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P31930

- QCR1_HUMAN

UniProt

P31930 - QCR1_HUMAN

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Protein

Cytochrome b-c1 complex subunit 1, mitochondrial

Gene

UQCRC1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. This protein may mediate formation of the complex between cytochromes c and c1.

GO - Molecular functioni

  1. metal ion binding Source: InterPro
  2. ubiquinol-cytochrome-c reductase activity Source: ProtInc

GO - Biological processi

  1. aerobic respiration Source: ProtInc
  2. cellular metabolic process Source: Reactome
  3. hydrogen ion transmembrane transport Source: GOC
  4. mitochondrial electron transport, ubiquinol to cytochrome c Source: Ensembl
  5. oxidation-reduction process Source: ProtInc
  6. oxidative phosphorylation Source: ProtInc
  7. respiratory electron transport chain Source: Reactome
  8. response to activity Source: Ensembl
  9. response to alkaloid Source: Ensembl
  10. small molecule metabolic process Source: Reactome
Complete GO annotation...

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Enzyme and pathway databases

ReactomeiREACT_22393. Respiratory electron transport.
SignaLinkiP31930.

Protein family/group databases

MEROPSiM16.973.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome b-c1 complex subunit 1, mitochondrial
Alternative name(s):
Complex III subunit 1
Core protein I
Ubiquinol-cytochrome-c reductase complex core protein 1
Gene namesi
Name:UQCRC1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 3

Organism-specific databases

HGNCiHGNC:12585. UQCRC1.

Subcellular locationi

GO - Cellular componenti

  1. mitochondrial inner membrane Source: Reactome
  2. mitochondrial respiratory chain Source: ProtInc
  3. mitochondrial respiratory chain complex III Source: Ensembl
  4. mitochondrion Source: UniProt
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA37216.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 3434Mitochondrion1 PublicationAdd
BLAST
Chaini35 – 480446Cytochrome b-c1 complex subunit 1, mitochondrialPRO_0000026786Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei111 – 1111N6-acetyllysine1 Publication
Modified residuei138 – 1381N6-acetyllysineBy similarity
Modified residuei163 – 1631N6-acetyllysine; alternateBy similarity
Modified residuei163 – 1631N6-succinyllysine; alternateBy similarity
Modified residuei248 – 2481N6-acetyllysineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiP31930.
PaxDbiP31930.
PeptideAtlasiP31930.
PRIDEiP31930.

2D gel databases

OGPiP31930.
REPRODUCTION-2DPAGEIPI00013847.
SWISS-2DPAGEP31930.
UCD-2DPAGEP31930.

PTM databases

PhosphoSiteiP31930.

Expressioni

Gene expression databases

BgeeiP31930.
CleanExiHS_UQCRC1.
ExpressionAtlasiP31930. baseline and differential.
GenevestigatoriP31930.

Organism-specific databases

HPAiCAB033782.
HPA002815.
HPA003525.

Interactioni

Subunit structurei

The bc1 complex contains 11 subunits: 3 respiratory subunits (cytochrome b, cytochrome c1 and Rieske/UQCRFS1), 2 core proteins (UQCRC1/QCR1 and UQCRC2/QCR2) and 6 low-molecular weight proteins (UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and a cleavage product of Rieske/UQCRFS1).

Protein-protein interaction databases

BioGridi113230. 36 interactions.
IntActiP31930. 10 interactions.
MINTiMINT-3012677.
STRINGi9606.ENSP00000203407.

Structurei

3D structure databases

ProteinModelPortaliP31930.
SMRiP31930. Positions 35-476.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG0612.
GeneTreeiENSGT00550000074701.
HOGENOMiHOG000242450.
HOVERGENiHBG006393.
InParanoidiP31930.
KOiK00414.
OMAiFFLQGQW.
OrthoDBiEOG74R1QJ.
PhylomeDBiP31930.
TreeFamiTF105032.

Family and domain databases

Gene3Di3.30.830.10. 2 hits.
InterProiIPR011249. Metalloenz_LuxS/M16.
IPR011237. Pept_M16_dom.
IPR011765. Pept_M16_N.
IPR007863. Peptidase_M16_C.
[Graphical view]
PfamiPF00675. Peptidase_M16. 1 hit.
PF05193. Peptidase_M16_C. 1 hit.
[Graphical view]
SUPFAMiSSF63411. SSF63411. 2 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P31930-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAASVVCRAA TAGAQVLLRA RRSPALLRTP ALRSTATFAQ ALQFVPETQV
60 70 80 90 100
SLLDNGLRVA SEQSSQPTCT VGVWIDVGSR FETEKNNGAG YFLEHLAFKG
110 120 130 140 150
TKNRPGSALE KEVESMGAHL NAYSTREHTA YYIKALSKDL PKAVELLGDI
160 170 180 190 200
VQNCSLEDSQ IEKERDVILR EMQENDASMR DVVFNYLHAT AFQGTPLAQA
210 220 230 240 250
VEGPSENVRK LSRADLTEYL STHYKAPRMV LAAAGGVEHQ QLLDLAQKHL
260 270 280 290 300
GGIPWTYAED AVPTLTPCRF TGSEIRHRDD ALPFAHVAIA VEGPGWASPD
310 320 330 340 350
NVALQVANAI IGHYDCTYGG GVHLSSPLAS GAVANKLCQS FQTFSICYAE
360 370 380 390 400
TGLLGAHFVC DRMKIDDMMF VLQGQWMRLC TSATESEVAR GKNILRNALV
410 420 430 440 450
SHLDGTTPVC EDIGRSLLTY GRRIPLAEWE SRIAEVDASV VREICSKYIY
460 470 480
DQCPAVAGYG PIEQLPDYNR IRSGMFWLRF
Length:480
Mass (Da):52,646
Last modified:April 4, 2006 - v3
Checksum:iE76B082166CAF48F
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti215 – 2151D → H.
Corresponds to variant rs17080284 [ dbSNP | Ensembl ].
VAR_034581
Natural varianti301 – 3011N → S.2 Publications
Corresponds to variant rs144710790 [ dbSNP | Ensembl ].
VAR_013629

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L16842 mRNA. Translation: AAA20046.1.
D26485 mRNA. Translation: BAA05495.1.
AK313090 mRNA. Translation: BAG35915.1.
CH471055 Genomic DNA. Translation: EAW64898.1.
BC009586 mRNA. Translation: AAH09586.1.
CCDSiCCDS2774.1.
PIRiA48043.
RefSeqiNP_003356.2. NM_003365.2.
UniGeneiHs.119251.

Genome annotation databases

EnsembliENST00000203407; ENSP00000203407; ENSG00000010256.
GeneIDi7384.
KEGGihsa:7384.
UCSCiuc003cub.1. human.

Polymorphism databases

DMDMi92090651.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
L16842 mRNA. Translation: AAA20046.1 .
D26485 mRNA. Translation: BAA05495.1 .
AK313090 mRNA. Translation: BAG35915.1 .
CH471055 Genomic DNA. Translation: EAW64898.1 .
BC009586 mRNA. Translation: AAH09586.1 .
CCDSi CCDS2774.1.
PIRi A48043.
RefSeqi NP_003356.2. NM_003365.2.
UniGenei Hs.119251.

3D structure databases

ProteinModelPortali P31930.
SMRi P31930. Positions 35-476.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 113230. 36 interactions.
IntActi P31930. 10 interactions.
MINTi MINT-3012677.
STRINGi 9606.ENSP00000203407.

Protein family/group databases

MEROPSi M16.973.

PTM databases

PhosphoSitei P31930.

Polymorphism databases

DMDMi 92090651.

2D gel databases

OGPi P31930.
REPRODUCTION-2DPAGE IPI00013847.
SWISS-2DPAGE P31930.
UCD-2DPAGE P31930.

Proteomic databases

MaxQBi P31930.
PaxDbi P31930.
PeptideAtlasi P31930.
PRIDEi P31930.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000203407 ; ENSP00000203407 ; ENSG00000010256 .
GeneIDi 7384.
KEGGi hsa:7384.
UCSCi uc003cub.1. human.

Organism-specific databases

CTDi 7384.
GeneCardsi GC03M048636.
HGNCi HGNC:12585. UQCRC1.
HPAi CAB033782.
HPA002815.
HPA003525.
MIMi 191328. gene.
neXtProti NX_P31930.
PharmGKBi PA37216.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0612.
GeneTreei ENSGT00550000074701.
HOGENOMi HOG000242450.
HOVERGENi HBG006393.
InParanoidi P31930.
KOi K00414.
OMAi FFLQGQW.
OrthoDBi EOG74R1QJ.
PhylomeDBi P31930.
TreeFami TF105032.

Enzyme and pathway databases

Reactomei REACT_22393. Respiratory electron transport.
SignaLinki P31930.

Miscellaneous databases

ChiTaRSi UQCRC1. human.
GeneWikii UQCRC1.
GenomeRNAii 7384.
NextBioi 28912.
PROi P31930.
SOURCEi Search...

Gene expression databases

Bgeei P31930.
CleanExi HS_UQCRC1.
ExpressionAtlasi P31930. baseline and differential.
Genevestigatori P31930.

Family and domain databases

Gene3Di 3.30.830.10. 2 hits.
InterProi IPR011249. Metalloenz_LuxS/M16.
IPR011237. Pept_M16_dom.
IPR011765. Pept_M16_N.
IPR007863. Peptidase_M16_C.
[Graphical view ]
Pfami PF00675. Peptidase_M16. 1 hit.
PF05193. Peptidase_M16_C. 1 hit.
[Graphical view ]
SUPFAMi SSF63411. SSF63411. 2 hits.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Complete coding sequence, intron/exon organization, and chromosomal location of the gene for the core I protein of human ubiquinol-cytochrome c reductase."
    Hoffman G.G., Lee S., Christiano A.M., Chung-Honet L.C., Cheng W., Katchman S., Uitto J., Greenspan D.S.
    J. Biol. Chem. 268:21113-21119(1993) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT SER-301.
    Tissue: Placenta.
  2. "A complete cDNA sequence for core I protein subunit of human ubiquinol-cytochrome c reductase."
    Islam M.M., Tanaka M., Suzuki H., Torii K., Hattori N., Ozawa T.
    Biochem. Mol. Biol. Int. 32:797-805(1994) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Fibroblast.
  3. Erratum
    Islam M.M., Tanaka M., Suzuki H., Torii K., Hattori N., Ozawa T.
    Biochem. Mol. Biol. Int. 33:410-410(1994) [PubMed] [Europe PMC] [Abstract]
  4. Erratum
    Islam M.M., Tanaka M., Suzuki H., Torii K., Hattori N., Ozawa T.
    Biochem. Mol. Biol. Int. 33:815-815(1994) [PubMed] [Europe PMC] [Abstract]
  5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Subthalamic nucleus.
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Bone marrow.
  8. Cited for: PROTEIN SEQUENCE OF 35-45.
    Tissue: Liver.
  9. Lubec G., Vishwanath V., Chen W.-Q., Sun Y.
    Submitted (DEC-2008) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 86-99; 214-225; 229-248; 397-415; 424-442; 448-470 AND 473-479, IDENTIFICATION BY MASS SPECTROMETRY.
    Tissue: Brain, Cajal-Retzius cell and Fetal brain cortex.
  10. "Vectorial proteomics reveal targeting, phosphorylation and specific fragmentation of polymerase I and transcript release factor (PTRF) at the surface of caveolae in human adipocytes."
    Aboulaich N., Vainonen J.P., Stralfors P., Vener A.V.
    Biochem. J. 383:237-248(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: PROTEIN SEQUENCE OF 143-165; 181-209 AND 397-415.
    Tissue: Adipocyte.
  11. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
    Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
    Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-111, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  12. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  13. "A mitochondrial cytochrome b mutation but no mutations of nuclearly encoded subunits in ubiquinol cytochrome c reductase (complex III) deficiency."
    Valnot I., Kassis J., Chretien D., de Lonlay P., Parfait B., Munnich A., Kachaner J., Rustin P., Roetig A.
    Hum. Genet. 104:460-466(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT SER-301.

Entry informationi

Entry nameiQCR1_HUMAN
AccessioniPrimary (citable) accession number: P31930
Secondary accession number(s): B2R7R8, Q96DD2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 1993
Last sequence update: April 4, 2006
Last modified: October 29, 2014
This is version 150 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Does not seem to have a protease activity as it lack the zinc-binding site.Curated

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Peptidase families
    Classification of peptidase families and list of entries
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3