiP31930.
REPRODUCTION-2DPAGEiIPI00013847.
SWISS-2DPAGEiP31930.
UCD-2DPAGEiP31930.

PTM databases

iPTMnetiP31930.
PhosphoSitePlusiP31930.
SwissPalmiP31930.

Expressioni

Gene expression databases

BgeeiENSG00000010256.
CleanExiHS_UQCRC1.
ExpressionAtlasiP31930. baseline and differential.
GenevisibleiP31930. HS.

Organism-specific databases

HPAiCAB033782.
HPA002815.
HPA003525.

Interactioni

Subunit structurei

The bc1 complex contains 11 subunits: 3 respiratory subunits (cytochrome b, cytochrome c1 and Rieske/UQCRFS1), 2 core proteins (UQCRC1/QCR1 and UQCRC2/QCR2) and 6 low-molecular weight proteins (UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and a cleavage product of Rieske/UQCRFS1).

GO - Molecular functioni

  • protein complex binding Source: Ensembl
  • ubiquitin protein ligase binding Source: ParkinsonsUK-UCL

Protein-protein interaction databases

BioGridi113230. 57 interactors.
IntActiP31930. 28 interactors.
MINTiMINT-3012677.
STRINGi9606.ENSP00000203407.

Structurei

3D structure databases

ProteinModelPortaliP31930.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG0960. Eukaryota.
COG0612. LUCA.
GeneTreeiENSGT00550000074701.
HOGENOMiHOG000242450.
HOVERGENiHBG006393.
InParanoidiP31930.
KOiK00414.
OMAiFFLQGQW.
OrthoDBiEOG091G05W9.
PhylomeDBiP31930.
TreeFamiTF105032.

Family and domain databases

InterProiView protein in InterPro
IPR011249. Metalloenz_LuxS/M16.
IPR011765. Pept_M16_N.
IPR007863. Peptidase_M16_C.
PfamiView protein in Pfam
PF00675. Peptidase_M16. 1 hit.
PF05193. Peptidase_M16_C. 1 hit.
SUPFAMiSSF63411. SSF63411. 2 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P31930-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAASVVCRAA TAGAQVLLRA RRSPALLRTP ALRSTATFAQ ALQFVPETQV
60 70 80 90 100
SLLDNGLRVA SEQSSQPTCT VGVWIDVGSR FETEKNNGAG YFLEHLAFKG
110 120 130 140 150
TKNRPGSALE KEVESMGAHL NAYSTREHTA YYIKALSKDL PKAVELLGDI
160 170 180 190 200
VQNCSLEDSQ IEKERDVILR EMQENDASMR DVVFNYLHAT AFQGTPLAQA
210 220 230 240 250
VEGPSENVRK LSRADLTEYL STHYKAPRMV LAAAGGVEHQ QLLDLAQKHL
260 270 280 290 300
GGIPWTYAED AVPTLTPCRF TGSEIRHRDD ALPFAHVAIA VEGPGWASPD
310 320 330 340 350
NVALQVANAI IGHYDCTYGG GVHLSSPLAS GAVANKLCQS FQTFSICYAE
360 370 380 390 400
TGLLGAHFVC DRMKIDDMMF VLQGQWMRLC TSATESEVAR GKNILRNALV
410 420 430 440 450
SHLDGTTPVC EDIGRSLLTY GRRIPLAEWE SRIAEVDASV VREICSKYIY
460 470 480
DQCPAVAGYG PIEQLPDYNR IRSGMFWLRF
Length:480
Mass (Da):52,646
Last modified:April 4, 2006 - v3
Checksum:iE76B082166CAF48F
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_034581215D → H. Corresponds to variant dbSNP:rs17080284Ensembl.1
Natural variantiVAR_013629301N → S2 PublicationsCorresponds to variant dbSNP:rs144710790Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L16842 mRNA. Translation: AAA20046.1.
D26485 mRNA. Translation: BAA05495.1.
AK313090 mRNA. Translation: BAG35915.1.
CH471055 Genomic DNA. Translation: EAW64898.1.
BC009586 mRNA. Translation: AAH09586.1.
CCDSiCCDS2774.1.
PIRiA48043.
RefSeqiNP_003356.2. NM_003365.2.
UniGeneiHs.119251.

Genome annotation databases

EnsembliENST00000203407; ENSP00000203407; ENSG00000010256.
GeneIDi7384.
KEGGihsa:7384.
UCSCiuc003cub.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiQCR1_HUMAN
AccessioniPrimary (citable) accession number: P31930
Secondary accession number(s): B2R7R8, Q96DD2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: April 4, 2006
Last modified: August 30, 2017
This is version 177 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Does not seem to have a protease activity as it lack the zinc-binding site.Curated

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Peptidase families
    Classification of peptidase families and list of entries
  6. SIMILARITY comments
    Index of protein domains and families